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and the actual if you can see in the city because we know they
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often it doesn't the n. n. c. e. talked about that yeah
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that has me you can tell well let the classified pages so so this where i had lost the same amount of body weight
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that was the idea so we that's why we have read a few because otherwise it got messy
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oh
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so so issue study that's a section
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the problem with some or have is actually which is not
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i i suppose that too
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and one of the spot is the did control for it i don't remember which one and
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what they thought was that if they the ones that have overweight models had it
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had an greater impact on the child's obesity but the still
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was that is still was an effect even without overweight
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and we have the same problem in our study that if you look at the ones that have have a c. section
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they have your three forty my points uh in general above the other
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so it it a second founder and eh
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i use okay in your uh uh when you measure when you should be impaired
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because times between the germ free and the non germ free animals uh
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but virtually larger flat sides that along reaches the free fatty
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acids and he'll remove their clothes in her calls or
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hopefully not it's not a normal that's just that's a consequence of having extra fine
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yeah we we uh i think that's one of the mac address and that's of course
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a given one and it's really hard to on couple that but even if we
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start to normalise for what awaited out of pasta we see a difference in the glucose tolerance
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so that's a beautiful we're done read on the experiment so many times now so we can sort of take the
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factors of the jeffrey lena stuff the common show mice and we can have
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the same fat mass we see still a difference in due course tolerance
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but uh yes it's a one contributing factor absolutely
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that was a very nice to could you clarify something for you when you talked with because they shouldn't place to go
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yep in relation to rest but it was never forget this user yeah a right but it actually
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lose more weight in hello look who's no longer uh_huh or that fit in
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with would be in the colleges were the same five six good yeah
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it's it's a very good question and i don't know that's my right if you should speculate i mean we're
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working on some exotic animal models i didn't have time to toyota about today is we work with wide brown bears
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and we get samples from the winter when we got him the force and the the
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the den and get a sample and then from the summer from same there
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you have is we if things where you have a more fat there in the summer
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and seems to be more isn't sensitive and then the winter you have interest distance and the same with uh to
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some extent about two things going on and and and pregnancies that you try to shuttle fuse to different spaces
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so what i'm trying to ramble about is that perhaps it's uh in a way
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that you want to shuttle energy to specific working so you have some kind of
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incentive systems in the periphery to allow because uptake in the brain for example
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i requested if you use weight loss using non surgical methods
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how the the changes in the back of their
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it's a quick question and we are trying to address that in randomised controlled studies now but it's
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we don't have the samples i can't answer it but i i would expect that many differences we would be due to weight loss
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and i think it would be very important to trying to parse out
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what are the sorta metabolic changes we find that's presumably are
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more benefit just uh have a increase benefit in the run wiped a client of intermittently one but today we don't know
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no i don't want to the uh the germ free up like the i just won the the germ free
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maurice was the the the normal one but the the normal uh factor
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oh with the fruit into the to the to the to the mall yes
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uh and get more actual will have no other gently ha it's more
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feel free yeah but they also so it's getting complicated here uh because
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we really would like to do very careful any bus studies
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and it's not reveal a it because one thing is it easy to see that it's
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more that put more so so did actually absorption interested to bring into the body
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this is on a chart died on a high fat diet does seem to
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be more eat more similarly and to exclude similar amount of energy
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so what we're doing now is that we have basic worked uh for the past year and
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a half to get with a a company called t. c. in germany to build
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and uh t. uh there's a fear masses system to and allow us to
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keep gender mice on the job the conditions for a week or so
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to allow them to adapt to the environment into proper energy yeah expenditure mission and so forth
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so hopefully we can address that and also see food preferences we think is important
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you can see that i guess was very nice thank you for calling up on this question
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i mean i've looked at all the papers and asked what
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is the nature off the carbohydrates in those days
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regardless of whether user high fan or a high heart it's always roll starch
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yeah ross starts has a low back just a bit so now's indexes need that extract the energy
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i think so has it been done any studies he's he each tree normal flute as compared
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to a cruelty and real i'll try it because then i would expect to see
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less pronounced affects the mikes okay i i'm very happy asked that question because this is a very very important question
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uh we haven't done the process to twenty five discussing noticed or just make human foods and
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and process accordingly but if i think you're spot on because what we find that's uh
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so part forty five years ago i shit my pants literally because of the paper with a title that job for
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my son not protect you have tried to distribute it was from a single michael out and the device that's
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and what they show what we sort of repeat as well is that if you have a high fat diets
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they just uh my son not so protective slighting this beast but if you have a high
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tech tightness sucrose are protected as opposed to me you shouldn't need microbes for the absorption
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but this must be something where this should close
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or the starch whether microsoft very much important
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so we think it's a signalling thing we think that the microbes are producing a
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signal when working with max to do this in humans are we working
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with a lot of people not to find those signals that then sickness is the body that not hey hey you have a lot of secrets
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because the mice do a devout type addressing and some of these instances we've done this also in the absence of facts
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the taking of died with your heart's sixty five percent of the die to support the germans do not develop statuses
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the other major changes in the morphology you see can i mean
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use high tech design which prints i mean yeah generally
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have to seeking like yeah yeah yeah the carbohydrate fag have like that and if they have like that yeah
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yeah it makes a difference even on the mass of yeah alright it if you put the market participants rings indigent as well
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that is good
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if we could use that was well thank you very much i'm issue would you did in your parents but
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maybe that was somehow when i'm using to give a lot of importance to suspicion of her breast feeding
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do you wanna do you do molecular mechanism nimble wouldn't human readable i. um
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well i uh i was i don't know so much about the breast feed it to be honest
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uh i have wanted to share some data with you at this point and to our mind
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it's the h. m. o. sort of favour during a growth of if it affected or for example another
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good bacteria supposedly good bacteria and when you remove the substrate the they are lost from the system

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Conference program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
504 views
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
381 views
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
232 views
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
166 views
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
275 views
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
107 views
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
731 views
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
563 views
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
252 views
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
176 views
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:02 p.m.
679 views
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:46 p.m.

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