Player is loading...

Embed

Copy embed code

Transcriptions

Note: this content has been automatically generated.
00:00:04
well good morning thank you for this nice introduction of thank you for the invitation
00:00:11
as you see i i'm close neighbour of uh the lastly research centre
00:00:16
uh by the same token i'm suisse though i will speak
00:00:21
swiss english i hope you you you you would understand
00:00:25
uh we have already she talked a lot yesterday about the pendulum between
00:00:33
nutrient which nutrient is good which nutrient is bit we have mentioned that the
00:00:39
which switched from that carbohydrates to bet fat and now with
00:00:44
the uh focus and earn a cushy bed should do
00:00:51
and i've just
00:00:53
extracted here one of the many posts you can you
00:00:57
can find the and the and the web about
00:00:59
the health problems related to fruit was intake and if you read that photos can do what about
00:01:07
everything which is better you'll have a uh including changes in the other evade
00:01:13
energy is metabolic diseases cancer gastrointestinal issues
00:01:20
mercury poisoning it's it there yes
00:01:25
partially science supported that's
00:01:30
what we think now that that's been already suspected on on what the more scientific bases
00:01:37
about fifty years ago and the uh most of you are no
00:01:41
the the work of generated key in at this time
00:01:45
now what i wheel then uh address and that's me look
00:01:50
a little bit over simplistic compared to the former
00:01:54
a presentation is what is special about fruit too
00:01:59
according to what bob around said just today i guess i am a a a man
00:02:04
of the twentieth century if i'm interested in
00:02:07
nutrients rather than a a foot classes
00:02:15
but i i want to make you with the inside of
00:02:18
reminding you what are tied to the carbohydrates but just
00:02:24
very pretty old digestible carbohydrate that means that
00:02:28
it's starchy chapter chaplin was of course
00:02:31
free should bills which are either group goes all freak too was and the
00:02:36
second arrives and that's essentially sue crows i didn't mention connect was he
00:02:43
i freaked dorothy found in free form in
00:02:47
fruits in some vegetables in high noon
00:02:52
uh but it's always found together with groups of
00:02:57
fruits contain free fruit tools and free group
00:02:59
goes and when you eat fruit to eat the mixture of group was it freaked
00:03:04
so for all of these now all major sources uh uh so cruel was
00:03:10
and that the second ride made of one molecule the group goes link to one molecule freaked out
00:03:18
historically him the off sugar consumption is quite high but
00:03:23
you can if it has been very very low
00:03:26
throughout most of men history and it started to increase really into
00:03:30
it is sent to reading between the eighteen century now
00:03:34
should we can some shouldn't increased almost twenty to thirty four so that's that's that's something
00:03:41
important to keep in mind it's very quickly part
00:03:46
of the concern regarding freak too was
00:03:50
the uh started in in in the in two thousand and four when jordan pretty
00:03:56
and uh by republicans arranged the the the should high fructose consider
00:04:01
high fructose corn syrup is uh not sufficient
00:04:07
should be a be made from corn starch and as a matter of fact
00:04:13
starch it's a corn syrup as it has been made for a
00:04:17
long time and starts was extracted and converted into groups
00:04:22
and the the new thing with high fructose corn syrup which appeared in the nineteen seventy
00:04:28
was the beauty to convert a part of this group goes into
00:04:32
football was and mix them together to make high fructose consider
00:04:38
when we use high fructose corn syrup that's a mixture of glucose and fructose related
00:04:45
a concentration may differ a little bit but roughly that's half group was how freaked us
00:04:51
so that's very similar in composition to to propose
00:04:56
okay very quickly also because we're already seeing that yesterday
00:05:02
what what is the consumption of fruit the words
00:05:05
uh in in the state and that the n. haynes
00:05:09
three a deposition to about two thousand and it
00:05:14
that s. change a little bit since then but not dramatically in the average
00:05:19
they didn't take or sauces confound you is about fifty grams but they
00:05:25
and their for presents about ten percent of total energy intake
00:05:30
well if you take that freaked all of this going just
00:05:35
it was google was that means that should be the
00:05:38
we we consume about hundred grams should be and that corresponds to about twenty percent
00:05:44
of all total energy there is a lot of lot of internally vigil
00:05:49
variability and the apple a ten percent of the population here
00:05:55
uh the consume fifteen to twenty percent of
00:05:59
the total energy has proved cry now
00:06:05
what is special about freak tops when we should go
00:06:10
so corinth that's the time uh i just separate my maid of group was
00:06:15
instructor was in the get it will be split into glucose and fructose
00:06:20
i'm both will be up sold and up here in the uh in
00:06:24
the portal circulation and it then we'll reach that you've google as
00:06:31
will be turned supported in the lever through good to transporters
00:06:36
and then we'll be metropolis from classic like a license here the first
00:06:41
