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so thank you very much for the uh the introduction so going my lecture i would like a
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first to describe the type of a research we are currently doing it that she says so
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um and then i would like to uh give two examples of these research
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which are both based on top of the grand touring so we're developing tools
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uh to bring targeting to a permanent going to the point of care
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so yeah she system is actually a lot university it is and we'll decide university
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uh it is this part full of a western switzerland's a it is the second largest
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the university in a speech segment really the university of zurich is actually larger huh
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so the yanks course ah dispatch of it everywhere so basically all of our
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voices which when you have a engineering school with some speciality is
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typically invite ever have especially thing life science uh uh uh
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with a focus in biotechnology that it's been diagnosed
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so for years ago with s. decided to try to featherweight
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all the different uh skiing send expertise retrain yeah sure
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so using research program in one or the other is a research program which is code diagnostic by chips
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um is based on a point of point of got diagnostics so the idea
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is easy to develop another technologies in try to apply these novel technologies
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to uh the development of the most waiter of um a point of care devices
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well they are popular us for this uh research program the first one is a myth disciplinary see
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so within the ashes is we can find the expertise in all
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the engineering um a feature like a bike and basically um
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and id takes imaging you have my critics electronics micro fabrication informatics and so on
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and so we try to develop projects which are combining
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all these different technologies because we we devalued
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that uh the innovation is it at the course or the at the interface between the different type of technology
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the second aspect uh uh which is a characteristic of these research program is to emit denotes sweet
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so the technologies are not developed to develop technologies but we
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have always a demonstrator in uh in the head
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so you would usually it is suggested by either medical doctors for by industrial
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park last for instance creation uh we have a server projects which um
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meaning that uh since awful hydro separately so basically
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extremely small sends out to measure pressure
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uh we have project uh first in and they're and they're nice aspect can be done at the dermatologist
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uh we have a hydration money to insist then we have a simple system
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to monitor and to measure via marcus uh at the point of care
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and uh we have one project where we try to develop a system
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to monitor products in the broad in these in the continues fashion
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so what is the what is different demonstrate that are uh somehow fit that way it and the
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development of technologies we tried to uh you need but the possibility to make a demonstrate
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so now i would like to give you a an example taken from
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our uh on research uh this is based on property brought monitoring
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so i would like to show you to project the first one was made out
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of these research program so it was basically how we came to the business
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and then while i would like to show you a product which is the
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ongoing but uh which is in a a framework for this research program
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so if adequate monitoring can is are the pack to make sure the consecration of a drawback
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in the broader so that we can change the those each adaptor but those uh uh to a particular page
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so you have yeah the particular case of the attack and so it
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isn't it against agent which is well known nothing about this
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no you see that uh this molecule that requires certain concentration to you if it crashes
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uh to have set to show efficacy the country concentration is too low then the cancer will continue to proliferate
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but very quickly uh the drug is toxic so very quickly you will get a lot of side effects you
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see that the the constitution which ah idea is they know it's a range between two point lately
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he went on to my grandpa i met in here you can ensure that uh you
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have a a treatment with if you could see but with less addressed it so
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now the problem is uh depending on the person uh the method is not the person
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would be very different that in so depending on the person some will be here
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so in that region in some will be here in that region using this in those so it's why you need to measure
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in into correlates to adapt the those to the to the person
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so we are in particular working with that product is an antibiotic circle to write my scene
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within a it is a drug which is a given no i'll move
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gathers to me only it's a also to uh to infants
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it is to a finite particularly a c. d. or bacterial infections
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when you see here because it is given to new needs to intrude on so the amount of lot play so i it's not approval thing
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to regularly take route from uh infant in here to have the possibility
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to use a very low mort is really a big advantage
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uh you need to have a meeting with consecration otherwise you will have factory proliferation
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but very quickly it gets toxic disney for toxic but it is also what
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the toxic it means that the to the child can become deaf in so it's it is of course something you want to avoid with uh you know
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so currently evaporating one monitoring for or classical a way of doing
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the analysis so a medical doctor we or the the test
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then you you will take a sample of law which is typically meeting it
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off route it is sent to the laboratory gets uh the measurements
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sometimes it depends it will be a um an innocent by the pharmacology east
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and then it comes back to the medical doctor for the interpretation huh
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so in a in a first project uh we want it to a bit uh developing a point of care solution for that
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so we have two advantages that we haven't advantages so basically the medical doctor would order the
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test then we would take only a drop of profit so much more or malls
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then you have the pocket analysis within ten or fifteen minutes and then you can directly make uh
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uh the change uh for the doubles service at three advantages allow uh uh amounts of route
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then it is much more rabbit which might yeah which is
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important in some cases especially for a drop recap patience
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and thought that it it also a better interpretation of the results especially if you have a
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margaret more or a witch and enable from the measurement
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to have a um a nader to the to the change in concentration
