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okay thank you very much and thank you for the opportunity to present in the technology uh i just noted that the
00:00:06
oh this is not the one i wanted but doesn't change or is it just that doesn't that they wanted so
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yes um i will present you um our vision of the obvious caught this is how this
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technology really or change or the patient joey and for its benefit so again it was
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founded in two thousand and fancy the spin off of the directory the technology was born
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in the laboratory of professor one or would present to it was this morning if
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and we have a button to metaphysics technology we have and i so certified facility with
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production capacity of almost one in yesteryear and so far we are but i'm sorry
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some test available already reason not to japan and ever discuss about this
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yet or we have a far rectify written test driving deficiency as one of
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the p. s. p. test assets december also thought about this one
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and since server recently we have a first panel and available in the us
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so the obvious cup is a small for footprint um devices this morning
00:01:07
who you learn about the an espresso offer molecular diagnostics and
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now we're speaking of than espresso of um even ascent
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this is a system that works was one drop of popular rewarded taken that the fingertip
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you get results in about five minutes and uh it's very easy to use and its maintenance free
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this is the media you just pick the finger you collect fifty much leader of blood that you mix it with the detecting reagent and
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load uh the cup so that you can see here it's more types of that content up to fourteen by the sense or
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but this capsule in the obvious copies it to street in and after five
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minutes you have the resident kentucky razor that are um directly available
00:01:49
now how's not affixed work
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you know that um if you want to rapidly quantify and i presented very
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very don't become a concentration complex much this is like the what
00:02:02
you need to find a way which is usually done by enhancing uh the
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surface or to volume ratio typically this is done with no no particulates
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nearly matter of mike from it or a three dixie spent and like this we
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increase the chance of having a molecular interaction you can write faster that examples
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and then the freedom basically this is an uh uh not of an exercise channel
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to which the somebody's going so it seems uh by men by the market the but since sorcerer is very small
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was a very small and simple button we speak about um you you might twenty or so
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none of it it to modify the difference you if you're not behaviour module which
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enhance money current direction in your and therefore reduce um i think time
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and how do you see um the capsule was designed the weather can have up to fourteen by
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the sense or allowing us to make some multiplexing and we have a member insistence that
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if it does the size of the word or two that this is basically a plus minute the depicting antibody that enter the chung
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now if we zoom into one of the sense or not here not there were just a sense or
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um the sample is here it's going through the channel thanks to capital with
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on the that we really do either be put to this channel
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so like a sense or than in the room with advanced micro fabrication techniques that
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and then comes the biological function isolation because we have here the sensing a real
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this is a laser that we quantified the bound them and the light up
00:03:29
and we want that an ally to really capture in the number channel but not
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in the seventeen sir face either but that protected the specific uh local molecule
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so the chart and was twenty hands molecular interactions where we want to but
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not at the cost of hand signals basically can correction whatever is needed
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and since it's not the channel was very very low volume there is basically no background given by
00:03:52
and and down depicting antibodies that are there for the to know wash rapid system
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and actually it works so in this experiment that are not in the obvious cope with it by the
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sense or put on the microscopic last side with fluorescent microscope would just makes uh the said
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that in the several not the patient with detecting region and the deposit what mike selector at the
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entrance of this number gender bending about one in this that there's going to charge a fee
00:04:20
yeah the buyer sense or and we can directly without the new washer uh
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collect the fluorescence signal in the microscope intrigue up an example of about
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eight to the patient centred to see the i g. against one of the most common knowledge in the water that
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or to put under gen and you can see was uh what mean it asset you can already detected
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not not run probably be purified g. rewind about the the two twenty p. come on
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our limit of detection in under one minute the basic uses enhancing effect easily working
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and now i would like to present to to project to show how this
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none of critics can be implemented in the reward i started started testing
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hope you are all aware of what is already this is an apparent that um human reaction
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to uh mm analogy basically which is a program that you can find in the air and food