enzymes in exact can't can isn't believe it's critical kind is
00:06:46
uh which is responsible for that and then it will be
00:06:50
converted to full two six phosphate and photos one says
00:06:54
the phosphate through frugal kind it's this pathway is dependent financially in
00:07:02
so when you eat group goes dyson increase will secrete into unit and you will regulate this pathway
00:07:08
and most important for for for for the crime is is regulated by the
00:07:12
energy status of the set so when eighty p. in the set increases
00:07:18
when site rate as a marker of a trip
00:07:21
cycle metabolism increases then you will in
00:07:26
the beautiful so fertile kind a it and you will slow down this process
00:07:34
when it gets to freak too was freaked always is almost the
00:07:38
same and uh and uh it it it does the same
00:07:45
four o. four chemical formula it it it is very clear we are
00:07:48
very close molecule to group with but it is very lethal
00:07:54
method when asked by acts of kindness it's so in belief or whoever can go except chi names
00:08:01
which is called folk cocaine is which will convert freaked always into football fun for six
00:08:07
this photo kind here is as a very high affinity a very high even hanks so all the freak
00:08:14
too was which getting to the to the the setup will be converted into fruit cause conflicts fact
00:08:21
photos one phosphate then will be converted into trials is phosphate than this
00:08:27
is done by entities be which would be the equivalent of first fruit okay so
00:08:34
and from there are trials is phosphate we join to norman will likely to to possibly
00:08:40
the major difference is that you have no feedback control of this
00:08:46
elderly speed so all the photos which gets into the diva
00:08:52
is immediately converted into fruit was one phosphate and forms a um
00:08:58
trials is so states and that has several consequences first
00:09:03
if you eat a lot of fruit or was
00:09:06
the initial step consume a lot of eighty p. m.
00:09:12
and the the uh speed that this reaction exceeds a
00:09:18
eighty p. rethink pace used to have a
00:09:21
did or a transient each p. depletion a. g.
00:09:26
p. crazies a. m. p. increase use
00:09:29
and that can lead to a the formation of you we cassie than i probably see
00:09:36
and the second thing is that since we have absolutely no regulation
00:09:42
if you reply to mark the fruit tools you will need the the cell will try was is to stay
00:09:48
and then you have to get up when i sneeze throws disrespect of course you can actually dies number but
00:09:55
a as soon as you have met the energy requirement of the sense you cannot
00:10:00
uh oaks advice this poses the state anymore and they
00:10:04
will be essentially released as lactate in the band
00:10:09
so one of the effect will be increased in glad lactate concentration
00:10:14
but they can also be re converted into course in
00:10:18
this group goes can be stored it's like which
00:10:21
i am but also released into circulation is cool cause
00:10:24
you will increase proposed protection and finally him
00:10:30
part of units can be converted into fantasy and and you the stored in the evil
00:10:36
as as a in track that's acceptable really is s. p. l. d. l. two closer it's oh
00:10:43
the the the the the results of eating spoke to was is that
00:10:48
you will convert fructose problems it to add the components the first
00:10:54
point i would like to to make is that we have a um
00:11:01
we have studied that's rather extensively about twenty to thirty years ago and
00:11:06
many of these studies have been done with uh every check c.
00:11:10
was my mentor it's this time will is present here and what
00:11:15
would we we have seen enough sorry is that all these
00:11:21
by a synthetic process of course cost energy so you can fall said yeah seats from freaked
00:11:28
was but that could cost energy that's certainly not an energy efficient way of storing
00:11:36
now quite often people believe that fruit was essentially you ordered method but i still believe
00:11:44
and we know all that it's that's the case that there are several different cell types
00:11:52
which can met about ice freaked out the evil but also
00:11:57
smaller low interest sides and renal proximal tubular sets
00:12:02
and all these sans every specific metabolic machinery
00:12:08
they have these folk politic enzymes but they also where have good connection can
00:12:15
sometimes and most important they are the only sells which have to go
00:12:20
seek specific fact is though the only said which which can actually really screw
00:12:25
goes into the circuit judge and all the cells although of the
00:12:31
with the ability to operate an overlap region is the sympathise a
00:12:37
uh like a pretty in and really is like property
00:12:43
now when we you you we need to uh fructose low would uh we don't know exactly
00:12:51
how proposes notably nicest uh with what you see here is
00:12:56
is a summary of several isotope studies showing what
00:13:00
happens after the ingestion of the pew fructose built and
00:13:04
let's say you wheat hundred grams of fruit towards
00:13:08
about fifty grams will be released in the black this
00:13:14
group goes over the six hours following ingestion
00:13:18
about twenty five grams will be really isn't exactly it's
00:13:24
about fifteen grams a little bit more will be
00:13:27
stored contemporary he is affected like h. m.
