Player is loading...

Embed

Copy embed code

Transcriptions

Note: this content has been automatically generated.
00:00:00
You think they we look appearance of
00:00:02
should change that yes you whether or
00:00:05
not because it's all over the world or
00:00:07
small I know yeah so I don't so what
00:00:10
you see is conflicting data right about
00:00:12
whether it's better that that's sure
00:00:14
that if you have less change that acid
00:00:16
sometimes associated with diabetes this
00:00:18
large but I do believe that all the
00:00:20
might be other study show that there's
00:00:23
less you great producers. That's for
00:00:26
the physical part of it I believe that
00:00:28
when you're looking at the changing
00:00:30
unity for example in the small
00:00:31
intestine where beer is very very
00:00:33
important. We have data on that on
00:00:35
macrophages function because I think
00:00:38
there are only a little bit of give
00:00:40
rate for switching video might do the
00:00:42
trick not so much only on the
00:00:43
demolitions all the sex on on on
00:00:46
glucose metabolism more look a
00:00:48
sensitivity that's specifically on the
00:00:50
immune system and so there may very
00:00:53
many few. So there were few nature
00:00:57
papers last year showing effectively
00:00:59
rate on T cell right regulatory
00:01:01
function. And we seem to produce that
00:01:04
humans. So it and that's only only
00:01:06
Right so I finally yes your nanny and
00:01:12
we'll start from the side. So you you
00:01:17
know from the easy but don't do it you
00:01:19
know then like do you previous vision
00:01:26
like or would you you bring someone
00:01:31
previously you respond for example okay
00:01:35
see different foxy yeah you mention
00:01:37
with the big change you know about
00:01:39
discipline the yeah yeah Y yeah I was
00:01:42
wondering difficult candidate or know
00:01:44
first looking at that in type one
00:01:46
diabetes now. And forever because
00:01:47
looking at the fickle sample
00:01:49
composition because it's also very
00:01:50
interesting to see if you give you read
00:01:52
what excuse or changes the market we on
00:01:55
the composition sell some not not even
00:01:57
if few contrast and giving them edible
00:01:59
I can see what it the changes also
00:02:01
previously memory yeah that's that's
00:02:05
something that we're looking into now
00:02:06
with the war clue was in excellent
00:02:08
immunology some type one diabetes
00:02:09
"'cause" as I said I'm I'm I'm not not
00:02:12
yeah because I think impersonal
00:02:16
university for Yeah and it's not how I
00:02:20
check this site increase tactics that
00:02:22
yeah yeah yeah I I we mexican and so
00:02:26
the fruit intake is the is the one that
00:02:28
we're looking at now the the body
00:02:29
weights remains the same show today
00:02:31
that doesn't seem that they move around
00:02:33
more so so and the final clue is now
00:02:36
that we we're we we see some increasing
00:02:39
use if you want so it is probably the
00:02:40
profit activation. That's what we think
00:02:43
but my problem is that as I said we're
00:02:47
all focusing on computer eight and I
00:02:49
don't think there is the only clue in
00:02:51
here the biases might be very important
00:02:53
that might be the bacteria itself
00:02:55
casual that has some or the fantastic
00:02:57
for me yesterday showing that there is
00:02:59
some my car in a regulation that kind
00:03:02
of stuff we have to look into just to
00:03:04
tease down the mechanism that we're
00:03:05
working on quite yes get the shot from
00:03:09
raw frost was nice to meet you this
00:03:11
meeting thanks to nestle. And have a
00:03:14
question about Monica lot campus
00:03:16
because I think in addition the
00:03:19
traditional three steps of the costs
00:03:21
postulate now we would like to to have
00:03:23
someone to collect the cans and it's a
00:03:26
it's a detrimental effect of rustling
00:03:28
you know well one and be beneficial you
00:03:31
but cherry and got what do you suggest
00:03:34
yeah I agree so so I think so I just
00:03:38
wanted to give you an example I don't
00:03:40
want you to focus on two strange itself
00:03:42
because it's more of an idea your that
00:03:44
we know that gram negative procure an
00:03:46
associate with diabetes all the time
00:03:48
the only thing we're doing is going to
00:03:49
target organ and see we found seven
00:03:51
different strains withdraws only was
00:03:53
the ones most perhaps if you're talking
00:03:55
about molecular mechanisms I think
00:03:57
we're only at the word starting there
00:03:59
are several which which you can do for
