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You think they we look appearance of
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should change that yes you whether or
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not because it's all over the world or
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small I know yeah so I don't so what
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you see is conflicting data right about
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whether it's better that that's sure
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that if you have less change that acid
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sometimes associated with diabetes this
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large but I do believe that all the
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might be other study show that there's
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less you great producers. That's for
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the physical part of it I believe that
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when you're looking at the changing
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unity for example in the small
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intestine where beer is very very
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important. We have data on that on
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macrophages function because I think
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there are only a little bit of give
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rate for switching video might do the
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trick not so much only on the
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demolitions all the sex on on on
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glucose metabolism more look a
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sensitivity that's specifically on the
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immune system and so there may very
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many few. So there were few nature
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papers last year showing effectively
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rate on T cell right regulatory
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function. And we seem to produce that
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humans. So it and that's only only
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Right so I finally yes your nanny and
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we'll start from the side. So you you
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know from the easy but don't do it you
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know then like do you previous vision
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like or would you you bring someone
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previously you respond for example okay
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see different foxy yeah you mention
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with the big change you know about
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discipline the yeah yeah Y yeah I was
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wondering difficult candidate or know
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first looking at that in type one
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diabetes now. And forever because
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looking at the fickle sample
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composition because it's also very
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interesting to see if you give you read
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what excuse or changes the market we on
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the composition sell some not not even
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if few contrast and giving them edible
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I can see what it the changes also
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previously memory yeah that's that's
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something that we're looking into now
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with the war clue was in excellent
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immunology some type one diabetes
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"'cause" as I said I'm I'm I'm not not
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yeah because I think impersonal
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university for Yeah and it's not how I
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check this site increase tactics that
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yeah yeah yeah I I we mexican and so
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the fruit intake is the is the one that
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we're looking at now the the body
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weights remains the same show today
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that doesn't seem that they move around
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more so so and the final clue is now
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that we we're we we see some increasing
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use if you want so it is probably the
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profit activation. That's what we think
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but my problem is that as I said we're
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all focusing on computer eight and I
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don't think there is the only clue in
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here the biases might be very important
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that might be the bacteria itself
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casual that has some or the fantastic
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for me yesterday showing that there is
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some my car in a regulation that kind
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of stuff we have to look into just to
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tease down the mechanism that we're
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working on quite yes get the shot from
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raw frost was nice to meet you this
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meeting thanks to nestle. And have a
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question about Monica lot campus
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because I think in addition the
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traditional three steps of the costs
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postulate now we would like to to have
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someone to collect the cans and it's a
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it's a detrimental effect of rustling
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you know well one and be beneficial you
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but cherry and got what do you suggest
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yeah I agree so so I think so I just
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wanted to give you an example I don't
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want you to focus on two strange itself
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because it's more of an idea your that
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we know that gram negative procure an
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associate with diabetes all the time
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the only thing we're doing is going to
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target organ and see we found seven
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different strains withdraws only was
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the ones most perhaps if you're talking
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about molecular mechanisms I think
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we're only at the word starting there
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are several which which you can do for
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example for for you how treatment we're
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gonna look at the table mikes before
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and after pregnancy whether are
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changing and then for example see what
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or if you if you try to to use those
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metabolites into some kind of injury to
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assistants you or whatever has an
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effect but that is multi disciplinary
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work in a very happy to that search
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team working Never lost a convict me so
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save elsewhere please to see brown I
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I'm not actually mission so I basically
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most channels is also a concern for me
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in the way that what showed us was the
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implementation in humans oh oh bacteria
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in the fat you know I always that
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remain ideas in the the literature what
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was on the white of visual a common we
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need buttons that are you happy. She
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bites. I haven't looked with the we
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need you suspect you region yeah our
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speech or yeah so so that's something
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that is ongoing of course we know from
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unit studies and monsters that beast
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your high fat diets give more of often
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good permeability and it's your
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transportation so if you ask me how
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does that your end up there we don't
