Player is loading...

Embed

Embed code

Transcriptions

Note: this content has been automatically generated.
00:00:00
well thank you for the invitation with which such a switch back
00:00:04
to english so uh my presentation is of that thinking
00:00:10
sure enough a current to seeing approaches
00:00:14
so some facts about them when i see it's uh and that right it's been frequently
00:00:18
used a new metallurgy and there's a lot of um the church sure about that
00:00:25
which goes in regiment she you and also the the way of administration
00:00:30
in it that you can't yes she thought and the indians
00:00:35
uh easy since it's the fact that that the the the evil that not well line
00:00:42
it also has a one in a rest not so she aims of this is that you worked
00:00:49
yet i come yeah well it's up there and
00:00:53
losing of from in order to facilitate normalisation
00:00:59
instead of someone else
00:01:02
so it's um yeah that it's human can i think has been long um monitored by t. v.
00:01:07
m. and targets with clinical praxis i usually the
00:01:11
the trial concentration media usually a mascot
00:01:16
between ten twenty depending on the severity of infection but
00:01:21
resent us that it's mostly adults special next
00:01:25
have because it's a vessel related due to exposure that is that's the measure
00:01:30
that divides the uh area under the curve so d. a. b. c.
00:01:35
and it's actually that's the related to the ratio of eighty c.
00:01:39
over to me then you know minimum he needed to
00:01:43
re concentration yes consider is it falls down there yesterday she
00:01:47
just yeah i think uh mice in every case
00:01:51
if it is
00:01:53
and the targets in every church or i don't usually do eighteen over
00:01:57
four hundred if we consider a bit of a one or less
00:02:01
and toxicity is observes a of a seven hundred s. are over
00:02:08
so the next year for this study was first uh uh not that
00:02:14
well and whether that can predict uh the
00:02:17
concentration union itself we ah means so
00:02:21
when we know already that a nation of income i think is best uh
00:02:26
even if you can supply the weight of the new nate brats name and no post menstrual h.
00:02:33
and with a smile we also uh collecting all the
00:02:37
regimens of the synchronising that make you find
00:02:41
in any church during nine sleaze need you in the frame of
00:02:44
those he's like those project in international guidelines in a retraction
00:02:50
so here you can see that the centre of them are evaluated instead so man
00:02:56
the um the international guy
00:02:59
no sign another important uh guidelines that um we use
00:03:05
and also some uh some articles that proposed a dosing regimen for for recognising
00:03:13
using is twenty reggie member we apply um i'm not sure if
00:03:17
your population of four hundred new mace with different characteristics
00:03:21
she see it which proportion more targets after one day of
00:03:25
treatment and seven days of treatment considering and uh the
00:03:31
go to denver uh of if it is either that discussed before one hundred eighty seven hundred
00:03:36
we also anonymity trough concentration but i will not discuss
00:03:40
these results because stuff up because of time
00:03:44
it's maybe easier to understand it uh understanding concrete examples here are our
00:03:50
they told us they use a lexicon read that
00:03:54
this function of post natal age and waits
00:03:57
so for the first patient for example um seven hundred
00:04:00
grand you should receive according to this regimen
00:04:04
fifty milligrams a perpetual wednesday and explorer would
00:04:08
be such that you would have
00:04:10
an estimated a easy that is to go according to our targets
00:04:15
another h. m. o. and so is the oven one point five to
00:04:21
go and what would the guy and you should receive a fifteen
00:04:25
meeting once a particular we pay in for him uh that's what
00:04:30
i would be in the dark it's according to our methods
00:04:34
so the results after twenty four hours you can see on uh
00:04:39
on the left the results from this disney who's we see
00:04:43
that it's mostly uh no actually except for less than
00:04:48
that because i work there but because it was a simple i reasoned that was uh that was uh
00:04:54
simulated fifteen milligrams per cubic three times a day for all when units
00:04:59
in um you know you can see the guidelines where there's a
00:05:02
flashback one it's big enough it's where the user login those
00:05:07
they scored a little bit higher than other regiments but the results are also usually
00:05:12
at below or range of the interval and on the right you can see
00:05:17
well what we actually tried to and your rates exposure by
00:05:22
adding a loading those to some of the regiments
00:05:25
new nato formula really new facts ninja it's it's
00:05:28
regimen but and also a model based uh
00:05:33
either meet him the results after seven days as you it it's a little bit
00:05:39
higher but still at the lower range of internal uh for
00:05:44
for all of the the guidelines we we tested
00:05:48
another way to present the results is to show the proportion
00:05:52
of patients in that i get and you see
00:05:55
that i'm done rate there and targets and that's for most of the regimens like less than forty
00:06:02
would be after twenty four hours in what is considered to be a a good exposure
00:06:09
after seven days it's a little bit higher but still less than fifty
00:06:14
percent of patients that are between four hundred and seven hundred
00:06:19
but that some of them yet either which is also not a not which
00:06:25
so the conclusion is that moves current dosing regimen for when
00:06:30
i think of my sin fail due to ensure that
00:06:33
it could be that instant efficiency dose regimen should be you
00:06:37
should be avoided in uh in units white resistance
00:06:42
and that there is a marginal improvement with complex regimen would not go into details but stunts
00:06:48
somehow i try to describe very very complicated regimens invite that
00:06:53
don't really seen g. e. u. uh enhanced expulsion
00:06:58
and our proposed proposal would be that adding unloading tuesdays simple dozing
00:07:04
regimen if you if we want to increase the proportion
00:07:09
twenty four hours for example new facts either was or you made to formulate real
00:07:15
uh and also tricks from little bayes uh approaches uh
00:07:20
to increase the proportion patients in a tight
00:07:26
and you write thank you and thank you to everyone who helped me she realises project
00:07:36
hi
00:07:38
you can import it's interesting talk there any questions from the audience
00:07:47
please
00:07:50
oh
00:08:04
um
00:08:27
uh actually it's the it's the next that so for harmonisation i think it's
00:08:31
a global problems not spit from i'm only but mm international a huge
00:08:37
everyone is using different direction so i can get in to wipe
00:08:41
an armour bonus approach that is one of the uh
00:08:46
the aim of this isn't you those project is that it would uh it's a good thing
00:08:51
uh after probably your first which i think is that i mentioned did not show that
00:08:57
there is a bass right you know all of this regimen that i tested
00:09:03
still the one that's and show that and it's interesting because it
00:09:06
shows that didn't seem well these two good exposure but
00:09:11
after uh what's more text which is that which is released
00:09:16
uh i think that maybe the most plans in a wreck shouldn't be
00:09:21
she pays a doze and a lot though on the first phase
00:09:26
because the uh the least worst i would say regimen or do you facts i mean jack this
00:09:32
and a new nato formula rebates seal fifty percent up a fifty sixty percent thing or
00:09:43
i really don't questions but it's a
00:09:51
no unfortunately i didn't have a data and that's
00:09:58
i have one question about kermit law to concern uh
00:10:02
um when you're elimination feet in all these infants
00:10:07
just knowing from uh oh i mean look like us art director or different
00:10:13
illumination pattern in different in firms depending on brigadier very sick or not
00:10:20
uh yeah i mean you know right in there
00:10:24
retarded age i don't know that so you you you found linear
00:10:29
elimination in all these infants to be expected even if you
00:10:35
based on the point data points you read you sometimes only had one or two back
00:10:40
to point a baby so it can be difficult to still be to your remote
00:10:44
ooh that point and actually uh in its own way back when you think it's away yeah