00:13:32
and the rest will be utility diced wall
00:13:38
converted into fat and store this through december i but all you really is this
00:13:43
v. l. d. l. tricky so right so that make sure the pathway is
00:13:47
for proposed disposal our group was protection and
00:13:52
lactic protection notes like which analysis
00:13:56
of course that depends most likely on the amount of through those you
00:14:04
you take with me in the uh the the the frequency of
00:14:08
opposing take and have the and very environmental factors what
00:14:16
okay well let's
00:14:19
turn to the the the question is really neat freak towards the bit guy is
00:14:25
it's toxic uh some people say and if if so why so they ah
00:14:34
quite a a a lot of data in the literature
00:14:39
to make you suspicious about two if it's not the venom comes from
00:14:45
animal studies and intimate with you can make animal abuse
00:14:50
by providing them with two pros always hooked us
00:14:54
and this high school cross i propose that it through didn't used to increased energy intake uh
00:15:00
basically you just keep it in yeah then that could reach thirty d. v. d. c.'s
00:15:07
like it happens most often in in in rats we have
00:15:12
quite an uh a frequency adequately t. v. b. c. is
00:15:17
and even seen resistance and type it's yeah of
00:15:20
course i the additional reasons to to support
00:15:25
the caution about script was in many stems
00:15:29
from a particular tickle studies showing association
00:15:32
between uh should be in the proposing to shoot the fridge should do sweetened beverages
00:15:38
in the ache and the incidence and prevalence of uh of metabolic disease
00:15:46
no the this that is i will show you this that is done by by a a an
00:15:52
ample medical physiologist and they they they are really
00:15:56
mechanistic studies so am i yeah oh
00:16:00
oh i i prefer to address this question first we didn't do studies to
00:16:08
actually reproduce what happens when conditions that's that
00:16:13
used to show all with the
00:16:16
damn mechanisms related to focus metabolism which may lead to
00:16:21
delete erase effects so i we show you
00:16:25
what we know
00:16:31
okay sorry what we know about high fructose studies
00:16:36
in humans regarding this repeating yeah regarding
00:16:42
in try to keep it in g. p. d. c. a. and
00:16:44
if it even deceive us and regarding who goes the mysteries
00:16:50
now it s. been loan known for a long time that when
00:16:55
you provide people was out there we high carbohydrate not yet
00:17:00
or whether it's so close all full tools will even starch
00:17:07
you you may have an increase in the black to decide concentration that's that's something that
00:17:12
i invented a show here is that the of my lab but many many
00:17:17
add the the investigative seen that what you see here uh is the effect of the
00:17:24
the over feeding with one point five grams flip tools that he'll be waiting but they
00:17:30
providing it is three innings in heavy subjects over four weeks period
00:17:37
and they are the measurement of to to to get a ride yielded critically thing right
00:17:44
after the uh fructose fried diet and over
00:17:48
four weeks on this high fructose line
00:17:52
and you see that within one week three of this increasing batteries here right
00:17:57
which is essentially accounted for by increasing the l. d. l. to decide
00:18:02
and that is increase is sustained throughout the four weeks expire
00:18:09
the mechanisms i'm not completely knowing but one mechanism which is being
00:18:17
where is correct there last is that with a high fructose diet you convert some of the freaked was
00:18:24
in two d. periods this increases credit uh
00:18:28
freaked was uh uh an exposition
00:18:32
and you have this high to decide right concentration which can't get uh with the very marked
00:18:39
increase in practically peed a a a synthesis is estimated by the tracer methods so
00:18:48
fructose conversion into repeats mean that the the major
00:18:53
by half way of fruit to disposal but it's still
00:18:57
a most lights instrumental in increasing batteries right concentration
00:19:04
now with the high supposed to yeah to increase fasting that's ugly so right
00:19:09
and you also increased markedly post canadian batteries alright concentration
00:19:15
do you see here uh uh us that you performed by kevin tess
00:19:20
about ten or fifteen years ago when which she gave mixed meals together with
00:19:25
logos of footballs to have different ideas and when it uh this
00:19:29
most current really not a good and she showed that with records with rented platitudes remain
00:19:37
relatively little and that they are markedly enhanced after the fruit is one of the
00:19:46
mechanism may be done overnight but yes yes but it appears also that's