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drag and uh most of the time it doesn't cause any problem to those people that are not allergic but when you are doing
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just talked about symptoms like your uh when it's no eating uh is the or entities
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with allergy you probably estimating testing so we have a first panel of seven tested
00:05:29
that really the target allergies to my it's the hot dog and to some
00:05:33
today and they brought only the most commonly confiding in central europe
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and we have a lot of other testing in the pipeline to respond to them and what why because of course
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uh put an exposure in switzerland is not the sentence of topic our topic are we also we have to adapt
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um the product portfolio to the different the region and we work only with what is no code molecular only gonna jean
00:05:56
meaning what we work with winnie the pooh refined knowledge and and not this complex extract the
00:06:01
it's basically a mixture of was approached then you can find the nights or in the cat or dog then there
00:06:08
uh just about performances we are performance exact me then you don't have the market to you have met
00:06:13
that comparison between the obvious cup and the reference laboratory method which is going in the car but
00:06:19
so you may be used to up over the datsun one line the tonnage is a bit special
00:06:23
field because there will matter yeah that useful capture is not a mannequin antibody like in most
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a sandwich even last say this is really beyond agenda and a source of knowledge and we
00:06:32
and my propane or comforting differ a lot from manufacturers are for
00:06:37
are you are more looking for um uh those response and normal speaking of agreement
00:06:41
it is what adviser twenty over eighty five percent of agreement you have a good product if you are managed to be above ninety
00:06:48
ninety percent of agreement with the gold standard you have a very good product so that was our pun there we are
00:06:54
not that far from having a very good product more in the first thing he
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sees i'm hoping it'll impact study if we have a manuscript in preparation
00:07:03
like an at this glow the final result but basically end this is what
00:07:06
was um also explains money will be would not prove their efficacy
00:07:11
of a proper proper of a profit product in the reward in in
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this study that was done at the shoes a professor splitting a
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me and it was only patient that need probably that's the patient we're
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visiting golly gee you got the normal brightness to workshop with them
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it was an and it's easy to get examination risking testing and then
00:07:32
anyone george's to estimate that there is a need to make a
00:07:35
blood test that it it's a blood test with different at the end is not this up and then you have an independent that
00:07:41
um committee adage expert that will be blinded to the i. g. muttered there and um
00:07:47
decide on a on the languages thing and we can compare sacramento
00:07:52
and actually have seen the data in rubber surprise how the abdomen is
00:07:56
high i mean that's using the obvious about the point of here
00:07:59
rather than as she think prada and a blood sample to the laboratory at the and the
00:08:04
medical decision is almost hundred percent the same which is very probable sure s. uh
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so just to show you how we could do and not really are um
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what defines a practised today and this is what was until today don't
00:08:20
in another another just to have the first is it starting with an analysis we scan test some of you have
00:08:26
probably experiences is is when you have some knowledge in existence on the screen and you react or not even though too
00:08:32
which company or uh jake then uh they take some um then
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you then use blowed she does a laboratory it often take
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days or weeks because knowledge testing is not done in the written by this in our in most the laboratory that
00:08:45
so you have to go to special laboratories and there when the device maybe once or two a week so it it takes time and then you have a
00:08:52
second visit when you discussed the final diagnosis and sometimes you can start treatment of
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the treatments talking without we can just replace it is obvious got sorry
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and it is what's wrong now uh testing in switzerland with a couple of phonology stuff
00:09:06
we would like to have what we call the one hour button there meaning that was
00:09:10
in what that what that interest is able to start with and then the the
00:09:13
then doing in power there or subsequently it's can test and uh one drop of blood in the obvious got
00:09:20
for that at the end she has ever seen to make the diagnosis in most of the situation
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of course we need to complete the best planet once work with the question of the allergies now seven dust cover
00:09:31
most of the news but we need to keep a much more that this
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is a four when situation uh for the patient because it's always
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nice to see them twenty thirty wizard of the blockbuster appearing in life and discussion objectives are to do stuff
00:09:46
um this is a win situation for the medical practitioner because in term
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of money can makes more by doing the 'cause buying certain also
00:09:54
by seeing more new patient in that same position repetitive basis
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and it's also very uh good to discuss in
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and that is the result that is the patient and not to send a number to retest there
00:10:05
reserve and this is of course punished for us and for his uh his
00:10:09
care system because you can see more position you have less busy time
00:10:13
and um the future which is starting right now it's another approach of where the reason
00:10:19
few or skin prick tests that is don't because regulation is changing and it will be more difficult to have
00:10:25
access to the material first interesting because it would be
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um consider art and the dreaded not as in
00:10:32
so it stands at a special election and now and because it was a better understanding of molecular technology
00:10:39
you can really take chip and how the value of using the molecular biology from a single drop of blood
00:10:45
rather than are going with extracting protected every scene and this will bring the adage diana was use
00:10:52
in turn the richer centre because the reality that must allergic patient can be really a diagonal was
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interrupted by the g. p. and all these are special cases was there with risk of
00:11:03
still there and if elected direction of there is complex allergy due
00:11:07
to prosper activity was full with input and so on those
00:11:10
cases must go to the specialist but the classical vine that um how did you run i to the hay fever
00:11:16
the under by primary care and for that you need to have but there's because g. p.
