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In fact the bottom but also altered my
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probably Quite a proportion if on of
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the changes that first step you through
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a stage. So microbial. Uh this is a
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very important the question. And also a
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difficult question and so that's why.
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We you know everything we we these seen
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human is association in nature. So you
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see when you give them diets you see
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changes of the micro about and you see
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improvement of the of the symptom. And
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but this can be also by we often just
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working on the host not says working on
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the microbe outside. But by
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transplanting the condom acrobat that
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before and after to the animal. And say
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what the if there is any difference
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relevant difference and then we may be
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able to catch the contribution of the
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got "'em" acrobat to them out to the
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recovery of the problem. But I don't
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think we have a way to quantitatively
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assess the contribution of micro about
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or to the recover a change of micro
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about and also chance of the host for
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the recorder. It's still a very
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important but difficult question Thank
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you. And references embassy gambia. So
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the metabolic antidote seem a story is
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driven by LPS canal square is just
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because that's an exact well we started
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with or whether it is more important
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than other bacterial degradation if you
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look at other button like about a
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structure many redneck to bacteria we
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have you know huge numbers of species I
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connected their LPS producing but the
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I'm not in the texting producers only a
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small number of species can the the LPS
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of those can produce a can you use
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inflammation. And so from ecological
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perspective we still don't know we see
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a general trend of that in the all
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these people's got some gram negative
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obtuse specific these volume reached to
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a certain level so some particular
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species can grow better in the movies
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people's got and but we don't know why
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ecologically. And those somehow they
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compete and they become you reached
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then the house you got like about but
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we still don't know I mean just for
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quickly I I guess I'm asking I mean
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that that that was very much a part of
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the arts about I what about the slides
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and what about all the project up of
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cost oh my god I am so be impossible
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through different problems perception
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of what I'm trying to understand what
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yes is just amended tops initially I
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don't know why but because if it's just
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a matter of the someone I really like
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to say but no no it's not just in the
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talks it's actually any ideas which can
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get installed blasting contributing to
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animation this isn't my guess and so
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you some people eat maybe a gram
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positive something or several grandpa's
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to present you some wait maybe virus we
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don't know and that that's why we use
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might have belonged to my turn to
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normal approach this has no prior
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hypothesis hopefully this can help us
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identify more relevant suspicion okay
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thank you very much for us to go then
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you can in the TV your name please
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especially if your problem is but but
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you know I was just wondering that you
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did you have a chance to look at the
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numbered it will a change based on the
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return of battery we yeah I'm not
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microbiologist shall we just check
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several even inmates released at all
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times. And we don't go any further into
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immunology yes yeah it can be very as a
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yeah yes yes yes and maybe we should
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work together yeah okay I also
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depending upon the entire. So since my
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wife is likely to see doctors or you
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six all the time. And the also here
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it's it's all good books and it's very
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rare to fine on substance looks like
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globally. So what's the Reading on this
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this is like you can call on centre to
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see Madison to be functional and
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secondly what was it slowly questions
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you know old on the history of of the
00:05:07
discovery of missing the other maybe we
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want to syntax which actually pointed
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to the next to somebody had a perfect
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examples and disappeared so it's not
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okay this is a very interesting
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question and I still believe that a
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single compounds identify the from
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traditional chinese medicine can be
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effective to some extent. However like
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what we did to to this beautiful as a
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child you know reducing body weight
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from a hundred forty two seventy a
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single common can not do that. You need
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a systems approach combining some of
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the chemicals from traditional
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medicine. And so if you want us to show
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we've which one is somehow active you
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can identify a pure combat but if you
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want to really recover all very
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seriously disrupted a I got a
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consistent you need a systems approach
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you need every story she you call it
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and can adjust for well because we were
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thinking about how you the man clinical
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tiles because it's cool really
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difficult to standardise you know we'll
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take the yes was given life but
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impossible to do yes for the for the
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chinese at the clocks and we use DC as
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LCMS and we try to control everything.
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And all from where you get to the plans
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from which is easy to get some plans
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how you process pretty process and
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everything. So they eventually we use a
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chemical fingerprints trying to make
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sure that others and minimise the batch
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to batch variation yeah it can be done
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it's very difficult but it can be done
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now okay we have a yeah So so this is
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just a colour and it's to tell you that
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in the traditional I know where that if
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you about this show I'm sorry which we
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talk go work for all a local use what
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we what what so yeah it's only settings
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as STC this this is okay we you know
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different people in different parts of
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the world reinvented the wheel and now
00:07:32
we we we went again I I used to one of
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those songs recorded in this is exactly
00:07:44
I wanted to address as well. So I think
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about it oh we see back to port Charles
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legacy. So my question is really do you
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see any reason to do something else
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that you have to you need to use lose
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three other in relation to do more than
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just we need to do see well I think
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that with now is the technologies we
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have we can't do much better than
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traditional chinese doctors you know
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and I think eventually the goal would
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be to identify all relevant components
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chemical components in treatment. And
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to transform the traditional medicinal
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each from a mixed define a mixture to
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it you find a mixture and we see each
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component has its known cognate and the
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molecular mechanism. I think that they
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can call and by using for example the
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variation of for better best variation
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of the composers of the drug considered
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to be a disadvantage of the Madison
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however we can take advantage of that
00:08:51
variation of the chemical composition
00:08:54
and the cleaning crew you think C and a
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link between you see got to microbe
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outside of those D expression profile
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variation. So by using a multivariate
00:09:03
statistics we would be able to identify
00:09:07
the component the the chemical
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components which a positive associated
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with you fixed it. And those which an
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active it associated so eventually you
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can identify the chemicals which are
00:09:18
responsible for these sexy and also for
00:09:20
attending specific species of gotten
00:09:23
like about this can be done but it's
00:09:25
very complex yeah okay now pack off

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Conference Program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
506 views
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
385 views
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
232 views
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
167 views
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
276 views
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
107 views
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
734 views
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
572 views
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
258 views
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
177 views
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:02 p.m.
679 views
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:46 p.m.

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Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
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