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the appreciation the promise and the but the according to its own i
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think this meeting and the the inviting me to participate and share
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some of us is in progress for understanding how it would be
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a cut in the system and the uh commence off microbial
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uh
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since we have in the behind schedule and uh we have fifteen minutes to go for the launch
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so probably i have to speak first and ah
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go for the walls
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so since i came from japan made me i have to
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go to the speed of trained ah ah express three
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but anyway uh
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again getting that uh uh our cat is can ditched who
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is a a common style of michael your uh
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then uh the divorce indicated that the um more than a comments all a light
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now and comments on meaning we had sharing the fruit sharing your table
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but and based on the is a presentation probably be on uh just sharing fruit and the
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table in terms of the interaction between the he comments or michael your hand to uh
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because all the immune system now the iris aided in
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this ah um comments i'll a microbe your uh
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provide a benefit show ah more active and midi and for the cost uh
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including the immune system shaking up immune
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system maintain appropriate immune system
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what was this mutual who system oh this up to some of the comments i'll microbe your
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can be regarded proctor or d. v. d. c. c.s and this susceptibility to the infection
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it is well known that comments of allah can influence on development or concerns
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system what cut immune system in more than thirty year the ball
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or yeah work was done by the the the the transceiver
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you nicely show that the uh comments or floor
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he is three gotten proctor for that development hold them cause says
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so the rest of it in decide if we maintain mice in the germ free he condition
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in terms of the shape of the people were nice before
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the structure so just got associate you put issue for
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our expertise they are very mature in terms of science in terms of the d. c. knowledge got function
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but once you explore words some of the comments of laura
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equal and what you what i didn't help us into these your movie mice use
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that notice that development of the onus infrastructure such as high as parties
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beginning to be you increase o. i. g. a. t. cells hand also at same time got
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the new system to grow or core it's so impressed no comments a microbe your
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oh it's a shot oh development modulation maintenance all the appropriate got immune system
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so other indicate it if you kept mice under the conventional
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condition you have high level call secretary actually it
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but in case something jumpy mice these figure could actually a is almost nothing
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they i would like to discuss ways in terms of
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the interaction between human system and the comments
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of roll them as you may know well we we identified so cold in a imports cell
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our current three central focus all the interaction between the comments
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are flora and it for cost yeah it's a set
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in the is innately informed sell now can be divided into three agree three groups
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based on the uh necessity oh transcription factor for that development oh different
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salsa and in terms of the side to kind production pounds
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and also in terms of the function
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it today i would like to focus on group for me what types me in eight me fourth so
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in terms of uh integrating say your cell to create a commence on each would be
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comments about it
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two years ago when we examine
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comments or or or uh and the interaction between a host immune system
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we decide to look at i got all associated organise the petition has parties
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that importance side of initiation and the regulation no got payment system
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so we decided to look at the interaction no parts patch and the comments of role
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then when we examined
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comments of roll up on the dole see you over the pilots might use
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we generally found so call segmented element this doctor
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as you may well be nice job so you just
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oh
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what missus saying quick time for nah ah sell anyway
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so uh
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look this now obsidian over the pirates budgets containing
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unique and begin sampling cells so and so
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so we sell that segment of the from and that's not the maybe
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uptake by d. m.s then we'll examine the inside of the house batteries being a surprise
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we couldn't find any exactly in step has investigated
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green what you're about how to get it changes
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well identified in inside over the pilots budgets
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and his other devices they the ways
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green progresses was
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given to the contests in the potential that in cell taken that
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these circuits chips inside of the pie that's that is
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nancy dimensional analyses should also showing that are gonna get as as can be
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cupcake by the concert
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other after
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uptake by by themselves as illustrated in this ride some of our
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local genesis can be taken ah by the end excel
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then we have no brainer data suggesting that somehow ah the eighties are doing this
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can be escaped or and begin processing room then that sell at
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the creating cohabitation h. in his side of the tent except
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oh
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this point plot bother compound by that simple analysis
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or are gonna gazes specific antibody responses
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so men when design ma minds get another it's your condition
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we could be tight against his space the secretary idea but not
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jump remarks
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however when we honest sam sample room is the uh and the germ free mice
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although it's a good idea of the body against again it's long enough equal sample
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we couldn't find any other per unit this serum hijacked and it's
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so this suggests that somehow our got the news system contain
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hardcoded in is is inside probably part much it's
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a presence so are gonna get itself in the inside of the parts
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parties has been also confided in a priming and if you
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so if we examine
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ours parties from passive monkeys what parts parties from no even
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issue over the human we could identify how god uses
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and also most of the class containing agreed erases space speak
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secretary idea i want to put enough you call some
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so what monkey as well
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so this is also the us that some of the common sulphur or can
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create cohabitation h. in his side of the organised the point structure
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so in the next we examine how he's indication cognition
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can be contained in that wilderness you poured structure
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together with is maybe us group at hand
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oh we're able to show that so called innately before to sell
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seems to be important prayer for the containment over the
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target changes in his side all the parts projects
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so if you do you are currently or excuse me repeatedly you make the important set
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we notice that
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innovative input cell expressing c. d. nine b. so if you inject and buy
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c. d. ninety you can probably we can be moved unity report so
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human you create these condition we start to notice that are gonna geniuses
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can be found in assisting the composite such as very deep
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which resulted in induction no c. d. uh
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information in the system compartment setter spring
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these findings well also
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uh
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can phone in human level um when ah they can these corridors
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compare patient ways to get it from disease and control group
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the problem that higher tighter oh according says
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specific i. c. g. companies patient ways
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you are not very well disease
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so these results suggest that again is maybe can bowl
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in the creation no promise that the condition
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when you move the oak article jenny or nay needing to
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the initiation note in this now in from age
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these findings well well the compound by d. a. colour study together with is a
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book to actually he was group but also gave us the we examine
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adele operation
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as i indicated in has a condition you can fine occult yeses in
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inside the parts but is but some of the crown disease patients
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we notice that significant reduction no recognises what their call from the past actions
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on the other hand in in terms of the opinion space p. i.
