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yes with regard to tap i think we are close the
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thing because as shown by the 'cause and just before
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now we know where we will go because i think those construction and basic sense would be
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issue now is how we'd have to be the the tire you know the two shows
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that it's working on that's that would be from one of the main issue
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so i i just want to show you how likes to look at copy of this is is
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is and how we as you know focus on a quick about it is this your form
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for french it was never a controversial issue whether or not cortical street was working
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because we we abs is it that that interest them marriages are more
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a long time ago with perform an individual may penalise is showing that
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cut to close to weed improve one mum survivor and just want
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to point out also which one things based engines is
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insisted that look at a per zeros paper have been beat up for one month survivors
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and people are looking at one you know and i would try to bring the issue
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whether it's whatever and statistically that you're looking for a late after one thing
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and i we shows the driver off hop comes at me explain several things but nevertheless
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as in those the big issue was um play several country how outside that we're not convenes
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whether or not we have to be patient and is a big paper came from
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the u. k. bans isn't it but uh we've all biopsy proven and quick
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but it is the the test in a for loop and whether or
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not pentax fifteen which was identity do all people will using all cortical
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still we did was walking on not and as you can see
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there is no survival been if it with the pentax fifteen as compared to call to go see so you need to
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buy in and and i swear it which is a great was close to the significance in when you look at
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the major right then arises fishing was associated with survivor
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was the fact that the people where are located to the pride user and group
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and the the severity of the disease which where are already one and before the study
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and the nouns is that how it's a sign of common it's even a amount of evidence
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testing on not twelve is is we have two and up and up on all this controversy
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so you know they submit an analysis that has been good because it's like it's it's admit tennis is a form
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oh classical me then it is meaning that you are just looking at the literature and then you
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combine you put that down and this uh study i would
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not go in detail forgot but what they did see
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uh_huh perform an extensive uh uh uh and you can uh
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oh search of of uh of that that nevertheless
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well the show again is that n. s. it's a loon did not walk
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patents issued in did not walk in a direct me then arises between
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it and the acme that arises is suggest that it may walk
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and conversely call to go through it again uh was independent yes as you could with survivor
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and then one thing we have and would have to test and if you choose that were
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but when you combine and that's it's it's just into got to close to it
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it's in in simple of not survivor because it as you know there's one study outside
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which have been p. b. from the group of and we're in a crack in france showing that it may be an interesting approach
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and in this the classical me then i is what it is is it okay we we now we'll hank to save it ends
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and as you can see using placid will was now not a good ranking
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because you are on a on a square from one to six
