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On multi-domain approaches for prevention trials
Miia Kivipelto, Karolinska Institutet, Stockholm, Sweden
Friday, Oct. 23, 2015 · 1:04 p.m. · 35m 09s
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And one fifteen a multi domain
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interventions are are more prone to in
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my my other research is focusing on the
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question can we prevent comedy team
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vehement dementia and alzheimer's
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disease. And the I was planning first
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to shoulder short at brief that at this
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they just what we know what I'll get
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there realistic of ease of zoning risk
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and protective factors put demands on
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alzheimer's disease. And then just
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mention our present if in the try all
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that one of that is one of the first
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multi domain intervention trials aiming
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to prevent quality in the map and
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image. And finally a little a little
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bit about our future directions and
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here is this really highlighting the
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need of multi domain model emission of
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studies approximately prevention
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programs just thought we'd I just want
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to remind us about this so that from
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level we are facing I'm know these
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numbers where present D yesterday
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evening during the dinner but in case
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you need some refreshment for your
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memory so you can see the numbers here
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actually a refill so ago someone there
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were is diagnosed with dimension I do a
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lot more than forty seven newly on the
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emancipation pitches to and because of
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the ending of the population is number
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is expecting do that by two thousand
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and thirty and more than three people
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like to that's enough if that you
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chuckle as a we all know that the
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master add close these a lot of
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suffering for patients and caregivers
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but it's also very costly you know we
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have us and you numbers for the
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international not also symmetrical
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report. And showing that it demands
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sell at cost much more what we thought
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previous these are the numbers more
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than I hundred billion dollars in this
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means that you demons like here where
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the country you could be that works
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eighteen blocks east it and that's why
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I don't think it is not so surprising
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maybe that is not anymore we we
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researchers and doctors who have so
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much interest for demons that but it's
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really getting a lot of political
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tension that's well recently G eight
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countries I had a dream is to some EWA
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small have organised a ministerial
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conference call role model for for for
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the men stuff. And all these is both
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these of lighting that message to be a
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public right interestingly has been
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also highlight the that prevention
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should PCRCD element if we want to
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match these these demons and at the
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same time it has been getting
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increasingly clear but finding their
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treatments for somebody sees is maybe a
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a good show us what we previously
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thought and if you really want to your
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new solutions we need to have a full
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picture but outside of DC and we need
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to have more elaborate you need to have
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more more more more collaboration
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between different stakeholders. But my
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topic today is about prevention I
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request and here is what can we do or
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can do something to prevent demon
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somehow I would say that we can do many
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things. And like really the beach or a
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I'll I'll somebody sees has changed
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quite a lot with the last ten to
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fifteen years. We know now that
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ultimately see is the very next this
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easier multi factorial and
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heterogeneous. And besides signs age
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and it's also a high case and genetic
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factors explosive too barrios
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environmental factors throwing throwing
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all throughout the whole line of course
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ethics we get the disease. I went and
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that's like the line forced perspective
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and multi factorial approach are so
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important. And I think this is much
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more optimistic picture of also it is
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it keeps the ones several possible it
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what the interventions that also
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several said about time windows when we
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can do the benches high age is you the
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most important risk factor forty
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minutes and alzheimer's disease. And
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and I think it's interesting but now we
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have a several reports for different
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countries reporting that and demands
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that you see as or an eight set a
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specific prevalence rate of events at
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ease may be raising in some come here
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you see every board you know at least
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two studies from US one for the net
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once we have a phone call from Sweden
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out for one study from UK think is this
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what these demons seconds against
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decrease do you have any suggestions no
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you have you know already that are of
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us are used con he if been on so why
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it's happening but it has been fine but
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this like that this has something to do
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we increase educational level read use
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an insidious for stroll past risk
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factors held the online only a you know
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we have always useful within countries
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and deal a summary reports that for
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example in china or the situation may
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be different and if we think if you
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share. BCD and diabetes decide
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increasing so we we on know all the
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trends will continue after some years
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later at the last you direct. Indeed as
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that prevention of demon something we
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will support at least partially in the
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same way is possible for many of the
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chronic diseases like cardiovascular
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and on this and strong and and this is
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a very much in line with our annual
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sick all studies need several
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modifiable risk factors to demons and
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ultimately yeah you can see in main
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factors and I have highlighted the
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factors where we have strong evidence
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where we have several high quality role
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to get real sick constantly pointing to
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the same direction. And that's about
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all I did a lot of that's a lot of us
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were related risk factors the also some