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t. g. activities other i figured i could get a case
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hi another oh id g. on companies against everybody uses was not it
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at the same time that or or secretary i see at the bodies
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against local changes what degrees in a patient with clones dizzy
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so are doing is is maybe important for the
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creating would be symbolic condition
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for the cup even system and outside compartment
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we recently succeeded to create are gonna do is this
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model associated one we'll talk about it mites
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when the is
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not about the mines was subjected to the
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the this induced
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in this now information
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compare ways equalise mono associated mites
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maybe i'm associated mice resulted in c. d. or
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information invested in some of my stuff
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but in case of thought are gonna genesis model associated minus
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well protected from the b.
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yes yes induced information suggesting that are gonna genesis to
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be important so that all may painting appropriate
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cool
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existence all the comments of aurora and also means system
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so this is all clearly indicating that some of the common sort of roller
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can be creating maybe cohabitation each in inside all the parts but he's
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yeah the innate giving voice said it's provide psychic line so called high up twenty two
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which applauding sideline for regulating could sit here function
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yeah i did not show you data but we have evidence
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that these signal in cascade hindus and the microbial peptide
00:16:04
which maybe him ball in of containment code the corporate genesis in his side of the parts budgets
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so ah floss part of the study
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we show that innate invoice sell producing out twenty two maybe
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in order for the creation no internet issues habitation nope
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some of the comments overlap how can give
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this study has been carried heidi oh
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don't attack actually what up who is now have the packet of pharmaceutical corporation when he
00:16:47
was a graduate student uh with us he may be carried out this project
00:16:56
in the second part of the coke out like to share some of
00:16:59
our car you must uh paper showing that these are seen
00:17:05
rain pour all like insulation that could still sell which also provide
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consultation each for the some of the comments of or
00:17:17
this study has been carried by be a look that you should call his name e. x. nickname is put g.
00:17:25
who is now in the columbia a university new york as possible for for
00:17:32
mental consolation no would be good serious uh has been shown
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to be important for the creation or corporation each
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for example will confirm particle nice we show
00:17:48
that some of the comments of roller produce courses
00:17:53
to create our phone calls and these are common to show calls
00:17:58
are important meeting for the some of the comments on low
00:18:05
you know not to induce consideration could do is important and so on
00:18:11
then put two mutation has been associated ways several
00:18:17
disease as well as some sort of
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a big d. to be you pitch has invested in this that will double
00:18:29
could do no sense mutated people has been shown to be there
00:18:32
just down to normal bias and a lot of virus detection
00:18:39
father i could to nonsense mutation admission to be also
00:18:44
see who is the incidents over the grounds disease
00:18:50
so consolation and inducing enzyme could to seems to be very important
00:18:58
well the creation note saying about the condition as well as possible jake converge
00:19:08
so we're wondering how they is put to sea expressions by
00:19:12
it so you know cells heightened use under li
00:19:19
so what you decided to look at
00:19:23
consolation of course elated it serious cell using your insist
00:19:30
so he seem pretty bad
00:19:32
small intestine into four or from you would be no too easy i think he's i mean
00:19:41
that are all what number or quasi dated city so i know
00:19:47
the last lady in decide in case of metering system
00:19:52
most of the also needed it's in your sells a lot so she who is pothole what you do
00:19:59
so when he isolated sell high number o. course interviewed at sears sells candy
00:20:05
well when compared ways up serious else isolated from the eugene well wow
00:20:15
in terms of the leather or should do expression
00:20:21
courtenay waste number oh of course sedated city sell so well
00:20:28
he isolated it's in your cell from the pop fall quickly
00:20:34
hi there or could do expression
00:20:37
can deals are when compared ways part one or or you didn't
00:20:45
so these suggesting that comments of laura made simple in induction no good to expunge
00:20:56
then as we horror based on the but joseph's nice introduction got consisted
00:21:03
ways live number all different type all in the competent sets
00:21:11
so go to next to decide perhaps some nobody
00:21:17
impulse i i located in a nominal population i'm contesting make they they could to induction
00:21:28
so because it different
00:21:31
gene manipulated mice
00:21:36
i'm i'm then i'm
00:21:39
our or gamma no caught mice
00:21:43
we can acting cleared seventeen cell and in a viewpoint cell
00:21:48
also these mice has been shown to the u. k. in the secondary you
00:21:53
point oregon development including past budgets and also induction up high g. okay
00:22:03
so
00:22:06
week subset of says i'm ball integration the course h.
