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the appreciation the promise and the but the according to its own i
think this meeting and the the inviting me to participate and share
some of us is in progress for understanding how it would be
a cut in the system and the uh commence off microbial
since we have in the behind schedule and uh we have fifteen minutes to go for the launch
so probably i have to speak first and ah
go for the walls
so since i came from japan made me i have to
go to the speed of trained ah ah express three
but anyway uh
again getting that uh uh our cat is can ditched who
is a a common style of michael your uh
then uh the divorce indicated that the um more than a comments all a light
now and comments on meaning we had sharing the fruit sharing your table
but and based on the is a presentation probably be on uh just sharing fruit and the
table in terms of the interaction between the he comments or michael your hand to uh
because all the immune system now the iris aided in
this ah um comments i'll a microbe your uh
provide a benefit show ah more active and midi and for the cost uh
including the immune system shaking up immune
system maintain appropriate immune system
what was this mutual who system oh this up to some of the comments i'll microbe your
can be regarded proctor or d. v. d. c. c.s and this susceptibility to the infection
it is well known that comments of allah can influence on development or concerns
system what cut immune system in more than thirty year the ball
or yeah work was done by the the the the transceiver
you nicely show that the uh comments or floor
he is three gotten proctor for that development hold them cause says
so the rest of it in decide if we maintain mice in the germ free he condition
in terms of the shape of the people were nice before
the structure so just got associate you put issue for
our expertise they are very mature in terms of science in terms of the d. c. knowledge got function
but once you explore words some of the comments of laura
equal and what you what i didn't help us into these your movie mice use
that notice that development of the onus infrastructure such as high as parties
beginning to be you increase o. i. g. a. t. cells hand also at same time got
the new system to grow or core it's so impressed no comments a microbe your
oh it's a shot oh development modulation maintenance all the appropriate got immune system
so other indicate it if you kept mice under the conventional
condition you have high level call secretary actually it
but in case something jumpy mice these figure could actually a is almost nothing
they i would like to discuss ways in terms of
the interaction between human system and the comments
of roll them as you may know well we we identified so cold in a imports cell
our current three central focus all the interaction between the comments
are flora and it for cost yeah it's a set
in the is innately informed sell now can be divided into three agree three groups
based on the uh necessity oh transcription factor for that development oh different
salsa and in terms of the side to kind production pounds
and also in terms of the function
it today i would like to focus on group for me what types me in eight me fourth so
in terms of uh integrating say your cell to create a commence on each would be
comments about it
two years ago when we examine
comments or or or uh and the interaction between a host immune system
we decide to look at i got all associated organise the petition has parties
that importance side of initiation and the regulation no got payment system
so we decided to look at the interaction no parts patch and the comments of role
then when we examined
comments of roll up on the dole see you over the pilots might use
we generally found so call segmented element this doctor
as you may well be nice job so you just
what missus saying quick time for nah ah sell anyway
look this now obsidian over the pirates budgets containing
unique and begin sampling cells so and so
so we sell that segment of the from and that's not the maybe
uptake by d. m.s then we'll examine the inside of the house batteries being a surprise
we couldn't find any exactly in step has investigated
green what you're about how to get it changes
well identified in inside over the pilots budgets
and his other devices they the ways
green progresses was
given to the contests in the potential that in cell taken that
these circuits chips inside of the pie that's that is
nancy dimensional analyses should also showing that are gonna get as as can be
cupcake by the concert
other after
uptake by by themselves as illustrated in this ride some of our
local genesis can be taken ah by the end excel
then we have no brainer data suggesting that somehow ah the eighties are doing this
can be escaped or and begin processing room then that sell at
the creating cohabitation h. in his side of the tent except
this point plot bother compound by that simple analysis
or are gonna gazes specific antibody responses
so men when design ma minds get another it's your condition
we could be tight against his space the secretary idea but not
jump remarks
however when we honest sam sample room is the uh and the germ free mice
although it's a good idea of the body against again it's long enough equal sample
we couldn't find any other per unit this serum hijacked and it's
so this suggests that somehow our got the news system contain
hardcoded in is is inside probably part much it's
a presence so are gonna get itself in the inside of the parts
parties has been also confided in a priming and if you
so if we examine
ours parties from passive monkeys what parts parties from no even
issue over the human we could identify how god uses
and also most of the class containing agreed erases space speak
secretary idea i want to put enough you call some
so what monkey as well
so this is also the us that some of the common sulphur or can
create cohabitation h. in his side of the organised the point structure
so in the next we examine how he's indication cognition
can be contained in that wilderness you poured structure
together with is maybe us group at hand
oh we're able to show that so called innately before to sell
seems to be important prayer for the containment over the
target changes in his side all the parts projects
so if you do you are currently or excuse me repeatedly you make the important set
we notice that
innovative input cell expressing c. d. nine b. so if you inject and buy
c. d. ninety you can probably we can be moved unity report so
human you create these condition we start to notice that are gonna geniuses
can be found in assisting the composite such as very deep
which resulted in induction no c. d. uh
information in the system compartment setter spring
these findings well also
can phone in human level um when ah they can these corridors
compare patient ways to get it from disease and control group
the problem that higher tighter oh according says
specific i. c. g. companies patient ways
you are not very well disease
so these results suggest that again is maybe can bowl
in the creation no promise that the condition
when you move the oak article jenny or nay needing to
the initiation note in this now in from age
these findings well well the compound by d. a. colour study together with is a
book to actually he was group but also gave us the we examine
adele operation
as i indicated in has a condition you can fine occult yeses in
inside the parts but is but some of the crown disease patients
we notice that significant reduction no recognises what their call from the past actions
on the other hand in in terms of the opinion space p. i.
