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Short report - Evaluation of exposure to vancomycin in neonates with current dosing approaches
Kim Dao, Lausanne
Tuesday, Jan. 22, 2019 · 10:01 a.m. · 11m 04s
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well thank you for the invitation with which such a switch back
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to english so uh my presentation is of that thinking
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sure enough a current to seeing approaches
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so some facts about them when i see it's uh and that right it's been frequently
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used a new metallurgy and there's a lot of um the church sure about that
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which goes in regiment she you and also the the way of administration
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in it that you can't yes she thought and the indians
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uh easy since it's the fact that that the the the evil that not well line
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it also has a one in a rest not so she aims of this is that you worked
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yet i come yeah well it's up there and
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losing of from in order to facilitate normalisation
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instead of someone else
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so it's um yeah that it's human can i think has been long um monitored by t. v.
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m. and targets with clinical praxis i usually the
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the trial concentration media usually a mascot
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between ten twenty depending on the severity of infection but
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resent us that it's mostly adults special next
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have because it's a vessel related due to exposure that is that's the measure
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that divides the uh area under the curve so d. a. b. c.
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and it's actually that's the related to the ratio of eighty c.
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over to me then you know minimum he needed to
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re concentration yes consider is it falls down there yesterday she
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just yeah i think uh mice in every case
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if it is
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and the targets in every church or i don't usually do eighteen over
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four hundred if we consider a bit of a one or less
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and toxicity is observes a of a seven hundred s. are over
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so the next year for this study was first uh uh not that
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well and whether that can predict uh the
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concentration union itself we ah means so
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when we know already that a nation of income i think is best uh
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even if you can supply the weight of the new nate brats name and no post menstrual h.
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and with a smile we also uh collecting all the
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regimens of the synchronising that make you find
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in any church during nine sleaze need you in the frame of
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those he's like those project in international guidelines in a retraction
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so here you can see that the centre of them are evaluated instead so man
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the um the international guy
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no sign another important uh guidelines that um we use
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and also some uh some articles that proposed a dosing regimen for for recognising
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using is twenty reggie member we apply um i'm not sure if
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your population of four hundred new mace with different characteristics
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she see it which proportion more targets after one day of
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treatment and seven days of treatment considering and uh the
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go to denver uh of if it is either that discussed before one hundred eighty seven hundred
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we also anonymity trough concentration but i will not discuss
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these results because stuff up because of time
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it's maybe easier to understand it uh understanding concrete examples here are our
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they told us they use a lexicon read that
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this function of post natal age and waits
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so for the first patient for example um seven hundred
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grand you should receive according to this regimen
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fifty milligrams a perpetual wednesday and explorer would
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be such that you would have
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an estimated a easy that is to go according to our targets
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another h. m. o. and so is the oven one point five to
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go and what would the guy and you should receive a fifteen
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meeting once a particular we pay in for him uh that's what
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i would be in the dark it's according to our methods
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so the results after twenty four hours you can see on uh
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on the left the results from this disney who's we see
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that it's mostly uh no actually except for less than
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that because i work there but because it was a simple i reasoned that was uh that was uh
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simulated fifteen milligrams per cubic three times a day for all when units
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in um you know you can see the guidelines where there's a
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flashback one it's big enough it's where the user login those
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they scored a little bit higher than other regiments but the results are also usually
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at below or range of the interval and on the right you can see
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well what we actually tried to and your rates exposure by
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adding a loading those to some of the regiments
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new nato formula really new facts ninja it's it's
