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heard this morning news sequencing methods which
allowed to describe large microbial communities
and the possibility to handle very large amount of take them
in possible to reach a more and more precise definition
uh of the human got some i cried out that it's competition and metabolic activity
the three presentations of this afternoon will
address mechanisms of crosstalk between the
microorganisms and the whole spied on you can have fun yeah
followed by mechanistic data on how they've got
micro by note that affects metabolism in early that
and later in the afternoon on the cracked microbiology not
on in all the people by plough some
they start to know that's well this symposium we'll hear more about the conversation up
the got i'm microorganisms in the first two weeks and months of life
and their impact in later life before starting with the presentations
let me present to you with some recent observations one of what might be
that really ask on that of the features an infant with microorganisms
before birth defeat this is thought to be protected against
infections by that's the really the outputs environment and
in the case of a normal pregnancy differs contact of the baby
but we've michael what denise this happens during its passage
through that that china and this keen on that
he's you know he's challenged by closely in recent findings
on the microbial content of nothing that's in three hundred
and twenty pregnancies by all guard and co workers
they show all that apply sent down hard with a
unique micro by on of little uh buttons
that meant that all they can be reached which when
compared to the micro pile of apartment buttons sites
resembles mostly all rules or not the mind of the chain
it'll tract which is much closer to the placid
based microbial community i is composed of norman pathogenic
commands little micro by the auto from
different foods tenderly cute scroll wheel bacteria bacterial
date is and from the bacteria fee
the authors propose that the plus and then the the c. d. nine came i don't
think i've read of these microorganisms you really that last caller station nothing changed
we know include that came at auctions threat of the
walls will right it's not uncommon healthy individuals
without consecutive infection to think a benign h.
so is it possible that the first contact the fifty this with microorganisms who this guy is
we now i hope then shouldn't useful want takes place much earlier than occurs
if these findings are can for that they raise the question the way that they were in on that
with a baby is innate and adaptive immune system before but
and whether that proof if a piece in human system as an
a. p. o. ricky learned to tolerate it why not
we know that if e. s. walls large quantities of um what it freak you just station
yeah he's immune system is by its king you to reach the maturity is
able to respond for instance in the case of youth and fixed
why would this symposium we we'll hear more about the role
of the cut macro by attacking the development of good
in may and yeah that if he did the provision of energy source despite the micro find out that
for the holes they're all invite the mean value to disease and
also they're very of function against conversation with microbial pathogens
then you can basically has two goals in steps
of sequential conversation by microorganisms and education
of this self both hits the nuances them in order
to learn to to distinguish between friend and in
we are in use to see this relationship in a pathogen saying man
that means that the main role of the immune system is defence against infection
but another function supported by yeah hypotheses developed by margaret mac file gate
and which is published in two thousand and seven might
be important as important as the defence against infection
but it competition on what is known on
the new one system in invertebrates invertebrates
have only i mean a new system and
told harper complex communities of bacteria
and the one invertebrates rich have an eight times an
adaptive immune system she postulates that the mainly based
the adaptive immune system may have involved because of the need to
really look nice and manage complex communities well beneficial microbes
in the can my calls lenient system we have to keep this morning of the got
however is more cells of the immune system
than all secondary implications take that
and the human gastrointestinal tract heartless that's hard with
such a complex come you have inefficient mike
therefore we can logically asked the question whether every every other yeah how to it
with potentially beneficial and calls look good any fish microorganisms can for her
might enable the baby's mccall's lose in one system to read
coke nice them as harmless all righty at rooms
facility in there by the column station of the card back welcome organised
building up an efficient and healthy macro value on as
really and this quickly possible starting even before or
is certainly in its interest since you would offer him
access to additional energy so mostly flattened something up
it eighty has seemed to be important energy after we've
and this is illustrated by simple fact i'd
like to recall you about the growth of an infant in the first week so flat
it is during these first weeks that so mackey
roles including parading goals is remarkably rapid
if we express the growth rate of pay people
in centimetres per year for his first weeks
of life it amounts to flaunt twenty up to twenty eight seventy meters per year
and his hat still conference increases style two centimetres in one month
these enormous growth rate drops progressively during the first remark
uh but remain stair steps counsel for the first your for
so it is dealing with a period where this microphone got that gets progressively retreat
that you must be able to sustain you scroll to the grocery
breast milk will provide the baby with it inappropriate in
a cheapo source of course but not all get
ah good ways components of the innate and yet that if you knew system
to fill the gap until his own immune system is able to take over
and he starts macro biotech is established function remember
it takes about them wants to mount
and a fish and i secretary i. t. a. response
but there are only at the micro by not that i've fully functional
that earlier people have access to energy sources provide right
so slogans constellations raise questions and scientific
evidence to sustain good response
this is the opinion expressed in recent review what i'd change and walk
they're all off the of all mean and fluctuating neonatal macro by not
not in influencing that development the function of the immune system
is still unclear and degree of involvement of the immune system in shaping
the competition of the got microphone don't that is and will
but from an evolutionary point of view it makes sense
and the idea that the human immune system does not on
the capable to just think i'm speaking friend and enemy
that it also contributes to shape got microbial communities to the benefit of the holes
is in just a concert these interesting answer it certainly deserves to be for school
what is clear is that there are a lot being micro by out that it really post natal light it's fraction
and extremely sensitive to external influences and
as we will hear later disturbances
up to my proprietor at this age have far reaching consequences in later that
with regard to the immune system we have to get away
from it exclusively pathogen centred view to have you
where it's role in establishing in managing a complex commune you're
in if you should got my coworker instances also explore
those of you laugh a six that this symposium of two thousand and ten on it teaching ethics
made him and that the title of the presentation of
the clock and wow i really environment matches
and in this case it may well be that
they're very early microbial environment you she lives
is important and even deterministic an as suggested
by size again bloomberg teenage enormity really this year
the first contact between the immune system and then michael organisation may
have ready to see effect on b. uh_huh uh_huh later
but now back to two thousand and four and i would
like to introduce our first cut the speaker and sydney
she'll change her p. h. d. at the interface three hundred plus
i forgot i had pasta you at each yeah eighteen zero
she then joined transition in strasbourg where she
worked for fourteen years and uh
after that he set up the department of microbiology of eco systems
in lille in nineteen ninety six what innate it's access you you research
programs developing faxing and probably optic applications of lactic acid bacteria
in two thousand and two she started in tradition
and health department at the nasty research stand
to be in north and as a group leader where she still he's a senior next
since the two thousand and eleven she's also effie yeah keep part
kind to the university of walking and as associate professor
and it is a little quarter of over one
hundred and five peer reviewed publications quarter of
pork chop this injury you would call in think of forty nine part so hot buttons
she also serves as a member on that is you probably ought
to have forced into lactic acid bacteria interest will platform
a presentation using title mechanism of crosstalk you

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Conference program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:02 p.m.
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:46 p.m.

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