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the resident at the Department for unity
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Muslim and I'm very proud to present our
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current project here which focuses on
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the association of axonal injury in
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preeclampsia as you know preeclampsia is
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a main reason for preterm birth and
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early diagnosis and adequate treatment
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can prolong pregnancy and reduce
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morbidity and mortality related to
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prematurity the biomarker we looked at
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to show x to show external damage
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external injury was new development
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light chain which is a scaffolding
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protein of the news and no cytoskeleton
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and which is very important for growth
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and branching in then dendrites and
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axons it is a it is increase in cns xml
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damage and is a very reliable and easily
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accessible biomarker it is and it has a
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plasma CSF ratio from around 12 50 and
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is sometimes already elevated before the
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onset of neurological symptoms and since
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summer 2016 we have access to this
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unique diagnostic technique seymour
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which stands for a single molecule array
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in basel this is the study design a
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single cent of prospective study was
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performed at the university hospital of
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battle and enrolling pregnant women with
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high risk of developing preeclampsia and
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these data here were recorded blood
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pressure you're in sampling the blood
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sampling apart from our NFL from our
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biomarker angiogenic Marcus
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fleet and PF those are the established
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biomarkers to predict preeclampsia were
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measured and neurological symptoms and
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maternal and neonatal outcomes were
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recorded and inclusion criteria where
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pregnant women above the age of 18
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singleton pregnancy and patients at high
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risk for developing preeclampsia and
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exclusion criteria where fetal
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malformations these are the baseline
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characteristics and not surprisingly you
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can see that the characteristics that
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contribute to preeclampsia significantly
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elevated in the preeclampsia group
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compared to the control group we want to
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do know which factors have an influence
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on the NFL and NFL and used NFL as a
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dependent variable in a mixed linear
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effect model and we could show that
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maternal age and as flute which is the
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established biomarker to predict
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preeclampsia
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we're highly significant in this model
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gravity and neurological symptoms were
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significant and systolic blood pressure
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and lipstick were not significant in
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this model our findings were in this
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plot you can see and the work on the
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x-axis other age groups on the left side
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there controls on the right side of the
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women with preeclampsia and the y-axis
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you can see the NFL levels and we could
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see that the older the women were the
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high the NFL levels were with this
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roc curves with the red with the blue
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line standing for the NFL levels and red
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4s flute and green for Pele GF on the
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right side and this flood you can see
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the again on the y-axis the NFL levels
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and on the x-axis the different groups
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the different times of visits so the
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more the more to the right to further
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the pregnancy is and here again the
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further the pregnancy has elapsed the
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higher the NFL levels where and we
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conclude with this work that NFL
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increases with age and if l is higher in
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women with preeclampsia and NFL is
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predictive for preeclampsia and all the
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women and we explain this by adding that
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the NFL is increased and that indicates
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that the blood-brain barrier integrity
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is impaired tip thank you very much for
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your attention

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Conference program

Welcome Words
M. Roth-Kleiner, R. Arlettaz Mieth
10 Jan. 2017 · 9:33 a.m.
Short Reports Introduction
E. Giannoni, T. Karen, Resp. Lausanne, Zürich
10 Jan. 2017 · 9:38 a.m.
Association of Axonal Injury and Preeclampsia
Katrina Evers, Neonatology UKBB
10 Jan. 2017 · 9:39 a.m.
Q&A - Association of Axonal Injury and Preeclampsia
Katrina Evers, Neonatology UKBB
10 Jan. 2017 · 9:44 a.m.
Retinopathy of Prematurity
Roland Gerull, Bern
10 Jan. 2017 · 9:47 a.m.
Q&A - Retinopathy of Prematurity
Roland Gerull, Bern
10 Jan. 2017 · 9:54 a.m.
Parechovirus Infection: A Rare Cause of Neonatal Encephalitis (in French)
Dr Truant AS, Cheffe de clinique, Néonatologie, CHUV, Lausanne
10 Jan. 2017 · 9:59 a.m.
Q&A - Parechovirus Infection: A Rare Cause of Neonatal Encephalitis
Dr Truant AS, Cheffe de clinique, Néonatologie, CHUV, Lausanne
10 Jan. 2017 · 10:04 a.m.
Genetic Susceptibility to Neonatal Group B Streptococcal Disease
Alessandro Borghesi, Fellay lab, EPFL
10 Jan. 2017 · 10:17 a.m.
Q&A - Genetic Susceptibility to Neonatal Group B Streptococcal Disease
Alessandro Borghesi, Fellay lab, EPFL
10 Jan. 2017 · 10:25 a.m.
Psychomotor Development in Children Prenatally Exposed to Methadone
G. Grand-Guillaume-Perrenoud, Pediatrics, Children's University Hospital Geneva
10 Jan. 2017 · 10:27 a.m.
Q&A - Psychomotor Development in Children Prenatally Exposed to Methadone
G. Grand-Guillaume-Perrenoud, Pediatrics, Children's University Hospital Geneva
10 Jan. 2017 · 10:34 a.m.
Introduction to Christoph Berger's Presentation
C. Kind, R. Gerull, Resp. St.Gallen, Bern
10 Jan. 2017 · 10:37 a.m.
Vertical Infections: An Update
Christoph Berger, Zürich
10 Jan. 2017 · 10:40 a.m.
Q&A - Vertical Infections: An Update
Christoph Berger, Zürich
10 Jan. 2017 · 11:15 a.m.
Introduction to Eric Giannoni's Presentation
R. Pfister, S. Kämpfen, Resp. Geneva, Basel
10 Jan. 2017 · 11:44 a.m.
Sepsis, Antibiotics and Resistances: Where Are We?
Christoph Bührer, Berlin
10 Jan. 2017 · 2:21 p.m.
Use and Abuse of Antibiotics in Neonatology
Martin Stocker, Lucerne
10 Jan. 2017 · 2:50 p.m.
Panel Discussion : Controversies on Use of Antibiotics in Neonatology
Martin Stocker, Christoph Berger, Eric Giannoni, Christoph Bührer
10 Jan. 2017 · 3:10 p.m.
Introduction to Christoph Bührer's Presentation
Romaine Arlettaz Mieth , Neonatologist, Zürich, President of the Organizing Committee
10 Jan. 2017 · 3:47 p.m.
Evidence-Based Haemodynamic Management in Neonatal Sepsis
Christoph Bührer, Berlin
10 Jan. 2017 · 3:48 p.m.
Q&A - Evidence-Based Haemodynamic Management in Neonatal Sepsis
Christoph Bührer, Berlin
10 Jan. 2017 · 4:16 p.m.
SwissNeoDose Project
Marc Pfister, Ped Pharmacology, UKBB
10 Jan. 2017 · 4:20 p.m.
Awards (Case of the Year; Milupa; Best Poster Case Report; Best Oral Short Presentation) & Closing Comments
Matthias Roth-Kleiner, CHUV, President of the SSN
10 Jan. 2017 · 4:30 p.m.