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Early assessment of "shift of the SpO2 vs. PiO2 curve" predicts bronchopulmonary dysplasia in extremely preterm infants
Ben Stöcklin, UKBB
Tuesday, Jan. 21, 2020 · 10:18 a.m. · 09m 03s
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00:00:00
good morning and thank you very much for your between each token to today's meeting
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what he's shaved off the pressure basis
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uh sorry okay i'm going suppression but since bibles she pressure have
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wording c. o. left hand side that bottom line is the ideal
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the situation to rinse your just next to it's the blue curve is the curve derive from
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health yeah other than that curve as you can see is shifted to the right about six
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why such if this is mainly due to the partial c.
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h. u. pressuring you realign we have studied two hundred and ninety
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on the right hand side of slide one of our infants we put him in the head
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box and low with a variety within the box
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step wise and simultaneously recorded the box imploding separation
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ah gave us the bottles here we were able to fit all use not written defeated curve
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stalls and then calculated how far off and have all
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the route that curve shifted compared to get the okay
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published out last year
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gene and the blue channel and what you can see is according to the german
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mark laurie application two thousand and one in the n. i. c. h. d. yeah
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categorisation of all wrong plumber displays yeah um the
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shift increases with increasing the severity of the state
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no as i can imagine using ahead box using hyper very
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option prior uh option me she is relatively complicated in online
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databases and job was asking and made twenty nineteen
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for simplify test and what we've done based on
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data collected two hundred nine is that we can now i'm pretty sure
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curve lies
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dependent on one single measurement level tim robbins operation was
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yeah sure
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you anything we need you
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he's pavement we've got create such based on a linear regression allies
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what you can see here is inspired pressure the says its operation of the end
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and twenty he'll caskets inspired hold pressure equals and i
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find it to of all point to wants a room here
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c. level and if that babies nile having a
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separation of nine said she thought equals twelve point so
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no they're using this approach we hypothesise that the
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sex that on a weekly basis in observation of study
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prospect if we could beavers you mean that the integrated you would have higher
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shift down these shift the says that one week of h. would allow us to
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really displays yep defined that's being dependent oxygen for longer than
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twenty eight days and lasted shifted actually lie was to critique
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and uh_huh will saw from ends of your problem is they see
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thirty six weeks post it's true
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demographics all of these infants were recruited in most that's really going to
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the more of hospital with renault thirty two infants about sixty percent of them
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the mail notes would expect just facial age was lower in infants with wrong
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they were on mechanical ventilation
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required a longer option there
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we just says shift in all this inference from week long tail thirty six weeks last menstrual lunch
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here we want to win for we we three of life she falls always signet
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it's big
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and that made us think maybe we can um look
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at that we can predict now from that we'd want assessment
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the fan license
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shift value of thirteen point three he'll hostels i've one
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week in fact a licensed privileged any problem or space yeah
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you've almost send full sentence this is
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the area under the curve point i've
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the less impressive the right hand side which she value fourteen
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point three cannot heal apostles which still license to predict more britons
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wrong owners blazer
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oops she said send in the specifics
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seven
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it's i mean
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but to allow systems tech infants up high risk of problem with place yeah
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early in life and might enable in the future targeting interventions as it hit
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the last year for example stem cell therapy um which is neither a big
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thing or try she talked earlier to post like this the ruins other with others
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however the graph on the right hand side and a right
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and a soft should that read consciously for the number of green
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infants in this that
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nine of them out more
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ah it's not any questions on the levels
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good question so the switch from week to us yet
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i doubt i'll have a broken takes place around forty to fifty four weeks last menstrual age
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dependent of the babies gestation oblige however i think i
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uh uh as we all know some of these infants receive
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a lot lot uh you wind it cools community to intensive care unit um
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these other macs and without a look at the look at the data
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and the block volume they receive both the period of time in the nietzsche
00:07:00
she can trent send out of hand loading and the life span of a gnat adult
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then every trust side in the neonatal infant is approximately two
00:07:13
weeks so if our bayes role lesson that twenty eight weeks
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assessing shift at this time
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uh and uh
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all life might have had an impact but it's very
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not yet but there are several schools at a. b. p. d. d. t. for example i was publishing twenty fifteen
00:07:59
thing to think about that they were able to predict the big yeah even
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earlier uh seventy two i was of age and i'm definitely good one thing
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and do you think it's usable for now
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this test is useful yeah it the best bayside and it's actually seen
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the only thing we got to be really careful is that we
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predict she if if we use that to give us the part of
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the curve ninety percent is always on steep part of the curve
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as soon as we approached a platter and they the separation has higher
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a difficult to appropriately assess
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what i wanna say as well is a separation of of ninety seven cents
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anyway normal these shaded area you sounds more students
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