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Antonio Moschetta, Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy
Thursday, Nov. 1, 2018 · 6:44 p.m. · 05m 15s
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i
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uh
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because this which is that the molecule should be acting going
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to the gym like these different setups it or
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use that says it makes time or some time changes the fix it you have some insight on that
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yeah so um there are some study on going to their few
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study published on the our idea of separating probably frasier metropolis
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there is this very nice nature communication with the group of a n. g. m. in um san francisco
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which they are able to modulate the the structure uh via different point let's say point
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mutations substitutions and they still different activity but your question was very pertinent why
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is up and we don't know we now that a bitter cold though is the receptor but i would well well
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have jeff make you words via s. g. f. r. four and medical so we didn't we at and
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together other i several other group in the world the the knockout of energy uh for for
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will body knock out of beta colder will body and in both cases you have nineteen is not working
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then they have done the dishes specific knockout of bitter cold or uh david
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mangled specifically that this has been one of the most the brilliant
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a way to to the sector partway any to uniquely departed specific knock out
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a bit that little blocks uh the uh but i see the fact
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and brain specific not cultivate that will build blocks the anti obesity fact and the the the the the fact
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you will see that have you have made you know the ad is gonna be yeah yeah a diabetic dry
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yes but but but your question is that what is happening oh why you can
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separate you can separate by modulate the molecule but we don't know yet
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uh if there is a a different way out with buys a receptor life is only the same result bigger called isn't it
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now look like the dickens incision like that's the noise no moderated by bus in you know we we
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take that you're in colour spaces it's tough stance being transcribed because the constitution becomes very high
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and we think that ethics on in the lever a starts to coming to game out
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once you have it that much is like one of the most important coping
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activity if you look at the affix out and the bus in concentration in the garden much higher
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that's why the first one that x. is the intestinal the lever is like a save got
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once you of course this is and bicycles edition increase then the lever starts and say well it's time
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to transcribe and that's why you find after of nineteen in colour starting condition transcribed into labour
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but it's to me i mean i'm not the pharmacology but to me that's coming up maybe we weren't your
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later on uh the importance of the adaptive response incorporate things but your question is that no one else
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uh well out to out the interaction between you or one of the receptor couldn't change the
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and when you when you would do this modulation the molecules looks very very similar
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and the binding to the receptor while i'm i mean i'm not in that case
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by the sound similar but the pathway afterwards into the bottle sites completely different
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so it's at people are working on that because if you could uh
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then target directly the receptor in the lever will be even better
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okay thank you do we have all the questions
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maybe i have one short question you shoot data uh on to seven six seven molecule
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easter also some date a or some clinical data will
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uh it's so so it was examined well to be honest you know what to receive these the right
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it was a a real pain we can say paying on the television right it was a real pay because
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i ask it i've it's only pain because you can for united states uh you know the other part
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so so so uh we ah for the company to receive is the right to
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the sixteen months because it's not easy i mean you kind of by
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and they gave us the seven six seven seven six five seven binds ethics are but it's also in a way activities
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your five and uh but she's in the f. x. on account there's no in fact we qualify that was
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effects on uh i think the of doing some clinical data but not in cancer
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not in apple because and i think one of the main goal now it's all working for mash
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which if they don't find do real soup type of national park i take this route
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will work perfectly once we qualified uh this subtype of nash patients that have
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um but alas it a threshold moderation if you have those guys
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i will work if you don't have it a little bit forecasts if you have to personalise
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the thought of you match so i don't know of a a human data with seven six seven i
Conference Program
FXR/FGF19 gut liver axis – new therapeutic strategies
Antonio Moschetta, Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy
Nov. 1, 2018 · 6:04 p.m.
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