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00:00:04
well good morning thank you for this nice introduction of thank you for the invitation
00:00:11
as you see i i'm close neighbour of uh the lastly research centre
00:00:16
uh by the same token i'm suisse though i will speak
00:00:21
swiss english i hope you you you you would understand
00:00:25
uh we have already she talked a lot yesterday about the pendulum between
00:00:33
nutrient which nutrient is good which nutrient is bit we have mentioned that the
00:00:39
which switched from that carbohydrates to bet fat and now with
00:00:44
the uh focus and earn a cushy bed should do
00:00:51
and i've just
00:00:53
extracted here one of the many posts you can you
00:00:57
can find the and the and the web about
00:00:59
the health problems related to fruit was intake and if you read that photos can do what about
00:01:07
everything which is better you'll have a uh including changes in the other evade
00:01:13
energy is metabolic diseases cancer gastrointestinal issues
00:01:20
mercury poisoning it's it there yes
00:01:25
partially science supported that's
00:01:30
what we think now that that's been already suspected on on what the more scientific bases
00:01:37
about fifty years ago and the uh most of you are no
00:01:41
the the work of generated key in at this time
00:01:45
now what i wheel then uh address and that's me look
00:01:50
a little bit over simplistic compared to the former
00:01:54
a presentation is what is special about fruit too
00:01:59
according to what bob around said just today i guess i am a a a man
00:02:04
of the twentieth century if i'm interested in
00:02:07
nutrients rather than a a foot classes
00:02:15
but i i want to make you with the inside of
00:02:18
reminding you what are tied to the carbohydrates but just
00:02:24
very pretty old digestible carbohydrate that means that
00:02:28
it's starchy chapter chaplin was of course
00:02:31
free should bills which are either group goes all freak too was and the
00:02:36
second arrives and that's essentially sue crows i didn't mention connect was he
00:02:43
i freaked dorothy found in free form in
00:02:47
fruits in some vegetables in high noon
00:02:52
uh but it's always found together with groups of
00:02:57
fruits contain free fruit tools and free group
00:02:59
goes and when you eat fruit to eat the mixture of group was it freaked
00:03:04
so for all of these now all major sources uh uh so cruel was
00:03:10
and that the second ride made of one molecule the group goes link to one molecule freaked out
00:03:18
historically him the off sugar consumption is quite high but
00:03:23
you can if it has been very very low
00:03:26
throughout most of men history and it started to increase really into
00:03:30
it is sent to reading between the eighteen century now
00:03:34
should we can some shouldn't increased almost twenty to thirty four so that's that's that's something
00:03:41
important to keep in mind it's very quickly part
00:03:46
of the concern regarding freak too was
00:03:50
the uh started in in in the in two thousand and four when jordan pretty
00:03:56
and uh by republicans arranged the the the should high fructose consider
00:04:01
high fructose corn syrup is uh not sufficient
00:04:07
should be a be made from corn starch and as a matter of fact
00:04:13
starch it's a corn syrup as it has been made for a
00:04:17
long time and starts was extracted and converted into groups
00:04:22
and the the new thing with high fructose corn syrup which appeared in the nineteen seventy
00:04:28
was the beauty to convert a part of this group goes into
00:04:32
football was and mix them together to make high fructose consider
00:04:38
when we use high fructose corn syrup that's a mixture of glucose and fructose related
00:04:45
a concentration may differ a little bit but roughly that's half group was how freaked us
00:04:51
so that's very similar in composition to to propose
00:04:56
okay very quickly also because we're already seeing that yesterday
00:05:02
what what is the consumption of fruit the words
00:05:05
uh in in the state and that the n. haynes
00:05:09
three a deposition to about two thousand and it
00:05:14
that s. change a little bit since then but not dramatically in the average
00:05:19
they didn't take or sauces confound you is about fifty grams but they
00:05:25
and their for presents about ten percent of total energy intake
00:05:30
well if you take that freaked all of this going just
00:05:35
it was google was that means that should be the
