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Q&A - Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Thursday, Oct. 22, 2015 · 4:59 p.m. · 09m 12s
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I suppose it's really interesting. So I
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questions yeah have one here since
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thank you very much. Very exciting I
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just wanted ass really big so getting
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back to these patients that have lots
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of amway. And why and this particular
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tangled okay but have no wholesalers
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Reggie disney's Susie LA or we having
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to you can my stuff No I think that
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would be something for for you know
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studies will people are actually
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looking into those patients to look
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into I mean you know it could not you
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Jenny died some not very easy to adhere
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to all you have to do is eat a little
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bit of carbs and you're done. So so I
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would be really really surprised about
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indian or are are are eating peter
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Jennings died but they may be genetic
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components like so for example what
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what what what he was talking about
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because I'm too and how term to
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regulates the the infiltrating Masai in
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the that give rise to micro clear and
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then regulate silent beta whereas the
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yolk sac to the or or origin eating my
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microbial resident remarkably actually
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performing a totally different task. So
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I think these things are not clear yet
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and it we also don't know whether these
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these cells actually producing any of
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these endogenous regulators that our
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restraining them parmesan this
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condition and maintaining a mistress so
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do you plan to be wonderful hypothesis
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just oh there you are last french Ascii
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oh very nice oh yeah the the probably
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tell from the borders combining this
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with the last oh it sounds like emily.
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So we I mean what was oh yes in certain
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states you're senile one beta
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expression perhaps that's a good target
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no but you know what I was also that
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they are I mean the way you're much oh
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yeah so what was the balance you need
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to do a bit old ones are what they
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don't know yes I think that's that's a
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very good point and we don't have an
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answer to it only because the mice I'm
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not old enough yet so so so so you know
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these studies yeah unlike alzheimer's
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my switch still or it nine months we
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have a desire most for two two years we
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actually don't know downstream of of of
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of you know artist plan was all because
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I showed you the data that I won't be
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that in fact mediates only part of
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these effects. So part of the other
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effects could be mediated by eighteen
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but I hate in this context is actually
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much more complicated because behind it
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and others have shown that in fact I
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leading is potentially a mistake in
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this case because it improves insulin
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sensitivity. So whether I wanna be a
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leading is driving those affects is not
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clear and it is also not clear that
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gasp is one it actually has multiple
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substrate some my SLA has has some data
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that suggest that it could also please
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certain black latex enzymes. So so I
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think the question in this from what we
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think is actually going upstream not
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bouncing and so so I think you probably
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seem to can you stated MCCNBSP so I
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think we think that going upstream is
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perhaps maybe a better better approach
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in this case so matter some comics are
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oh Some are nice but not much more to
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also use sort of like a specific for
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both forms of PHP digit SC last a yes
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this is a like yeah it has no effect
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and as Aussie so basically be it as a a
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bad doctor you could write plastic
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toward that's that's a bit and that
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it'll go then go to these here. I
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suggest it has no effect so we knocked
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out Scott from the macrophages which is
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one of the set sail quite transfers
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which is critical for people with us
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and then you knock it out in
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macrophages PHP still blocks dilemmas
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on this however one major caveat of
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this experiment and the meter caviar is
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that those macrophages are still
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exposed to blue colours. And yeah I
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didn't show you the data in fact that
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in these in these situations when they
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have glucose they are they just
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preferentially use glucose. They just
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wired to use logos. So I think those
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experiments have to be done in people
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in much more you know regulated
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conditions I think some of these data
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that I showed you I think is is not
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perfect because a lot of it is in in is
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in vitro and individual work is kind of
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going on right now to see how much of
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this this activation is the is the
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mediated by some of these enzymes that
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are required and and that it's actually
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have machinery for these things of this
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is data published image madison. And
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they had actually machinery forty
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dollars is so obviously there is a
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reason for this I I work at my it's
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slight victory but a are what's what's
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a you GI about you want these house a
