Player is loading...
Q&A - Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Thursday, Oct. 22, 2015 · 3:59 p.m. · 07m 22s
Embed
Transcriptions
Note: this content has been automatically generated.
00:00:00
Are there many questions one here one
00:00:02
here we why we must have time for some
00:00:04
questions. So please we question
00:00:07
Christine I really need you know if you
00:00:10
want to be no one once we on TIBO three
00:00:16
months though they can become
00:00:18
unification Yeah so what we did was we
00:00:22
we we actually use an APP not a mouse.
00:00:25
And in fact that's why the papers not
00:00:26
coming up image is read the paper this
00:00:29
paper to show which is also a positive
00:00:31
integer for six months three revisions
00:00:34
in any end because we "'cause" when we
00:00:35
did EPP knockouts. We had a trend
00:00:38
toward them be more susceptible to
00:00:40
infection but a significance think is
00:00:43
as you try to argue to them you know
00:00:45
it's incredible redundancy in need a
00:00:47
new system you can't you can't go wrong
00:00:49
with it. So we were seeing other any
00:00:51
and you can I think about thirty seven
00:00:52
defendants going up any P knockout
00:00:55
mice. So they had some susceptibility
00:00:57
but it was a significant. So I think I
00:01:00
want you cannot express a data in CTO
00:01:03
protection. But we not only PP you get
00:01:06
some reduction in susceptibility but we
00:01:08
don't see I think it doesn't let you
00:01:10
see the whole thing and that's why it's
00:01:12
coming up the size transitional Madison
00:01:14
and that image. Oh I am too nasty
00:01:17
nutrition counsellor oh yeah people are
00:01:20
also said it's hard to predict anything
00:01:22
in especially future so I have a
00:01:25
question how does low social economic
00:01:27
stages critic you draw fire isn't what
00:01:30
it is that in a few months not myself
00:01:33
Well I not my area of of of of
00:01:37
expertise but there are studies to
00:01:38
suggest that for sure and I think we
00:01:41
doubts that you just think not only
00:01:43
about aspects of education but aspects
00:01:46
of hygiene because the the most
00:01:48
probably the the biggest source of
00:01:50
chronic infection information the body
00:01:52
you columns. Um I'm taken much better
00:01:54
care my teeth now tonight so this data
00:01:57
by the way but also gonna think about
00:01:59
about a a microbiology die have that
00:02:02
thing bugs in the right I'm this is our
00:02:04
one china territory we're actually
00:02:05
doing experiment now. So in hour
00:02:07
catalogue in the microbe by of the
00:02:08
brain because it's small amounts of yet
00:02:11
to do are anything to do it is very
00:02:12
small amounts. But from normal you know
00:02:15
a young to help yelled off time is is
00:02:18
they're changing them at the bottom of
00:02:19
the brain could explain somebody
00:02:21
results and stuff oh Reduces schools
00:02:27
the how I exclaimed in the the
00:02:32
phenomena that you talked about really
00:02:34
or which she is we can find people at
00:02:37
lowe's but okay we don't have to use
00:02:41
your series norms of course diseases
00:02:44
because there's no point in her. So I
00:02:48
was happy with it I mean why don't they
00:02:51
have a bacterial infection yeah what I
00:02:53
will plaques the security that and then
00:02:59
I say no yeah I mean so these were
00:03:03
people where you see I mean that's
00:03:05
pretty we're we we found sixteen brains
00:03:07
around the country that had high price
00:03:10
levels or in some cases backstage five
00:03:12
or six tangles. And it that it is not
00:03:15
to mention that was real nation. I
00:03:17
guess if they were living you know
00:03:19
several hundred one thousand years ago
00:03:21
they might not have supplied because
00:03:22
maybe they bring I'd of had less
00:03:24
ability to fight infection because
00:03:26
might also also less likely "'cause" it
00:03:28
invitations to go to that ignorance
00:03:31
assignment or they put in today's
00:03:33
society the we live there probably just
00:03:35
when challenged unjust and that's all
00:03:38
they had a good afternoon system
00:03:40
ability yeah I was wondering actually a
00:03:47
pretty dress reduce in yeah increase
00:03:51
the consequences of our actions. So
00:03:54
some drive to talk about yeah I yeah so
00:03:57
I skipped past sliding sometime base
00:03:59
right sane is if you use an example way
00:04:01
drawing style a to do cluster but don't
00:04:04
like out and god knows don't do not
00:04:06
that solution because you can't control
00:04:07
that afterwards. So if you're gonna use
00:04:10
it is it is heavily games dissenters
00:04:12
maybe a civilisation. But at the
00:04:14
vaccinations probably not a good idea
00:04:16
oh what's that S so at the end of the
00:04:24
cities are they you need to read your
00:04:27
conclusion was that a clinical
00:04:29
diagnosis right any stacker yes. So am.