00:05:38
we we consume about hundred grams should be and that corresponds to about twenty percent
00:05:44
of all total energy there is a lot of lot of internally vigil
00:05:49
variability and the apple a ten percent of the population here
00:05:55
uh the consume fifteen to twenty percent of
00:05:59
the total energy has proved cry now
00:06:05
what is special about freak tops when we should go
00:06:10
so corinth that's the time uh i just separate my maid of group was
00:06:15
instructor was in the get it will be split into glucose and fructose
00:06:20
i'm both will be up sold and up here in the uh in
00:06:24
the portal circulation and it then we'll reach that you've google as
00:06:31
will be turned supported in the lever through good to transporters
00:06:36
and then we'll be metropolis from classic like a license here the first
00:06:41
enzymes in exact can't can isn't believe it's critical kind is
00:06:46
uh which is responsible for that and then it will be
00:06:50
converted to full two six phosphate and photos one says
00:06:54
the phosphate through frugal kind it's this pathway is dependent financially in
00:07:02
so when you eat group goes dyson increase will secrete into unit and you will regulate this pathway
00:07:08
and most important for for for for the crime is is regulated by the
00:07:12
energy status of the set so when eighty p. in the set increases
00:07:18
when site rate as a marker of a trip
00:07:21
cycle metabolism increases then you will in
00:07:26
the beautiful so fertile kind a it and you will slow down this process
00:07:34
when it gets to freak too was freaked always is almost the
00:07:38
same and uh and uh it it it does the same
00:07:45
four o. four chemical formula it it it is very clear we are
00:07:48
very close molecule to group with but it is very lethal
00:07:54
method when asked by acts of kindness it's so in belief or whoever can go except chi names
00:08:01
which is called folk cocaine is which will convert freaked always into football fun for six
00:08:07
this photo kind here is as a very high affinity a very high even hanks so all the freak
00:08:14
too was which getting to the to the the setup will be converted into fruit cause conflicts fact
00:08:21
photos one phosphate then will be converted into trials is phosphate than this
00:08:27
is done by entities be which would be the equivalent of first fruit okay so
00:08:34
and from there are trials is phosphate we join to norman will likely to to possibly
00:08:40
the major difference is that you have no feedback control of this
00:08:46
elderly speed so all the photos which gets into the diva
00:08:52
is immediately converted into fruit was one phosphate and forms a um
00:08:58
trials is so states and that has several consequences first
00:09:03
if you eat a lot of fruit or was
00:09:06
the initial step consume a lot of eighty p. m.
00:09:12
and the the uh speed that this reaction exceeds a
00:09:18
eighty p. rethink pace used to have a
00:09:21
did or a transient each p. depletion a. g.
00:09:26
p. crazies a. m. p. increase use
00:09:29
and that can lead to a the formation of you we cassie than i probably see
00:09:36
and the second thing is that since we have absolutely no regulation
00:09:42
if you reply to mark the fruit tools you will need the the cell will try was is to stay
00:09:48
and then you have to get up when i sneeze throws disrespect of course you can actually dies number but
00:09:55
a as soon as you have met the energy requirement of the sense you cannot
00:10:00
uh oaks advice this poses the state anymore and they
00:10:04
will be essentially released as lactate in the band
00:10:09
so one of the effect will be increased in glad lactate concentration
00:10:14
but they can also be re converted into course in
00:10:18
this group goes can be stored it's like which
00:10:21
i am but also released into circulation is cool cause
00:10:24
you will increase proposed protection and finally him
00:10:30
part of units can be converted into fantasy and and you the stored in the evil
00:10:36
as as a in track that's acceptable really is s. p. l. d. l. two closer it's oh
00:10:43
the the the the the results of eating spoke to was is that
00:10:48
you will convert fructose problems it to add the components the first
00:10:54
point i would like to to make is that we have a um
00:11:01
we have studied that's rather extensively about twenty to thirty years ago and
00:11:06
many of these studies have been done with uh every check c.