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but that's fifteen was not so good it got to go sit in a crappy outboard does for them the best option even
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four ounces raise few that that when you one that that's supporting this and conversing cause it was too it was
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uh the the the best one with the association of not call me because because
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we didn't but is it in but i would just point out that
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now we have that assures him that cortical tested and pentax if you inform is not an interesting approach so um
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oh so you okay
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okay now so in order to and it definitely every time you have a control as you can say okay now i can tradition more
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what with the base away that night become a little bit fed up with this and
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i think we i hope after that which would be finished so what we did
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we ask all the the data from all the studies that i mean could beach which we call the individually make
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an analysis meaning you are combining the end if we did that that which is a pew our porch
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and what we did we put we how not to files and to see that two hundred patient
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where one demise and this was in our database because
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of the in maine investigators say sends the individual
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and what we did show is that again cots goes to we had
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to survive within a few that's compared to the non control loop
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and one thing which is important that was because nothing is magic because as julian bite or
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by chris yeah every time we have to tested well one thing i can tell you
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is is the what is not associated we finally improvement whatever you are using
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the remote at all build bins you 'cause whatever you believe in
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is it all is not impacting at unholy points you also your
00:05:25
your build been your improvement up eventually it will not walk
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and the sixteen as an example that the percentage of restaurants in this individual of
00:05:34
that are made an analysis was improving the call to go so we then
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was simple when you compare quotes because so we to pentax fifteen significantly says it's means
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that the the the the effect was driving mainly buys improvement of liver function
00:05:51
and when you look at pentax if in the same like brothers so you'd if you test that passive investors know but that's
00:05:57
if you didn't know survivor benefit at one moment and in
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addition to that no difference in percentage of licensed copy
00:06:05
this is the log seems not to affect the lever so therefore i don't think in the future you will have please
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even and i do think that this would have to get rid of that exhibit would
00:06:15
say i would say not as safe to out it seems not to work
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and the combination therapy we did our way to test it a long time
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ago long time for years but the time is going so fast anyway
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what we did it was a biopsy proven are critical but it's is pew o. one zero is on the mice
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i would make it a short story as a individual data meet an analysis nothing at all
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the only thing that we do have said is that it may have some high net
00:06:43
effect as suggested but since we're not effect was not associated with any survival improvement
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so the for this is why probably at least in our centre we not
00:06:53
using the community to walk in and do things that the individual that
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i mean and meet an analysis that we just we it would be submitted
00:07:00
in the following days will at least and the pen clarifies issue
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and the best probably is the most interesting of course we'd have to test as i said
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quite easily not and then as it is seen in watching was interesting in this in this study
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as i mentioned who are not part of it so it's a complete independent
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point of view is that when you look at the community group
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z. observe and hurley improvement in the high a magnitude of improvement
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and everytime labs that is is is is i can