00:04:01
example for for you how treatment we're
00:04:04
gonna look at the table mikes before
00:04:05
and after pregnancy whether are
00:04:07
changing and then for example see what
00:04:09
or if you if you try to to use those
00:04:12
metabolites into some kind of injury to
00:04:14
assistants you or whatever has an
00:04:16
effect but that is multi disciplinary
00:04:18
work in a very happy to that search
00:04:20
team working Never lost a convict me so
00:04:25
save elsewhere please to see brown I
00:04:31
I'm not actually mission so I basically
00:04:33
most channels is also a concern for me
00:04:37
in the way that what showed us was the
00:04:40
implementation in humans oh oh bacteria
00:04:42
in the fat you know I always that
00:04:45
remain ideas in the the literature what
00:04:48
was on the white of visual a common we
00:04:52
need buttons that are you happy. She
00:04:55
bites. I haven't looked with the we
00:04:59
need you suspect you region yeah our
00:05:02
speech or yeah so so that's something
00:05:04
that is ongoing of course we know from
00:05:06
unit studies and monsters that beast
00:05:08
your high fat diets give more of often
00:05:11
good permeability and it's your
00:05:13
transportation so if you ask me how
00:05:14
does that your end up there we don't
00:05:17
know what are there like we only found
00:05:18
the signature are looking now what are
00:05:20
what are with an arabic kind of country
00:05:22
we confine so that's very big
00:05:24
connotation. Um I think it's either
00:05:27
trends locations so directly going over
00:05:29
the more permeable it estimable and
00:05:32
then you end up in this pontiac face
00:05:33
right opposed issue. And the other way
00:05:36
which we think might be the way is that
00:05:38
a co travel with the colour microns but
00:05:40
you eat we know that you have a short
00:05:42
term and the top senior that's known
00:05:44
for a long time. So they just piggyback
00:05:46
rides on on dietary particles into the
00:05:48
bloodstream am I had here is that
00:05:50
nobody really looked at that in that
00:05:53
but I know it from clinical experience
00:05:54
that diabetics have much more
00:05:55
infections much easier affections are
00:05:57
is a real disturbance of the immune
00:06:00
system in these people maybe by heart
00:06:02
brings leaning I maybe by approaching
00:06:04
or react what's species. So in some
00:06:06
kind of maybe a allowed inspect your
00:06:08
travel around because we know and
00:06:10
editing as normal right university
00:06:12
issues. It's known for a long time
00:06:14
light signals any other issues yeah
00:06:17
it's one going progressive in human in
00:06:23
you you yeah the see control. not not
00:06:26
not we did an opening to study because
00:06:28
the IRB they get crazy for me of course
00:06:31
because I'm pushing towards the limit
00:06:32
what you can do this and open label
00:06:34
study where we only give you great
00:06:37
after we finish that page the baseline
00:06:39
we're now doing the randomised control
00:06:41
trial where we look at the effect
00:06:43
computer rate for example on so tightly
00:06:45
with brain scans and and there we do
00:06:47
controlled totally right I was just
00:06:52
wondering how much for if I yeah I
00:06:54
don't yeah yeah yeah mantis yeah how
00:06:57
much a defect to see could could you to
00:07:00
reset my biotech independently of the
00:07:03
yeah that's a good order. yeah very
00:07:06
good question so we think we think in a
00:07:12
specific decisions that doesn't really
00:07:13
matter. I mean that exposure of ego
00:07:17
material into a small intestine that's
00:07:19
why I'm each time stressing the small
00:07:20
intestine that that might also do some
00:07:23
kind of resetting effect or change we
00:07:25
see some changes in autumn unity
00:07:27
reaction of T cells. So so what is
00:07:31
exactly driving it is the introduction
00:07:33
of the total new speech and you have to
00:07:34
imagine that you give this well this
00:07:37
transplant of of of of of theses in an
00:07:39
environment where they cannot suffice
00:07:41
you get survival of the fittest
00:07:42
basically only just raise it really for
00:07:44
five it will stay there but there
00:07:46
before that you or three days interval
00:07:48
where suddenly mess amount of bread
00:07:50
negative material aurora stuff so
00:07:52
that's something that we're looking
00:07:53
into now butters in donor transplant or
00:07:56
equal transit person So what difference
00:08:00
I don't know I'm just wondering so all
00:08:03
you actually the purpose of the whole