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so there are many ways to try to tackle that problem so we wanted to go for uh how much is the same
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so uh the type of this you have to do here will be newman or say it would be
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of course up a competitive in the no is it because you have a very small my cool
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so here you will have an antibody which is specific for about my scene and then you have competition between
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a a derivative of the drought which is fluorescent you leave it in the
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drawer get set so basically if you have new drug in the broad
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the derivative with bind to the antibody while if you have a lot of drug in the broad
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basically then the derivative will be alone into a bit of a drug which is mine
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now we wanted to go for how much of this is a country to the most obvious which i
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had a region is because uh how much it's it's a is that nixon measures it's usually
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in a heterogeneous is the you will makes you will let the reaction happen and then you
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need to separate know how much genesis it you only need to mix and match
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so there are many ways to uh to how much is to see a we went
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to the most classical one which of the forces already station human we say
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it's a very well with the uh you know say forty also want them the principles of the
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following it is to monitor the degree of polarisation other for instance a meeting by the derivative
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you excite cheesy arise light enough to excitation depending on the size so whether the tracer
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is alone it's a small whether that way size bones in a very large
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then i you will get a loss of the polarisation which is a which would be different so basically the tree
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size allowed to get deeper our eyes light while if it is bonding you get a rather or rice lights
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so using a calibration curve hook you you get a distant at the c. is where
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that uh in absence of the drought would the tracer is bound
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and then you get highly or long or right right
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while in presence of a lot of drawing the quasar is along and then you get the people right
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so these when you can have is it twenty five and you can get this is which all very hard
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now the question is how can you integrate that to get a point
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of get device so one person has to go for my critics
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the other possibility to do it is to go to be powerfully dixon which is now
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uh in a real trend that particular due to our keynote speaker so since uh more less than yours
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uh the question is is it possible to do for us for a station even
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we see in papers so we want it to the investigator at that
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and we create it's more chambers up in different type of people in
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try to look whatever these would be possible the downing issued
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that um that darling to paper in particular out of course and
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scattering by the paper which could make the measurements impossible
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i mean the the it is quite critical so you see that uh many of
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the paper actually very for us and so you can make a great measurements
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and then maybe the other people will have some scattering and so the valuation digit i'm not actually
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but there are about the type of people which is actually not we'll pay pipe is glass fibre membranes so
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uh these are structure like paper by the but but made out of class in there
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you can do that have been a lot of press sense and the values of pronunciation
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huge accurate then you can measure in this type of uh of uh matrices
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the problem we had that was really the c. d.'s so uh so
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we could better i correctly but there were a lot or
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of uh variations in this is clear because you have your your very heterogeneous system
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so we had the hair here to uh um use but a lot of three weeks to itemise
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the size of a the nation to measure its every location so to decrease them
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the variability to be able to measure on a a correctly
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uh uh the the the correct then it's good performance
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so you have here no measurement measurement to last month in these chambers so
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in the in the range uh for two grams in which is important
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and we ah now with a c. d. speech uh below twenty percent deceased or not you really to uh
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the paper itself but more to the back to that it's still art is an alliance media by hand
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and so uh you have a broad variability which would decrease in in
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the case of a for real um of a really nice i
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must say four to run i see in the medical requirements are eighteen
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percent so basically well we have already in this thing which
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uh would be meaningful in terms of uh would you can um or requirements
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no what is interesting you repeat by that you can uh had had the function in one of the function is
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to a separate uh is the the the brought to separate the
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red that's that's the cellular component and the blast now
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so uh the the big trip into was he's actually been written a lot or what we so
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is that somehow or the rabbits and i can relate to it the junction between the fibres
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is so these things that we haven't actually a separation coming from
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the top with the with the make sure with uh brought
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in uh and the button where you it's not um but rest now we have more less clear glass smart
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perfect we need to buy a died with a little bit the broad before only ten time
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but if we mad i'm ten times and uh we get values which i
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can read uh by using directly brought it not or that are just
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so the the current tests like that so we take 'em a small amount of uh of uh brought
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so actually one not sufficient that you take a bit more because the uh it's a difficult matter
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then uh we incubate and then we are the small amount on uh how gender
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and we can directly measure it oh the measurement takes three minutes so uh
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in the incubation it is something like a five minute so and so it is redirected
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and you get the performance so basically we have more the same performance
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has with brass muscle we are currently within the twenty percent
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so for this type of proof of principle that this is a actually would still
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uh it's it is also a great we could see the data
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recovery star within a twenty percent so basically there that is
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okay so we were working on that particular project then then uh in the in
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a everywhere then suddenly asking the question so can we go of further
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in particular the aston directs where a single measurements in that is not sufficient uh this is the case
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for instance for an aesthetics or here for some antique inset ages like me to trick say that
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so these trucks i i'd even during long periods so you can
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vary here finest still cycle might is typically seven hours