00:11:10
was my mentor it's this time will is present here and what
00:11:15
would we we have seen enough sorry is that all these
00:11:21
by a synthetic process of course cost energy so you can fall said yeah seats from freaked
00:11:28
was but that could cost energy that's certainly not an energy efficient way of storing
00:11:36
now quite often people believe that fruit was essentially you ordered method but i still believe
00:11:44
and we know all that it's that's the case that there are several different cell types
00:11:52
which can met about ice freaked out the evil but also
00:11:57
smaller low interest sides and renal proximal tubular sets
00:12:02
and all these sans every specific metabolic machinery
00:12:08
they have these folk politic enzymes but they also where have good connection can
00:12:15
sometimes and most important they are the only sells which have to go
00:12:20
seek specific fact is though the only said which which can actually really screw
00:12:25
goes into the circuit judge and all the cells although of the
00:12:31
with the ability to operate an overlap region is the sympathise a
00:12:37
uh like a pretty in and really is like property
00:12:43
now when we you you we need to uh fructose low would uh we don't know exactly
00:12:51
how proposes notably nicest uh with what you see here is
00:12:56
is a summary of several isotope studies showing what
00:13:00
happens after the ingestion of the pew fructose built and
00:13:04
let's say you wheat hundred grams of fruit towards
00:13:08
about fifty grams will be released in the black this
00:13:14
group goes over the six hours following ingestion
00:13:18
about twenty five grams will be really isn't exactly it's
00:13:24
about fifteen grams a little bit more will be
00:13:27
stored contemporary he is affected like h. m.
00:13:32
and the rest will be utility diced wall
00:13:38
converted into fat and store this through december i but all you really is this
00:13:43
v. l. d. l. tricky so right so that make sure the pathway is
00:13:47
for proposed disposal our group was protection and
00:13:52
lactic protection notes like which analysis
00:13:56
of course that depends most likely on the amount of through those you
00:14:04
you take with me in the uh the the the frequency of
00:14:08
opposing take and have the and very environmental factors what
00:14:16
okay well let's
00:14:19
turn to the the the question is really neat freak towards the bit guy is
00:14:25
it's toxic uh some people say and if if so why so they ah
00:14:34
quite a a a lot of data in the literature
00:14:39
to make you suspicious about two if it's not the venom comes from
00:14:45
animal studies and intimate with you can make animal abuse
00:14:50
by providing them with two pros always hooked us
00:14:54
and this high school cross i propose that it through didn't used to increased energy intake uh
00:15:00
basically you just keep it in yeah then that could reach thirty d. v. d. c.'s
00:15:07
like it happens most often in in in rats we have
00:15:12
quite an uh a frequency adequately t. v. b. c. is
00:15:17
and even seen resistance and type it's yeah of
00:15:20
course i the additional reasons to to support
00:15:25
the caution about script was in many stems
00:15:29
from a particular tickle studies showing association
00:15:32
between uh should be in the proposing to shoot the fridge should do sweetened beverages
00:15:38
in the ache and the incidence and prevalence of uh of metabolic disease
00:15:46
no the this that is i will show you this that is done by by a a an
00:15:52
ample medical physiologist and they they they are really
00:15:56
mechanistic studies so am i yeah oh
00:16:00
oh i i prefer to address this question first we didn't do studies to
00:16:08
actually reproduce what happens when conditions that's that
00:16:13
used to show all with the
00:16:16
damn mechanisms related to focus metabolism which may lead to
00:16:21
delete erase effects so i we show you
00:16:25
what we know
00:16:31
okay sorry what we know about high fructose studies
00:16:36
in humans regarding this repeating yeah regarding
00:16:42
in try to keep it in g. p. d. c. a. and
00:16:44
if it even deceive us and regarding who goes the mysteries
00:16:50
now it s. been loan known for a long time that when
00:16:55
you provide people was out there we high carbohydrate not yet
00:17:00
or whether it's so close all full tools will even starch
00:17:07
you you may have an increase in the black to decide concentration that's that's something that