00:08:05
study provide stuff that are trying to
00:08:08
find out a one providing fits all or
00:08:11
you actually try to see Mary C
00:08:14
personalised monica. So yeah yeah very
00:08:18
good questions so no I don't think one
00:08:20
problematic fits so I'm just in it to
00:08:23
show it you within five years we don't
00:08:25
have to do FT which which is can give
00:08:27
back strains. And any minutes and then
00:08:29
study effect Assisi newman's with hard
00:08:33
and point could one set for the one
00:08:34
that's why stressing it it's only an
00:08:36
example and this is just the first that
00:08:37
we can attest you I think in the ends
00:08:41
when you hear all these stories about
00:08:42
core microbe I'll probably might dad
00:08:44
and being a cocktail but are rather
00:08:46
layer it up and and this and this sex
00:08:48
effect each specific picture before
00:08:50
adding them in in the whole one once
00:08:52
again not knowing what you're really
00:08:53
looking at so I think in the end to end
00:08:56
up with drinks are not rings but a
00:08:58
couple of combination of trains for
00:09:00
different disease just as you're saying
00:09:02
as opposed to sort of once to have
00:09:06
different for different style depressed
00:09:08
are right there at the same time we are
00:09:11
seventy yeah having the same everybody
00:09:14
gets said most of these sounds to me a
00:09:16
contradictory yeah but I don't but I
00:09:19
think that's that's that's why we still
00:09:22
have to scroll salad question we know
00:09:24
that diet I mean we are are fickle
00:09:26
francine type to it of twelve weeks
00:09:28
might the other competition is back to
00:09:30
normal which means that the diet is
00:09:32
really pushing it. And we know that
00:09:34
it's not that not for each disease easy
00:09:36
different like a time a long transplant
00:09:39
last different an Albany diseases than
00:09:41
an apple dimension. So that that's the
00:09:43
way you have to think of it. And I
00:09:45
fully agree it one size doesn't fit all
00:09:47
which you have to start some stuff I
00:09:51
think that's because from from sleep oh
00:09:55
but in a question from a non
00:09:57
microbiologist it seems that you rely
00:10:00
in many of the of the speakers on the
00:10:02
presence of those strings to fervent
00:10:04
number computer support but do we know
00:10:06
whether they always behave in the same
00:10:08
way and whether they contribute or not
00:10:10
to the environment in the same way
00:10:12
question so so that is something that
00:10:14
so we we that's why for example we
00:10:17
we're go we're we're looking for this
00:10:19
biopsies because these your adhere to
00:10:21
the mucus layer which we wrote about
00:10:23
you think that in that place you can
00:10:24
also signal and do someone things more
00:10:27
at least and and then and PC so yes I
00:10:30
think but what you cannot do that in
00:10:32
humans but you can do it in my eyes to
00:10:34
see and what it is with here and it's
00:10:36
different segment of the got as a
00:10:37
different role effect on buses
00:10:40
transporters that and that's exactly
00:10:42
work oh willing three one question for
00:10:48
you. this is to evident of also on the
00:10:52
on stuff on certain mark I think that's
00:10:54
more helium is important because we can
00:10:56
take biopsies exactly concerns also
00:10:58
remotes well happens to schools and
00:11:00
look at our site you can look like us
00:11:03
you yesterday at the activity of the
00:11:05
microbes in the what I think that's
00:11:07
important because people samples don't
00:11:09
if you only read out of of what's
00:11:10
happening there don't give of the last
00:11:12
five minutes. So you have to get the
00:11:14
samples there to what the market alone
00:11:16
like you say you have to that you have
00:11:18
to that wonderful talk so how deeply
00:11:20
can sequence you can lose a reset or
00:11:22
problems to look at them. Okay I do I'm
00:11:28
trying to sell us unit yeah I mean true
00:11:31
that I haven't had I yeah thanks very
00:11:34
if the didn't make investment in a
00:11:37
resistant bacteria and differences
00:11:39
between different genera. It's mass why
00:11:42
why hasn't anyone mentioned well I
00:11:45
backed off I on the like oh yeah well I
00:11:49
don't know at it. And looking little
00:11:52
that Frederick but that's there of
00:11:53
course they're looking at at at at what
00:11:55
are what are these different key
00:11:57
elements are doing and but that I don't
00:11:59
wanna it's it's not my specific my so I
00:12:02
want to do that is usually that's it