00:07:30
tell you that it may be interesting and so you don't have side effects correlated to that will go looking for
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so hard to improve management of this vision you can and i do think that's now it's time to tell our
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what they're happy so as an example in in our send a connecting now worldwide set wasn't are using it
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we now classified as a according to the scroll we divide this
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going fried in passenger which is a a a is not
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every time looking at people when people start to cut off to to to cut the you know
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come the um uh continue scroll without the goods that's a colour porsche everytime everything is fading
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so what we did for the zero point is the the limo there is uh you know
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you have to have high isn't zoo point fortify your consider as an honest on the
00:08:17
you know that we have more insight with devices got in person see which is a
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pew up was meaning that you are not choosing anything is not the post up
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shows of the of the cut off and we show that there is a kind of guy who are complete rest on the else
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possible aspen does it seems to take been if it as compared to the placebo
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group and this guy which are we codes and a new less on those
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didn't take any banishing so the door and i do think in those patients we
00:08:43
have to stop call to go still we can probably if the patient is
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a good one you may consider and discuss that this leave it on some vision because we don't
00:08:51
have anything to offer them at that at at present time and one thing which is important
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using the cortical story does that definitely in this paper is that
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the arab surveys it increases risk of infection which was
00:09:06
always a main concern for fission to use courts goes
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to it in this uh appropriation and um
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and we already have it's a study looking on this
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in this study will look at uh it was a perspective our perspective database of patient what we look at
00:09:24
we look at infection before you use the way then we look at what was happening after so it and by the way
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every time you have this type of patient you have to
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perfume and next sense even systematic screening of infection
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because as you can see twenty five percent of them out already infected at admissions so
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this is what we are doing now you need to be performed extensive screening
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before starting any t. i. p. and then after that the the screening is negative then you can consider specific i
00:09:52
and what we did show is that when you are infected before
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uh before uh uh uh uh a contiguous to it and you
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start so it after you controls the infection it doesn't matter
00:10:06
because you would not have a high increase risk of infection because always people are telling me all this infection we're not
00:10:12
using or you can use it is only side which is where you have to be very prudent is alongside
00:10:17
and i do things that when you have a long attraction out at least now you
00:10:20
need we're not considering so cortical state and see we have several i would say
00:10:25
a a strong argument suggesting that the patient is controlled because as you know store long interaction is
00:10:30
is a tweak you want you know the to be sure that the vision is control
00:10:34
and what we did show is that when you up look at what is happening
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after still we'd the development of affection was associated with a pool art calm
00:10:43
and this is very important that you would have probably to repeat screening when your point okay
00:10:48
but the issue is that everything is related to the restaurants apparently because
00:10:52
what is happening is that when you are best on the aisles
00:10:55
is that you you are in a in a in a in a plane you are able to decree is
00:11:01
your altitude and therefore your risk of infection is decreasing but when you on that last one out of anything you have
00:11:07
state of racy valuable dysfunction and this is probably f. associated with risk of infection as you can see
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we did shows that uh most of the interaction was coming forms an honest wonder well is
00:11:18
the infection was a a very uh it was around ten percent is our best wanda
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and in in there for when you look at what is associated with
00:11:28