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so continuously and the gigantic contract concentration
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it's almost anymore in the brought a so ideally it should be around seven hundred michael moore
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and then now uh you will either a um antidote uh to the drought
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so that you can rescue the person after given no this was not
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and then uh you have to money to uh how the person uh uh the the the drought
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we'll get a get out it especially here it's important it should be below one of them
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so yeah if yeah the case of what you can get if you do meaning measurements if you
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do mention my measurements you can more or less steady light the concentration of the drought
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because you have the huge variability basically we are not to need to have a
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a concentration in the meeting the low range of this type of uh of products
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and so the the the through the the concentration of the drug we've fucked with the remote
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you can study lies but maybe having a lot um so these it's more less twenty thirty measurement during the treatment
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this is nice this is not unlike that does just impossible from
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a logistic good point of view to take some measurements
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so does with that in hospital actually what we do is to measure only once you once here and
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in between the two of you to eat up with a high risk of adverse
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effect or or the treatment treatment that uh uh does not work properly
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so he it would be interesting to the possibility to me measure continuously
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and we had a sauce with this still an ongoing projects or
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we'll show you only preliminary results but i think it it shows
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clearly what you can do by further waiting different as expertise
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so one thing is to measure and you do need to measure um repetitive lean for that we are developing
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what type of molecular buyers and sellers is i'm a cool stuff which are uh emitting
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light and in presence of the drug the full then then then quench the light
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in this is reversible so what the when the dog is getting out then uh you get
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since our back and so this way you can measure several time
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it's still the and the proof of principle concept but you can see
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that uh it does work so we're able to measure actually yeah
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uh twenty five in the macro malawi but we can also make sense or a different uh concentration
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for the high concentration wage neither concert reception range and then maybe later at the low concentration
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no the mention that it says it's only one part but you need to automate that ultimately as uh the whole thing and it does
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what we are kind of current yeah the real thing so this is just tend to be able to take automatically brought sent
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so we want to use that um an entry which is maybe we use to for instance for um
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have greeting the patients so you have the hydration any every
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fifteen or thirty minutes we take us more simple stops
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then uh this is a there is also the possibility to watch afterwards so that uh you have no crowding
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and then uh you have to bring the the broad here so we have actually a small
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sense so with the micro three d. chamber yeah the sentence answer here and then uh
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compact uh uh reading device so this is currently under development
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so we have a so in the first prototype
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but uh it's yeah it's where we want to make the the bios and so so it's some micro predicts way we have here
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hydrogen hydrogen we have the bison so attached to be eats it so you can react well the presence of the blue
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so i would i would have like to show you a results uh i can assure you only a
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printer is that's where we had used f. p. h. sense aren't just to see whether we can
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uh repetitive only bring in take out a solution some measure
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here we can monitor so it's to show solution uh different uh th and
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we can monitor that uh is at the present stage uh the project
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okay so so what i wanted to give us a favour
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the activities in a in a university applied sciences
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our control you that um we are really dedicated to
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point of gathered mistakes that on many projects ongoing
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uh we need input from medical doctors in from industry so
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if you have a a visions of uh of devices
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you can always come to us in the initial the these we projects
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i have shown you that uh um for instance say they so uh the possibility to do point of care to appleton
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der der monitoring can think of a paper devices and probably
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it's possible to go full continues a red money too
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so i just wanted to thank jen uh uh but this window couple the me
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who worked uh here for the people are thank you for the above sensor
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and i want to thank my two quoted from the organisation pretty unmarked favour and
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the people who were involved in the project uh paper my crutch and so
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and of course they a lot of people because uh we try to
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work really by corporations so i think before it ha ha
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how much for
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oh thank you chop trying o. t. question
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one oh well i'm sure you've also
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i saw for products very strong chromatography f. f. t.
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so he it's not an issue because basically the it is not platter we'll
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removing his so you had the broad it is actually separated so you don't
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uh it might be an issue if you would have um belong to aluminium paper
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paper paper and then uh along the filter we could get to promote roughly
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but here you we're just heading in measuring it to some location so days
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no motion of uh what the broad of of the component only actually
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and it is a review of one having my computer systems for sure
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further questions
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oh yeah i would like to thank you okay session thing
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cass ah scared so i would be an extra second often session okay

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Conference program

Welcome Note
Gaëtan Cherix, Director - School of Engineering
26 Oct. 2017 · 10:08 a.m.
Welcome Note
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 10:15 a.m.
349 views
Point-of-care Diagnostics: what are the real needs of general practioners?
Nicolas Senn, PMU, UNIL
26 Oct. 2017 · 10:19 a.m.
Recent developments in microtechnologies for point-of-care testing
Philippe Renaud, EPFL
26 Oct. 2017 · 10:47 a.m.
GenePOC, a breakthrough solution in molecular point-of-care testing
Patrice Allibert, GenePOC
26 Oct. 2017 · 11:19 a.m.
Reglementary aspects ruling the reimbursement of laboratory analyses in the context of the compulsory health insurance
Michèle A. Fleury-Siegenthaler, Federal Office of Public Health
26 Oct. 2017 · 2:12 p.m.
114 views
Recent advances in non-invasive diagnostics
Samantha Paoletti, CSEM
26 Oct. 2017 · 3:53 p.m.
How nanofluidics bring diagnostics closer to the patient
Fabien Rebeaud, Abionic
26 Oct. 2017 · 4:17 p.m.
Keynote Session introduction
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 5:07 p.m.
Keynote session: Accessible Bioanalysis for the Developing World and the Point of Care
George M. Whitesides, Harvard University, Cambridge - USA
26 Oct. 2017 · 5:09 p.m.
126 views
Conclusions
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 6:25 p.m.