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Neurofilament serum levels as biomarker of neuronal injury in very preterm born infants
Antoinette Depoorter, PhD Candidate
Tuesday, Jan. 16, 2018 · 9:49 a.m. · 09m 19s
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but
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okay
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so good morning everyone um during this short presentation i will um
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sell a bit more about two two data sets that investigate for the very
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first time buyer marker called nearer filament in very preterm born infants
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as illustrated on this figure interview them and access the site has got some of urine
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and it's release into the server spinal fluid in here for a lot in case of internal damage but
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there for them and is a promising by marker
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of neural injury and disease progression in adults
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it has mainly been investigated in your degenerative diseases but from
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the recent literature we know that serum your filaments concentrations
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in house the adults are round twenty because grams per millilitre
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paris in madness and the man show their around forty
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and instruct patients even higher around hundred ten ten because grams for me
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now we were interested in investigating this by marker in a different a patient population
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which possible there are no damage to just preterm born infants since we know that they have
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at high they are at high risk for later in or developmental deficits
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the aim of the study was to better understand the impact of premature already on brain development
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and secondly to look for possible indicator for three terms why
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who are at higher risk for later never developmental deficits
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the first study was conducted at the university hospital of battle
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where are very preterm born infants with just a show age below thirty two weeks were included
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lots have collected at the of life seven and this serum or filament light chain
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concentrations were measured using an ultra sensitive single would go every called seymour
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in this day does that ninety nine patients were included within
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mean just station or age of twenty nine weeks
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and then a average birth weight of around thousand two hundred twenty grams
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so um we found that did medium nearer filaments air concentrations in d. c.
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very preterm born infants were around hundred thirty programs are we are
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we found that these um your filament levels strongly
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correlated with clinical variables such as birth weight
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just station out h. oxygen generation broke up on your display
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share intervention hemorrhage anti hacker score at five minutes
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on of figure you can see to strong negative correlation between dinner filament levels and persuade
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so meaning higher dinner filament the lower to birth rate and vice versa
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from a multiple linear regression we found it mainly just station or
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h. proceed an oxygen generation predicted the inner filament levels
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we note is that um i d. h. or interrupt into
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liquor hemorrhage has an influence on the inner filament levels
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but in our sample we only had a few patients with i. v.
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h. in fact we're only eleven out of um ninety nine patients
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so we wanted to have a closer look at the effect of i've each on dinner filaments
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levels and therefore we obtained a second data sets from vienna
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we're very preterm born infants with an i. v. h. equal to or above grade three
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were included and he also had a gestation our age below thirty two weeks
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here blot samples were taken at five time points and the
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inner filaments you don't concentrations were again measured using it
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forty eight patients were included to it i mean just station on each of about this week
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i have to say that the state are very preliminary there for i will only be
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and your filament levels in the sample
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so what we found is that the mediums concentration in this group with i. v. h. was around
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three hundred and twenty five week appearance for me later
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so a lot higher compared to the previous sample
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and when we group um at the data base on gestation o. h. we obtained following figure
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where i you can see that extreme um preterm sort one below
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i'm twenty six weeks of gestation h. a half the highest near for them and i thought
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if not we compare um it is data off to save your i. v. h. group weights
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the previous data sets of the preterm for infants
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without acting h. so on the speaker
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you can see that the inner filaments levels are clearly you know where
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and that there is a decrease in um dinner for them and with increasing age
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so it then we have a look at the inner filament levels over time based on the
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second data sets a up to three terms with um so if your i. v. h.
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you can see that's around today of flies eighty eight or
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wrong turn d.'s a mirror filament levels normal nice again
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so in conclusion um we found um very high serum
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concentrations in the the first data sets these um
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values were about five foot higher compared to healthy
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adults and comparable to levels of stroke patients
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then in the second data sets um we found that in preterm sweet severe i. v. h. these
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uh near filament levels are even higher but um we see that they decrease um over time
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we found that the inner filament levels are negatively correlated twitches station or h. and birth weight
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and possible explanations for these high values could be
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brain immaturity with a high turnover of murals
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uh like which of the plot brain barrier or internal injuries associated with premature
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so here but i i want to thank the team that makes this interesting uh study possible engine for you
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oh
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thank you for this nice presentation in question yes
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i've
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so do you want to pollution new option dependency uh_huh we probably
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shouldn't there is an ideal for the associations chronicler users
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you turn it explanation would be stricter well we haven't looked at it's closer but we
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think also that the um preterm infants who receive a longer um oxygen supply
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those are the ones who are more to say davies and probably um that's why also their levels are
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uh_huh thank you very much that was very interesting how did you under which
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we should know that you choose your first said well into point
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like the study of lice that then why did you choose that today
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to take your said oh well it was actually i'm a retrospective
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kind of study that the lot samples were already collect it and then we decided to penalise
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as well beside other via markers display more often refer them and but um we want to see the
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immediate effects and there for we didn't want to wait too long to um to the plots
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thank you very much for very clear presentation you maybe speculate
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what really huge you've shown us the overall osprey automotive variable more what mobile point to
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my uh_huh what that means that more than seventy percent of the variability in bottles
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does not exploited by the by the real thing what what else could explain
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from those values well um first of all i think that the sample is pretty
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low we like we should increase the sample size with ninety nine and um
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patients we probably don't have all the the variables
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um and we also think that um
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there is like it it's not such a whole monkey how mention sample so there
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are some have a new cities i've each only few but people so
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influence on this data but uh and the main thing that that we found this does justice shaw h.
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so we think that the sooner to bally's earlier to
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babies are born the more there will be
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an overproduction of neurons and i'm also the immaturity of the blood brain barrier will cost
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that piece a mirror filament levels are found in the plot and then the next step is also to look of
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despair or spinal fluid to see if they're the also find these high values um in to see patients
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