survivor on is the severity of the disease in the probability
00:11:33
of response to therapy was associated well is infection was not because that here at least in our aunts
00:11:39
that's inflation was related to breast cancer therapy off continuous improvement if you're not using so what it means
00:11:45
it means is that if you are still a guy with any i don't want to use the with because you are not
00:11:51
i would say having a statistical uh portions that a person apportion
00:11:55
at least if you're patient do not that means fontana simple
00:11:58
one carefully look at in is a lease clean infection because of ways of of inflation is very kinds of speech
00:12:05
and u. i. things if you chose to we have to look at over things that show that could
00:12:09
manger is is paper from the group of common was interesting because what issue is that only a
00:12:14
increase of you know what's the accurate i act act like a a network a quicker yeah of
00:12:19
could major which is just an augmentation of carotene by zero point three or fifty percent increase
00:12:26
this was clearly associated with the outcome of vision we are we are pressing this was pretty early in our database
00:12:32
you know the to show it because this is maybe also interesting
00:12:35
approach to to to all your uh your management of patients
00:12:40
and if you not also to have a more interesting point of view of
00:12:44
patient and for future tired because i do think that for future tired
00:12:48
people we have to look at car for that that that before telling it's not walking oh it's working as an example
00:12:55
if any guys is coming to your unit beat well formatted the uh hong forty
00:13:01
thirty eight let's say the guys coming property and you want to have
00:13:05
uh survivor who is a hound ten to twenty percent it
00:13:11
means that your blog has to work fairly hot
00:13:14
because otherwise you're patient even for his arrest wonder to tap it easily scoff about mortality
00:13:20
with this is very yeah as an example if this guy he's forty eight
00:13:25
he's asked wanting to to happy but not so much which is for uh in
00:13:29
another guy very good uh uh uh the uh outcome you will have
00:13:35
see the high risk of the so what it i'm means that every time you need
00:13:40
to look at the baseline and this is why some patient walk to seek
00:13:44
for me i'm not quite a one four studies because what you are expecting forms it will
00:13:48
it will be too much i only live a confrontation me may i can make that
00:13:53
and this is uh as i said this we we have
00:13:56
to consider those isn't have stronger commendation for future studies
00:14:01
and in order to to show you a a simple example
00:14:05
you have to look at both sides is like you are not looking at one thing one by one just
00:14:09
look at both thing in order to have kind of combination of your partner six as an example
00:14:14
you have a a guy who is comes consider as a complete trust wonder as an said it which
00:14:19
uh liz call is arms all points seven seeing as you can see the risk of deaf
00:14:26
we change form eight percent to forty nine percent
00:14:30
just because of the severity of the disease
00:14:34
because in every last one those are not the same according to the severity of the disease
00:14:39
and this is for a while you you we will have to look at this because otherwise
00:14:44
if we are not making strong strong strong argument you will have some study would completely
00:14:50
fade because patient would be to seek admission for at least being in any trial
00:14:58
so i i always a little little solution is couldn't because every time they listen to
00:15:04
is in the controversial issues so it is our job willows we love that
00:15:09
and what we start in fact we start because who are
00:15:12
fed of having patient who are dying without doing anything
00:15:16
and is and how it's in to give a with a surgeon we start to have a up on
00:15:21
so don't about it how we can make it and one thing was appearing as a consumption since it seemed
00:15:28
who was clear uh happy the accepted by six uh santa including
00:15:33
the belgians and uh is that first of all we
00:15:35
want to have on a patient with coming with us first
00:15:38
event because don't forget but because we'll consider this indication
00:15:42
the guy would would rank as the first one in your centre because he would be so sick
00:15:48
that you will income of equipped c. to access to the buttons addition you have to be very strict on this otherwise i think
00:15:54
would put only all the other day that a a good but it's would be on that
00:15:59
waiting it which is not a which we have to avoid because we need to be it's you got on this issue
00:16:04
and we use a non less from the using the the scroll and
00:16:08
again as user as in the score is not good sometimes or
00:16:12
do score is telling you also community score because people business community score
00:16:17
you can log on to listen to you have this score
00:16:20
and according to the community score you can things that the person have a good or
00:16:24
a bad problems to call good and sometime as an is quite me it me
00:16:29
she'll ends if zero it was a was a way to look at it is that when the patient
00:16:34
is improving according to the disco is supposing to have an improvement of video been over the time
00:16:39
and when the list goes failing you can't tell the shows that because you can see the patient is improving and then after the four
00:16:46
and no no reason it's deteriorating is conditioned this is why every time in this type of a porsche
00:16:52
you have to be pizza what politics call because you know that nothing is perfect
00:16:56