00:11:20
cannot do this contest and there will also change no treatment which until now the notoriety
00:11:26
you want to go to the specialist to receive an injection or weekly or monthly basis
00:11:31
not on the treatment assisted living body not therapies that can be given by g. p. as well because
00:11:36
the safety profile is much better than uh the um current are you not the regulatory injected
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the second project is east p. s. p. what we could the city's markets and by the marker
00:11:48
for said see so um which might be a solution to any drug about his challenger
00:11:53
so it's it's it's a um is a very common problem we have
00:11:57
twenty seven million of case unions award it's not very well
00:12:00
known actually even in developed countries almost hard for the good of the people do not know what is a sexy set
00:12:07
it's tricky everyone it's basically a complication of of an inspection if you have to remember anyone since that
00:12:12
from my talk today try to remember the sets the finnish and
00:12:16
it's a life threatening hogan dysfunction goes by this regulated
00:12:19
course response to an infection and he you well this season info graphic that you publish and the social media
00:12:26
september because september was someone's office i just wanna say that can show
00:12:30
you that really eight million people die from cities worldwide um
00:12:35
uh the sepsis is the server by real instead specific most diagnosed and treated
00:12:39
at the right time ye reap everybody so there is something to be done sausages so
00:12:44
and actually things are moving because or does this year's uh w. which will general assembly
00:12:49
adopted a resolution sepsis which one of the chain this it was really too
00:12:53
uh when sepsis is quickly recognise untreated life are saved and the nice which is an organisation in the
00:12:59
u. k. to give guidelines on guidance on um
00:13:03
on page here i'm also say that tough
00:13:07
sepsis should be um identify within an hour and then what happened recognition
00:13:12
say okay there's a very simple way to to treat said
00:13:15
sees within an hour we give antibiotics to everybody therefore there is no complication of infection but is it really the solution
00:13:21
clearly not because of antibiotic to a resistance if nothing is though it's estimated that by two
00:13:28
thousand fifty so it's basically tomorrow there will be ten million people are dying from
00:13:33
um because of a resistance to antibiotics so paper that uh you see out there that have um
00:13:39
basic infection urinary track infection or plot pneumonia just because
00:13:43
the bacteria is resistant to or treatment modalities realities
00:13:46
of this but you could come back therefore there's a trade off between treating everyone with antibiotics and
00:13:53
and but having less sepsis at the cost of more antibiotic resistance and more probably more in the future
00:13:59
or to be more rational in the use of antibiotics but was not the clinicians to have new tools so
00:14:05
because tools are not existing today and that we want to believe that there is something to do with the
00:14:09
so the p. s. p. which is upon for text on for ten is uh by the marker
00:14:13
but i've been so far evaluated in nineteen because the design more than that there's a thousand patients in or just tell you show that you
00:14:20
buy more clear was receiving or super your to determine could stand are
00:14:24
for the only protection of sepsis for the prognosis of disease severity
00:14:28
for a production of post surgery in fiction related complication you can
00:14:32
make some risk stratification introduction mortality in probably tonight's patient to
00:14:38
uh does a good accuracy for sepsis in i. c. u. and uh it is not is for your
00:14:42
two was the marker in emergency department so this is very promising department is all retrospective stadium
00:14:49
and what we want to do now is a point after devices is to bring this by mark or
00:14:54
yes a patient enough to get out and really see the impact of using keep there were several users
00:14:59
by the marker can be you was in intensive care unit to identify patients at risk of sepsis
00:15:04
two one it tore treatment uh efficacy to optimise use on on to buy that it it can also be used
00:15:10
in emergency room for today are forty musician for source and to ensure that vision received the best treatment
00:15:16
and test is basically would develop there is initially you might have thought a bit eliza data transfer to our
00:15:23
mm obvious couple years you have some uh performance characteristic more
00:15:27
interesting use this is a comparison between the obvious
00:15:30
got and i'm the market at the plate allies are and share with very small but you wanted to