00:12:04
because many of them are cops
00:12:06
syndicates are fermented if the end of
00:12:09
ups and that they don't have always at
00:12:11
least a lack of transportation. So
00:12:13
don't you that's only one of the
00:12:16
complex explain my of course of the
00:12:18
court cases the the the eye ropes they
00:12:21
need got to have the option for
00:12:23
installation that's one of the reasons
00:12:25
but but other studies that have a lot
00:12:28
of work your use of well I don't like
00:12:31
about how materials systemic as to how
00:12:34
different populations both well done
00:12:37
all and no no population react in terms
00:12:42
of wine administration with the one me
00:12:46
no I think that's the kind of studies
00:12:48
that will come up right if you have the
00:12:50
well match phenotype patients
00:12:52
multiethnic different diets you know
00:12:54
but what what the amount of iron aren't
00:12:56
tied to use in in the plasma that kind
00:12:58
of studies will comment that sense
00:12:59
still associated. But I think that will
00:13:02
open up next couple years one more that
00:13:05
for a with from burning university I
00:13:11
wonder said that every everything is
00:13:14
there and the of our selects and were
00:13:17
approach with the hey how are you is to
00:13:20
bring back my yes you have been there
00:13:24
so you see opportunities to stimulate
00:13:27
me abundance of that organism by
00:13:29
directory intervention or other means
00:13:30
yeah so that's a very good question one
00:13:33
cannot do all but I know for example
00:13:36
that that examine courts in in
00:13:39
Minnesota for example does if expensive
00:13:41
reproducing our data you also puts
00:13:43
patience on the dot it's to see what
00:13:45
are the adherence is longer I think the
00:13:46
those kind of studies are crucial we
00:13:49
just now focus on the on the stranger
00:13:52
probably the next studies after we find
00:13:53
it save to give it into you just
00:13:55
combine it with specific dies
00:13:58
containing specific products yeah sure
00:14:00
oh well thank you the you when it comes
00:14:06
to transplantation yeah do we need to
00:14:09
actually clean or should the before and
00:14:13
I know that this system so we started
00:14:17
isn't two thousand eight and had many
00:14:20
discussions about for example in in in
00:14:22
the ice you you do ST D.'s like they've
00:14:24
got the company the contamination we
00:14:27
thought it would introduce extra bias
00:14:29
because you have and to the knowledge
00:14:30
that are mixing up the environment
00:14:32
which is normally there so we chose not
00:14:34
to do it and just closely monitoring
00:14:35
the dietary intake and looking at heart
00:14:38
and points it could make in fact we
00:14:41
know that for example you guys have to
00:14:43
see if they run into the objects till
00:14:45
couple days when you get the fickle
00:14:46
transplants to to lower the amount of
00:14:48
of CDF so yeah I I don't have a real
00:14:52
and stupid but I I I think that if you
00:14:54
wanna get to create your results the
00:14:56
less biased you have the better it is
00:14:58
so that's one you didn't choose to to
00:14:59
reduce the amount of extra as part of
00:15:02
the same question this is the last one
00:15:04
so my easier event this evening was
00:15:08
telling that there are some traditional
00:15:09
medicinal actually on the regular. And
00:15:13
P and then to explore the structure. So
00:15:16
this something that you you think it
00:15:18
works for yeah but also I think for to
00:15:23
if I allow half a minute. So for
00:15:25
example we were we really knew that
00:15:27
rethought that for example if you
00:15:28
treated diabetic page with much for men
00:15:30
to get gastrointestinal complaints
00:15:32
everybody gets that you tell them keep
00:15:34
on going and that sort of a couple
00:15:35
weeks it's gone. And what I know from
00:15:37
at least Fredericks papers is that
00:15:39
there's not so much a massive changes
00:15:41
in the microbe I'm so we should really
00:15:42
focus too narrow what's happening there
00:15:45
there are mechanisms going around as
00:15:47
well but I think it's very interesting
00:15:49
to to study of these these these kind
00:15:52
of traditional medication or study per
00:15:54
se what's what interventions doing yeah
00:15:56
so they can enjoy but this is
00:15:59
fascinating so you thought you know we

Share this talk: 


Conference Program

Introduction of the Session 1 : The Gut Microbiome: Facts and Figures
Josef Penninger, Institute of Molecular Biotechnology, Vienna
Oct. 23, 2014 · 9:07 a.m.