in clinical disease but at least i can tell you is that in our hands only ten percent
00:17:02
of patients have been fate using zap force of the community score and that we are still
00:17:08
up some patients who are completely uh not intensified by is
00:17:11
a is a is a portion of the remote it
00:17:16
one thing is important and the thing i just want to point everytime i'm
00:17:19
with the presence in our data sheets this is it seem a porsche
00:17:23
it's it's a map porch wellness haas vision assistance and and i have to and to get a
00:17:28
golf to work to give a you know the two intensifies a page and then this is
00:17:33
one thing for me which is now more and more important is whether or
00:17:36
not there's a family circle what i mean the connection between the patient
00:17:41
or his family members whatever it's family member always well let's see voice
00:17:45
always a partnership anyway if this is broken don't go for over because this patient would
00:17:51
have a new things to be the but after d. but completely would be alone
00:17:55
it's not yeah i don't think it's a good have aspect and then after is is this is where uh the addictions besides coming
00:18:01
is doing is independent evaluation because is bringing some very interesting thing
00:18:06
and we are trying to avoid contamination between the minutes
00:18:10
so he's doing is her own evaluation and at the last meeting is coming with his own evaluation
00:18:15
we know that too and sometimes you play some points that we miss and conversely we are basing some point that should mean is
00:18:22
and the surgeons and nurses are going into that point so all those guys are coming together and i would make
00:18:27
it a simple so because you must be but internal survivor it so was the uh the last c.
00:18:32
change because as you can see you have switching the outcome of patient who is an honest one though
00:18:39
to address from the income happy just because you you are
00:18:42
performing the buttons digital position like you are switching everything
00:18:47
so one thing is important as you know when i i presences this people long time ago in a seven day i was
00:18:54
some have some people particularly from the uh i make inside was close to keep us telling is that we are not it's
00:19:00
a good is to be the exeter next into but as usual that every ten things are changing which is very interesting
00:19:07
and i just want to be in the paper that i've been paid presented it is it yeah it is yeah up in my
00:19:12
one of my team and the brings this uh that that because we
00:19:16
perform pictures so with beings and for you i think it's interesting
00:19:20
it's a there is a phones i make an consortium early the
00:19:23
buttons condition so find is adopted at least some centre
00:19:28
this is a which is very interesting we observe the same thing is that the number who've of centre
00:19:33
who agree to do it we have the same thing when we stances in
00:19:36
the new england initially was for including the it's it's there's a disseminated
00:19:40
a a a sim bay's awaits the salmon having strong wait bane said because only wins jump in
00:19:46
she bring two or three guys we shame you know what i mean so if we communicated go for that
00:19:51
so never as uh as you can see after we could does this paper uh that a poet a progressive
00:19:57
is they haven't 'cause number of centre who agreed is that i agreed that we need to do it
00:20:04
and the total number of competition over the time is increasing in united states
00:20:10
they use the same m. poisonous and and is on the choosing still with as frequently as
00:20:14
us but nevertheless as you can see suspicion of hastings m. l. score is high
00:20:21
shots totally be uh is strong implement also i've or i'll
00:20:25
call use zap a gong twelve thirty two percent
00:20:30
the hard for this relapse hours just thing which is very important because as you can see
00:20:36
this is just anal code is associated with purple outcome which you would already know because
00:20:41
those just anal colour also it's early owns early onset of elapsed
00:20:45
our design yeah a sound coming very uh uh soon
00:20:49
and when i look at this we what we have and we completely agree on
00:20:53
this are correlated to legal issue it's interesting because in our centres on not
00:20:59
we're not putting them on the waiting is why because what we did she has
00:21:04
an example when you have any violence between the uh get a patient
00:21:08
we've uh any member of the society including is i mean outside we descended to do it because we don't
00:21:13
want to have just a moving like after that you have a male the offer finals the mystical violence
00:21:19
so in our centre in the front centre we're not doing so it was a
00:21:23
kind of come kind occasionally it with a lot so as an example
00:21:27
suspicion will not be now wasn't a younger age we're completely agree
00:21:31
lack of self admission to hospital i don't know what it means but lack of
00:21:36
complete acceptance of them is the so it wasn't very interesting because again
00:21:40
when as an in our son to a patient after to the the
00:21:44
the the evaluation do not woken eyes that she has a quick about it is
00:21:49
we don't consider again the references are because we consider the cannot work on anything because
00:21:54
if you are not organising the disease divide you go to work on it anyway
00:21:58
so in in term of outcome of craft and patient no difference
00:22:03
and nationals a guidelines uh in two thousand twelve said that we need
00:22:07
to uh as a father valuation in highly uh selected patient
00:22:12
this is a study perform again visor united states sauce
00:22:15
totally again very uh uh uh attractive wizard
