Embed code
the resident at the Department for unity
Muslim and I'm very proud to present our
current project here which focuses on
the association of axonal injury in
preeclampsia as you know preeclampsia is
a main reason for preterm birth and
early diagnosis and adequate treatment
can prolong pregnancy and reduce
morbidity and mortality related to
prematurity the biomarker we looked at
to show x to show external damage
external injury was new development
light chain which is a scaffolding
protein of the news and no cytoskeleton
and which is very important for growth
and branching in then dendrites and
axons it is a it is increase in cns xml
damage and is a very reliable and easily
accessible biomarker it is and it has a
plasma CSF ratio from around 12 50 and
is sometimes already elevated before the
onset of neurological symptoms and since
summer 2016 we have access to this
unique diagnostic technique seymour
which stands for a single molecule array
in basel this is the study design a
single cent of prospective study was
performed at the university hospital of
battle and enrolling pregnant women with
high risk of developing preeclampsia and
these data here were recorded blood
pressure you're in sampling the blood
sampling apart from our NFL from our
biomarker angiogenic Marcus
fleet and PF those are the established
biomarkers to predict preeclampsia were
measured and neurological symptoms and
maternal and neonatal outcomes were
recorded and inclusion criteria where
pregnant women above the age of 18
singleton pregnancy and patients at high
risk for developing preeclampsia and
exclusion criteria where fetal
malformations these are the baseline
characteristics and not surprisingly you
can see that the characteristics that
contribute to preeclampsia significantly
elevated in the preeclampsia group
compared to the control group we want to
do know which factors have an influence
on the NFL and NFL and used NFL as a
dependent variable in a mixed linear
effect model and we could show that
maternal age and as flute which is the
established biomarker to predict
preeclampsia
we're highly significant in this model
gravity and neurological symptoms were
significant and systolic blood pressure
and lipstick were not significant in
this model our findings were in this
plot you can see and the work on the
x-axis other age groups on the left side
there controls on the right side of the
women with preeclampsia and the y-axis
you can see the NFL levels and we could
see that the older the women were the
high the NFL levels were with this
roc curves with the red with the blue
line standing for the NFL levels and red
4s flute and green for Pele GF on the
right side and this flood you can see
the again on the y-axis the NFL levels
and on the x-axis the different groups
the different times of visits so the
more the more to the right to further
the pregnancy is and here again the
further the pregnancy has elapsed the
higher the NFL levels where and we
conclude with this work that NFL
increases with age and if l is higher in
women with preeclampsia and NFL is
predictive for preeclampsia and all the
women and we explain this by adding that
the NFL is increased and that indicates
that the blood-brain barrier integrity
is impaired tip thank you very much for
your attention

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Conference program

Welcome Words
M. Roth-Kleiner, R. Arlettaz Mieth
10 jan. 2017 · 9:33 matin
Short Reports Introduction
E. Giannoni, T. Karen, Resp. Lausanne, Zürich
10 jan. 2017 · 9:38 matin
Association of Axonal Injury and Preeclampsia
Katrina Evers, Neonatology UKBB
10 jan. 2017 · 9:39 matin
Q&A - Association of Axonal Injury and Preeclampsia
Katrina Evers, Neonatology UKBB
10 jan. 2017 · 9:44 matin
Retinopathy of Prematurity
Roland Gerull, Bern
10 jan. 2017 · 9:47 matin
Q&A - Retinopathy of Prematurity
Roland Gerull, Bern
10 jan. 2017 · 9:54 matin
Parechovirus Infection: A Rare Cause of Neonatal Encephalitis (in French)
Dr Truant AS, Cheffe de clinique, Néonatologie, CHUV, Lausanne
10 jan. 2017 · 9:59 matin
Q&A - Parechovirus Infection: A Rare Cause of Neonatal Encephalitis
Dr Truant AS, Cheffe de clinique, Néonatologie, CHUV, Lausanne
10 jan. 2017 · 10:04 matin
Genetic Susceptibility to Neonatal Group B Streptococcal Disease
Alessandro Borghesi, Fellay lab, EPFL
10 jan. 2017 · 10:17 matin
Q&A - Genetic Susceptibility to Neonatal Group B Streptococcal Disease
Alessandro Borghesi, Fellay lab, EPFL
10 jan. 2017 · 10:25 matin
Psychomotor Development in Children Prenatally Exposed to Methadone
G. Grand-Guillaume-Perrenoud, Pediatrics, Children's University Hospital Geneva
10 jan. 2017 · 10:27 matin
Q&A - Psychomotor Development in Children Prenatally Exposed to Methadone
G. Grand-Guillaume-Perrenoud, Pediatrics, Children's University Hospital Geneva
10 jan. 2017 · 10:34 matin
Introduction to Christoph Berger's Presentation
C. Kind, R. Gerull, Resp. St.Gallen, Bern
10 jan. 2017 · 10:37 matin
Vertical Infections: An Update
Christoph Berger, Zürich
10 jan. 2017 · 10:40 matin
Q&A - Vertical Infections: An Update
Christoph Berger, Zürich
10 jan. 2017 · 11:15 matin
Introduction to Eric Giannoni's Presentation
R. Pfister, S. Kämpfen, Resp. Geneva, Basel
10 jan. 2017 · 11:44 matin
Sepsis, Antibiotics and Resistances: Where Are We?
Christoph Bührer, Berlin
10 jan. 2017 · 2:21 après-midi
Use and Abuse of Antibiotics in Neonatology
Martin Stocker, Lucerne
10 jan. 2017 · 2:50 après-midi
Panel Discussion : Controversies on Use of Antibiotics in Neonatology
Martin Stocker, Christoph Berger, Eric Giannoni, Christoph Bührer
10 jan. 2017 · 3:10 après-midi
Introduction to Christoph Bührer's Presentation
Romaine Arlettaz Mieth , Neonatologist, Zürich, President of the Organizing Committee
10 jan. 2017 · 3:47 après-midi
Evidence-Based Haemodynamic Management in Neonatal Sepsis
Christoph Bührer, Berlin
10 jan. 2017 · 3:48 après-midi
Q&A - Evidence-Based Haemodynamic Management in Neonatal Sepsis
Christoph Bührer, Berlin
10 jan. 2017 · 4:16 après-midi
SwissNeoDose Project
Marc Pfister, Ped Pharmacology, UKBB
10 jan. 2017 · 4:20 après-midi
Awards (Case of the Year; Milupa; Best Poster Case Report; Best Oral Short Presentation) & Closing Comments
Matthias Roth-Kleiner, CHUV, President of the SSN
10 jan. 2017 · 4:30 après-midi

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