00:15:37
actually it's indicating specifically from the by along here from um clinical studies that was
00:15:42
initially analysing them allies that and then in the obvious copping basically phone
00:15:47
the somebody which means that we are very comparable to a nicer that
00:15:50
was years until today in a clinical evaluation of his body more
00:15:56
and you can you can impact i can show you want kids report to work quite actually because we
00:16:00
made a feasibility study in the ball in the centre and don't versus people of the jury chip
00:16:06
so the problem was born patient to that that went there which are uh this i. c.
00:16:10
u. or value marker every high because of the troll might even by the cedar bar
00:16:14
and yes it is very promising because in going patient gets given and we go
00:16:19
which means that you can really money tore patient on a daily basis and this is one of the patient before loaded
00:16:24
the tree first they say that there was no and so then you start to raise
00:16:29
and they for the five and here only in this day and the medical team
00:16:34
identify the patient having infection and this started antibiotics here
00:16:39
yeah the breed but time but antibiotics that
00:16:42
we're up for the efficient and the patient recover and get better from this infection and if you had access to
00:16:48
the p. s. p. for this patient you put up a net is already here that there is an increase
00:16:53
which is continuing the next day so you could however at the uh senior that something is happening and maybe take some
00:16:59
uh decision antibiotic or some your or your and avoid the
00:17:04
to subsist is here because you could chew the infection
00:17:08
quicker and just is such um cases that we hope to worm
00:17:13
controlling the larger uh impact in the custody that we
00:17:16
are starting soon uh we will go in a five european
00:17:20
countries fourteen cents or more than two hundred patient that
00:17:23
and when when it or or suspicion like we did here on the big your place did it um basis with p. s. p.
00:17:30
and then to see if the s. p. where available to the nicotine couldn't
00:17:35
we how um improve or um patient management and um use of antibiotics
00:17:42
because the reality in a speaker today that when you have an elective
00:17:45
surgery it's very common to save um antibiotics are the property taxes
00:17:50
if you are in an emergency surgery or where managers
00:17:53
department was a petition consider arteries cassettes you
00:17:57
source inspection they give you an to buy it to each other prefer nazis or empirically
00:18:02
and it's very common also when you go to the jeep you the patrician that
00:18:06
idea um antibody empirically calls itself increase antibiotic
00:18:11
resistance but we can actually um
00:18:15
say that they are doing their job one without having it forced to know whether they need
00:18:19
antibiotics or not of the are doing what they can to to say that patient
00:18:23
and therefore it's needed to have new by marker in new technologies
00:18:27
to really improve patient management you nice you um the sepsis
00:18:32
proponents goes from ten to ninety percent depending on the country sits
00:18:36
on and in university hospital like in those ingenue rather
00:18:40
but the read we are going to be honest the best in the war there was very few sets isn't it
00:18:46
this um associated with that is has a very low we were recently in india in um
00:18:52
you need us people money by the government and i can tell you that basically all with patients
00:18:57
is i see you wearing sexy said most of them are unfortunately uh probably that today
00:19:01
and it has been estimated that the cost of sepsis in the us just twenty four billions dollars so
00:19:06
if you had better by the market is a good sensitivity and a good specificity and
00:19:11
the rapid platform that deliver wasn't within minutes or hours then you can really
00:19:15
contribute to a more rational use of antibiotics and what we want to do
00:19:20
uh with the p. s. p. is to have a real time monitoring of this by you mark your um
00:19:25
ins i see you so that we can really start antibiotic when it is needed and stop antibody teach
00:19:30
when the treatment is over because most of the antibiotic resistance they
00:19:34
come here when you are an antibiotic treatment for seventeen
00:19:37
days and you don't need it because in most of the situation after four days of the infection which you
00:19:44
and so we hope that we can detect cities over your meaning that we will have less complication
00:19:50
of infection shorter i see you stay in this is really the key driver of um
00:19:55
optimising costing us big time because the senses cost an average fifty thousand seats right yep
00:20:00
