Embed code
Note: this content has been automatically generated.
00:00:00
and we're going to defy surprises and it's a privilege for me to have um
00:00:05
the hundred to give the by matter award and to i'm a member of the parameter come
00:00:11
a foundation and so i can give them but not to award two thousand and seventeen
00:00:19
and the surprise he's going to lose time and to anita totem on
00:00:33
there will be a lot of research work on then brain development on ice fix yeah and on
00:00:38
them out of thirty and i'm very happy for her very weird on any type thing
00:00:50
but there is no but not a whole lot without the but not a lecture
00:00:55
and this lecture is very well structured since we have to i don't know what we can you
00:01:01
develop this structure is a few years ago when he was the president of the foundation
00:01:06
this is a lecture louisa lost in for exactly
00:01:10
nine minutes three minutes for medical students three
00:01:15
minutes for clinicians and three minutes for research so any thought that to you okay
00:01:25
so thank you so much i'm i'm very one or two and uh
00:01:31
it's it's a great a pleasure and i would like to thank
00:01:34
of course all the committee who choose me and uh oh
00:01:39
it's uh
00:01:41
re station and and uh and the gift after all these years so it's it's quite
00:01:48
and achievement in the career to get such a price but i have to say uh
00:01:52
also for the other candidates that uh maybe sometimes it's
00:01:57
a little bit of luck and just uh the good moment and the good person and
00:02:03
uh i hope the other ones will have to look to see
00:02:07
so when i came here this morning to see just a little
00:02:10
story um i realised that exactly twenty five years ago
00:02:16
i was here in this room it was open here and it was the e. c. f. and g. text
00:02:24
so i was stressed at that time you know what is the c. f. n. g.
00:02:29
it's the american exam and that's once i started my tree in my dream
00:02:34
of being an academic noon that'll adjust so for those who know me
00:02:40
it's not a has it for the other ones you maybe think it uh_huh
00:02:46
so i once or
00:02:51
so i have three minutes for the students i will give
00:02:55
them in french i have three minutes for the clinicians
00:03:02
and i have five minutes for the research
00:03:07
so i uh and tied my my um
00:03:11
just to do um my lecture protect the new ron's the challenge
00:03:17
of then you're not all the just and the research
00:03:22
um that's sixteen near enough that that eighteen conditional save their key
00:03:27
to shoot one eight two four and then it starts
00:03:30
it emerged more but well i'd flap effective is fuchs yeah you
00:03:34
could make a sticker that's you don't sell secrets you
00:03:41
oops
00:03:44
uh in a gem of bodily doesn't that's the keys l. p. e. still take domestic senior natasha
00:03:51
maybe it was you know the best to keep clean eek tree a dozen perspective do cash
00:03:57
s. t. c. l. s. is just to fall in baghdad you look see
00:04:01
i i in yeah yeah the the skinny at least do installs
00:04:06
just go back to what distance yeah um i don't know i speak t. v. still expected
00:04:12
that this sounds of well secure little when amy can not but a lot of yeah
00:04:19
will will do you good job in when you make a kennel but that will only send it out
00:04:24
this is used to listen to christian school three protect is and it's just a a
00:04:29
um no over ah of wow huh uh you know you never want to how fat
00:04:34
you know when they only would last it's you know shores more that the mighty
00:04:38
a polite if they don't see now the you put down me to happy t. i. do s. boxes off
00:04:46
i'll let you see now that that it either on or in um
00:04:52
uh in problematic too salty uh p. b. to measure a high priest or a a
00:04:57
focus not on people more general kept me you know do they stay behind
00:05:03
on our streets in a in a uh also we should move on their own people do i can't call for
00:05:11
a move when it at am best sixteen unit than the honey also ease
00:05:15
sample packet for trips and a um don't all the way in
00:05:22
the only uh problems it will be good to get your than the than winnie the
00:05:27
mom yeah that that steve on top of course all say uh uh the
00:05:33
the the move when they actually mel don't look at the last it's a state dump optimistic i must
00:05:39
admit it l. v. we l. e. d. four accused only pay yeah i'm too scared easy
00:05:43
may a landmark between older she if he calls the calls
00:05:48
pulses awful when you've will option intimately side by
00:05:52
when evil what are more time if i don't know most also yeah so uh again what is it
00:06:00
lou for two c. v. tells them mm mom does are not given more epochs eek
00:06:06
men sleeve was should set a foot to you later epochs each
00:06:10
test it on cloud i i'd have no interruptions um a
00:06:14
would you want to pull all those that was sounds about the uh
00:06:19
evaluate don't that cannot divest get cut back on the like at the proxy
00:06:25
a lot and it's also if that's about the only yeah let's see
00:06:29
uh it call lee yeah that that's almost asleep by the time all uh uh come come oh
00:06:37
it is all cease affair the problem and per study is this war
00:06:42
these huge us your time i teach to proceed only couple the
00:06:45
decoder more press out there due to reconvene back so
00:06:50
yeah was you've known samples all this se seen unit that you know can cool
00:06:57
yes much dish uh that simply nigger uh and pay him one tiny uh i knew file
00:07:04
for standing fun not and even as a yet strangely outlined
00:07:09
yeah but i must i mean people than i don't fancy kinds you can china shaft vocal plano was
00:07:15
uh but i know i know i tune contemplates leash contests so
00:07:19
i know for time practicality here just to take a um
00:07:25
easy yeah to to give light light minded trained done here
00:07:29
i introduced yeah for time in a a
00:07:34
classy
00:07:36
should be a a fertile and a trace that
00:07:45
its contents yes yeah it's what i'm not for insects you
00:07:50
asking type up go off and we'll do we'll do
00:07:55
can get if they i mean me at how to pull mono in uh the atlanta who
00:07:59
put tell me is that just as as can did not have that in nineteen
00:08:04
the entire venues contests with a two stage won't exist explain blasts to compete and it once was you
00:08:11
that's not a problem for not time
00:08:16
not on hard to boss up they assumed was up i've yeah
00:08:20
that's into goofy a city of ten and one fellow from
00:08:24
in the fairfield what's and they're a strong much often uh how often
00:08:29
does the uh goofy say this huge yeah target site so
00:08:35
um what do you think if it's taken and the event yeah a
00:08:40
couple of a and discuss what a fork on as a hoop
00:08:43
to be yeah what does it stand for doubt as to uproot that's
00:08:47
done uh that you just can't teach their janelle extending yeah
00:08:51
yeah i know placenta which isn't a goofy is intact or does is deep lights
00:08:57
and stuff and not some want to use it in c. for like
00:09:02