00:22:20
very few relapse highly selected and as you know the u. u. k. decide
00:22:25
not to go uh for uh for of it to go forward
00:22:29
and they decide to to perform a pilot evaluation of this indication
00:22:34
and the uh this is one we are going on the web this is what you can see
00:22:39
to communicate buys a major ones is the new uh a
00:22:44
pilot study it's not very attractive or you can imagine
00:22:48
and the nevertheless action james number gods uh a contrast the
00:22:52
the the the the good it's is a good thing
00:22:56
he said we are confronting human not injured and buys a we none of us down in georgia
00:23:01
and i think we have to keep this in mind you know the to think about it
00:23:05
so this is what we did today now that now we're trying to again i
00:23:08
think this issue would be fairly it would not be any more controversial uh
00:23:13
eh uh at situation in the future that may have we we do that we have been funded to perform uh
00:23:18
i've got a a control of this uh the uh the buttons
00:23:23
edition program so what should we it's a control study
00:23:26
so patient where the control group we are could be considered for buttons edition selected which the six men could yeah yeah
00:23:32
we jennings uh in england would perform now which which is a a no good tone um
00:23:37
what would you simple uh the elements it's not uh and the bus objective algorithm
00:23:42
so if we decide which you have more than two hundred twenty you are selected if you are not
00:23:47
you are not selected for the uh the buttons edition programs the primary objective was
00:23:51
the non entirely to income of focal elapse the secondary one was the so
00:23:57
i would if it i can tell you we already touch it
00:24:00
and uh i just brings the last a bit this is a two year study we i visit
00:24:05
the last patient would be we uh um we and his follow up
00:24:10
by june so i hope to prisons is in the next it is a wise that the
00:24:14
so just what we have at at at time of presentation at one you know
00:24:19
eleven percent of the that thing out it was just a seventeen percent
00:24:23
and the survival is around eighty five percent which is the same as in the survival of the six one criterion group
00:24:29
and the survival question one not selected we compute images and that's a
00:24:33
good one because uh there so i was very poor as expected
00:24:38
so i just one now to bring several thing what we need now if chris now is coming we've do
00:24:44
okay i have to fit make any state you know the not to favour my approach to test it
00:24:50
and this is a things the most important thing because it never think whatever
00:24:55
the progress we make in the shade of the of this is is
00:24:58
if we are not performing strong study like we did in in
00:25:01
it but i just see annex it ah it would be a mess so i just want to tell you that for so long
00:25:07
i think that we will also to agree on something whether we are using live
00:25:11
about john i can tell you in phase one and phase two yes
00:25:14
because phase one and phase two you need to be sure about what you all working for
00:25:19
interface we it's more complicated because face we if it's international you want to have
00:25:24
five hundred four hundred six and that bush i don't things that lever betsy would be
00:25:28
really neat for the development so i don't i think that as examples are porsche
00:25:32
off the n. i. t. police said okay you have dishing it out quick about which
00:25:36
which is concrete agnes and biopsy proven in portable a quick about it is
00:25:41
is that if you don't have any over confounding factor you consider it's improbable
00:25:46
and i things except watches all of an for features that is
00:25:49
for big face we maybe we have to use is you know the to be sure that we are not a green in the put
00:25:55
about a gig about it is we have to be discovered forms of future trial even from some patient may have the disease
00:26:02
and uh i just i would go go a very quick why we need that because as an example
00:26:09
when you in how looking at it from the u. k. state a group from that group of uh uh 'cause they
00:26:16
this is if a patient where admit that we've suspected ugly but that is when they
00:26:20
perform a guy that is twenty five percent of them do not have the disease
00:26:26
this is forms a group of rogers at and z. does the same apportion half
00:26:31
of the person do not have the disease so if you are looking
00:26:36
in addition to whatever on not having as a by obsessive hysterical recognising is
00:26:42
affecting the outcome definitively yes is that makes him playing bass awake
00:26:47
wise a survivor of the u. k. study was so good because probably is is nice classification to study
00:26:53
and i just want to bring you it's that's that's a good approach that you need to understand
00:26:58
if i'm doing this type of apportion antennae okay uh uh he says coming for the like
00:27:04
phase one phase two on here and i tell him okay according to
00:27:08
matt mango and we're going to have this i put is
00:27:11
this is my control group and doing a study we for babs improvement was sliced the it it doesn't
00:27:17
this is my sample size but if i don't have the the betsy and
00:27:21
let's say that a fifty percent of we've all the during this this
00:27:24
hen we have the survivor which is not the same than expected because
00:27:28
as an example you can things that is why would be
00:27:31
less all better anyway i just want to show you well you are
00:27:34
you are in a new way because you cannot calculate anything
00:27:39
and if you are like in twenty five percent without a quick about
00:27:44