00:17:12
i invented a show here is that the of my lab but many many
00:17:17
add the the investigative seen that what you see here uh is the effect of the
00:17:24
the over feeding with one point five grams flip tools that he'll be waiting but they
00:17:30
providing it is three innings in heavy subjects over four weeks period
00:17:37
and they are the measurement of to to to get a ride yielded critically thing right
00:17:44
after the uh fructose fried diet and over
00:17:48
four weeks on this high fructose line
00:17:52
and you see that within one week three of this increasing batteries here right
00:17:57
which is essentially accounted for by increasing the l. d. l. to decide
00:18:02
and that is increase is sustained throughout the four weeks expire
00:18:09
the mechanisms i'm not completely knowing but one mechanism which is being
00:18:17
where is correct there last is that with a high fructose diet you convert some of the freaked was
00:18:24
in two d. periods this increases credit uh
00:18:28
freaked was uh uh an exposition
00:18:32
and you have this high to decide right concentration which can't get uh with the very marked
00:18:39
increase in practically peed a a a synthesis is estimated by the tracer methods so
00:18:48
fructose conversion into repeats mean that the the major
00:18:53
by half way of fruit to disposal but it's still
00:18:57
a most lights instrumental in increasing batteries right concentration
00:19:04
now with the high supposed to yeah to increase fasting that's ugly so right
00:19:09
and you also increased markedly post canadian batteries alright concentration
00:19:15
do you see here uh uh us that you performed by kevin tess
00:19:20
about ten or fifteen years ago when which she gave mixed meals together with
00:19:25
logos of footballs to have different ideas and when it uh this
00:19:29
most current really not a good and she showed that with records with rented platitudes remain
00:19:37
relatively little and that they are markedly enhanced after the fruit is one of the
00:19:46
mechanism may be done overnight but yes yes but it appears also that's
00:19:52
but i still unknown mechanism proposed me in that post pendleton just so right here
00:20:00
yes well how much for people to you need to have this effect but gladly periods
00:20:07
you see here a compilation of severance that youth and you see that you have
00:20:11
an increase in fasting but we decide concentration
00:20:16
when you reach about fifteen percent
00:20:20
total energy is football
00:20:24
and then it increases the with dependent so that something which
00:20:28
is observing a few subjects but which correspond to
00:20:33
very high concentration in the normal put peer into very
00:20:36
high um in taking the in the normal population
00:20:42
the same is true for post trendy l. and um i mean the the the the
00:20:49
for analysis of all data present in the literature suggests that you
00:20:55
have the first effect with fifty grams through tools that they
00:21:02
okay is it specific was freaked tools we sit observed with other substrate
00:21:08
it's pretty specific was freaked what you see here that was a hyper can wreak high fructose time
00:21:15
yet you have this market increase in class much ugly seventy if you have the same
00:21:23
excess energy was fat you don't observing increasing class batteries are
00:21:29
now furthermore it does not always depend on excess energy so here
00:21:36
if you have thirty percent freaked those in your diet
00:21:40
freaked those replacing starch such that the that it remain eyes look at american
00:21:46
people do not gain weight you can still observe increase think attributes
00:21:55
and that's something which is controlled by
00:22:00
several math than an easy i'm not personally find of math and i it's
00:22:06
always nice showing that because it it it it shows difference that using you
00:22:10
see here that most eyes look at or extent of youth and
00:22:15
hyper kinetic studies show this increase in practically so
00:22:21
by the same token you can see that this effect is observed in thirty subjects overweight subject
00:22:28
it's less if you didn't invite beaches go and lie if you quite often
00:22:35
here uh in in in conference is there was no strong evidence that
00:22:40
the effect of fruit to these enhanced in you know be subject
00:22:46
okay and then at the effect of fruit was is that
00:22:52
it increases small dance l. d. l. particles delete increases
00:22:57
the data which in the city of l.
