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can we can we can thank you sitting in the correct does a great pleasure to present you the results of the study
there's been conducted within the this was not on a network and forgot group and
you're in the last ten years in switzerland survival rate of infants born below ten to six weeks of gestation
a constant increased but still centre to centre viability no not a mortality is substantial
and it's not associated to case makes and variability in quality of care
on the other end no not tolerate a of now that i'm rate of no not the mobility remains
constant among centres and see if you data on our developmental outcome of this population group is known
so the objective of the study was to investigate the association between
centre specific levels of pretty not that intervention activity and mortality
major now that are more b. t. and enter the real method i'll call my two years of age
uh we conducted a perspective geographically defined cord study where all in fun slide
born which in two thousand six in two thousand and thirteen sweets and
with the gestation age below twenty six week uh where eligible and we exclude him from morning
to get in step down units and in front with a major congenital muff the abnormalities
uh according to our modified metal uh previously described
by senior centre collaborators of the expects study
in this weekend with a fine they had that intervention activity based not on a score
which was based on the rates of freaky upstate tick indicators in four
key now not only as you can see here in this light
um for each indicate those the centre with the highest rate
um was a sign a maximum score of one hundred in their main centres will assign
a proportionate score and we use a an average been out there intervention activities core
to group uh um uh just recently and i thought the the she's been out that centres
into a high analogue t. v. t. group using that to show score of eighty
the uh measured out comes where death so battle with any major not our mobility and survival
with moderate to see another developmental impairment at the correct that each of two years
and we calculated odds ratio between high level of pain out the intervention of activity and outcomes
using my to valuable logistic regression models which way war where that
adjusted for the main in that uh partially the or mainly
uh no not uh in principle but enough to risk factors and socioeconomic status
uh amount the nine hundred seventy seven eligible infants we
included in the study nine hundred twenty seven infants
among them five hundred sixty four infants that i which is on sixty one percent mortality rate
and three hundred nineteen in france has been assessed at the h. two years
which correspond to a followup rate of eighty eight percent uh among survivors
a baseline characteristics of infants with follow up where similar to those of infant lost
to follow up except for a new a lower rate of about one
in the slide you can see the old citric gives it exactly the score
i don't know that that activists activities colour with the corresponding
key indicators and the average maybe not that activity score
for easier reading and uh the rates of all indicators are
not uh uh shown here as you can see
uh there is quite a variability in the score among the nine but
not the centre in switzerland ranging from one hundred two fifty seven
and using these threshold of eighty we group five three speaking at the centres
into high activity in for me now that's interesting to allow activity group
baseline characteristic between uh infants born in high activity
centres and uh uh where similar to the
those of infants born indoor activity centres except for
a higher a rate of male individuals
concerning the outcomes the um the the mortality the crude mortality rate of infants
born in i activity centres was lower than infants born indoor activity centres
among survivors the rate of any major no not that might be the
key was low very nice activity centre staining low activity centres white
the rates of moderate to severe um and the ice it two years of age where similar
in the group in both groups uh from these that that we obtain following alteration
the crude odds ratio of mortality in infants fourteen i activity
centres was point forty two and after risk adjustment i'm
sorry it was point twenty two with a confidence interval of point fifteen two point thirty one thirty one
uh when restricting the court to survive course the adjusted odds ratio of any major
no not the mobility was point seventy one and they adjusted odds ratio
of uh a moderate to severe and the i was point that eighty seven however i'm sorry
all these uh results did not to reach static statistical significance
the study of some limitation there are a bit are um represented by the fact that data is limited
to pretend light burst that's still at about ten percent of survivors as being lost to follow up
that the neural developmental outcome as being assessed it a very hurley hated two years
and that compose the definition of the painting not that exposure and the neural developmental out called uh
still based on these study results i would conclude that compared to a
low baritone intervention approach i care enough about intervention activities associated with
decrease the risk of mortality comparable rates of major
no not that mobility incompatible never developmental outcome
these results are consistent with the previous report having i
uh they not our intervention approach that's still
for the research is required to greater estimate the accompanying button at that to survive its children
i would like to thank you uh twice a for being a part of this was
not the network so in a way for being a quarter sorts of the study
and uh for your attention and your interest thank you
okay thank you jennifer the interesting presentation we have one question in from
thank you very much very nice presentation by a good suggestion
i i think that there's some discovery discrepancy between use you to track
engine unit approach for instance centres where you'd have a hundred percent absolutely um unit is just a g.
one percent did you look at the data for for these differences as well
well enough to obstetricians are very active in junior total just i'm not as active there's there is maybe some
no we didn't act no we did not uh look at the uh that point to which is interesting and
okay so it it could but no the i don't have a a an explanation for these uh these kittens is uh
that these are not present results score based on the percentage it is that it is possible that in summer
in some of these uh the key indicators that are still some other the uh
discrepancies hold concerning the the different only the kittens
okay anyone else
my cat is that this is data from my two thousand six to two thousand thirteen i can think change and
i don't know to any evidence uh for saying that i speculate t. a.'s yes um
i had to to uh we would have to look at the data that i would expect yes

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Conference program

Matthias Roth-Kleiner, Lausanne
16 Jan. 2018 · 9:34 a.m.
Welcome words
Mathias Nelle, Bern
16 Jan. 2018 · 9:36 a.m.
Neonatal red blood cell (RBC) transfusion practices in Switzerland
L. Gosztonyi, C. Rüegger, R. Arlettaz, Neonatology USZ
16 Jan. 2018 · 9:58 a.m.
NEO (Neonatal Esophageal Observation) Tube - A feeding tube with monitoring function
Patrizia Simmen, Department of Neonatology, University of Basel Children's Hospital
16 Jan. 2018 · 10:25 a.m.
Less invasive surfactant Application - Pro
Angela Kribs, Köln (DE)
16 Jan. 2018 · 11:33 a.m.
Less invasive surfactant Application - Contra
Sven Schulzke, Basel
16 Jan. 2018 · 11:51 a.m.
Stem cells and birth
Martin Müller, Bern
16 Jan. 2018 · 2:32 p.m.
Stem cells and white matter disease
Raphael Guzman, Basel
16 Jan. 2018 · 3:16 p.m.
Protect the neurons: The challenge of the neonatologist and the researcher
Anita Truttmann, Service de Néonatologie, CHUV
16 Jan. 2018 · 4:12 p.m.

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