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maybe danceable cycles also factors
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like eighty percent and the stress. And
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there are also many probably factors
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for example a device by both physically
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mentally and soul something. And that's
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you can see many dietary Dunning
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related factors explicitly eating lot
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of for weeks and vegetables and the
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occidental and white them is from for
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not so much evidence for the
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supplements may be one hell people. And
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he's is and even coffee may be project
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next question to what extent and also I
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demands that can be prevent easy ten
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percent though is it fifty percent
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ninety percent what do you think yeah
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you can put it right here discourse and
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it's also difficult that we don't know
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have been defined inmates around fifty
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percent or sixty percent one of the
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most recent ones should says that
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around thirty percent of all Simon case
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these can you relate to the east and
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bad modifiable risk factors diabetes
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hypertension obesity physically
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activity deeper smoking and low
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education out like this is simply more
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at thirty percent is that this was a
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bit more yeah for one so that it it
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makes it it may show you need to call
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that these factors are open in the
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really deeply may not you or they are
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not totally. Indeed and at what these
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course are quite high for me at least
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thirty per cent of eighty eight maybe
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it's not realistic that we can totally
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take away all of these risk factors but
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it doesn't mean also it's it may be
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that you would change read all of these
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same end of risk factors around ten per
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cent. K and to two thousand and I
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suppose we would need at that we reduce
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the amount of eighty nations by eight
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process. E we will be the union as
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school that we can we use these risk
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factors when the person gate is would
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be to fifteen percent reduction and in
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absolute numbers keep this would mean
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around. S sixteen million fewer cases
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so he's is a reduction. And not like
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talking about prevention sometimes I
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think that we are not exactly sure if
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it's really a green preventing or
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probably more roles boarding the onset
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of the demon stuff maybe I personally
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have started to talk more about risk
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reduction that's maybe the more yeah
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really stick to what we should use and
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what of games all parties the impedance
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from a randomised control trials as you
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know my field we have very famous quote
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that we have many trials in suspension
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on English these what has been shown in
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a difficult of bodies when we do that
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right we have some evidence here I the
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the the previous drawing on what comes
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to five or one second I'll lifestyle
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factors and not to prevent only T
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impairment even methanol if we look the
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pharmacological agents this strong
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maybe this is for one type that is the
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crux at but okay there is really
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nothing or is something even it all the
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side effect or aside results like was
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the a lover replacement there for an
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ultrasound because we have maybe I
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would say some postings amounts hope
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you twelve supplementation post some
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comes mainly what the pray for some
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spot what does it may know to be more
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of them is the we have some I'm single
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CD signals from sort smaller monitor
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trials or certain physical activity
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only training some dietary factors for
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dietary patterns for example that
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mediterranean. So there is something we
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can of course I like you so many trials
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I'm sure the one will talk more about
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these are the Mike two O one son what I
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just want to mention already know he's
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we know ultimately CE multi factorial
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the disease or or disorder. And maybe
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it's not enough if we only focus on one
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risk factor old one wine I mean we may
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need to topic several risk factors
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simultaneously to get a team Mart
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prevent it effect something what we all
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multi domain approach and problems has
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been working very well for a probably
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this C here is an example from the
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thing is diabetes prevents sense not
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that that's really a more a randomised
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control trial. So that the line and
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intervention we dietary counselling and
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physical activity a reviews diabetes
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easy that's right in the only sixty
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first on probation as well in there
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proposal colour so it seems that these
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multi domain concept is working and the
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only and other other stimulus. OK for
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aspiration to start feeling dry I think
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there isn't being there is one of the
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first multi domain in the desert trials
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really trying to prevent cognitive
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impairment this two thousand and nine
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unexplored in a by conventional
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national good for health and welfare in
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Helsinki in one but as you can see is
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conducted in a collaboration between
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many universities both in the mountains
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we oh yes a proof of concept from I R
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really take that multi domain approach
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to only DVD quite prepared here we
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thought was one a trees made of send
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the wrong every population. So always
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good to remember that these will not
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based. And are the the thing that while
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this as a two year multi domain
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independent should we go on the fact
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those from beneath right so you know we
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had the strong and they're just not
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possible to check. So you know we have
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a oh bonus to try if did not functional
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items physical activity only training
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house also activities and wondering and
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Maggie smith the one bit muscular and
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may not only risk we have only one all
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summer to one thousand two hundred and
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sixty processing to try a case based
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craze was from sixty to seventy seven
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years. And process where randomise into
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two groups to get these Indians device
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that intervention or four to lock it.
