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Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
Thursday, Oct. 23, 2014 · 11:44 a.m. · 10m 38s
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calls of consequence a question but really contribution
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oh from zero to one hundred percent of which
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one and this zero percent race consequences one
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hundred percent is a call so you really looking at the continuum so commercial down
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rather than quarter in fact what do you think the contribution shape from zero to a hundred percent so
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yeah thank thank you for the question i think it's it's a it's a button of the right ways of looking at it
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because you are helping me escape does that caught them with which i think is not
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the only that it's it's really cool counterproductive because if you're expected
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to show sense in which right now that exists like as single colours
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we all be blocked and that's not what we should be doing like real and said you
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know i'm getting all i mean the hard i want to see these things happen
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so uh yeah not let's not be distracted by pursuing that very elicit go let's
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do something concrete and of course try to find out how things work
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but if i was really great ah with you about your uh
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hi all the house because as you know there are big differences social economic status
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you how or is it so hard i would like to know status
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you are
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no the the the didn't intend thank you for the codebook comment to
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frederick uh as i said that they may be many many causes and that i'm on
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the list of things like that i put down is that is that i happened because it could be exposed to bolton sort
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to what whatever you have as initial j. there but it
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would be certainly worse that looking into the into the
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i guess i guess that's up to you just expressed very uh and number one of the mind
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yeah so i don't know how we are good for all
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the press the send troops all gross and what about christ like oh well
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now when i say that we're just hostile stuff so
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and yeah i i i think i do
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now i don't expect to show some green beans ah complex
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well i never heard that one works for when finals or something like that
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association i'll sell insufficient translated because that's on this or
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myself no thank you for the for the common to
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no just just to start with it lays in mind it is not the permanence syndrome yeah
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that's why i'm talking about the try to get people out of that frame of mind because it's extremely it's
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much too simplistic to say show only the call
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because it may not be the the texas sky but probably took what you say
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at present we are building does not that's not in the best sellers
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we can see factors which clinicians with that
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very diligent in careful work has established impact these
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the not like these cannot be this complication of lever solos
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well we're saying that there isn't as much ah recaps signals that these factors
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may be due to the mike about so what would you like us to do intervene okay these
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interventions very raw and i say mechanistic only not document
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to the benches and i gave you accept the
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they would chase out this mike about and you feel better so that you know if i want to do really
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to push my cases that you have a demonstration it may break now what happens is that of course this
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toxic microphone ease and they establish is itself so i would plead with clinicians
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let's try to do an intervention like max that's okay and tried to
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slapstick should this an l. c. michael been in people we mark has c. but
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and then to prevent its beak deterioration maybe one should also
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consider medication the to the store the body yet
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big bad thoughts are but it's also a key when there's a list of medications that could be tried
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and i'm not saying that it should be done now with everybody because school of course
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you as a a medical doctor not much more about it then and i can just suggest
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maybe that would be lovely approach in not only the current way what is going on that
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and beyond that beyond that we'd only does longitudinal studies we're trying to see that in d.
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the compensation results from accumulation of these signatures
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and that's we're trying to do these
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things you say you're opening thing i'm not advocating that everybody should go
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on that but i would like to do mine set whatever i can to
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try to screen people at least with lower regions simple pest she
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test maybe out of their pocket or maybe what ever could could help with that
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and use that to try to improve that has been done to wait paint
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obligatory to show yes indeed you have no l. p. s. producing bacteria have like people have
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more information between u. c. a. plate i can show it is that that 'cause control
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there is a little bit of looked a bit on the on the trainable bulges that
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as if to this day i could not tell it but what else uses solicit
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careful is is a lexus or right so i i
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what they are
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okay
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what i did not really need to uh to to to it automatic amanda us is because
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i don't know very much about it then i have recurred to elements that the clinicians
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then uh are important for them all i can say is that we do see the potential
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for production of these molecules in this michael down if these molecules and
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known to contribute to the disease and if you can get help me
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making my least longer it so we can go and look at
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that well i would say is yes they a toxic element in your
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body in body officer psychotic patients which doesn't generate these molecules
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i still to last christians you'll just as yours
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uh_huh yeah even with the factual conception of disease
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click on it you know to be fast for that psychological
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stress might be able you the onset of many diseases
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my question is how do you think the psychology of us could affect my computer with us
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and with which could be because it's between psychological stress alteration of my for you
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uh the might might very quick answer is i don't know and it might be a little longer answer is
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it can't is said that the study very would look at people that stress and see if you're not
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i i know there are some animal studies where it okay
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and i put it in the mouse in the plastic bottle in the cage and then let it
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big huge at atlanta down bits of the mouse is very stressed in one can use
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that without much intervention and look at the end at the mike about at
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i didn't really talk with you or whoever might be interesting to try to find out what would
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be the best model to see in a lot of stress on evolution map of up
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and you know we wanted much more impatient i and most much more in his younger and has the
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energy so he can i pull out the modified pull out the model also if button i'm lazy
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final question in
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the action between the richness of the microphone and the number of chronic diseases you're my
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obesity diabetes cardiovascular disease even dental carries in
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recent question about stresses exactly for it
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all those diseases as a stress on my decision kinetic stages
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and you have to prove much more in the rich
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so my question is what is the link between the wishes of because microphone and the
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actual which that's how does how does it yeah by social economic status and incomes
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yes i think it it i mean sometimes i i say it's better to be reached into
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okay that it socially one would tend to agree and that
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my my probably article we we seem to have the the evidence for that
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but i can't really go beyond what i have already said i'd
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we have found some association be plunked um it by putting
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buttons like people who eat more fruit and vegetables
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then to have had regions we have not been in a position to estimate correlation with the the the
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social economic status in the the people kind of now but the more obese metabolic
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syndrome guy some and so if you can all go together it's yeah
Conference Program
Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
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The role of commensal bacteria in the gut
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Gut microbial richness impacts human health
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Oct. 23, 2014 · 11:07 a.m.
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Q&A : Gut microbial richness impacts human health
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Cross-talk between the mucosal immune system and environmental factors
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