00:23:00
g. s. though that's turned to the effect an intrepid to keep it and here uh
00:23:08
i show you the same will go to to get with the same kind of
00:23:12
that that we we ran a a couple of studies in which we
00:23:17
it had people don't see us and it was submit it to a fructose free diet for one week
00:23:24
and then the high fructose diet for one week and
00:23:29
in one study it was fifteen percent excess energy is for two hours thirty forty and you
00:23:36
see that with thirty percent and forty percent through
00:23:41
tools within six uh or seven days
00:23:46
you have this huge increase in intricate except that's
00:23:50
very high fructose concentration but that's really uh
00:23:55
and common in in in the uh in the
00:23:59
general population and even with this very high
00:24:05
the uh freaked was intake you increase in trade back to keep kids
00:24:10
quite market it but that's still mark to market the lower than what is observed in
00:24:17
of these patients with that extend tools it's so that's significant but that's not yet
00:24:25
it doesn't reach battered urge and that's the point which
00:24:30
has to be made regarding this intricately plotted
00:24:33
is that it is observed not only fruitful fruit was but it's
00:24:37
also observed was group was in here you have the
00:24:41
the study which was recently uh than by uh the the groupie for uh
00:24:48
the group of uh yeah and active in that and in which they
00:24:51
gave to help the subjects to to to overweight healthy subject
00:24:56
hit the and i so can wreak highly who cool sources to pose i yeah
00:25:01
or in high pig can read i suppose versus look was back
00:25:06
and you see that with the i. so can read by you knew the group goes no freak tools
00:25:11
increase in trade for a while with the hypo caloric
00:25:15
diet who goes and fruit tools increases integrated
00:25:21
well in additional concern which stems from an email uh back to and it's not
00:25:29
being a really substantiated in in humans but still remain the real concern
00:25:36
is that freaked doors compared to causes an additional effects and and the user
00:25:41
due to its method when you split it exerts some stress and believe uh it will produce you requested
00:25:48
uh and a reactive oxygen species to eat may by itself
00:25:53
you'd be pro inflammatory in the gaps it's me
00:25:58
change that that might be the increase l. p. s.
00:26:01
absorption and that may also tweak the information
00:26:06
and finally one of the metadata freak too isn't that you've arithmetic easy looks i'll which
00:26:11
may be pro celebrity it's possible that freaked
00:26:15
was maybe not only favour the position
00:26:19
that's set in delivering but may also be a favour the
00:26:24
switch from it but it's that was used to
00:26:27
then the match good unique uh to to stay active at the time
00:26:33
okay now another way of looking at things is
00:26:39
we can you can look at whether by giving large amount of fruit to was you reproduce
00:26:46
the disease that you can go the other way around and take
00:26:52
subjects with this is easily look with a by taking golf should the u. correct this
00:26:58
so this guy just yes it uh the net could leak static the fact if
00:27:05
yes including resistant and it just started should be free diet
00:27:12
so what will happen so we should be very quick to the three studies
00:27:16
one study with then my lab and was a published last year really
00:27:24
recruited twenty seven overweight male and female
00:27:28
where high sugar sweetened beverages actually
00:27:31
we wanted to recruit fifty but in switzerland it's difficult to recruit such people
00:27:38
deal with a lot of a trap tribal recruiting and the subjects
00:27:44
at the four week whining period and then be added
00:27:48
measurement of that intrepid take fat dynamic reasons spectroscopy
00:27:53
and then they were randomly assigned you the to switch
00:27:59
to achieve should should this week at to artificially sweetened beverages
00:28:05
or to go unless the ah should be sweetened beverages
00:28:10
they continue with a normal diet at what's
00:28:15
and the study lasted twelve really can after twelve week we
00:28:19
measured integrate attic fat and add the metabolic power meat
00:28:25
after this twelve weeks we see that the subject which when the intervention group
00:28:31
had a significant twenty five percent reduction in try tactics at what the
00:28:38
control group had no change there was no changing differently post issue
00:28:43
that was no changing but you wait till after or not
00:28:48
and that is that he comes from mexico and it's
00:28:51
quite recent that's fifty four obese children where huh
00:28:57
subjected where high fructose consumers and they were subjected to scoop those restriction
00:29:04
over six weeks and in new stadium they might need the
00:29:09
the uh the intrepid takes that and and the
00:29:15
the best actress by retry found and and clinical marker of