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know what are there like we only found
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the signature are looking now what are
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what are with an arabic kind of country
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we confine so that's very big
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connotation. Um I think it's either
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trends locations so directly going over
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the more permeable it estimable and
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then you end up in this pontiac face
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right opposed issue. And the other way
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which we think might be the way is that
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a co travel with the colour microns but
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you eat we know that you have a short
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term and the top senior that's known
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for a long time. So they just piggyback
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rides on on dietary particles into the
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bloodstream am I had here is that
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nobody really looked at that in that
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but I know it from clinical experience
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that diabetics have much more
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infections much easier affections are
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is a real disturbance of the immune
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system in these people maybe by heart
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brings leaning I maybe by approaching
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or react what's species. So in some
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kind of maybe a allowed inspect your
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travel around because we know and
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editing as normal right university
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issues. It's known for a long time
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light signals any other issues yeah
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it's one going progressive in human in
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you you yeah the see control. not not
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not we did an opening to study because
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the IRB they get crazy for me of course
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because I'm pushing towards the limit
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what you can do this and open label
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study where we only give you great
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after we finish that page the baseline
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we're now doing the randomised control
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trial where we look at the effect
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computer rate for example on so tightly
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with brain scans and and there we do
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controlled totally right I was just
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wondering how much for if I yeah I
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don't yeah yeah yeah mantis yeah how
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much a defect to see could could you to
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reset my biotech independently of the
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yeah that's a good order. yeah very
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good question so we think we think in a
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specific decisions that doesn't really
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matter. I mean that exposure of ego
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material into a small intestine that's
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why I'm each time stressing the small
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intestine that that might also do some
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kind of resetting effect or change we
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see some changes in autumn unity
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reaction of T cells. So so what is
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exactly driving it is the introduction
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of the total new speech and you have to
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imagine that you give this well this
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transplant of of of of of theses in an
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environment where they cannot suffice
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you get survival of the fittest
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basically only just raise it really for
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five it will stay there but there
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before that you or three days interval
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where suddenly mess amount of bread
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negative material aurora stuff so
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that's something that we're looking
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into now butters in donor transplant or
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equal transit person So what difference
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I don't know I'm just wondering so all
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you actually the purpose of the whole
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study provide stuff that are trying to
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find out a one providing fits all or
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you actually try to see Mary C
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personalised monica. So yeah yeah very
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good questions so no I don't think one
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problematic fits so I'm just in it to
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show it you within five years we don't
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have to do FT which which is can give
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back strains. And any minutes and then
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study effect Assisi newman's with hard
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and point could one set for the one
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that's why stressing it it's only an
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example and this is just the first that
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we can attest you I think in the ends
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when you hear all these stories about
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core microbe I'll probably might dad
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and being a cocktail but are rather
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layer it up and and this and this sex
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effect each specific picture before
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adding them in in the whole one once
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again not knowing what you're really
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looking at so I think in the end to end
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up with drinks are not rings but a
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couple of combination of trains for
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different disease just as you're saying
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as opposed to sort of once to have
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different for different style depressed
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are right there at the same time we are
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seventy yeah having the same everybody
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gets said most of these sounds to me a
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contradictory yeah but I don't but I
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think that's that's that's why we still
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have to scroll salad question we know
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that diet I mean we are are fickle
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francine type to it of twelve weeks
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might the other competition is back to
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normal which means that the diet is
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really pushing it. And we know that
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it's not that not for each disease easy
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different like a time a long transplant
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last different an Albany diseases than
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an apple dimension. So that that's the
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way you have to think of it. And I
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fully agree it one size doesn't fit all
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which you have to start some stuff I
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think that's because from from sleep oh
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but in a question from a non
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microbiologist it seems that you rely
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in many of the of the speakers on the
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presence of those strings to fervent
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number computer support but do we know
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whether they always behave in the same
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way and whether they contribute or not
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to the environment in the same way
