Parechovirus infections show a variety of clinical manifestations. Infections in early childhood are often severe. We present a patient with neonatal encephalitis. Conclusions: 1) Parechovius infection has to be taken into consideration in newborns with sepsis like symptoms, and apnea, in particular when a bacterial cause is not probable or excluded. 2) Normal findings in lumbar puncture do not exclude parechovirus encephalitis. 3) Neurological follow up is essential in children who experienced parechovirus encephalitis.