Transcriptions
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thank you mister chairman and the basic abnormality in cambridge diseases goal to
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be a impaired vascular supply to the to the loo nate
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and uh a previous studies using contrast enhanced him or i have suggested that a hyper enhancement
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yeah it is yeah i'm sharing a viable bottom
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whereas a hyper enhancement is suggesting a next multi band
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a recent studies uh it has shown that it's possible to assess the best
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clarity in the couple buttons using it dynamic contrast announced them right
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yeah and in this technique eh a region of interest is created in the call button
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yeah and the the signal intensity meaning the contrast in house meant is assess
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in the specific button creating a curve like this where
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the signal intensity is plotted uh to what's time
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so the aim of our study was to assess the fusion in the loony but
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i'm in patients with keen books disease using dynamic controls calls them on
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and in additional aim was to assess the or and compare
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profusion with is the pathology uh with focus on bible
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we yeah included faulting consecutive patients treated at the buttons and so green moments when
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uh and we compared the results from the animals cans with nineteen healthy controls
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we use a three to slam a scanner and a a a dynamic gallium contrast and protocol
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the scanning time full for the dynamic examination was a six minutes and
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forty seconds so this is in addition to the normal scare
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and the result is presented like this you get a curve
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uh where where you can characterise the maximum slow the time to be
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and the maximum signal and the signal it means the contrast enhancement
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and if we compare the the entire material all
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fourteen patients yeah we see that the um
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the patient with keen books disease have a significantly shorter time to peak it meaning that
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below the contras foster and they have a higher contrast enhancement compared to the control
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and um we has seven patients with the richmond stage three b. and six out
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of these patients were operate that with the proper tomorrow cop back to me
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allowing us to to do histology on the extract the bones
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this is one of the patients and this is the the specimen extract from on the patient
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and this is the histology um where we can see a um
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on the boulder and also part of the uh do we have more normal but um
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uh if we continue down into the centre part of the bone there are areas
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with formation of new bone and these areas on mainly quite well last arise
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on the other hand the the middle part here good is mainly made up also too hard and fibrous tissue
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and next project issue and with very scarce vascular station
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and if we look at the curves on this patient we can see that the next known uh enhancement
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the meaning the most load of the contrast is in fact in the middle
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part here where we have mainly or stay or it and dropped them
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so if we compare the the curves we can see that uh we have a a higher signal uh an
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in in the entire bone and we have a similar signal in viable bone and in crop backbone
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uh so to conclude the dynamic contrast enhanced demo i can diagnose
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a pathological profusion in the lunatic inpatient would kingdoms disease
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however and increased the fusion yeah cannot be used as a mark of
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a viable bone it could indicate austin eh the crock pot holes