t. g. activities other i figured i could get a case
hi another oh id g. on companies against everybody uses was not it
at the same time that or or secretary i see at the bodies
against local changes what degrees in a patient with clones dizzy
so are doing is is maybe important for the
creating would be symbolic condition
for the cup even system and outside compartment
we recently succeeded to create are gonna do is this
model associated one we'll talk about it mites
when the is
not about the mines was subjected to the
the this induced
in this now information
compare ways equalise mono associated mites
maybe i'm associated mice resulted in c. d. or
information invested in some of my stuff
but in case of thought are gonna genesis model associated minus
well protected from the b.
yes yes induced information suggesting that are gonna genesis to
be important so that all may painting appropriate
existence all the comments of aurora and also means system
so this is all clearly indicating that some of the common sort of roller
can be creating maybe cohabitation each in inside all the parts but he's
yeah the innate giving voice said it's provide psychic line so called high up twenty two
which applauding sideline for regulating could sit here function
yeah i did not show you data but we have evidence
that these signal in cascade hindus and the microbial peptide
which maybe him ball in of containment code the corporate genesis in his side of the parts budgets
so ah floss part of the study
we show that innate invoice sell producing out twenty two maybe
in order for the creation no internet issues habitation nope
some of the comments overlap how can give
this study has been carried heidi oh
don't attack actually what up who is now have the packet of pharmaceutical corporation when he
was a graduate student uh with us he may be carried out this project
in the second part of the coke out like to share some of
our car you must uh paper showing that these are seen
rain pour all like insulation that could still sell which also provide
consultation each for the some of the comments of or
this study has been carried by be a look that you should call his name e. x. nickname is put g.
who is now in the columbia a university new york as possible for for
mental consolation no would be good serious uh has been shown
to be important for the creation or corporation each
for example will confirm particle nice we show
that some of the comments of roller produce courses
to create our phone calls and these are common to show calls
are important meeting for the some of the comments on low
you know not to induce consideration could do is important and so on
then put two mutation has been associated ways several
disease as well as some sort of
a big d. to be you pitch has invested in this that will double
could do no sense mutated people has been shown to be there
just down to normal bias and a lot of virus detection
father i could to nonsense mutation admission to be also
see who is the incidents over the grounds disease
so consolation and inducing enzyme could to seems to be very important
well the creation note saying about the condition as well as possible jake converge
so we're wondering how they is put to sea expressions by
it so you know cells heightened use under li
so what you decided to look at
consolation of course elated it serious cell using your insist
so he seem pretty bad
small intestine into four or from you would be no too easy i think he's i mean
that are all what number or quasi dated city so i know
the last lady in decide in case of metering system
most of the also needed it's in your sells a lot so she who is pothole what you do
so when he isolated sell high number o. course interviewed at sears sells candy
well when compared ways up serious else isolated from the eugene well wow
in terms of the leather or should do expression
courtenay waste number oh of course sedated city sell so well
he isolated it's in your cell from the pop fall quickly
hi there or could do expression
can deals are when compared ways part one or or you didn't
so these suggesting that comments of laura made simple in induction no good to expunge
then as we horror based on the but joseph's nice introduction got consisted
ways live number all different type all in the competent sets
so go to next to decide perhaps some nobody
impulse i i located in a nominal population i'm contesting make they they could to induction
so because it different
gene manipulated mice
i'm i'm then i'm
our or gamma no caught mice
we can acting cleared seventeen cell and in a viewpoint cell
also these mice has been shown to the u. k. in the secondary you
point oregon development including past budgets and also induction up high g. okay
week subset of says i'm ball integration the course h.