you can avoid save system just having infection that is true it with a huge
00:20:05
it continued to make make a if we can contribute to these global fighting
00:20:09
against the antibiotic resistance and it would be certain to very positive
00:20:15
sort can clothe and just to give some stout so lot of has been said already
00:20:19
today and and i want going back to the same but if we know it
00:20:24
today the technologies available are many technologies to make a rapid p. c. r. to make rapid mean was it make
00:20:30
quantitative data market there isn't anything available but the reality there is very
00:20:34
few point of getting a speaker in g. p. actually so
00:20:37
and i guess that the bar you're i'm not the technology today with
00:20:41
the bar there are more and difficulties to implement a new product
00:20:46
in those settings so of course quality must meet condition needs but
00:20:50
we have point of care of high quality rhapsody this one
00:20:54
but there is clearly um and integration into existing infrastructure which is difficult
00:21:00
also because resistance to change it's much more easy to take notes
00:21:04
input in g. p. to the laboratory and training uh
00:21:08
a lot of person in austin tied to implement the new technology to implement new unusual
00:21:12
to have quality control outside the laboratory it's not easy for therefore you really have
00:21:18
to develop a impact study to show the value for the patient economy confusing
00:21:24
the point of care rather than waiting hours uh for us at home
00:21:29
and we speak to a lot about the the chinese of point of care that we have to keep
00:21:34
in mind that there was a lot of opportunity especially to improve access to diagnose the chip
00:21:39
when are we observe more what to the access to the laboratories very complicated and when we think about i see you with that
00:21:45
uh it's it's and it's not a good example because you can get or who brought the stress that wasn't wasn't
00:21:50
john and but if you do not that far from sits on and on and virgin
00:21:53
countries access to laboratory not to be done absolutely terrible and when you come
00:21:59
with the point of care solutions are much more motivated to test it into implemented because it can really makes a difference in
00:22:05
and and also as soon as you have an emergency situation um the reason
00:22:10
was a solution that even go rapid past the point of care
00:22:14
oh i would be happy to take questions now or later and thank you very much for your attention how
00:22:25
hi
00:22:39
oh
00:22:49
oh
00:22:55
for
00:22:57
if
00:22:59
yeah it's a yeah it's a complicated with the complex and i guess if you
00:23:03
think of treating the sexes patient you have to take into consideration several parameters
00:23:07
you first need to identify which patient arteries confiding assets is because most of the infection
00:23:13
you can sure naturally our without special nature but when that there was
00:23:17
complication of infection and you go to organ dysfunction you need
00:23:20
to live support in the i. c. u. but then when the station has been identified as being at risk of said cease
00:23:25
then you need to understand uh which is the cause of the sexy so the nature of
00:23:29
the but the gene and also exhibited in um has a resistant or not that
00:23:33
and therefore the p. s. p. alone is not the solution to to treat sepsis is not the solution
00:23:39
to avoid antibiotic resistance but this is one of the very valuable tool that two guys over the rapid
00:23:44
a p. c. r. and with all there are a lot of them that
00:23:48
in this without yes of contribute to to reduce the number of said
00:23:53
'kay disease and the only need the pressure on the operation of antibiotic resistance
00:24:06
oh
00:24:09
hi
00:24:12
yeah
00:24:20
so it's
00:24:22
let this be substantially that doesn't this u. r. p. because this yuppie we own as a limitation that it is good to
00:24:27
be allowed to condition but as soon as this yuppies hide doesn't tell your in anything more than oh there's a problem
00:24:33
as a p. c. t. i. is better this it is very good for a following this television authentic
00:24:38
your therapy it's very you know there was a lot of chemical even and that can be used
00:24:43
but to money toward patient and decide whether or zero means that
00:24:46
um something happening not require live support the the piece
00:24:51
it is not good because p. c. it is racing in a lot of a condition that are not related
00:24:56
disinfection for example of a setting burn patients the ribbon but patients it is it is very
00:25:00
high most of the patient and there is no infection at the time of the board
00:25:04
and there is also some trauma are some cancer that early
00:25:08
to um they're non specific race of p. c. t.