00:19:52
but i still unknown mechanism proposed me in that post pendleton just so right here
00:20:00
yes well how much for people to you need to have this effect but gladly periods
00:20:07
you see here a compilation of severance that youth and you see that you have
00:20:11
an increase in fasting but we decide concentration
00:20:16
when you reach about fifteen percent
00:20:20
total energy is football
00:20:24
and then it increases the with dependent so that something which
00:20:28
is observing a few subjects but which correspond to
00:20:33
very high concentration in the normal put peer into very
00:20:36
high um in taking the in the normal population
00:20:42
the same is true for post trendy l. and um i mean the the the the
00:20:49
for analysis of all data present in the literature suggests that you
00:20:55
have the first effect with fifty grams through tools that they
00:21:02
okay is it specific was freaked tools we sit observed with other substrate
00:21:08
it's pretty specific was freaked what you see here that was a hyper can wreak high fructose time
00:21:15
yet you have this market increase in class much ugly seventy if you have the same
00:21:23
excess energy was fat you don't observing increasing class batteries are
00:21:29
now furthermore it does not always depend on excess energy so here
00:21:36
if you have thirty percent freaked those in your diet
00:21:40
freaked those replacing starch such that the that it remain eyes look at american
00:21:46
people do not gain weight you can still observe increase think attributes
00:21:55
and that's something which is controlled by
00:22:00
several math than an easy i'm not personally find of math and i it's
00:22:06
always nice showing that because it it it it shows difference that using you
00:22:10
see here that most eyes look at or extent of youth and
00:22:15
hyper kinetic studies show this increase in practically so
00:22:21
by the same token you can see that this effect is observed in thirty subjects overweight subject
00:22:28
it's less if you didn't invite beaches go and lie if you quite often
00:22:35
here uh in in in conference is there was no strong evidence that
00:22:40
the effect of fruit to these enhanced in you know be subject
00:22:46
okay and then at the effect of fruit was is that
00:22:52
it increases small dance l. d. l. particles delete increases
00:22:57
the data which in the city of l.
00:23:00
g. s. though that's turned to the effect an intrepid to keep it and here uh
00:23:08
i show you the same will go to to get with the same kind of
00:23:12
that that we we ran a a couple of studies in which we
00:23:17
it had people don't see us and it was submit it to a fructose free diet for one week
00:23:24
and then the high fructose diet for one week and
00:23:29
in one study it was fifteen percent excess energy is for two hours thirty forty and you
00:23:36
see that with thirty percent and forty percent through
00:23:41
tools within six uh or seven days
00:23:46
you have this huge increase in intricate except that's
00:23:50
very high fructose concentration but that's really uh
00:23:55
and common in in in the uh in the
00:23:59
general population and even with this very high
00:24:05
the uh freaked was intake you increase in trade back to keep kids
00:24:10
quite market it but that's still mark to market the lower than what is observed in
00:24:17
of these patients with that extend tools it's so that's significant but that's not yet
00:24:25
it doesn't reach battered urge and that's the point which
00:24:30
has to be made regarding this intricately plotted
00:24:33
is that it is observed not only fruitful fruit was but it's
00:24:37
also observed was group was in here you have the
00:24:41
the study which was recently uh than by uh the the groupie for uh
00:24:48
the group of uh yeah and active in that and in which they
00:24:51
gave to help the subjects to to to overweight healthy subject
00:24:56
hit the and i so can wreak highly who cool sources to pose i yeah
00:25:01
or in high pig can read i suppose versus look was back
00:25:06
and you see that with the i. so can read by you knew the group goes no freak tools
00:25:11
increase in trade for a while with the hypo caloric
00:25:15
diet who goes and fruit tools increases integrated
00:25:21
well in additional concern which stems from an email uh back to and it's not
00:25:29
being a really substantiated in in humans but still remain the real concern
00:25:36
is that freaked doors compared to causes an additional effects and and the user
00:25:41
due to its method when you split it exerts some stress and believe uh it will produce you requested
00:25:48
uh and a reactive oxygen species to eat may by itself
00:25:53
you'd be pro inflammatory in the gaps it's me
00:25:58
change that that might be the increase l. p. s.
