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00:00:00
can we can we can thank you sitting in the correct does a great pleasure to present you the results of the study
00:00:06
there's been conducted within the this was not on a network and forgot group and
00:00:13
you're in the last ten years in switzerland survival rate of infants born below ten to six weeks of gestation
00:00:19
a constant increased but still centre to centre viability no not a mortality is substantial
00:00:26
and it's not associated to case makes and variability in quality of care
00:00:31
on the other end no not tolerate a of now that i'm rate of no not the mobility remains
00:00:37
constant among centres and see if you data on our developmental outcome of this population group is known
00:00:44
so the objective of the study was to investigate the association between
00:00:48
centre specific levels of pretty not that intervention activity and mortality
00:00:54
major now that are more b. t. and enter the real method i'll call my two years of age
00:00:59
uh we conducted a perspective geographically defined cord study where all in fun slide
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born which in two thousand six in two thousand and thirteen sweets and
00:01:09
with the gestation age below twenty six week uh where eligible and we exclude him from morning
00:01:14
to get in step down units and in front with a major congenital muff the abnormalities
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uh according to our modified metal uh previously described
00:01:26
by senior centre collaborators of the expects study
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in this weekend with a fine they had that intervention activity based not on a score
00:01:34
which was based on the rates of freaky upstate tick indicators in four
00:01:38
key now not only as you can see here in this light
00:01:42
um for each indicate those the centre with the highest rate
00:01:48
um was a sign a maximum score of one hundred in their main centres will assign
00:01:54
a proportionate score and we use a an average been out there intervention activities core
00:01:59
to group uh um uh just recently and i thought the the she's been out that centres
00:02:05
into a high analogue t. v. t. group using that to show score of eighty
00:02:12
the uh measured out comes where death so battle with any major not our mobility and survival
00:02:18
with moderate to see another developmental impairment at the correct that each of two years
00:02:24
and we calculated odds ratio between high level of pain out the intervention of activity and outcomes
00:02:31
using my to valuable logistic regression models which way war where that
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adjusted for the main in that uh partially the or mainly
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uh no not uh in principle but enough to risk factors and socioeconomic status
00:02:49
uh amount the nine hundred seventy seven eligible infants we
00:02:53
included in the study nine hundred twenty seven infants
00:02:56
among them five hundred sixty four infants that i which is on sixty one percent mortality rate
00:03:03
and three hundred nineteen in france has been assessed at the h. two years
00:03:07
which correspond to a followup rate of eighty eight percent uh among survivors
00:03:13
a baseline characteristics of infants with follow up where similar to those of infant lost
00:03:20
to follow up except for a new a lower rate of about one
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in the slide you can see the old citric gives it exactly the score
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i don't know that that activists activities colour with the corresponding
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key indicators and the average maybe not that activity score
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for easier reading and uh the rates of all indicators are
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not uh uh shown here as you can see
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uh there is quite a variability in the score among the nine but
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not the centre in switzerland ranging from one hundred two fifty seven
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and using these threshold of eighty we group five three speaking at the centres
00:04:02
into high activity in for me now that's interesting to allow activity group
00:04:07
baseline characteristic between uh infants born in high activity
00:04:11
centres and uh uh where similar to the
00:04:15
those of infants born indoor activity centres except for
00:04:19
a higher a rate of male individuals
00:04:23
concerning the outcomes the um the the mortality the crude mortality rate of infants
00:04:29
born in i activity centres was lower than infants born indoor activity centres
00:04:35
among survivors the rate of any major no not that might be the
00:04:38
key was low very nice activity centre staining low activity centres white
00:04:43
the rates of moderate to severe um and the ice it two years of age where similar
00:04:48
in the group in both groups uh from these that that we obtain following alteration
00:04:54
the crude odds ratio of mortality in infants fourteen i activity
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centres was point forty two and after risk adjustment i'm
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sorry it was point twenty two with a confidence interval of point fifteen two point thirty one thirty one
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uh when restricting the court to survive course the adjusted odds ratio of any major
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no not the mobility was point seventy one and they adjusted odds ratio
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of uh a moderate to severe and the i was point that eighty seven however i'm sorry
00:05:27
all these uh results did not to reach static statistical significance
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the study of some limitation there are a bit are um represented by the fact that data is limited
00:05:41
to pretend light burst that's still at about ten percent of survivors as being lost to follow up
00:05:47
that the neural developmental outcome as being assessed it a very hurley hated two years
00:05:52
and that compose the definition of the painting not that exposure and the neural developmental out called uh
00:06:00
still based on these study results i would conclude that compared to a
00:06:03
low baritone intervention approach i care enough about intervention activities associated with
00:06:09
decrease the risk of mortality comparable rates of major
00:06:13
no not that mobility incompatible never developmental outcome
00:06:17
these results are consistent with the previous report having i
00:06:23
uh they not our intervention approach that's still
00:06:26
for the research is required to greater estimate the accompanying button at that to survive its children
00:06:33
i would like to thank you uh twice a for being a part of this was
00:06:38
not the network so in a way for being a quarter sorts of the study
00:06:43
and uh for your attention and your interest thank you
00:06:52
okay thank you jennifer the interesting presentation we have one question in from
00:06:59
thank you very much very nice presentation by a good suggestion
00:07:04
i i think that there's some discovery discrepancy between use you to track
00:07:09
engine unit approach for instance centres where you'd have a hundred percent absolutely um unit is just a g.
00:07:16
one percent did you look at the data for for these differences as well
00:07:22
well enough to obstetricians are very active in junior total just i'm not as active there's there is maybe some
00:07:29
no we didn't act no we did not uh look at the uh that point to which is interesting and
00:07:35
okay so it it could but no the i don't have a a an explanation for these uh these kittens is uh
00:07:42
that these are not present results score based on the percentage it is that it is possible that in summer
00:07:50
in some of these uh the key indicators that are still some other the uh
00:07:56
discrepancies hold concerning the the different only the kittens
00:08:03
yep
00:08:08
okay anyone else
00:08:20
please
00:08:26
my cat is that this is data from my two thousand six to two thousand thirteen i can think change and
00:08:33
i don't know to any evidence uh for saying that i speculate t. a.'s yes um
00:08:40
i had to to uh we would have to look at the data that i would expect yes