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And we use our previous nations and
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also the base to recruit these verses
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that came to us very many free baseline
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data set that is not normally available
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in this type of try and you can see see
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centres that we're in for a wee bit two
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years intervention was for eighty two
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thousand and fourteen so we have had
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very exciting year and times to analyse
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the data we are now working also we
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extended the law that will last until
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seven years in this I provide mentioned
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that this is risk their population and
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we used to include some criteria to to
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to try first one is the demands the
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risk for that we have no over there so
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persons have time for that you need
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that we support remote risk factors for
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demands that as you can see here by age
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low education I press the high body
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must index little pieces that are so it
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means that these verses had different
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risk profiles for device that they can
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have different combinations of these
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facts. This criteria was cornish
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donation but I mean it was like you
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know what that expected for hates soul
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practically we to away personal so
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perfect memory but we also excluded
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versus what rear on the TV yeah so I
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think is at risk population yeah yeah
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and then in addition. So I you see we
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have didn't we shot here we see a
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nutrition now I don't know was that not
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recently of these sessions. And we use
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both group sessions that individual
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sessions F with this maybe we have both
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I will be on I would become a training.
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And that was also led like a
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physiotherapist specificity at it when
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we started the interventions because
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many people had they had not been doing
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so basic that I and I think that's the
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training is getting more and more
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intense even frequent the we could talk
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if a training we used a computer based
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training program to in April
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individuality I just think difficulty
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level doing this study and then we had
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finally these metaphoric a risk factor
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control where we had this seaside
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doctors we not prescribed any
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medication think the trial but of
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course if the person had high values be
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highly recommended that person to be
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see it all up how how and the quote
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from where we are as previously the
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question about the antique all issues
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and that was the same here because of
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the issues we contract that blast but
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we need to do some advice about these
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factors email for this so called
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control group I if it must your these
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verses got their practical size. Well I
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would say won't even more because they
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came to us so they came to us more than
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ten times during these two years. So I
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only need the intervention versus a
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intensity that's we have been talking a
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lot about oh and that's why I want to
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show a little bit what we need for the
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directory affection basically we have
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been following the recommendations but
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healthy diet that is no to prevent
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diabetes and cardiovascular disease is
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so we but a lot of thought was not
00:17:41
related to top holes whole grain
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products that if we use so far in Tae
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and increase it as an unsaturated Fats
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vegetable always and that's quite most
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of the military yeah yeah I would say
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but we try to also use some of the low
00:18:01
other products for example not only
00:18:03
only oral but also rhapsody oil. And
00:18:06
also look out for that like for we are
00:18:08
like Paris blueberry and all this we
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have a a four insulate in our countries
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to really use also the local products
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that are easily available I'll I'll one
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specific thing in our intervention was
00:18:21
that we try to have to be more indirect
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you can find a little more week also we
00:18:27
do not only of Reading this please but
00:18:30
thoughts upon the really cool together
00:18:32
with the dietician they really doing
00:18:34
more practical examples and seem to be
00:18:37
very successful. And also I think that
00:18:40
they were doing the training in the
00:18:42
same call C to increase the motivation
00:18:45
and also keep some source of
00:18:47
stimulation for the person still
00:18:49
experience is happy variables see you
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on these spot right we are of course
00:18:58
many interested about nation and we
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said I knew outside psychotic that is
00:19:02
battery as the primary all on you use
00:19:06
the the fourteen different tests that
00:19:08
are in there it's just like suspect
00:19:11
they re very well break dancing or
00:19:14
hence the misery different aspects of
00:19:17
or ms we have also we specify secondary
00:19:21
outcomes what these main quality
00:19:24
domains executive function including
00:19:26
these this process things be a memory
00:19:29
but we also long list of secondary out
00:19:34
outcomes you somehow somebody sees you
00:19:36
know we need a really say many years of
00:19:38
all to really have enough power. But
00:19:41
that we also want to miss a depression
00:19:44
deceptively deep the quality of life.