she yeah i knew to be at a ski face as the skin tight it i'm in him a partition shock
00:09:09
want a of fun to just pacman i see launch of touch
00:09:15
rice i succeeded by the shop and that's pocket of that time issue as fixed yep and
00:09:22
it's into his delusion past sixty plus i'm twenty i'm phones tries to go yeah i'm cool can
00:09:29
i'm not going to be used to be able to wouldn't test a
00:09:32
drastic c. to asked how to join keen tend to kind of
00:09:37
movies check up to be as its cons clark done months each increase
00:09:42
yet no one touches multicast seen you want me to focus
00:09:47
when kinds long hot man and decent entertainment would make up by to be mine
00:09:51
yeah me much to invest some unkind human uh and assignments our stuff even though it
00:09:57
might need to be ends on mon and t. v. and vi i'm so mine
00:10:01
sure it's a pretty common motion as these are these events and stuff and what and then uh uh
00:10:07
good poked um manhattan game act as a um
00:10:12
uh to kinda foolish and fun to evaluate and all that
00:10:17
uh no location probably no harm for item no logo should probably not as a set
00:10:22
da man get not get nasty should make the uh and to get some by speaker we class and now up to go
00:10:29
that does and he does mind that stuff was the best time
00:10:32
to conduct about pages to one incident seemed a bit yet
00:10:37
i want to ask and demand on most on don't come down a a b.
00:10:43
do i pull me to who put them into ted operator should be put to me right yeah you know what
00:10:48
you more time it takes an encounter other i'll there's
00:10:51
no solution of concepts and code orange um the
00:10:58
as a as a scientist at the question of course is
00:11:01
what are the fundamental questions and you heard about
00:11:06
as income my cells you heard about uh uh and uh in the long run in
00:11:12
the brain in the white matter injury uh so there are many ways to
00:11:18
to uh uh to propose questions of course i have one question
00:11:23
as a uh scientists is when i see the stammer
00:11:27
here is an enter i have a very savvy or a stick to page would die
00:11:31
what i see is this black lesions here in that talent
00:11:36
was in the special nucleus of the taps and
00:11:39
this new clothes is very sensitive to i sixty and to hike box and my question is how
00:11:47
how is the new on dying in this in this um
00:11:52
in this area so when i look at the histology i see i'm going excels like here you
00:11:58
see in a big magnification you see that um the how i'm going make they are
00:12:05
going to die maybe programmed cell that men maybe not in when
00:12:09
i look at other markers i find apocalyptic markers and i
00:12:14
find out to fade to workers and that's the last a couple of die as a slides i want to show
00:12:21
is more for logically what are the different types of selfless well there is apple chose this
00:12:27
macros is because this is eve or irreversible you cannot do anything probably
00:12:32
will never do we will never have a treatment for the groups
00:12:36
up to this the programs l. s. meaning that the cell get the information
00:12:41
to die in one week to die in three weeks and then
00:12:46
since the nineties there is another form of cell that's which is called will to fight age
00:12:51
or all to fey g. excelled switches the type to twist described first
00:12:56
by one of my mentors who was peter clarke in ninety nine
00:13:01
and uh what is it actually it's some it's a it's a physiological um
00:13:06
sell yes okay you her before by i think it it was the
00:13:11
first speaker um he told you that the new round half to to
00:13:16
be cleared huh they die physiologically and they have to come back
00:13:21
so it's a recycling fabric that gets the new
00:13:24
rounds and get some some uh energy back
00:13:28
from the nuance to get it in a in a modern humans again into in order process
00:13:34
so i cannot go into the details but they are different compartments or to fake was on auto lies
00:13:40
and there are different types of uh to fey g. but i speak about maker who to fit each
00:13:47
so what did my group using several models of in the evil in vitro
00:13:53
and um and also human tissue we had
00:13:58
uh access to adopt it to should we looked at enhanced also fey g.
00:14:06
after high proxies kenya and what the role because if it's how right you don't know if it's good
00:14:12
or not so you want to know uh what is the role of the sort of thing
00:14:17
and i'm just going to show you one uh which was for me and i think
00:14:22
for our one of our best publications wasn't an ounce of neurology two thousand four
00:14:29
we looked at brass rise spend which you model it's uh hypotheses
00:14:33
kenya model and we looked at how to teach teach
00:14:36
and what we see using specific markers uh of auto fey g.
00:14:42
that in the racks or to fey jeez very much enhanced
00:14:48
and in the u. t. should we had um i haven't babies
00:14:54
five died from c. viewer is fixed yeah and six
00:14:58
died from audio conditions all actor and we saw that oh
00:15:03
to fate excelled as in the ten numbers with very
00:15:07
a a much enhanced uh in this baby's around ten times
00:15:14
and this somehow was called for in the demo right of three of the patient
00:15:21
that show that the lesions where in the channels these lesions
00:15:25
were seen early emma right on diffusion waited much
00:15:31
so we could show in all the models that
00:15:36
um oh to fade you was enhanced and that all in all the models that are
00:15:41
in purple but of course in the human have not the answer that the inhibition
00:15:47
we tested several inhibitors that the inhibition was new or protect
00:15:55
so this is the end of my um my matter tool i would
00:16:01
like to thank not down and his family he likes coldness
00:16:08
uh and he got a just a a little uh that's the state
00:16:17
and he's very good very fine a despite his zero zero up go
00:16:23
i would like to thank my research lab and all the collaborators from a
00:16:29
a nationally but also internationally specially a soapy to clark and this guy
00:16:35
here it's not my collaborator but it's the nobel prize two thousand sixteen year
00:16:41
she normally me who was a a nobel prize for to fiji
00:16:47
and my mentor this is uh john mack weekend was physiologist
00:16:54
and magnesium specialist make um are you again
00:16:57
k. c. also never alleges magnesium specialist
00:17:01
no yeah they've all yeah but but don't put out she's onion at allergies from philadelphia
00:17:05
peter clark he with the fundamentalist and sell their specialist
00:17:10
and i really am missing out of course um hum
00:17:14
took me from burn too laws and and uh
00:17:18
i was his first part time uh stuff uh comedy
00:17:24
stuff doctors so it was quite an achievement
00:17:28
and of course my boss and mentors office what does a could not attend i thank you for your change
00:17:43
actually i know simple who when you topple fit presenter
00:17:47
some fantastic only got this enough mutable doris
00:17:52
not about the little chip a city fussy no i don't