00:29:20
and i won't go into the detail of these uh
00:29:23
these table but they showed that uh that wasn't
00:29:28
a a partial regression of a a a d. v. d. c. is in many of these cheap
00:29:35
and final e. m. reasons that you published a few weeks ago a
00:29:42
lecture much pots and the whole bit early stick in san francisco
00:29:46
that's forty one children are high where i should be consumed should two males
00:29:52
and they were studied doing nineties restricted
00:29:55
was substituted a with starch
00:30:01
yeah and so that the total energy intake was
00:30:05
aimed at it remained in constants that was
00:30:09
energy balance i so can wreak substitution of should before stuff and you see that
00:30:17
the the whole group intrepid fat content decrees oh no that
00:30:23
that's the the mean intricately fat content decreased by about
00:30:27
twenty five that's the study was not controlled that some
00:30:31
trouble controlling the the the way to the subject
00:30:36
but in the subject would not lose weight that a small group the results where refugee seen it
00:30:45
okay
00:30:46
so let's get to the third point i would like to mention which is recorded those pieces
00:30:56
and you quite often reading the literature that it is well known that
00:31:02
should go through those associated with him sitting resistance would just
00:31:06
remain that it's even this effect and they're really
00:31:10
oh and in many different issues and regarding make i believe me both effect and that
00:31:16
you've uh and these effect will be mainly to suppress it but to request protection
00:31:22
and that's effects which are exerted it related few low when sitting yep
00:31:28
and effecting mass and and in in the math and it will stimulate group
00:31:34
was empty and you've effect ah upset at higher in seeking left
00:31:41
so when you went to assess it ever licensing resistance you will
00:31:47
have different experimental approach here you will have traced a method
00:31:52
going sit in infusion and money to a request protection year you will
00:31:57
have high inserting fusion and little group was mediated look was dispose
00:32:03
yes no you see here a study in which we
00:32:07
measured it uh it tactic gonna propose production
00:32:11
suppression by go to sincerely in in heavy subject after the low fruit goes by it
00:32:19
and after six days on high fructose die and you see quite
00:32:23
clearly yeah that there there really is a significant reduction
00:32:28
in in salinas acted there is some degree of inches apart you can see it
00:32:35
going and that is that you can we measured messaging resistance
00:32:41
in subject all the feds ways through could was
00:32:45
although full wits and here you don't see any effect on massive insulin
00:32:51
resistance so intimidated requests disposal is not affected directly by c.
00:32:59
these are two studies from my nap but recently it as being a method energies is
00:33:06
which shows basically that's it i mean he he
00:33:10
did with lots of studies he uh uh
00:33:16
getting accessed it back to concern sensitivity and you see that
00:33:21
three times did you see that you can see in sensitivity with the it's eyes of hello recall heifer can read
00:33:28
while studies having assessed massive insulin sensitivity all intimidated 'cause
00:33:33
disposal lurch still any effect when insulin since it
00:33:40
i know i'm good to go get it quickly in us the last
00:33:46
point i would like to to make is that all these studies
00:33:52
our experiment that's that is in which we try to see with
00:33:57
the fruit was can f. t. v. t. v.s effect
00:34:01
any for these studies with it okay a full to
00:34:05
date subjects did not do too much exercise
00:34:10
and two of them quite during the the the experiment
00:34:15
but of course that's that's not real live and uh um
00:34:20
we know that athletes can consume a lot of should be and that done not
00:34:24
prone to make that with this is that we did once that you
00:34:29
there are the studies it in june this in i'm this that you we compare ad
00:34:35
the effect of a low fruit was by a high fructose than yet
00:34:40
and the sedentary condition all with physical activity
00:34:45
is that it wouldn't with physical activity
00:34:47
of course energy output increases though we increased also energy intake twelve energy back
00:34:55
and to make it short you see here uh that with the photos into each
00:35:04
and said into reconditioned you have this increasing practically separate consideration which
00:35:09
was maintain my small doses of freaked or with and that's completely prevented by
00:35:15
exercise so that the the effect will of course depend on physical activity
00:35:23
the same is true for then overlap agencies which increased and the second week and you should
00:35:29
but with even slightly it suppressed in uh exercise condition
00:35:36
yeah the thing which i once briefly to mention is that
00:35:42
