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okay thank you very much for this they kinda invitation effective it it's
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on the the second part of my talk we we we
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got this uh innovation i want it was my not my site has my student got that that price i wanted precise
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for someone to thanks also mask and for the and all the the team that put that he
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said is they a with so many people i think is really great to be able to
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to put together all the different uh multi disciplinary in aspects physicians uh he sees the
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chemistry everything that that's really a great trip that actually that that you know
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so i'm not really on the at the very beginning your oh i'm not at all up the point of clear
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uh the proper role researcher i'm really uh at the beginning
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of the discovery i'm trying to find a new market
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as you know that at the end of the day we potentially be how are not part of care
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and uh uh that first uh i want to talk a little bit on
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the the spot do the first of all the beer market discovery
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and talk about some feed for us and some other opportunities that uh
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we have in front of us with a white markers but it's still not easy and you will
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see a different things and the second part i will talk on a i. k. is
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my ultimate it to be i and uh where this still nothing
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uh on the on the market i would say four
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for this uh uh injury but things are just coming like now in many countries in the
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stays in europe and the companies are working on that and so i will show you
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just that example on the academic side and potential the translation to to patients
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so coming back to the discovery so we know in my lab we have mainly using those put
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your mix and the double mix and sometimes combining also with judges trusted probably still path analysis
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there was a mass spec a mass spectrometer is our discovery tool and uh
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what you can see yeah is the question that uh we have since
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uh actually is is does the all these all mixed uh technologies
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willie bridge you know to the clinics and uh
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yeah but that that is what we've put your makes but we can you can do with any of the whole makes technologies and this is
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just plugging in button and the you know the number of papers that
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i've been to a beach input or makes combining two diagnostics
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and you can see that has been uh since uh ninety four when i put on it has been a lounge
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the now these ah an exponential i'll i'll increases on
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the number of papers that publish with that
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but then when you brought it you know with that the number of n. e. a. approved
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my mark uh so that nothing market you know this as not you did
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that uh i major impact on that you don't see the same curve
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and this is the these many reasons fall for that but this
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has been for a although makes the code is somewhat that
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ah kind of button like and that people are saying about that these are not the right technology is
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a two for that uh we have to find another way is you know is very costly and nothing is coming
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out from the the supporters so we have to thought i think about it and try to see
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what what we're the reason and try to circumvent also the these different bottlenecks that yeah
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so one of the the reason that an open somebody specially probably bellwether that
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myself even the that's not the validation a ah is very difficult
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is very costly you have to do it in in a way to
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civic study using a perspective way on the bedside and uh and
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did you have the c. e. marking the one the oldies woody is yeah as a i. b. cost and if we
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look in fact to the you know to i was it to the classical pipeline that we
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are in mind when we are in on the basic science side on the discourse side
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we can realise that in fact when you do take all the papers of that which most of them you know the study and after
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the the vacation on all pretty valley dishes that and that's the most of the time the end of the of the story
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and these very few you know that i'm going to to the last that
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offer the um of the of this work for the other pipeline
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an addition you know the the the the cost to develop you know i'd agnostic
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is our own depending but it could be up to hundred millions and the we
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see the the benefit also for the dallas companies is not very big
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so all you know there's a trend that uh before the goal in
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investing that in about market have to really sure justin issue where
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where what is the by and uh what part of the by you you will be able to to share on the market
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another thing is also you know being gain in the fields in sin now close to
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thirty years and saying you know they're all these markers that we all self
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detected than others and not seeing them coming up to the marketing we thinking also
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in fact or long does it take you know i've been teaching school that the four drives
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okay it takes ten years you know to be able to go to the market quite a long
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time so we're thinking okay so that means that we are not things probably shorter the exact
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when i just took five quite well on a would you know we're out markers that you know that
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that in the market in the the market then when you look from the first day when
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i've been uh uh i would say quote unquote this coverage and publish and then