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question so so that is something that
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so we we that's why for example we
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we're go we're we're looking for this
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biopsies because these your adhere to
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the mucus layer which we wrote about
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you think that in that place you can
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also signal and do someone things more
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at least and and then and PC so yes I
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think but what you cannot do that in
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humans but you can do it in my eyes to
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see and what it is with here and it's
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different segment of the got as a
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different role effect on buses
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transporters that and that's exactly
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work oh willing three one question for
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you. this is to evident of also on the
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on stuff on certain mark I think that's
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more helium is important because we can
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take biopsies exactly concerns also
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remotes well happens to schools and
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look at our site you can look like us
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you yesterday at the activity of the
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microbes in the what I think that's
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important because people samples don't
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if you only read out of of what's
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happening there don't give of the last
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five minutes. So you have to get the
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samples there to what the market alone
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like you say you have to that you have
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to that wonderful talk so how deeply
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can sequence you can lose a reset or
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problems to look at them. Okay I do I'm
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trying to sell us unit yeah I mean true
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that I haven't had I yeah thanks very
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if the didn't make investment in a
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resistant bacteria and differences
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between different genera. It's mass why
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why hasn't anyone mentioned well I
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backed off I on the like oh yeah well I
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don't know at it. And looking little
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that Frederick but that's there of
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course they're looking at at at at what
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are what are these different key
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elements are doing and but that I don't
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wanna it's it's not my specific my so I
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want to do that is usually that's it
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because many of them are cops
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syndicates are fermented if the end of
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ups and that they don't have always at
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least a lack of transportation. So
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don't you that's only one of the
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complex explain my of course of the
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court cases the the the eye ropes they
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need got to have the option for
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installation that's one of the reasons
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but but other studies that have a lot
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of work your use of well I don't like
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about how materials systemic as to how
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different populations both well done
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all and no no population react in terms
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of wine administration with the one me
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no I think that's the kind of studies
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that will come up right if you have the
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well match phenotype patients
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multiethnic different diets you know
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but what what the amount of iron aren't
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tied to use in in the plasma that kind
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of studies will comment that sense
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still associated. But I think that will
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open up next couple years one more that
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for a with from burning university I
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wonder said that every everything is
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there and the of our selects and were
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approach with the hey how are you is to
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bring back my yes you have been there
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so you see opportunities to stimulate
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me abundance of that organism by
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directory intervention or other means
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yeah so that's a very good question one
00:13:33
cannot do all but I know for example
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that that examine courts in in
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Minnesota for example does if expensive
00:13:41
reproducing our data you also puts
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patience on the dot it's to see what
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are the adherence is longer I think the
00:13:46
those kind of studies are crucial we
00:13:49
just now focus on the on the stranger
00:13:52
probably the next studies after we find
00:13:53
it save to give it into you just
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combine it with specific dies
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containing specific products yeah sure
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oh well thank you the you when it comes
00:14:06
to transplantation yeah do we need to
00:14:09
actually clean or should the before and
00:14:13
I know that this system so we started
00:14:17
isn't two thousand eight and had many
00:14:20
discussions about for example in in in
00:14:22
the ice you you do ST D.'s like they've
00:14:24
got the company the contamination we
00:14:27
thought it would introduce extra bias
00:14:29
because you have and to the knowledge
00:14:30
that are mixing up the environment
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which is normally there so we chose not
00:14:34
to do it and just closely monitoring
00:14:35
the dietary intake and looking at heart
00:14:38
and points it could make in fact we
00:14:41
know that for example you guys have to
00:14:43
see if they run into the objects till
00:14:45
couple days when you get the fickle
00:14:46
transplants to to lower the amount of
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of CDF so yeah I I don't have a real
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and stupid but I I I think that if you
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wanna get to create your results the
00:14:56
less biased you have the better it is
00:14:58
so that's one you didn't choose to to
00:14:59
reduce the amount of extra as part of
00:15:02
the same question this is the last one
00:15:04
so my easier event this evening was
00:15:08
telling that there are some traditional
00:15:09
medicinal actually on the regular. And
00:15:13
P and then to explore the structure. So
00:15:16
this something that you you think it
00:15:18
works for yeah but also I think for to
00:15:23
if I allow half a minute. So for
00:15:25
example we were we really knew that
00:15:27
rethought that for example if you
00:15:28
treated diabetic page with much for men
00:15:30
to get gastrointestinal complaints
00:15:32
everybody gets that you tell them keep
00:15:34
on going and that sort of a couple
00:15:35
weeks it's gone. And what I know from
00:15:37
at least Fredericks papers is that
00:15:39
there's not so much a massive changes
00:15:41
in the microbe I'm so we should really
00:15:42
focus too narrow what's happening there
00:15:45
there are mechanisms going around as
00:15:47
well but I think it's very interesting
00:15:49
to to study of these these these kind
00:15:52
of traditional medication or study per
00:15:54
se what's what interventions doing yeah
00:15:56
so they can enjoy but this is
00:15:59
fascinating so you thought you know we

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Conference program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
504 views
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
381 views
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
232 views
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
166 views
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
275 views
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
107 views
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
731 views
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
563 views
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
252 views
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
176 views
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:02 p.m.
679 views
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:46 p.m.

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