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00:00:01
thank you mister chairman and the basic abnormality in cambridge diseases goal to
00:00:06
be a impaired vascular supply to the to the loo nate
00:00:11
and uh a previous studies using contrast enhanced him or i have suggested that a hyper enhancement
00:00:18
yeah it is yeah i'm sharing a viable bottom
00:00:22
whereas a hyper enhancement is suggesting a next multi band
00:00:29
a recent studies uh it has shown that it's possible to assess the best
00:00:34
clarity in the couple buttons using it dynamic contrast announced them right
00:00:39
yeah and in this technique eh a region of interest is created in the call button
00:00:45
yeah and the the signal intensity meaning the contrast in house meant is assess
00:00:51
in the specific button creating a curve like this where
00:00:55
the signal intensity is plotted uh to what's time
00:01:02
so the aim of our study was to assess the fusion in the loony but
00:01:06
i'm in patients with keen books disease using dynamic controls calls them on
00:01:12
and in additional aim was to assess the or and compare
00:01:16
profusion with is the pathology uh with focus on bible
00:01:22
we yeah included faulting consecutive patients treated at the buttons and so green moments when
00:01:29
uh and we compared the results from the animals cans with nineteen healthy controls
00:01:36
we use a three to slam a scanner and a a a dynamic gallium contrast and protocol
00:01:44
the scanning time full for the dynamic examination was a six minutes and
00:01:49
forty seconds so this is in addition to the normal scare
00:01:54
and the result is presented like this you get a curve
00:01:59
uh where where you can characterise the maximum slow the time to be
00:02:04
and the maximum signal and the signal it means the contrast enhancement
00:02:09
and if we compare the the entire material all
00:02:13
fourteen patients yeah we see that the um
00:02:18
the patient with keen books disease have a significantly shorter time to peak it meaning that
00:02:23
below the contras foster and they have a higher contrast enhancement compared to the control
00:02:30
yeah
00:02:32
and um we has seven patients with the richmond stage three b. and six out
00:02:38
of these patients were operate that with the proper tomorrow cop back to me
00:02:42
allowing us to to do histology on the extract the bones
00:02:47
this is one of the patients and this is the the specimen extract from on the patient
00:02:53
and this is the histology um where we can see a um
00:02:58
on the boulder and also part of the uh do we have more normal but um
00:03:05
uh if we continue down into the centre part of the bone there are areas
00:03:10
with formation of new bone and these areas on mainly quite well last arise
00:03:16
on the other hand the the middle part here good is mainly made up also too hard and fibrous tissue
00:03:23
and next project issue and with very scarce vascular station
00:03:30
and if we look at the curves on this patient we can see that the next known uh enhancement
00:03:35
the meaning the most load of the contrast is in fact in the middle
00:03:40
part here where we have mainly or stay or it and dropped them
00:03:47
so if we compare the the curves we can see that uh we have a a higher signal uh an
00:03:54
in in the entire bone and we have a similar signal in viable bone and in crop backbone
00:04:01
uh so to conclude the dynamic contrast enhanced demo i can diagnose
00:04:06
a pathological profusion in the lunatic inpatient would kingdoms disease
00:04:11
however and increased the fusion yeah cannot be used as a mark of
00:04:15
a viable bone it could indicate austin eh the crock pot holes

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