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you look at when it has been a or even the approval commission nice
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you know the the fastest one if the p. c. and the beginner close to twenty years so mothers you
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know it's even more than thirty years in teal these market how hooey found their niche you know
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and if you talking about brain you know this is my yeah i feel of interest
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is a few markets on the b. g. valid or not it's a long time and these non
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that that really use in the click on settings none of them is if he approve
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and somehow commission as but not when was that the inches so
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really the the dining and also potentially also the you
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know the the standing at the time to go to the the market is much longer but with what uh without
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so the the other thing is also the the the clinical utility of what i've been uh
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ah discover most of the time was not with the
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i'm see interesting and this is mainly because i did discover label as basic scientists
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you know uh anybody sometimes immature physicians we always think uh we have
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to find a ruling marker we want to detect that disease
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and in fact when you look at the uh with the one i don't know degeneres yuppie many markers physically deposit
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they use as i without marker and so it but at the beginning
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when you start that's not the first thing you without will not
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try to find something that gives you a negative results you want something with these other positive results but other than that they
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it doesn't bother because it's not really the that in some cases because this decision we
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did not see you we without you you bought marker you need something else
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and another thing also is that we're being really looking at
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classical agnostic markers and the the something that analysing coming with the all
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these a route precision me this interest i may be seen
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yeah he's the company indignant stick thing that that's also something that doing that by the basic discovery
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we're not looking at companion diagnostic we're just looking at you diagnostic
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market yeah i think it's important to to look at that
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that's where you can you know to basically was five brigade nasty
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combinations to the the the the all in quality and
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exhibit was sixty three and in any in many different disorders so
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you can clearly see that in that is yeah these is something you know that that is going into in that
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area and clearly you know markers for to try start vibration
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that's where we should go and the discovery level
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yeah
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we've been just the op expand the design this also has been something
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that with the time we learned that uh we're not very efficient on that and uh
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problematic is also when we we want to look at ah i. d.s order most of the time you know we could be
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a very complex and most of the time it is attached to ah and all done uh
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and the when you are working with some more dance is quite easy to a lot types the of that order
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for example and look at it and see what is different shall express and then go to the blond
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they now because there's not much more difficult and possibly the brain throat with a brain biopsy of somebody was a
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stroll cool watch omar this isn't absolutely possible so you have
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to find alternatives because going directly to the blood
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do the discovery that's what ah what we've been doing in the in the bass at the
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beginning and then you have been doing that to look at proteins getting the blood
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that was marcus that we highly sensitive we could find the glasses yuppie for example this type of
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what what because inflammatory particles i. sensitive but this busy busy busy busy was close to
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to um to zero in addition we would just looking at the most important buttons you know that that you know that
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concentration difference within the most abundant unless someone in
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the press my twelve log of magnitude concentration
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and so the technology that we still even to the ad can only see five to six log maximum so
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for example uh something that like that is that one and wondered mediator
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is very difficult to see bypassed the committee just and examples all you can imagine that
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everything that is lower than that we will never see it directly on the plaza
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so that is really too fine but then at the centre but i kind of filter of the information and to go to
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to phrase that approximate on to the the old kind of interesting and
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that's in that that we should look to that we we
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finally something that ah i'm convinced that we we need is really and that's and now it's coming in your field
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of park is really that the multiplexing aspect in a point of get test next to to the patient
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potentially this will also be will be complicated in the them's also of cost and
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insurances reimbursement and also in need of some i'm sure it's but with
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all the different technology that it's going going i'm sure that we will go to do that type
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of uh approach but so far as to do that this type of uh of matter
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so that was maybe what i think ah some drawbacks and what it is
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is very many others that each of you can i mean nine
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that you have to face that so being being in that as a basic scientists so i'll just
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an example here of how we we try to deal with all this said different problems