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year or so I was like lot of buttons
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for you for oh oh the story. BI also or
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thought you should be much and you know
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I I IUISORSP that's lot of money
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possible you so you can use as a I
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That's that's what I was I yeah I I I
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think that's what I was what I have a
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question I you I I I I what I what I
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saw yes just because it's four times up
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it doesn't mean it has at the same
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level as when you have people. So those
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those experiments are not done with my
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stupid yes on ways an infection. So
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that's a totally different thing and I
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know this yeah point has these short
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finding out I don't exactly that's how
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you know telephone or basically by
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spiders inactivity. So most of these
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and one below. So that I don't data
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that is present in these animals didn't
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read the data is not measurable in
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circulation. And the un one be that
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that I'm showing you is present in the
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hippocampus but it is a relative to
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present in the old healthy animal. So
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what you're looking at is you cannot
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compare that level bit with an animal
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that has been in use would be a lot or
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you have gone have mastered by one and
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by the way these animals do not have a
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loss of appetite but they have no
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anorexia. So in this case I won't be
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nice not driving the hyper climbing is
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not writing like a hundred effects that
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that all your LO and you guys have
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started to bleed detail as far as we
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can discuss more if you buy me another
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bottle away I think I have one that's
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go Change that to be a particular about
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one more problem both common oh I just
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love to do that we should constantly
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with information example of the old
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site so what is this this is want but
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each of these and also at the same five
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oh is that multiple scroll this this
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CSI somewhat easy in terms of
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information or otherwise it's basically
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and I think is important if you want to
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target the that essential up there sure
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so of course I mean and S is is is very
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different from in this case and the
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reason why the MS is listed is because
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I want rising major regulator of the P
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at seventeen responses and if you
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target I want data you get improvement
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of several of these T at seventeen
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associated diseases in animal models is
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of improvement so of course you're not
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during the underlying cause of and
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that's by a targeting you know I won't
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be not get seventy in this case with
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regards to after role in fact these
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data had been published by us or not
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but in the actual model but increase
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off a set of lights and fee cholesterol
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that happens in the macrophages with
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age and the different by so you can
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actually call was really quite that
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many of these things that the actually
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really isn't macrophages. So and then I
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can last show that that these
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macrophages in that role models have
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also cholesterol pistols rejected the
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blinders on at least a progression of
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the outpost also so that like a lot of
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things. So in this case that are
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happening not just cholesterol crystals
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not to speak last role but also
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advantage that is that is happening
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that macrophages are sensing and
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getting activated but and this happens
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in in several of these these disease
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including that's as close success and I
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think candles trial like that a policy
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is potentially going to answer this the
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this question but with the several of
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these people that are gonna be treated
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mechanic you don't have some of them
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are older and some of them have
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different BMI so so we look forward to
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those type of data about thank you very
Conference Program
Introduction to the 12th Nestlé International Nutrition Symposium
Thomas Beck, NRC Director
Oct. 22, 2015 · 8:57 a.m.
790 views
Introduction to Session I - Cognitive & Brain Development
Susan Gasser, Friedrich Miescher Institute, Basel, Switzerland
Oct. 22, 2015 · 9:04 a.m.
164 views
The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:16 a.m.
398 views
Q&A - The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:56 a.m.
Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 10:49 a.m.
155 views
Q&A - Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 11:29 a.m.
Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 11:38 a.m.
226 views
Q&A - Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 12:10 p.m.
Introduction to Session II - Cognitive Decline
Kathinka Evers
Oct. 22, 2015 · 2:02 p.m.
Brain health & brain diseases - future perspectives
Richard Frackowiak, CHUV University Hospital, Lausanne, Switzerland
Oct. 22, 2015 · 2:11 p.m.
120 views
Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:15 p.m.
Q&A - Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:59 p.m.
Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:21 p.m.
160 views
Q&A - Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:59 p.m.
Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
Oct. 23, 2015 · 9 a.m.
Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:16 a.m.
413 views
Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:53 a.m.
Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:29 a.m.
Q&A - Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:57 a.m.
Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:09 a.m.
152 views
Q&A - Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:49 a.m.
Introduction to Session IV - Decline & Nutritional Intervention
Tamas Bartfai, The Scripps Research Institute, La Jolla, USA
Oct. 23, 2015 · 12:48 p.m.
179 views
On multi-domain approaches for prevention trials
Miia Kivipelto, Karolinska Institutet, Stockholm, Sweden
Oct. 23, 2015 · 1:04 p.m.
218 views
Q&A - On multi-domain approaches for prevention trials
Miia Kivipelto, MD, PhD, Karolinska Institutet
Oct. 23, 2015 · 1:39 p.m.
Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 1:49 p.m.
124 views
Q&A - Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 2:32 p.m.
We are what we remember: memory and age related memory disorders
Eric R. Kandel, Columbia University, New York, USA
Oct. 23, 2015 · 3:03 p.m.
231 views
Concluding Remarks
Stefan Catsicas, Chief Technology Officer, Nestlé SA
Oct. 23, 2015 · 3:50 p.m.
168 views