Share this talk: 


Conference Program

Welcome words
Matthias ROTH-KLEINER and Philipp MEYER, resp. Lausanne and Aarau
22 Jan. 2019 · 9:34 a.m.
Welcome words
Markus Hodel, Lucerne
22 Jan. 2019 · 9:39 a.m.
Short report - Outcome of very preterm infants
Philip Thwaites, Zürich
22 Jan. 2019 · 9:42 a.m.
Short report - Bronchopulmonary dysplasia (BPD)
Ikbel El Faleh, Lausanne
22 Jan. 2019 · 9:50 a.m.
Fetal diagnosis and therapy (part 1)
David Baud, Lausanne
22 Jan. 2019 · 11:33 a.m.
Fetal diagnosis and therapy (part 2)
Nicole Ochsenbein-Kölble, Zurich
22 Jan. 2019 · 11:51 a.m.
Minimal invasive therapy of congenital malformations
S. Holland-Cunz, Basel
22 Jan. 2019 · 12:03 p.m.
Discussion
22 Jan. 2019 · 12:26 p.m.
Management of PPROM around 34 weeks (part 1)
R. Pfister, Geneva
22 Jan. 2019 · 2:48 p.m.
Management of PPROM around 34 weeks (part 2)
B. Martinez de Tejada, Geneva
22 Jan. 2019 · 3:06 p.m.
Late termination of pregnancy : legal, ethical and medical aspects
R. Favre, Strasbourg (France)
22 Jan. 2019 · 3:58 p.m.
The beginning of life
T. Berger, Lucerne
22 Jan. 2019 · 4:40 p.m.
103 views
Awards and Closing words
22 Jan. 2019 · 5:04 p.m.