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and so i will toggle to dump how what it is a mile dramatic uh
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uh i'm i to be i'd wanting brain injury to trade you a little bit about that
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all we need to discourage occasion validation and then the perspectives now
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the fall what we we've done the last a few more
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so when they're talking about traumatic brain injury in fact it means it's very hard you know
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it can be firms sound somebody within come out because it developed from one one thing up to
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you and me here but you just have a a small uh oh you fall with a bicycle and you
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you get up again then you feed more less well but okay you you feel a little bit to uh
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props you you've been ball meeting a little bit uh uh and not well and
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the so the that's the type of what record mile to my team
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injury this is a c. v. a. directed injury and this is really important to go
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what does the the different sometimes and i would come back to do that so i'm just so the set
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what i would do to is really the my one day so it could happen you know when you
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from us they are some nice bought with the type and also and that's
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quite important yeah that's why the stays the so much attention on that
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it happens on the the the second field on the eye socket feel rugby
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at the heart me uh in addition to you know with the streets and
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so on and so on so they is many uh conditions where
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you know you can have this type of my dramatic really enjoying probably many of you one
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it is a it is live all in you said i mean so i mean
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so all the diagnostic of that so when you are in the
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street soul uh it's somebody see you on all falling
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yeah and you will see that the we take a few
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potentially we'll call them millions all of the police
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all we not do anything that's also another passivity but most of the time you know you go if
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you i'm sure you will go to the hospital all too i'd even ah i do not practitioner
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all to somebody in the f. k. or a system
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the question is it do you about green day she is what using you know you
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probably add that with one of your child when they differ from the status
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unable k. e. stop crying fall thirty seconds and then it's not a crime but the question is always should i go to the
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pay that to and the question is because i'm afraid that is as potentially a small brain asian last one metal now
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so the the problem i think is that when you go to the hospital so you we need to wait a long
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time because you are fine all you babies completely fine yeah
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but enough to fifteen minutes you're completely back to normal
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so the the way also to classified you know the the patients without ultimately
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green injury i does people is to use the glasgow coma scale
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that anybody can do you know when you are looking to the ice movement to move we get to
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the the the bottle uh all to the motor movement and you can give us cool with that
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and usually to be so to motivation are classified without a fourteen or
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fifteen scroll which is the maximum we all here fifteen but
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then she fourteen for the one that uh sleeping you know but the but most likely all fifteen all the one that ah
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if you have too much alcohol up at noon you can be fourteen we've been thirteen so
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that's also you shows you you know the the sensitivity of these all these uh school
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so you know to classify that my t. v. i. is read that you are completely fine fourteen or fifteen
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and then when you that's okay he's fine but we still have the doubt the
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potentially visit relations so the only way to to know that without a clear
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answer is to us it's get it so that's what the i is done on
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all the patients yes it is again to see if these are really
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and the main obviously the main healthcare cost problem here is that
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ninety percent of the c. t. scan and you get a
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and only ten person i positive
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so all of us here the question is we to see if
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we can into news marker before this this guy in
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rather than it just you for example a market they can tell you okay this market is negative or we're not
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so you can go oh no need to do as it is kind of the cities can we be they get even lot completely well
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so well the one which is the most widely known is that a standard b.
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and master site a marker with with this not completely specific sorry
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and the commercial i've by writers the number of years but you can see that it
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is not under this and sensitive is always a ah you force a negative
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and it is i want to been go the studies between eighteen and twenty five percent
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of specificity meaning that approximately you can send my call to patients out of them
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so this as we never know who live um for the d. n. a. to buy into the sea
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just because in fact the in the terms of beneath these cost benefit sorry did
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more less neutral in on the most of the guys that you remove
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this is the the test that you have to do is finally do many test for napping or so so they found that
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it was neutral so that's why it was not accepted so then these other market is also that i've read the overall
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but i'm not really much better than ascended the s. and would be
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some companies you know and that are trying to to push for some of these markers to be accepted by the d.