that is more here you would have to sample centre my you
00:27:47
have you ever discussed miss classification is that you aren't lynching according
00:27:52
to have an answer because your power is fifty two percent
00:27:56
so if we are doing study we've octave above c. would
00:27:59
have to pass is that decision to calculate the sample
00:28:02
size taking into account the skis coffins configuration over wise all
00:28:06
the jobs that creases doing will be just trash
00:28:10
and i think clinician need to do that and i go to do the i would go to tell you
00:28:14
as an example they score is social golf score from the group of common which are very interesting
00:28:20
but that is a maybe input and i think that we need and we stayed because going system
00:28:25
so one thing now and i just want to finish because i would have had
00:28:29
to uh try to get one time is the time frame for testing week
00:28:34
so can look at the kneeling on uh and i was very i try to tell you cannot
00:28:39
do that but it does that in any of it is a we never do that
00:28:42
they calculate one month and sends a good to one year as a as a control and then
00:28:48
at that time that was probably different for just one month and you're looking at when you know if you are doing
00:28:53
that it means that josh was that is is is associated with your outcome i will show you not at all
00:28:59
and when you are looking outside this disease as an example of this is that
00:29:03
contacted me stand probably would come back to me after a tone goodies
00:29:07
you know it's very efficient i wonder no worries are using it now more and more look
00:29:12
at the paper it's in new england i would say it's a good show not
00:29:16
this then is how come is the primary outcome as defined the outcome was
00:29:21
defined for forty days is so weak overlay of the notion call function
00:29:27
no no data on long term know that on survivor why you know why because
00:29:32
long term survival is not associated with a score they already shows up
00:29:36
it's associated with the the the code mobility of the patients so whatever you we do
00:29:41
on your p. young patient would have a good survival after that but the other one we not have
00:29:46
so you just had to mix everything you don't you will not find out and if over things
00:29:50
this is as an example patient behaviour for long term you're looking
00:29:53
at oversight dissipate perform a bit twos repeat loop while they
00:29:58
look they look at a long term according to whether or not people are quitting smock too small course to smoking
00:30:05
one thing they never provide is what was the cap which
00:30:09
was applied for those well us but that is at
00:30:14
jane just the decision what i mean is that when you have a a a as an example for corn eye disease
00:30:21
if you are looking at ten years you doesn't impact anymore the survivor the
00:30:25
things that will impact your survey but whether or not to smoke
00:30:28
and if you mix everything you don't get anything and i just want to show you as
00:30:32
an example of this is expose ought to to happy we need to work on this
00:30:36
if i want to go to work on the the uh on the on the on the day and this is like a quick about it is
00:30:41
i would have to say okay and working from the time of x. was i need free month
00:30:46
and i'm looking at freeman and i don't look after that and i will show you why we don't have to look after that
00:30:51
this as an example a study what the the the types of pressure in the diabetes
00:30:56
they do that for two for for two years and this paper was producing new england
00:31:00
survival been if it everything was perfect okay well they did after that
00:31:05
they said okay it's perfect you have to type quite sure you have to have a
00:31:08
a a regular consideration in exeter and senses it okay what is happening later on
00:31:15
this ad is that a good one z. to be the same thing ten
00:31:19
years late at the time the expos i was not there anymore
00:31:25
because a patient one two of would seem to apply uh taxes so minis are
00:31:29
not coming to to control those uh pressure annex it annex it up
00:31:34
so it's fun is that or outside the lever we are considering this it's a i would say is
00:31:39
a sense if we kept watch when we are talking of about are quite good is completely crazy
00:31:44
okay as an example lasting in appetite is c. is we are using zap or so far
00:31:49
quicker with this is no on t. v. ad copy would be in the market
00:31:52
look at the co constantly telling us that we need survivor data for testing drugs
00:31:58
so therefore ten means that every question you have to to to build a scientific field to answer your question
00:32:04
and i we show you know that we try to do that every ten comprises good for only because we have doing studies
00:32:10
but i want to point out what we all uh with uh with trying to look at it's what is associated with survivor
00:32:15
why we want to avoid that when you are testing the dog you and you don't have to look at the wrong time
00:32:21
so we look at shop them and all the patient were alive we
00:32:25
look at them later on and first of all we show says
00:32:28
that we that is a co curving around four to six months was there for the risk of the papers and give your
00:32:35
you want to have to get rid of it because more you will have this more you will have some confronted by about but nevertheless
00:32:41
when you look at short term outcome what is
00:32:44
associated with survivor is improvement series at baseline
00:32:50
no impact of i've got on shop them because a patient have a very civil eventually it
00:32:55
that do not affix approve of things that would affect is hard work would be efficient