00:25:12
well basically ah somebody when it's use um the right way but i guess most of the position
00:25:17
use the c. d. c. t. two to identify city station in the are a disappointed by
00:25:22
this and the data we how that the t. s. p. seems to remain low
00:25:27
um and there are a lot of non specific situation which means that the rise is really specific to
00:25:33
to the complication of the infection of course there was much more studies that are needed to evaluate the p. s. p.
00:25:39
a in in a lot of different condition for example in in contract type is because it's proteins
00:25:43
acquitted by the palm tree out so we aren't of of the beginning but so far
00:25:47
out of the nine studies we have the p. s. p. similar better of the p. c. t.
00:25:51
in all the content situation whereas yeah that's been evaluated so the potential is here
00:25:56
and the potential is not only on the by marco but on the combination of the body marker with the rubber platform
00:26:06
oh
00:26:13
so they had to be honest to be honest i don't know when nobody knows
00:26:16
um this president has been discover more than forty years ago it is read most
00:26:20
pretty by the contrast nobody even know what does and it is only in two thousand and nine that there was
00:26:26
uh first study and i don't know how to study ten it
00:26:29
was just destruction by between different medical doctor in zurich because
00:26:33
the results by the market has been associated with organ dysfunction and and said see so
00:26:39
and it is only clear that when there is an organ dysfunction there is a range in the p. s. p.
00:26:45
uh nobody has been able to identify what is than the p. s. p. we know that advanced and the two files
00:26:51
uh we know that address very quickly it but the exact molecular
00:26:54
and cellular mechanisms as pertains remains to be to be discovered
00:27:04
for
00:27:06
oh
00:27:08
hi

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Conference Program

Welcome Note
Gaëtan Cherix, Director - School of Engineering
Oct. 26, 2017 · 10:08 a.m.
210 views
Welcome Note
Marc E. Pfeifer, Symposium Chair
Oct. 26, 2017 · 10:15 a.m.
564 views
Point-of-care Diagnostics: what are the real needs of general practioners?
Nicolas Senn, PMU, UNIL
Oct. 26, 2017 · 10:19 a.m.
157 views
Recent developments in microtechnologies for point-of-care testing
Philippe Renaud, EPFL
Oct. 26, 2017 · 10:47 a.m.
215 views
GenePOC, a breakthrough solution in molecular point-of-care testing
Patrice Allibert, GenePOC
Oct. 26, 2017 · 11:19 a.m.
272 views
Reglementary aspects ruling the reimbursement of laboratory analyses in the context of the compulsory health insurance
Michèle A. Fleury-Siegenthaler, Federal Office of Public Health
Oct. 26, 2017 · 2:12 p.m.
166 views
Recent advances in non-invasive diagnostics
Samantha Paoletti, CSEM
Oct. 26, 2017 · 3:53 p.m.
198 views
How nanofluidics bring diagnostics closer to the patient
Fabien Rebeaud, Abionic
Oct. 26, 2017 · 4:17 p.m.
220 views
Keynote Session introduction
Marc E. Pfeifer, Symposium Chair
Oct. 26, 2017 · 5:07 p.m.
Keynote session: Accessible Bioanalysis for the Developing World and the Point of Care
George M. Whitesides, Harvard University, Cambridge - USA
Oct. 26, 2017 · 5:09 p.m.
230 views
Conclusions
Marc E. Pfeifer, Symposium Chair
Oct. 26, 2017 · 6:25 p.m.

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