i think one of the point with missed so far regarding fructose that is it
00:35:47
that when when you start the the effect of freaked all was fructose
00:35:52
in the diet will always either increased energy intake or replace some she would
00:35:57
both uh um most most of the time that's both ate it
00:36:03
increases energy into a gifted but she replace at the subject
00:36:09
so we have no that's really obsessed with the the effect would
00:36:13
be different according to which the park substrate the two cases
00:36:19
so we just finished a study in which we can compare and the effect of a
00:36:25
high school cruise by yep and that the fifty percent excess energy we soup fourth
00:36:31
and that was than twelve effusive in when healthy
00:36:35
subjects according to randomised crossover trial winds
00:36:40
they had a one week heist cruise low protein diet and
00:36:46
the second time the hives two crow's high protein by
00:36:52
what you see here are the affect and infect that click it and with the highest to
00:36:59
pros low protein diet you have very marked increase in intrepid to keep it within one
00:37:05
and this effect is match decreased was pretty
00:37:11
that two possible explanation for that and most likely both
00:37:16
artful wine with that of course when you have
00:37:19
hi pretty you and you have louis liquid intake but the
00:37:24
second is that this being shown that high protein intake
00:37:29
reduces intricate except the position through mechanism which
00:37:34
i'm not yet complete it's not clear but that's likely direct effect on a on a and and if
00:37:43
okay so
00:37:46
oh what what i show you very quickly is that freaked
00:37:50
those in human can cool with this stupid in yeah
00:37:55
so the the hypothesis that it's made clear rule in uh in the pathogen is youth
00:38:01
of a a metabolic diseases disprove was good but that's not prove for this
00:38:09
it i think it can increase the practically peed concentration and there was concerned that it made clear
00:38:15
role in uh the pathogen is is up and then not magically fifty fifty c. is
00:38:22
it does little effect and i see yeah i'm any tears direct
00:38:26
effect on me and you the insulin sensitivity and i would
00:38:31
i think that you you can't say whether in the very long term
00:38:37
fructose would cause massive insulin sensitivity but i would bet it if it does
00:38:42
that would be through in direct that that rather than direct mechanisms
00:38:49
and finally that fructose effect can merge related by other factors like a five
00:38:56
and that how freaked was consumption affects the diet composition
00:39:02
is most likely uh uh uh uh uh in issue which
00:39:07
is being and the rest are estimated so far
00:39:13
and uh of course many open questions which i want uh
00:39:18
command and i would like to and by an uh thinking
00:39:24
all the people worked uh with me in the land
00:39:28
and outside but i but most particularly my colleagues in there and we did all the
00:39:34
magnetic resonance spectroscopy kick measurement of that into attached to thank you for your
00:39:46
yeah
00:39:53
thank you very much it should be a specially such i used
00:40:09
sure sure question it's
00:40:16
after you're from atlanta x. talk about comment or question so first of all um
00:40:21
i like the i like it a on a exercise to modulator died effects
00:40:26
um because so far this meeting as the first date we've seen exercise or physical activity
00:40:32
can modulator mediate some potential a that sex and ah so that was nice um
00:40:39
so are the effects of high fructose on liver metabolism
00:40:45
partially mediated but effects on i i asked oxidation
00:40:51
yeah
00:40:55
the difficult question to to to address one of their facts of of freaked tools
00:41:03
when they leave a is to that even though that is uh eh it's a
00:41:07
whole back in the the will be two in the bits set oxidation
00:41:12
and uh of course the accumulation of setting that you've uh
00:41:17
would depend on sets up the that will be
00:41:22
she said yes it uh attic from the plant the language in
00:41:27
is is the l. d. a. uh on one end and
00:41:31
uh uh uh stages disposal that you've and that will be
00:41:35
the l. d. l. to decides seclusion and and oxidation
00:41:39
in in in this regard to decreasing in type attic set oxidation
00:41:46
most likely contributes to to set accumulation with it
00:41:51
contributes to additional uh s. acts like a
00:41:57
effect on a on a attic insulin sensitivity you all information i i don't think so
00:42:08
anyway i care much there was a great presentation and here or there
00:42:15
i tried i understand it myself how toxic shock rates and i'm struggling
00:42:21
so i'll yeah you can give us a actually message yeah our isn't as strong toxicity which ah
00:42:29
i would like to have any oh yeah i get a comment i i also scientific question
00:42:36
yeah that's okay sorry hold produce a letter from fox in essence actually i'm here
00:42:47