yeah as i indicated
well packed mines and allow drama no cop which hobbies actions
no of course eluded sears sells can be found in and you have the you could become an apart oh
so in terms of the number or close ended up zero sells
a significant to me did you just and never oh
could you expression was also significantly reduced in these markets
so the reason is also just think th seventeen sell i'll see
when i was structure well id producing these sell maybe oh
in induction
no good to stretch
okay decided to look at forced to sell the shunt mice including t. seventeen set
he's he's edition minus all this normal rubber or close it
it gets it sets so probably case seventeens looking ball
next he examined the cell action ice
again showing normal level or consideration of course it it it
it's it so so probably pieces on the ball
bounce all all i didn't point structure we can create hearts patch
deficient mice by injecting it and that has some except for on top
that shows your parts but it still maintain
no matter how close they'd tips it sells so with all
naked people cells could be he sells for the induction not conceding obsidian says
as i briefly indicated days innate before the cell okay is unique transcription
proctor requirement ivy to and hard work among all their development
in terms of the panel type expression maybe pressure to produce aisle twenty two and
they express c. d. ninety two seat you want twenty seven and so on
so next but you decided to
examine id to knockout mice
which attacking
i uh see
hazardous i did in this ah
i didn't do deficient mice
we couldn't find proceeded obsidian sets
next using indigo system
to inject anti c. d. ninety and what could be pretty
these high c. has us i did in this right
i'll see express how little l. c. d. nine
so how
we couldn't get mice ways and by c. nine
income problem to deal with this
as a pet control and
which resulted in the mobile or
in a report cells
resulted in reduction overlap oh conceded obsidian sets
so there is a result clearly indicating that piracy
is she operation for the induction regulation not considered obsidian sets
to follow up group gaze we tested not one option it's
based on the study done by heart here look that's our group
what books i wonder is corey except posture showing that not deficiency
resulted in in good news letter or
in a report said
so when we examine in them so
course it it it could save yourself
in a pile pothole what did you notice that increase so close in it if it's in your cells
even pop want you being generally been inactive what of course it it
it it's it's all pretty agrees number oh higher c. resulted in
induction of consolation in that part what you've been model suggesting that i was
sees importance of population well induction a regulation no consolation no bitsy sets
in terms of the seaside crime as i indicated i'll
see special type city preferentially produce ah twenty two
so we can on that when we isolated different subsets sell house c. c. d. produce
the price very highly trained the two
then no one local mice which pull this high number or higher c.
what really worries about c. d. ninety everybody which deeply i uh see
resulted in no production not high out twenty two
other higher twenty two production by i. s. c. c. d. seems to be
regulated by the comments or program so if you treat mice responded by alex
we start to notice that deduction no i'm twenty two production by i assisted
to further prove i twenty two is she cited crime for inducing could do expression
for the consideration nobody have serious else what to use
hi the dynamic caravan injection know personally containing how twenty two gene
so one day is
oh do global mice what created with s. m. p. preston and prosody containing how twenty two
when we notice that they're all calls out twenty two
went very high
then when we examine these nights we notice that induction no closely
serious up in in a pop one duty in an
interview zero condition you will find these consideration as
suggesting that all bubbles hold i definitely to chain
deuce custody up to sell showing that creator
importance of a twenty two mediated signalling task
so when i mean i don't twenty two knockout mice number of consideration that used
and if we do expression logo but studio cells was also that you just
so for our data query showing that you need to be for the cell
producing i work twenty two which acted won't sell your cell
to induce you to expression did into the induction of quasi tipsy so
so yeah it was a nation of it is zero sceptical human testing what will happen
so what does that mean in terms of the fruit to fiction ice compared with
his control mice we notice that profile all the comments our product changed
in terms of the segmented tremendous bacteria which attached to the it
serious l. didn't thing pop up about enough yeah yeah
well it's reduced in uh
most selecting could too
well considered tipsy sets
in terms of the susceptibility to the infection
put two engine and the control my so effective ways some uptight from you
both my site infected with this
uh some some net are tightly meeting but security for
disease what much higher enough to action minus
and number oh oh
a six foot excuse me that sermon attack community
in the sickle to she is much higher input to the action minds
suggesting that like to put to work because rated 'cause
various out increase susceptibility to the sermon or pitch
so our findings suggested that i don't see types three
or groups c. r. c. i. t. cells
all the regulation or do expression by itself sell you hire twenty two
he is considered a good studio sell contribute for the creation no no more
comments i'll make and also important for the some of the u. h.
in this case sound um how protective barrier
since our study was published in the summer will listen to be
two seater papers came out in nature and self last micro
but i talked a term on skis group up to d. e. s. of which got well
and also had to follow these group cups i'm not used to the u. k.
in addition to our findings we have shown that l. p. s.
can stimulate in excel to produce our twenty three
we just need a irises three to produce higher twenty two
our disruption no for two expression our meeting we could be just not
s. time you mean she'd wouldn't an infection susceptibility also increased
and also created this bible says acting what would be considered it up c. set
so these results clearly indicating that as you might expect
reconciliation the big city also the very important
well the creation not a common so a niche for her and it also protection against assets
so finally i would like to ignore each other quarries who have been
involved in this project especially i should have an orange ah
good key use you people and the but the question what
are all the occurrences study as well as uh
oops he hires see generated a workstation up
it's a cell together with is excellent

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Conference program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:02 p.m.
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
24 Oct. 2014 · 3:46 p.m.

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