00:33:00
conversely longterm only one thing is that the two things that is affecting yours yours is a relapse
00:33:06
and so in your improvement what it means that if you're able to impose some patiently we drink i we
00:33:11
shoes it's like don't you would i would always come they would be let's what i means that
00:33:16
the importance of fire code is there but what is is is this one
00:33:20
if you're using arrest one don't know our colour kentucky as of if you're on the
00:33:24
list of deaf in this guy is at five years five years is five percent
00:33:30
it is a guy is anonymous wonder and no i'll call usually if i i a risk of dashes twice
00:33:37
even is not drinking but it doesn't take been if it for your drawing if
00:33:41
is our best wonder but you want to drink zen she would die
00:33:45
so if you're looking at the guy uh do what was walking june just drop them and
00:33:49
then after saddam looking at five years only is a patient behaviour would mix everything
00:33:54
and if you are non restaurant or you want to doing therefore you're gonna die so this covers upwards of being alive ins
00:34:00
is good non last one the thoughts into doing is less than ten percent of them were still alive five years later
00:34:06
so then it means that the way of looking at it is this is where the battery just have to be there to
00:34:12
walk in order to improve shopper markham this is after is up to get peaks things it's not our in our and
00:34:19
because if you are doing our job the guy's not a
00:34:22
relapse singing accord minneapolis covered if you make your job
00:34:26
if it's a guy have no luckily that's but your isn't your dog was not working so
00:34:32
much because was classify as an honest one that uses have a disk of this
00:34:36
and high risk of if if you have a relapse so in fact it means that
00:34:40
we'll have to improve the rest once adaptive cause it work and ask to
00:34:45
the first to the uh the f. urgency to focus on and drop them and
00:34:49
buys it was the l. c. d. or would you accept to support
00:34:52
because it did concede as that we were mixing the driver off come in stages and we have to
00:34:57
focus on shopping which is it better to job and not um what we're gonna have a job
00:35:02
so screwed months or six months having freeman is better is for testing dog
00:35:07
and says after that it's not to avoid steady testing what because as i mentioned is to eventually
00:35:13
so just to show you pfizer phase one and i'm done i'm done because i'm just did a too late
00:35:18
so phase one i want to tested what we were to walk to ask
00:35:22
people to work here this is well phase one has to be
00:35:25
phase one is sifted work is you are testing on is the safety so
00:35:29
what you need you need a guy with a minimal risk of deaf
00:35:33
you are we want to be sure that you will have a time of expose or we've our timings is how come so
00:35:38
if crusade coming to me and i would tell him okay we will use a guy with a male low wasn't twenty
00:35:45
we will look at the patient correspond panel simple one before starting the divide this vision of
00:35:50
a risk of limited it is less than ten percent this is a phase one study
00:35:54
it's not if you're doing phase one around here is completely crazy because the time effect is it
00:36:00
would be limited and you will not find out anything isn't you we could yard work
00:36:06
and don't for finishing one thing is is the edges are the french were trying to do
00:36:14
one thing this is a study it's sensible call we are close to be finished
00:36:18
next yeah it would be done what we did quite is around and less able quite
00:36:22
is it and augment them always people pay needs to pay that meant there
00:36:26
is associated with only the side effects i'm not convinced about it i don't know why to be increasing ugly but it
00:36:31
is up to now we have one two hundred patient we don't have observe it would not accept any side effects
00:36:37
and he said it's two months of ever because we are sticking on our apportion we're not looking at long term
00:36:43
and uh uh isn't isn't with with it becomes it more civil guys
00:36:47
and we are expecting to enclose a survivor because this is a calculation
00:36:51
that we did perform according to our that that is so
00:36:55
biopsy proven and so you know there is another study which isn't what action to the stage to the presentation of krishna
00:37:01
z. you know there is an ice skate one any beater which
00:37:04
is a developed by jihad which is at best it nash
00:37:08
there is a study who isn't is way actually on a fifty page
00:37:12
and i've been included in this study circle with the study
00:37:15
the pungent yeah the and uh we are part of it it's quite an is an impassable gestures combination of the two happy
00:37:21
a panel it's fifty seven or is it a function in twenty the survivor so
00:37:26
gotta go so it is improving shop down not meat in them that long term we agree
00:37:32
combination of fantasy not why a guy is not effective we have with the progress in the
00:37:36
management also in the components even as a future studies and i do things that
00:37:41
the future will be to perform study to woo to have a network and now and now two wings or study
00:37:48
in a safe area over wise as i mentioned just that you would never just a a kid would nevertheless
00:37:54
and i just want to finish with the big guys in maui units so like some movie was
00:37:58
a young fellow when eating our unit in beijing most uh that could use a paper
00:38:03
yeah okay but it is in a crisis abetting bouncy with a letting our our transplantation a program now i'm

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