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Conference program

Opening
Matthias Roth-Kleiner, Lausanne
16 Jan. 2018 · 9:34 a.m.
Welcome words
Mathias Nelle, Bern
16 Jan. 2018 · 9:36 a.m.
Personalised prediction of weight changes in the first week of life
Severin Kasser, UKBB
16 Jan. 2018 · 9:41 a.m.
Neurofilament serum levels as biomarker of neuronal injury in very preterm born infants
Antoinette Depoorter, PhD Candidate
16 Jan. 2018 · 9:49 a.m.
Neonatal red blood cell (RBC) transfusion practices in Switzerland
L. Gosztonyi, C. Rüegger, R. Arlettaz, Neonatology USZ
16 Jan. 2018 · 9:58 a.m.
NEO (Neonatal Esophageal Observation) Tube - A feeding tube with monitoring function
Patrizia Simmen, Department of Neonatology, University of Basel Children's Hospital
16 Jan. 2018 · 10:25 a.m.
Less invasive surfactant Application - Pro
Angela Kribs, Köln (DE)
16 Jan. 2018 · 11:33 a.m.
Less invasive surfactant Application - Contra
Sven Schulzke, Basel
16 Jan. 2018 · 11:51 a.m.
Q&A - Less invasive surfactant Application
Panel
16 Jan. 2018 · 12:14 p.m.
Stem cells and birth
Martin Müller, Bern
16 Jan. 2018 · 2:32 p.m.
Stem cells and white matter disease
Raphael Guzman, Basel
16 Jan. 2018 · 3:16 p.m.
Protect the neurons: The challenge of the neonatologist and the researcher
Anita Truttmann, Service de Néonatologie, CHUV
16 Jan. 2018 · 4:12 p.m.

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