Share this talk: 


Conference program

Opening
Matthias Roth-Kleiner, Lausanne
16 Jan. 2018 · 9:34 a.m.
Welcome words
Mathias Nelle, Bern
16 Jan. 2018 · 9:36 a.m.
Neonatal red blood cell (RBC) transfusion practices in Switzerland
L. Gosztonyi, C. Rüegger, R. Arlettaz, Neonatology USZ
16 Jan. 2018 · 9:58 a.m.
NEO (Neonatal Esophageal Observation) Tube - A feeding tube with monitoring function
Patrizia Simmen, Department of Neonatology, University of Basel Children's Hospital
16 Jan. 2018 · 10:25 a.m.
Less invasive surfactant Application - Pro
Angela Kribs, Köln (DE)
16 Jan. 2018 · 11:33 a.m.
Less invasive surfactant Application - Contra
Sven Schulzke, Basel
16 Jan. 2018 · 11:51 a.m.
Stem cells and birth
Martin Müller, Bern
16 Jan. 2018 · 2:32 p.m.
Stem cells and white matter disease
Raphael Guzman, Basel
16 Jan. 2018 · 3:16 p.m.
Protect the neurons: The challenge of the neonatologist and the researcher
Anita Truttmann, Service de Néonatologie, CHUV
16 Jan. 2018 · 4:12 p.m.

Recommended talks

Augmented Reality-assisted surgery
Luc Soler, Directeur de la R&D et Professeur PAST, IRCAD, IHU
9 June 2017 · 11:22 a.m.