or yeah sorry tell as a product up tells metabolism or
00:42:54
okay maybe maybe maybe the the question of us uh no i i've not
00:43:01
measured that and i i don't know if i would
00:43:06
expect much so beetle being synthesise from freak too
00:43:10
the the the there is a an indigenous focus
00:43:15
production uh which will lead to go
00:43:18
from group was been converted to so beautiful and so beetle to freak too
00:43:24
that's some indication that you may of indigenous freaked was production in
00:43:30
that you've and and that it may play a role in
00:43:37
then that could effectively disease that that that's not really
00:43:41
well substantiated now and i'm i'm presently working and
00:43:47
so be too and so close and goes to maybe i will be able to answer
00:43:55
a couple of years from now regarding the effects toxic effective should do
00:44:02
it's difficult to make politically correct hands
00:44:07
the if you didn't see the trick to this can be deteriorates it very high do these
00:44:13
is very strong in the evidence that it is easy to use
00:44:20
it usually do with is that we and but by
00:44:25
itself you would not be sufficient to support
00:44:29
but we we have to reduce should the intake to less than five percent
00:44:36
now i would make another comment in a showing that uh i should
00:44:43
get a that is responsible for metabolic disease is one thing and
00:44:50
thinking in showing that should the reduction will
00:44:56
b. if efficient to reduce body which isn't that the thing
00:45:00
that may not be this scene question
00:45:04
i yeah i it's worked out quite source that solar office now also all right
00:45:17
uh oh here are experimenting yep that's extreme shapes
00:45:26
well i froze out it's
00:45:33
well how is ah
00:45:39
i sort sort o. s. i'll start stuff which is still
00:45:45
i i i just change things yeah
00:45:50
that that's a very good point
00:45:54
uh there's been an n. i. h. the consults its concerns
00:45:59
three or four years ago and one of the major conclusion of
00:46:03
the conference is that most of the data and that
00:46:08
actually you with sure freaked was and that we should study
00:46:13
fructose together with schools but maybe you didn't pay attention but our last that
00:46:18
you was that was so close state of the fruit goes the
00:46:24
as you as you uh you have seen that they affect and infect attics that is
00:46:28
to that we have already also read than a couple of the trace experiments
00:46:35
to trace the the the the major metabolic possibly useful for those disclose it and
00:46:41
it's a little bit or to a mike lynn just it could cause but
00:46:46
who goes production then like to it's a really is remained the me to
00:46:52
uh possibly you don't want to of putting she she and of uh of like which
00:46:57
analyses like the sector of cool cause in its it in at the same time
00:47:06
thank you for i. o. row i i point
00:47:11
ooh it out
00:47:18
for i
00:47:23
i want to know what yeah i think it's high fructose corn syrup was so cruel as
00:47:36
and unless it's really very high in front of but that's not used by the big gastric
00:47:43
it's absolutely to see that they have been many many studies trying
00:47:47
to show differences between the two and all turn out
00:47:52
to to be negative you you you don't see any different effect

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Conference program

Nutrition advocacy in action: the politics of sugar vs. fat
Marion Nestle, New York University, USA
28 Sept. 2017 · 9:27 a.m.
Fat and carbohydrate recommendations - Have they changed?
Barbara Schneeman, University of California, Davis, USA
28 Sept. 2017 · 10:14 a.m.
Promoting equitable health and wellbeing around the globe
Nancy Brown, American Heart Association, Dallas, USA
28 Sept. 2017 · 11:30 a.m.
Gut hormones and nutrition
Sir Stephen Bloom, Imperial College London, England
28 Sept. 2017 · 1:38 p.m.
Nutrition, metabolic health, cancer and NCDs
Elio Riboli, Imperial College London, England
28 Sept. 2017 · 2:27 p.m.
Infant and child nutrition and cognitive development
Wendy Oddy, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
28 Sept. 2017 · 3:51 p.m.
Microbes, metabolism and autoimmunity
Ramnik Xavier, Massachusetts General Hospital, Boston, USA
29 Sept. 2017 · 9:06 a.m.
Lipid metabolism in high fructose fed humans
Luc Tappy, University of Lausanne, Switzerland
29 Sept. 2017 · 10:03 a.m.
Food, health and disease: The evidence and reporting the evidence
Dennis Bier, Children's Nutrition Research Center, Baylor College of Medicine, Houston, USA
29 Sept. 2017 · 11:11 a.m.
Deeper down the rabbit hole of data, analysis, and inference errors and suggestions for digging back out
David Allison, Indiana University School of Public Health, Bloomington, USA
29 Sept. 2017 · 1 p.m.
Neural circuits of food intake - is it all about calories?
Harvey Grill, University of Pennsylvania, Philadelphia, USA
29 Sept. 2017 · 1:55 p.m.

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