00:19:47
You elicitation of health resources we
00:19:49
are interested to see what was that
00:19:51
don't benefit of these type of
00:19:53
intervention. And have a lot of black
00:19:56
markers I mean even for a number I yeah
00:19:59
because we want to understand what the
00:20:01
mitigating with what is happening in
00:20:03
the body when we get to this type of
00:20:05
legitimate like that there is no well
00:20:11
we a great that's not what was only
00:20:14
twelve per cent that is quite good I
00:20:16
think up to to to years for the main
00:20:19
analysis we use more divided into three
00:20:22
but I see including or persons who have
00:20:26
at least one old baseline mister what
00:20:31
do you think about the results did we
00:20:33
see something process we saw that we
00:20:38
were why why oh where we not this
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project because of course keeping the
00:20:44
background so many negative trials but
00:20:46
also we do not know if two years is
00:20:49
impose the all white have the
00:20:50
population. And you see what happened
00:20:53
after two years of the control group
00:20:56
and individual who is getting better
00:20:59
that is something happening in our
00:21:00
trials it would be because of the price
00:21:02
is and what because of these meanie
00:21:04
intervention what we did but you see
00:21:06
that the red alike intervention is
00:21:09
getting even better the intervention
00:21:11
simple you for twenty five percent more
00:21:14
well I wonder about that was highly
00:21:16
statistic thinking and the difference
00:21:20
was even what the free by secretary out
00:21:25
of the different domains here you see
00:21:28
what the executive function here in the
00:21:31
very simple piece improving eighty
00:21:33
three person more what the processing
00:21:35
speed one hundred feet the person more
00:21:38
improvements or you know the difference
00:21:39
is even bigger and the more complex
00:21:43
memory functions forty percent more
00:21:45
people we don't want to see if we can
00:21:49
see some difference what the quantity
00:21:51
decline. We do not have enough basis
00:21:54
what dementia also disease so this is
00:21:57
all type of it only the decline that
00:22:00
happened with the two years. And it was
00:22:02
around twenty eight per cent of of this
00:22:05
population who declined to with this
00:22:07
time. And you see that one who had a
00:22:11
around thirty percent increased risk
00:22:13
for the decline at two in the two years
00:22:18
that for me please increases the
00:22:20
feeling that these findings also
00:22:22
clinically if if it it's not only the
00:22:24
statistical we also wanted to see what
00:22:29
happens with the lifestyle factors than
00:22:31
it was nice to see that there was a
00:22:33
very positive change sees deal after
00:22:36
two years as you can see here for
00:22:38
example feeds into a daily intake of
00:22:41
beta toppled physical maybe I feel
00:22:44
after two years in sense improved. So
00:22:46
we must stand there and I think that's
00:22:48
quite interesting because we all know
00:22:51
that the long lasting change seaside
00:22:53
difficult we can change the like stuff
00:22:55
for two months and then we all went
00:22:57
back to control well we're doing a lot
00:23:03
of interesting stuff on a nice is at
00:23:05
the moment you wanna show you only a
00:23:07
few examples of these us feel very
00:23:09
preliminary. So take it as such we are
00:23:13
interested about the interactions
00:23:15
between eight forty four and we have
00:23:19
that evidence from males other studies
00:23:22
that eight people areas may be more
00:23:24
vulnerable for a healthy lifestyle
00:23:26
factors but we have not all if there
00:23:30
was like is true if these verses card
00:23:32
that more the lights that intervention.