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regimen but and also a model based uh
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either meet him the results after seven days as you it it's a little bit
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higher but still at the lower range of internal uh for
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for all of the the guidelines we we tested
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another way to present the results is to show the proportion
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of patients in that i get and you see
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that i'm done rate there and targets and that's for most of the regimens like less than forty
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would be after twenty four hours in what is considered to be a a good exposure
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after seven days it's a little bit higher but still less than fifty
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percent of patients that are between four hundred and seven hundred
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but that some of them yet either which is also not a not which
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so the conclusion is that moves current dosing regimen for when
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i think of my sin fail due to ensure that
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it could be that instant efficiency dose regimen should be you
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should be avoided in uh in units white resistance
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and that there is a marginal improvement with complex regimen would not go into details but stunts
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somehow i try to describe very very complicated regimens invite that
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don't really seen g. e. u. uh enhanced expulsion
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and our proposed proposal would be that adding unloading tuesdays simple dozing
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regimen if you if we want to increase the proportion
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twenty four hours for example new facts either was or you made to formulate real
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uh and also tricks from little bayes uh approaches uh
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to increase the proportion patients in a tight
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and you write thank you and thank you to everyone who helped me she realises project
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hi
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you can import it's interesting talk there any questions from the audience
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please
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oh
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um
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uh actually it's the it's the next that so for harmonisation i think it's
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a global problems not spit from i'm only but mm international a huge
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everyone is using different direction so i can get in to wipe
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an armour bonus approach that is one of the uh
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the aim of this isn't you those project is that it would uh it's a good thing
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uh after probably your first which i think is that i mentioned did not show that
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there is a bass right you know all of this regimen that i tested
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still the one that's and show that and it's interesting because it
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shows that didn't seem well these two good exposure but
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after uh what's more text which is that which is released
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uh i think that maybe the most plans in a wreck shouldn't be
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she pays a doze and a lot though on the first phase
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because the uh the least worst i would say regimen or do you facts i mean jack this
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and a new nato formula rebates seal fifty percent up a fifty sixty percent thing or
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i really don't questions but it's a
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no unfortunately i didn't have a data and that's
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i have one question about kermit law to concern uh
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um when you're elimination feet in all these infants
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just knowing from uh oh i mean look like us art director or different
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illumination pattern in different in firms depending on brigadier very sick or not
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uh yeah i mean you know right in there
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retarded age i don't know that so you you you found linear
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elimination in all these infants to be expected even if you
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based on the point data points you read you sometimes only had one or two back
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to point a baby so it can be difficult to still be to your remote
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ooh that point and actually uh in its own way back when you think it's away yeah
Conference Program
Welcome words
Matthias ROTH-KLEINER and Philipp MEYER, resp. Lausanne and Aarau
Jan. 22, 2019 · 9:34 a.m.
384 views
Welcome words
Markus Hodel, Lucerne
Jan. 22, 2019 · 9:39 a.m.
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Short report - Outcome of very preterm infants
Philip Thwaites, Zürich
Jan. 22, 2019 · 9:42 a.m.
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Short report - Bronchopulmonary dysplasia (BPD)
Ikbel El Faleh, Lausanne
Jan. 22, 2019 · 9:50 a.m.
360 views
Short report - Evaluation of exposure to vancomycin in neonates with current dosing approaches
Kim Dao, Lausanne
Jan. 22, 2019 · 10:01 a.m.
353 views
Short report - Characterization of postnatal sodium fluctuations in very preterm neonates
Roland Gerull, Basel
Jan. 22, 2019 · 10:12 a.m.
Short report - Readiness for discharge in mothers of hospitalized neonates from a Swiss NICU: a study
Chloé Tenthorey, Lausanne
Jan. 22, 2019 · 10:24 a.m.
389 views
Fetal diagnosis and therapy (part 1)
David Baud, Lausanne
Jan. 22, 2019 · 11:33 a.m.
199 views
Fetal diagnosis and therapy (part 2)
Nicole Ochsenbein-Kölble, Zurich
Jan. 22, 2019 · 11:51 a.m.
368 views
Minimal invasive therapy of congenital malformations
S. Holland-Cunz, Basel
Jan. 22, 2019 · 12:03 p.m.
111 views
Discussion
Jan. 22, 2019 · 12:26 p.m.
118 views
Management of PPROM around 34 weeks (part 1)
R. Pfister, Geneva
Jan. 22, 2019 · 2:48 p.m.
Management of PPROM around 34 weeks (part 2)
B. Martinez de Tejada, Geneva
Jan. 22, 2019 · 3:06 p.m.
141 views
Late termination of pregnancy : legal, ethical and medical aspects
R. Favre, Strasbourg (France)
Jan. 22, 2019 · 3:58 p.m.
The beginning of life
T. Berger, Lucerne
Jan. 22, 2019 · 4:40 p.m.
480 views
Awards and Closing words
Jan. 22, 2019 · 5:04 p.m.
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