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although the c. but it's still ongoing i'm not sure that maybe they will succeed due to the performance of the of the bank
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so we don't want that uh on that a stream input to try to see if we
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can do only to be better than the others you know to so to at least
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at the to replace isn't the be all too you would compliment under that's without become
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and then on the banister complement ascended b. and tried to improve the the performance
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you know to um a discharge you know a maximum of of patients
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and those without but also potentially also in the in the fields uh
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in the sports fields and and and other type of of places
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so how would we needed on how we need all the discovery just to to do that but we
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when when i was looking on the proximal femoral free but we decided to do you
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know to increase the signal not to be in in a very low abundant
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a problem of plasma so we we finalise the service wonderfully often yeah patients and
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the brain is that you have read as you've seen this morning also stop role but uh
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that would be in the brand of the patient weight is the injury this just to control
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that on and remember my put on its also covering to some markers on that
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so we found the obsolete ten markers that we found in in a very small record of patients that were interesting
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the most amazing that came out was was a standard b. and the
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h. e. v. p. and others where less yeah interesting at all
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we went further to try to buy a friday if if anybody
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can be as good or better than not ascended be
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and in this post cold operations on the uh uh all the geneva accords so you can see that effectively you can e. p.
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so i think we you can see that i was in the or around
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the work of is not very good but yeah the question is
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this point we want to we are but it's it's it's it's it you don't want to miss any relation
00:19:01
and only sent back home the one that we are sure and if you could see that relate to ascended be we have
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approximately thirty five having of say thirty five to forty five percent
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so meaningful patients ultimately that guy can go back or
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then we went to combination two panels you we just with these two markers with other
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panels that on a computer with a with a i'm limited number of america
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combining also with age ages really important though is of sixty five in t. v. i. is really important
00:19:33
yeah yeah because the the vessels the normal prone to to
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um to prevent an orange yeah in or patient
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and combined with a few of them you can see that with a hundred percent thing and it was and we we are
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ah above sixty percent of specificity so willie increasingly you know
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than the patient you can send back well we
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comfy mentality that that and number security with these index thirty two oz people in spain and
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one in uh in geneva again and compare them with the or more as the the
00:20:07
similar results if you maybe that one third of the patients can be the hours and i called and the panel
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about sixty percent against all two third of the patient that you can be sent
00:20:19
back home and not going to the city scam a pipeline
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so what on the the next step now full for that so we uh i i just so the us
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yes but that patent all on that this two buttons in fact because other medical succumbing uh and panels
00:20:38
uh how but just here uh uh you uh the disease finalising can discuss
00:20:43
slices on in fact they know they agreed to design a next week
00:20:47
but these are and there's 'cause it nice and that that's the the cell
00:20:51
to uh to induce yikes that is here i we can do
00:20:56
now next steps for selected nice them to try to go
00:21:01
for than commercial lies no relief in e. p. first
00:21:04
and uh on our side what we want to do is to to to push bacon e. p. with a pot that
00:21:11
already exist so eva operative king i let our throw out of get test typically for a t. v. p.
00:21:17
with uh with that we'd or what but typically measurement and uh the goal is really to start in january
00:21:23
a prospective study to the the c. mark with all the different understudy
00:21:27
on that that it would be good this type of uh
00:21:30
of of work and on the medium term with the mask
00:21:34
and f. e. d. player placeholder on geneva infirmities
00:21:38