00:23:35
And looks like that that the the person
00:23:38
if that is more pronounced for two
00:23:40
spurs sets will have a twenty four and
00:23:43
that's again is for me quite optimistic
00:23:45
fine we are doing an interesting
00:23:49
analyses for the elevators and yeah it
00:23:53
looks like that intervention is EDOE
00:23:57
counteract the shortening of the
00:23:59
kilometres is your very preliminary
00:24:01
data but again it kind of shows that
00:24:04
thing is happening in the body
00:24:06
independent is really doing something
00:24:08
something like there we also interested
00:24:12
about these on their T about secondary
00:24:15
outcomes is like submit bit BBC I'm
00:24:19
sorry about that. But is is again only
00:24:21
preliminary findings but I wanted to
00:24:23
share them with you health related
00:24:25
quality of life in general this
00:24:28
population had very poor quality of
00:24:30
like so it was not so much decline
00:24:34
drawing that time the decline is to the
00:24:36
left for the minus but as you can see
00:24:39
the green and screen is is the
00:24:41
intervention. So yeah it was just that
00:24:44
improvement for the intervention for
00:24:47
but general feel every lady quality of
00:24:50
light as well as man. And fifty
00:24:53
function relate that the quality of
00:24:56
life and I thing I want shot in the
00:25:00
morning Tuesday very preliminary date
00:25:03
posted in the functional abilities that
00:25:07
eighty hours I thought ID as a function
00:25:10
and he's that again very preliminary
00:25:12
day at but it looks like that in
00:25:15
intervention cool has to all what role
00:25:19
has to high risk of be activities of
00:25:23
daily living in all these two in two
00:25:25
years as you can see here yeah every
00:25:29
school equine about one point five
00:25:32
buttons ideally the control group we
00:25:35
did not see anything specific for a if
00:25:38
we out of a luxury short for a for a
00:25:41
physical performance test but as they
00:25:44
these versus that very healthy we when
00:25:46
we thought okay together these the
00:25:49
increases the value of these these
00:25:51
intervention that he's having more
00:25:53
clinical more prone clinical effects as
00:25:56
well two slides about one is about the
00:26:02
side effects that's always an
00:26:04
interesting question if these type of
00:26:06
intervention say and it looks like
00:26:09
that. There was no serious adverse
00:26:12
events during the two years. And it was
00:26:14
a little bit more side effects in the
00:26:17
information simple but as you see but
00:26:19
mainly it's line muscular skeletal pay
00:26:22
off to achieving training. So and that
00:26:26
disappear when the training and andy. I
00:26:29
if you were to see also what's
00:26:31
happening with the stress if this
00:26:33
intervention is too stressful. But I
00:26:36
feel that this was not the case it was
00:26:38
only a few purses with three or more
00:26:40
stress and we don't know if if it has
00:26:42
anything to do with that right. So I
00:26:45
think that these intervention is is how
00:26:50
how dress all these three person is
00:26:52
able to follow our parts we don't know
00:26:57
yet forty eight case is that only
00:26:59
always reported numbers for
00:27:01
participation. But I nearly any of the
00:27:05
person's game two us at least a few
00:27:07
times they they participate in these in
00:27:10
these interventions and is a
00:27:14
participation was for nutrition that
00:27:16
was really the popular people like
00:27:20
that. Well in training it was a beep or
00:27:22
at ideas may have something to do that
00:27:25
we use the computer based training and
00:27:27
some elderly people did not really they
00:27:30
were not used to use that as you know I
00:27:31
think that numbers a white and while
00:27:35
Winston nist here he's a person is able
00:27:38
to pull it don't make a so they only
00:27:41
taking one of them. But that you see
00:27:44
here more than seventy person of the
00:27:47
person of the verses say that they
00:27:49
could participate in all four domains
00:27:52
me that these type of multi domain
00:27:55
intervention may also be white piece.