00:22:14
yeah as i indicated
00:22:17
well packed mines and allow drama no cop which hobbies actions
00:22:25
no of course eluded sears sells can be found in and you have the you could become an apart oh
00:22:36
so in terms of the number or close ended up zero sells
00:22:41
a significant to me did you just and never oh
00:22:47
could you expression was also significantly reduced in these markets
00:22:56
so the reason is also just think th seventeen sell i'll see
00:23:02
when i was structure well id producing these sell maybe oh
00:23:08
in induction
00:23:10
no good to stretch
00:23:16
so
00:23:18
okay decided to look at forced to sell the shunt mice including t. seventeen set
00:23:26
he's he's edition minus all this normal rubber or close it
00:23:31
it gets it sets so probably case seventeens looking ball
00:23:38
next he examined the cell action ice
00:23:43
again showing normal level or consideration of course it it it
00:23:49
it's it so so probably pieces on the ball
00:23:53
bounce all all i didn't point structure we can create hearts patch
00:23:59
deficient mice by injecting it and that has some except for on top
00:24:09
again
00:24:11
that shows your parts but it still maintain
00:24:15
no matter how close they'd tips it sells so with all
00:24:21
naked people cells could be he sells for the induction not conceding obsidian says
00:24:33
as i briefly indicated days innate before the cell okay is unique transcription
00:24:40
proctor requirement ivy to and hard work among all their development
00:24:47
in terms of the panel type expression maybe pressure to produce aisle twenty two and
00:24:54
they express c. d. ninety two seat you want twenty seven and so on
00:25:01
so next but you decided to
00:25:05
examine id to knockout mice
00:25:09
which attacking
00:25:12
i uh see
00:25:15
hazardous i did in this ah
00:25:18
i didn't do deficient mice
00:25:21
we couldn't find proceeded obsidian sets
00:25:30
next using indigo system
00:25:34
to inject anti c. d. ninety and what could be pretty
00:25:39
these high c. has us i did in this right
00:25:45
i'll see express how little l. c. d. nine
00:25:52
so how
00:25:55
we couldn't get mice ways and by c. nine
00:26:02
income problem to deal with this
00:26:06
as a pet control and
00:26:10
which resulted in the mobile or
00:26:14
in a report cells
00:26:18
resulted in reduction overlap oh conceded obsidian sets
00:26:25
so there is a result clearly indicating that piracy
00:26:32
is she operation for the induction regulation not considered obsidian sets
00:26:42
to follow up group gaze we tested not one option it's
00:26:49
based on the study done by heart here look that's our group
00:26:54
what books i wonder is corey except posture showing that not deficiency
00:27:01
resulted in in good news letter or
00:27:06
in a report said
00:27:10
so when we examine in them so
00:27:16
course it it it could save yourself
00:27:20
in a pile pothole what did you notice that increase so close in it if it's in your cells
00:27:29
even pop want you being generally been inactive what of course it it
00:27:36
it it's it's all pretty agrees number oh higher c. resulted in
00:27:43
induction of consolation in that part what you've been model suggesting that i was
00:27:50
sees importance of population well induction a regulation no consolation no bitsy sets
00:28:01
in terms of the seaside crime as i indicated i'll
00:28:06
see special type city preferentially produce ah twenty two
00:28:12
so we can on that when we isolated different subsets sell house c. c. d. produce
00:28:20
the price very highly trained the two
00:28:24
then no one local mice which pull this high number or higher c.