so we are project a bridge project the three we're waiting dances but the views really not to to push
00:21:43
to make texting blocked combining sort of all of the money makers that i showed you the the fall
00:21:50
and adding new ones that are coming in the pipeline to really about ipod okay test in and it it takes it from
00:21:57
so now just to conclude the just to finish on the bin if it
00:22:00
is true that the the the important so off we play that part
00:22:04
for the smile commenting brain injury first for patients taking each really it avoids you
00:22:11
know when this is the way the asians and especially for the kids
00:22:13
we can yeah whether additional c. stand this is really a something important
00:22:18
and i think the that is important is it along with in time that you can adding images you'll suspicion because you're
00:22:24
completely well so you will will be the last one that the that will go to the to see the doctor
00:22:30
and then there is also this question on to to be used on the field
00:22:34
as that elusive diagnostic organised it by the the team that is enough
00:22:38
on the on the spot feel on the docks show or even in the in the in balance
00:22:43
force without all this patient in the waiting list patients with individual so that's a major
00:22:49
a question for the it it gives the system is all these patients other waiting and that use resources there
00:22:56
but i'm not really needed for that i needed for the beings and also to to free the c. t. scan to other diseases
00:23:03
and funny for their care cost we yeah we calculated as if it's about papers on that you know
00:23:09
for sure that to decrease the number c. t. scan it something good on the f. get cost
00:23:14
it's in europe and we'll probably see a comedian appear it is not so huge
00:23:20
what is your age is that it is the method that is and minimum of one hour the patient
00:23:26
of waiting time on the resources that will be reduced and this is just
00:23:32
having one hour for this nation is one billion reduction in cost
00:23:37
so i think that's where really bizarre i need and these are a
00:23:41
potential big benefit also on the the l. c. or assist them
00:23:47
just to finish so this is a yeah we but effectively on what to think or
00:23:50
four is gives you work with the they can again but the the the price
00:23:55
the free hospitals that about dissipated you know that without the patients at that position we could not
00:24:01
go all the all the directions so mark a pity for the for the uh the the complex saying that we we want to
00:24:07
put in place and finally also obviously it's it's easy now helping us to go up to the patient visits which is that
00:24:14
a company that he owned by the university of virginia and the valuable was because it's
00:24:19
we're kind of commission on all the institutions i think if we have enjoyed high
00:24:30
thank you very much and some we have time for one or two short question
00:24:41
you know
00:24:44
hi and thanks for the the re interesting talked especially to talk about
00:24:48
how difficult it is to put it by remarking on the cost
00:24:51
and uh you specific questions for dues you mark your what is still mostly to
00:24:58
and the noises when do wear dark efficient because we know that me you to design markers in the
00:25:03
past have some issues with the you don't need to just too soon because don't not already in
00:25:08
the blood but not too late because disappeared you want to just into sealed or in the billions
00:25:13
disease of the week prior question so what is how to deter from shooting so there's the
00:25:18
so that was on one of the problem of this under the for example the g. five foot also
00:25:23
depending on the the thing they they're coming out eight hours all even twelve hours that is the the peak
00:25:28
but if you pay the peak is uh is it was image in the blood of the one hour
00:25:33
which is the bit but we have a as a minimum time frame that it's already in the in uh in the blood
00:25:39
and the in fact this this is is coming also from the the way we have been selected
00:25:44
because doing for them is you can imagine is not one two three markers that
00:25:47
we find potential market is under this you know with the different models
00:25:51
so then we have ah ah filter selection one of the
00:25:56
theatre is the stability of the the proteins and there
00:25:59
really is potential really is in the blood uh from the you know from the brain in the brown
00:26:05
and so all the buttons that we get you know in our well i i accept ascended
00:26:10
be that whether there will only for things that are going very quickly the blood
00:26:15
we do this in store for example is the same we've also you know to division between shame you can right click stroke
00:26:21
it's a it's a question also way you need the c. t. scan you know to detect the magic wands
00:26:26
so in this case is is the same we we obliged with a more opportunities within
00:26:31
two hours because it because he's the trip and treat men window the tamales
00:26:36
but you can use the t. p. a. can has to be there and even in the four
00:26:40
first are so the blood markers that to be very quickly with is in the blood

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Conference program

Welcome Note
Gaëtan Cherix, Director - School of Engineering
26 Oct. 2017 · 10:08 a.m.
Welcome Note
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 10:15 a.m.
How nanofluidics bring diagnostics closer to the patient
Fabien Rebeaud, Abionic
26 Oct. 2017 · 4:17 p.m.
Keynote Session introduction
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 5:07 p.m.
Keynote session: Accessible Bioanalysis for the Developing World and the Point of Care
George M. Whitesides, Harvard University, Cambridge - USA
26 Oct. 2017 · 5:09 p.m.
Conclusions
Marc E. Pfeifer, Symposium Chair
26 Oct. 2017 · 6:25 p.m.

Recommended talks

Imaging modalities to assess splanchnic vein thrombosis
Prof. Fabio Piscaglia, University of Bologna, Italy
21 June 2018 · 6 p.m.
Deeper down the rabbit hole of data, analysis, and inference errors and suggestions for digging back out
David Allison, Indiana University School of Public Health, Bloomington, USA
29 Sept. 2017 · 1 p.m.