00:04:35
I using here. I lost sight to us steady
00:04:40
fixations away or we just give it want
00:04:43
to be on a semi up till now we had that
00:04:45
we only accept jeans which is a tiny is
00:04:48
you know fraction of a percent of GD
00:04:49
yeah they probably for which is highly
00:04:51
addictive but you need the rest of
00:04:52
these genes together with it you Ross
00:04:54
only gave us the genes only
00:04:56
transitioning out into the whole genome
00:04:58
sequencing. So I won't be publishing
00:05:01
with that holding know paper you know
00:05:03
just tons of excel seats of the
00:05:05
variance that we found in those jeans.
00:05:09
And the ones that were so she really DR
00:05:11
gonna maybe some of those at some point
00:05:13
will be on the chip altogether we would
00:05:15
test for maybe a hundred two hundred or
00:05:17
even the thousand functional brilliance
00:05:19
and empirically determined which ones
00:05:21
you determined respect that still work
00:05:23
in progress people over there was just
00:05:25
beginning to to do the base these no
00:05:29
because you can you can you actually go
00:05:31
to the dock after forty years old you
00:05:33
get any of its name family you you can
00:05:36
use it as high we do spinal tap your
00:05:38
proselytise hire maybe that that's
00:05:40
these protests but I was even easier
00:05:42
ones that comes online. And and then
00:05:45
you say that you're the seventy
00:05:47
percentile finger age for how much time
00:05:49
you have entangled we can tell you
00:05:51
gonna get a sinus trouble your wrist
00:05:53
just like my cardiologist says you have
00:05:54
a family history of heart disease you
00:05:55
have high cholesterol and taken apart
00:05:57
or so if you have a safe draw like that
00:06:00
that you can take to bring your family
00:06:02
down and you know yeah white tie and
00:06:04
you have about Marcus already there why
00:06:06
not do it. So you do maybe start doing
00:06:08
that after forty years all the future
00:06:09
that's as possible yeah yeah I know
00:06:15
going back to the three dimensional
00:06:16
tissue culture I just had a question
00:06:18
regarding we're rewriting engine target
00:06:21
that this is a theory research just
00:06:23
want to ask if the activity patterns
00:06:25
you Sir as a normal in the three
00:06:27
dimensional culture for before the fax
00:06:32
number to look like you were looking
00:06:33
very early in the culture in since
00:06:35
we're considering stream cease for yeah
00:06:38
yeah I could the dynamics in plano
00:06:42
formation and as we look at a very
00:06:44
early difficulties before any platform
00:06:46
to sit there are differences yeah so
00:06:48
that's a great question we have to do
00:06:49
more time line on that but at any rate
00:06:52
so other countries that's when you
00:06:54
start seeing the fire is down at that
00:06:56
point you don't have plaques you have a
00:06:58
beta like numbers lot and and you also
00:07:01
start C passport are detergent system
00:07:03
again as but no plaques and tangles
00:07:04
effort that's been used asking
00:07:05
dysfunction okay I think we all know
00:07:14
just want to dress with that value
Conference Program
Introduction to the 12th Nestlé International Nutrition Symposium
Thomas Beck, NRC Director
Oct. 22, 2015 · 8:57 a.m.
790 views
Introduction to Session I - Cognitive & Brain Development
Susan Gasser, Friedrich Miescher Institute, Basel, Switzerland
Oct. 22, 2015 · 9:04 a.m.
164 views
The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:16 a.m.
398 views
Q&A - The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:56 a.m.
Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 10:49 a.m.
155 views
Q&A - Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 11:29 a.m.
Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 11:38 a.m.
226 views
Q&A - Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 12:10 p.m.
Introduction to Session II - Cognitive Decline
Kathinka Evers
Oct. 22, 2015 · 2:02 p.m.
Brain health & brain diseases - future perspectives
Richard Frackowiak, CHUV University Hospital, Lausanne, Switzerland
Oct. 22, 2015 · 2:11 p.m.
120 views
Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:15 p.m.
Q&A - Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:59 p.m.
Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:21 p.m.
160 views
Q&A - Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:59 p.m.
Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
Oct. 23, 2015 · 9 a.m.
Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:16 a.m.
413 views
Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:53 a.m.
Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:29 a.m.
Q&A - Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:57 a.m.
Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:09 a.m.
152 views
Q&A - Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:49 a.m.
Introduction to Session IV - Decline & Nutritional Intervention
Tamas Bartfai, The Scripps Research Institute, La Jolla, USA
Oct. 23, 2015 · 12:48 p.m.
179 views
On multi-domain approaches for prevention trials
Miia Kivipelto, Karolinska Institutet, Stockholm, Sweden
Oct. 23, 2015 · 1:04 p.m.
218 views
Q&A - On multi-domain approaches for prevention trials
Miia Kivipelto, MD, PhD, Karolinska Institutet
Oct. 23, 2015 · 1:39 p.m.
Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 1:49 p.m.
124 views
Q&A - Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 2:32 p.m.
We are what we remember: memory and age related memory disorders
Eric R. Kandel, Columbia University, New York, USA
Oct. 23, 2015 · 3:03 p.m.
231 views
Concluding Remarks
Stefan Catsicas, Chief Technology Officer, Nestlé SA
Oct. 23, 2015 · 3:50 p.m.
168 views