00:28:33
what really worries about c. d. ninety everybody which deeply i uh see
00:28:40
resulted in no production not high out twenty two
00:28:47
other higher twenty two production by i. s. c. c. d. seems to be
00:28:55
regulated by the comments or program so if you treat mice responded by alex
00:29:01
we start to notice that deduction no i'm twenty two production by i assisted
00:29:11
to further prove i twenty two is she cited crime for inducing could do expression
00:29:18
for the consideration nobody have serious else what to use
00:29:24
hi the dynamic caravan injection know personally containing how twenty two gene
00:29:34
so one day is
00:29:36
oh do global mice what created with s. m. p. preston and prosody containing how twenty two
00:29:46
when we notice that they're all calls out twenty two
00:29:52
went very high
00:29:54
then when we examine these nights we notice that induction no closely
00:30:02
serious up in in a pop one duty in an
00:30:06
interview zero condition you will find these consideration as
00:30:11
suggesting that all bubbles hold i definitely to chain
00:30:15
deuce custody up to sell showing that creator
00:30:20
importance of a twenty two mediated signalling task
00:30:27
so when i mean i don't twenty two knockout mice number of consideration that used
00:30:36
and if we do expression logo but studio cells was also that you just
00:30:47
so
00:30:49
so for our data query showing that you need to be for the cell
00:30:55
producing i work twenty two which acted won't sell your cell
00:30:59
to induce you to expression did into the induction of quasi tipsy so
00:31:07
so yeah it was a nation of it is zero sceptical human testing what will happen
00:31:15
so what does that mean in terms of the fruit to fiction ice compared with
00:31:22
his control mice we notice that profile all the comments our product changed
00:31:31
in terms of the segmented tremendous bacteria which attached to the it
00:31:36
serious l. didn't thing pop up about enough yeah yeah
00:31:43
well it's reduced in uh
00:31:47
most selecting could too
00:31:49
well considered tipsy sets
00:31:55
in terms of the susceptibility to the infection
00:32:01
put two engine and the control my so effective ways some uptight from you
00:32:11
both my site infected with this
00:32:17
uh some some net are tightly meeting but security for
00:32:22
disease what much higher enough to action minus
00:32:30
and number oh oh
00:32:33
a six foot excuse me that sermon attack community
00:32:37
in the sickle to she is much higher input to the action minds
00:32:44
suggesting that like to put to work because rated 'cause
00:32:48
various out increase susceptibility to the sermon or pitch
00:32:55
so our findings suggested that i don't see types three
00:33:02
or groups c. r. c. i. t. cells
00:33:06
all the regulation or do expression by itself sell you hire twenty two
00:33:12
he is considered a good studio sell contribute for the creation no no more
00:33:18
comments i'll make and also important for the some of the u. h.
00:33:25
in this case sound um how protective barrier
00:33:31
since our study was published in the summer will listen to be
00:33:36
two seater papers came out in nature and self last micro
00:33:42
but i talked a term on skis group up to d. e. s. of which got well
00:33:48
and also had to follow these group cups i'm not used to the u. k.
00:33:55
in addition to our findings we have shown that l. p. s.
00:34:01
can stimulate in excel to produce our twenty three
00:34:07
we just need a irises three to produce higher twenty two
00:34:14
our disruption no for two expression our meeting we could be just not
00:34:22
s. time you mean she'd wouldn't an infection susceptibility also increased
00:34:30
and also created this bible says acting what would be considered it up c. set
00:34:39
so these results clearly indicating that as you might expect
00:34:43
reconciliation the big city also the very important
00:34:46
well the creation not a common so a niche for her and it also protection against assets
00:34:55
so finally i would like to ignore each other quarries who have been
00:35:00
involved in this project especially i should have an orange ah
00:35:06
good key use you people and the but the question what
00:35:09
are all the occurrences study as well as uh
00:35:15
oops he hires see generated a workstation up
00:35:20
it's a cell together with is excellent

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Conference program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
23 Oct. 2014 · 9:07 a.m.
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 9:31 a.m.
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
23 Oct. 2014 · 10:29 a.m.
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:07 a.m.
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
23 Oct. 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 11:56 a.m.
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
23 Oct. 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
23 Oct. 2014 · 1:41 p.m.
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 1:55 p.m.
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
23 Oct. 2014 · 2:34 p.m.
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 3:52 p.m.
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
23 Oct. 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 9:16 a.m.
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
24 Oct. 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:19 a.m.
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
24 Oct. 2014 · 10:53 a.m.
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:04 a.m.
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
24 Oct. 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
24 Oct. 2014 · 12:46 p.m.
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
24 Oct. 2014 · 12:56 p.m.
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 1:47 p.m.
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
24 Oct. 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
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Q&A : Perspectives for nutrition and the gut microbiome
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