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Questions & Answers Session
Friday, May 13, 2022 · 12:40 p.m. · 09m 32s
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okay was stored from the back of a million all buff or or in
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right
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because this is all recorded now until yellow the afternoon we're on t.
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v. but it's uh h. that a patient has to have to be allowed
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to get it into bits and adding channel because i have a lot of
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patience that would fulfil the criteria yes so its approval post menopausal women only
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apply because the pros use of course so the all trials you re going on
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will completely with bar you scroll some keyboard is you know why your food with disease
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uh we use of mixed results but there is no indication there yet
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oh okay
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a little bit easier a fence this document says that they are key which ones
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or if you're a full proved it's forever really removes monies available since february
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okay with it should abolish bob kerrey abolished see oscar pfennigs a feasible no
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thank you very much uh uh a chance to ask a conundrum
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roll is working on the wobbly probably but
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the structure the effect he was highly rated
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eh and as you know so what is your explanation for this and what is your guess
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uh on patients uh i'll have it helps a response from it
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yeah i have excellent questions so so i think and that once it
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being devious plans we see um in in the structure trial is because
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these basic already had the end to be sorted effect which is part of
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yeah so you don't you don't get that b. m. d. gained from reducing
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remodel in which is also a part of what you see with well hole
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so so so i think it's so it's probably be in
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that in this patient's it's probably put dominant team model and
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uh independent i'll be muddling so i think so i think
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it's because you already suppressed always option at b. modelling sites
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as i think that's the reason why we don't see such a big on b. m. d. increase um as we do um
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and um i think it's very interesting request and have a selection eight out because we
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actually gonna test that out in a clinical trial um in in denmark and because it
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to me it's not really clear yeah i am how much the effect of all this
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fascinates giving weekly how much the effect out also is directly on the us to blast
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um because it's there all the time in this year um our at least once a week um
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because at least for you know it has been shown before in
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models that i'm a negative effect on our still passed and and confirmation
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is less when you give it on i i. v. at at more infrequent our timing so so we
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hole that um so i don't i wouldn't have the same an implication yeah but we'll have to see
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yeah if if i dare to do was to you will because what it's actually a very good question
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of why you're molding based therapy is so much influence by the previous onto resort give
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particularly after the nulls the mob that seems to be strongly attenuate the room we facts and
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we have some experimental data models going on and i think that in general the i. d.
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that remote building and modelling a completely separate
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biological things in the bone is is not adequate
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and in remote building has meaning that remote being surfaced season
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still have an impact on the way that molding use before so
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uppermost suspect that put you up zero remote link like after the
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nulls him up there is no choice not sociable information from remotely
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but also moldings effect it's all um we're we're still studying the x. o. question thank you next question
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thank you very much um i will will have
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a comment on the facts calculation for the reimbursement
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and so i don't think we can use if you use c. with
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the t. p. s. reports that are given by the t. yes um
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uh it's else um you'll have now also the calculation of the
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he's score adjusted for t. v. yeah so when the tedious is very low
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even thought the peace corps is not very low you may have also
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uh uh you can say that you have a t.
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score billowed mean is three point five so that's another
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hand to to get to this condition tutoring burst of the remote doesn't matter would
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i'd difficult and then i have a a question to to professor and and and
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two two questions actually first thing is that you the strip
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show that uh there is no decrease of we know function
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uh but in all the status it was limited to the thirty uh i mean it is permanent
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um so that we would you use it
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in a lot stronger uh or uh yeah worse
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uh right now uh functions situations or the cardiovascular risk is so high that
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you can see the released as a surrogate and then you want to use it
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and the other question is about this fascinates and the
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uh remote says amount uh somehow we would say that
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we it's it's less if he considers after a piece for us tonight so
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how long do you think we have to wait let's say to see the full effect so
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uh because this is a very friction situation that we we see is that uh
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uh we we see patients that received to be stressed and it says
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the point and we would like to give to them had the strongest treatment
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so how long do you think you have to wait to have for the night native i think
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thanks yeah so um add festival am i think we're
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probably talking about paste it with your kidney question is probably
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what we consider would be patients with c. k. d. for so between fifteen and thirty and
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and this is a highly heterogeneous group of patients as we all know
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some of them had well known well despite kidney disease have a lot so
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things going on with their at calcium phosphate and everything and i would probably not use role in these
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patients out that's all would know how it would work and secondly because they've most of them have high
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a kind of asterisk up because of all the these disturbances but also have patience
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i have an e. d. f. r. of twenty five and just maybe
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due to old age and no structural kidney function at it as our it
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kidney diseases been detected and and so so i'm
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not really certain of course have would evaluate cardiovascular risk
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i very much but if they have normal p. chase normal gaussian normal phosphate nominate line facilities no indication
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of men all um i you know it it's a trade off i i don't have any proof
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that it will work very well but you know thirty is not a magic number so um yeah anyway
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and and and still with the l. and an eight um or this fascinates um
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i think first of all we don't know who yeah it's probably the answer to your
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question and i'm i'm because we also had this discussion also whether we should take patients off
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this was an eight and wait for a while before we started chair care type because this was also well known already
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for many years and i am you know especially if you think of a patient
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with the new fracture high imminent fracture is despite being on
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an internet maybe for many years i'm in there we not
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interested in taking them off to it because sat in that waiting time
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yep might deteriorate things so i think i would just switched directly from
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and and make if the patient suffered things that would tell me that something
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is not working right and the spacing is at high risk and then
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i'll just get as close as i could out of that money on remote
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and perhaps one more comment on the renal failure of patience stage for us
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at the mention of pull things i mean we should not forget that this treatment
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has an unknown to resort to effect that is equivalent put an audit of sort of course you will very
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much depend on the ball tone over in those patients and certainly not in bowls with with global internal work
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and your think years though the risk of like focus email uh maybe even worse
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than was the nulls about because this retreat that requires a lot of calcium in double
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one last burning question or not
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perfect great well we we we really with only fifteen minutes
Conference Program
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Questions & Answers Session
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Short- or long-term denosumab therapy? Part 1
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Short- or long-term denosumab therapy? Part 2
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Clinical debate: Short- or long-term denosumab therapy?
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