00:27:57
Well I if you liked about the future
00:28:02
yeah I think yeah Venus studies of
00:28:07
course the important but it's not
00:28:09
enough. And I'm very happy that in are
00:28:13
we have also are there lots multi
00:28:15
domain independent trials I mean at
00:28:18
least something more european demons
00:28:21
that prevents it immediately to get
00:28:23
that we this to other try. We have not
00:28:26
try all in France led by for not the
00:28:29
alliance with here today have well I we
00:28:32
have free divers starting even
00:28:34
netherlands. And I know that man free
00:28:37
for the first results already during
00:28:40
the eight AIC meeting the people also
00:28:42
the meeting last july. And it looks
00:28:45
that these results are also close it it
00:28:48
especially in these trial. And there
00:28:50
was a lot different parts and inspected
00:28:53
the army the model domain lifestyle
00:28:56
intervention and all make that three
00:28:58
seem to have that effect way the
00:29:01
intervention was finished and that was
00:29:03
a bit longer it was three for three
00:29:05
years problem noise like happy to
00:29:07
answer what they more for instance but
00:29:09
but I think it's really encouraging
00:29:11
that this is still the same thing and
00:29:13
the thing is that but tight but I do
00:29:16
not know but I'm not that they should
00:29:18
if we want the results doing the next
00:29:21
we breed I don't want to be different
00:29:24
because that was the plus they're
00:29:25
randomisation they be not randomised it
00:29:28
process but they randomise the she
00:29:31
chi's that that they tried to keep more
00:29:33
is the possible a way with all these
00:29:38
studies have you reporting intimate
00:29:40
freestyle we have I did not feel a the
00:29:43
poor for something I to put together
00:29:46
all that and in that way we will have
00:29:49
more than six thousand parts. And this
00:29:52
one came to us possibility to do even
00:29:55
more some analyses and for example also
00:29:59
the question how much physical activity
00:30:01
all how people physical activities need
00:30:04
to where that the the effect what we
00:30:08
want to see see here and the rest of
00:30:12
what we have been in and we starts a is
00:30:15
the implementation I we do have enough
00:30:19
maybe to implement these freaks out.
00:30:22
And one where you're down use you know
00:30:25
nazi somehow to disseminate these
00:30:28
findings to wider population. So we
00:30:31
have can see a PDF on this project help
00:30:35
the paging through internet account
00:30:37
sitting in the L three and he seemed
00:30:39
really we have been trying to feel and
00:30:43
indirect the internet or we already
00:30:46
available no support that come what
00:30:49
debate as to or likes to change the
00:30:52
randomised control trial includes a
00:30:54
four thousand six hundred persons in
00:30:57
three different countries and we'll
00:30:58
keep some are accessible disgraced what
00:31:03
I saw a menu for all these speak multi
00:31:06
nation of these is mine eighty project
00:31:10
I'm really in in the supported by that
00:31:13
CD and D and and here shortly what we
00:31:16
try to do is to take a multi domain
00:31:19
protocols forefinger around that and
00:31:22
then then memory cleaning bases we're
00:31:25
already have my all seventy six and I
00:31:28
think that's an important question
00:31:30
because we do not have all evidence
00:31:32
space line lies but these patient
00:31:35
groups that we do not have so what
00:31:36
medications when you see it in with the
00:31:41
normal directory find out what do we
00:31:43
need to keep this I usually have limit
00:31:46
or medical four so that one based on
00:31:49
what we will start in the mine eighty
00:31:51
problem I finally I would say this is
00:31:56
the big chance what we still had free
00:31:59
version I think it has been going quite
00:32:01
well at least we have some tools what
00:32:04
we can to already know but when you
00:32:06
really have to drop about somebody sees
00:32:09
disease modifying trucks has been yeah
00:32:12
you can feel or or well being trials is
00:32:15
a bigger has been a date two thousand
00:32:18
thirteen so if it's not exactly a
00:32:22
person button support be sure what is
00:32:25
happening in the field yeah you can see
00:32:28
everything for the frequently about
00:32:29
base one two and three and these spend
00:32:32
hours at every person different colour
00:32:35
everything that is right has something
00:32:37
to do with the PI remote nation trials
00:32:40
for example. So you can see that the P
00:32:43
I'm like dusting clearly don't mean a
00:32:45
thing if I would say that last you're
00:32:48
not clearly to be more try also even
00:32:51
focusing on other topics for example
00:32:54
tile and and agent that I use already
00:32:57
in there we have like easily that he is
00:33:01
and he occupied. So and no one will
00:33:04
tell you more about that some of these
00:33:06
here. But I would think that you if the
00:33:08
same thing like for for for the for the
00:33:11
prevention we need to have a folder
00:33:14
picture about alzheimer's disease. And
00:33:16
probably we need to start earlier
00:33:18
prevention is the key here as well. You
00:33:21
know we also need to do more fit not
00:33:22
typing on somebody sees is complex and
00:33:25
multi factorial it's heterogeneous so
00:33:27
what I have three as we need to
00:33:29
solidify the right it up that's what
00:33:31
the white trucks well my take home
00:33:35
points how to prevent dimension I think
00:33:38
timing is very important we need to
00:33:40
start early maybe we need to start
00:33:43
already I mean wiping finger but the
00:33:46
older population and who use for
00:33:49
injuries that it's never too late it
00:33:51
seems that you can always do something
00:33:53
but probably use start you you can even
00:33:55
better better results multi factorial
00:34:00
and you'll see me I really we need
00:34:02
multi domain interventions to really
00:34:04
have the effect even yeah outcome here.
