Association of Axonal Injury and Preeclampsia
Katrina Evers, Neonatology UKBB
mardi, 10 janvier 2017
Preeclampsia (PE) is a main reason of preterm birth and is characterized by maternal hypertension, proteinuria and neurologic symptoms. Neuronal damage is the morphological substrate of acute or persisting neurological disability. Neurolaments (Nf) are specific scaffolding proteins of neurons and their quantification in serum serves as biomarker for axonal injury e.g. in neurodegenerative diseases. The aim of this study was to determine serum Nf concentrations in pregnant women with and without preeclampsia. Conclusions: In pregnant women who develop preeclampsia the axonal injury serum marker NfL is significantly increased. The underlying mechanisms are unknown. A possible explanation is that the preeclampsia underlying endothelial dysfunction causes blood-brain-barrier disruption and concomitant neuronal dam- age. In summary, NfL may be an early marker to predict the occurrence of preeclampsia.