648 views
The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
Oct. 23, 2014 · 9:31 a.m.
568 views
Q&A : The role of commensal bacteria in the gut
Willem de Vos, Wageningen University, The Neterlands
Oct. 23, 2014 · 10:29 a.m.
145 views
Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
Oct. 23, 2014 · 11:07 a.m.
354 views
Q&A : Gut microbial richness impacts human health
Dusko Ehrlich, INRA, Jouy-en-Josas, France
Oct. 23, 2014 · 11:44 a.m.
Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
Oct. 23, 2014 · 11:56 a.m.
331 views
Q&A : Cross-talk between the mucosal immune system and environmental factors
Hiroshi Kiyono, The University of Tokyo, Japan
Oct. 23, 2014 · 12:31 p.m.
Introduction of the Session 2 : Host - Microbiome Interaction
Susan Suter, University of Geneva, Switzerland
Oct. 23, 2014 · 1:41 p.m.
143 views
Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
Oct. 23, 2014 · 1:55 p.m.
393 views
Q&A : Mechanisms of cross talk in the gut
Annick Mercenier, Nestlé Research Center, Lausanne, Switzerland
Oct. 23, 2014 · 2:34 p.m.
106 views
Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
Oct. 23, 2014 · 3:52 p.m.
241 views
Q&A : Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
Oct. 23, 2014 · 4:27 p.m.
Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
Oct. 24, 2014 · 9:16 a.m.
1377 views
Q&A : Gut microbes and their role in malnutrition and obesity
Rob Knight, University of Colorado, Boulder, USA
Oct. 24, 2014 · 10:01 a.m.
The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
Oct. 24, 2014 · 10:19 a.m.
157 views
Q&A : The gut metagenome - your other genome
Jun Wang, BGI, Shenzhen, China
Oct. 24, 2014 · 10:53 a.m.
103 views
Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
Oct. 24, 2014 · 11:04 a.m.
735 views
Q&A : Fecal transplant to mine for novel probiotics
Max Nieuwdorp, Amsterdam Medical Center, The Netherlands
Oct. 24, 2014 · 11:25 a.m.
Introduction of the Session 4 : Nutritional Interventions
Keiko Abe, The University of Tokyo, Japan
Oct. 24, 2014 · 12:46 p.m.
108 views
Interactions between gut microbiota, host genetics and diet
Liping Zhao, Jiao Tang University, Shanghai, China
Oct. 24, 2014 · 12:56 p.m.
465 views
Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
Oct. 24, 2014 · 1:47 p.m.
265 views
Q&A : Pediatric intervention - what works and what doesn't work
Hania Szajewska, The Medical University of Warsaw, Poland
Oct. 24, 2014 · 2:15 p.m.
Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
Oct. 24, 2014 · 3:02 p.m.
1297 views
Q&A : Perspectives for nutrition and the gut microbiome
Nicholas Schork, J. Craig Venter Institute, La Jolla, USA
Oct. 24, 2014 · 3:46 p.m.