00:34:08
And I hope that there can be a much
00:34:10
more that can be this than I
00:34:13
embarrassed things population and
00:34:16
finally for the future I think it's
00:34:18
really important to have a small nation
00:34:20
out the trials and I'd really like to
00:34:23
see more trials combining non
00:34:25
pharmacological pharmacological
00:34:27
battery. And not really we have enough
00:34:31
yes or dictate sounds if I said
00:34:33
immediate action. And here we should
00:34:35
start timing pragmatic prepare some
00:34:38
progress and think that the risk
00:34:41
factors plus year old menu risk factors
00:34:43
us here we we have a party I receive if
00:34:48
we make use should start that an
00:34:49
integrated interventions what the major
00:34:52
chronic diseases I I want to thank all
00:34:56
my oh I the different introduced and
00:34:59
all the funding agencies. And I one do
00:35:03
penis with this possibly beach. Thank
Conference Program
Introduction to the 12th Nestlé International Nutrition Symposium
Thomas Beck, NRC Director
Oct. 22, 2015 · 8:57 a.m.
790 views
Introduction to Session I - Cognitive & Brain Development
Susan Gasser, Friedrich Miescher Institute, Basel, Switzerland
Oct. 22, 2015 · 9:04 a.m.
164 views
The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:16 a.m.
398 views
Q&A - The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:56 a.m.
Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 10:49 a.m.
155 views
Q&A - Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 11:29 a.m.
Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 11:38 a.m.
226 views
Q&A - Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 12:10 p.m.
Introduction to Session II - Cognitive Decline
Kathinka Evers
Oct. 22, 2015 · 2:02 p.m.
Brain health & brain diseases - future perspectives
Richard Frackowiak, CHUV University Hospital, Lausanne, Switzerland
Oct. 22, 2015 · 2:11 p.m.
120 views
Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:15 p.m.
Q&A - Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:59 p.m.
Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:21 p.m.
160 views
Q&A - Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:59 p.m.
Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
Oct. 23, 2015 · 9 a.m.
Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:16 a.m.
413 views
Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:53 a.m.
Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:29 a.m.
Q&A - Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:57 a.m.
Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:09 a.m.
152 views
Q&A - Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:49 a.m.
Introduction to Session IV - Decline & Nutritional Intervention
Tamas Bartfai, The Scripps Research Institute, La Jolla, USA
Oct. 23, 2015 · 12:48 p.m.
179 views
On multi-domain approaches for prevention trials
Miia Kivipelto, Karolinska Institutet, Stockholm, Sweden
Oct. 23, 2015 · 1:04 p.m.
218 views
Q&A - On multi-domain approaches for prevention trials
Miia Kivipelto, MD, PhD, Karolinska Institutet
Oct. 23, 2015 · 1:39 p.m.
Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 1:49 p.m.
124 views
Q&A - Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 2:32 p.m.
We are what we remember: memory and age related memory disorders
Eric R. Kandel, Columbia University, New York, USA
Oct. 23, 2015 · 3:03 p.m.
231 views
Concluding Remarks
Stefan Catsicas, Chief Technology Officer, Nestlé SA
Oct. 23, 2015 · 3:50 p.m.
168 views
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Dennis Bier, Children's Nutrition Research Center, Baylor College of Medicine, Houston, USA
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