00:26:01
absorption and that may also tweak the information
00:26:06
and finally one of the metadata freak too isn't that you've arithmetic easy looks i'll which
00:26:11
may be pro celebrity it's possible that freaked
00:26:15
was maybe not only favour the position
00:26:19
that's set in delivering but may also be a favour the
00:26:24
switch from it but it's that was used to
00:26:27
then the match good unique uh to to stay active at the time
00:26:33
okay now another way of looking at things is
00:26:39
we can you can look at whether by giving large amount of fruit to was you reproduce
00:26:46
the disease that you can go the other way around and take
00:26:52
subjects with this is easily look with a by taking golf should the u. correct this
00:26:58
so this guy just yes it uh the net could leak static the fact if
00:27:05
yes including resistant and it just started should be free diet
00:27:12
so what will happen so we should be very quick to the three studies
00:27:16
one study with then my lab and was a published last year really
00:27:24
recruited twenty seven overweight male and female
00:27:28
where high sugar sweetened beverages actually
00:27:31
we wanted to recruit fifty but in switzerland it's difficult to recruit such people
00:27:38
deal with a lot of a trap tribal recruiting and the subjects
00:27:44
at the four week whining period and then be added
00:27:48
measurement of that intrepid take fat dynamic reasons spectroscopy
00:27:53
and then they were randomly assigned you the to switch
00:27:59
to achieve should should this week at to artificially sweetened beverages
00:28:05
or to go unless the ah should be sweetened beverages
00:28:10
they continue with a normal diet at what's
00:28:15
and the study lasted twelve really can after twelve week we
00:28:19
measured integrate attic fat and add the metabolic power meat
00:28:25
after this twelve weeks we see that the subject which when the intervention group
00:28:31
had a significant twenty five percent reduction in try tactics at what the
00:28:38
control group had no change there was no changing differently post issue
00:28:43
that was no changing but you wait till after or not
00:28:48
and that is that he comes from mexico and it's
00:28:51
quite recent that's fifty four obese children where huh
00:28:57
subjected where high fructose consumers and they were subjected to scoop those restriction
00:29:04
over six weeks and in new stadium they might need the
00:29:09
the uh the intrepid takes that and and the
00:29:15
the best actress by retry found and and clinical marker of
00:29:20
and i won't go into the detail of these uh
00:29:23
these table but they showed that uh that wasn't
00:29:28
a a partial regression of a a a d. v. d. c. is in many of these cheap
00:29:35
and final e. m. reasons that you published a few weeks ago a
00:29:42
lecture much pots and the whole bit early stick in san francisco
00:29:46
that's forty one children are high where i should be consumed should two males
00:29:52
and they were studied doing nineties restricted
00:29:55
was substituted a with starch
00:30:01
yeah and so that the total energy intake was
00:30:05
aimed at it remained in constants that was
00:30:09
energy balance i so can wreak substitution of should before stuff and you see that
00:30:17
the the whole group intrepid fat content decrees oh no that
00:30:23
that's the the mean intricately fat content decreased by about
00:30:27
twenty five that's the study was not controlled that some
00:30:31
trouble controlling the the the way to the subject
00:30:36
but in the subject would not lose weight that a small group the results where refugee seen it
00:30:45
okay
00:30:46
so let's get to the third point i would like to mention which is recorded those pieces
00:30:56
and you quite often reading the literature that it is well known that
00:31:02
should go through those associated with him sitting resistance would just
00:31:06
remain that it's even this effect and they're really
00:31:10
oh and in many different issues and regarding make i believe me both effect and that
00:31:16
you've uh and these effect will be mainly to suppress it but to request protection
00:31:22
and that's effects which are exerted it related few low when sitting yep
00:31:28
and effecting mass and and in in the math and it will stimulate group
00:31:34
was empty and you've effect ah upset at higher in seeking left
00:31:41
so when you went to assess it ever licensing resistance you will
00:31:47
have different experimental approach here you will have traced a method
00:31:52
going sit in infusion and money to a request protection year you will
00:31:57
have high inserting fusion and little group was mediated look was dispose
00:32:03
yes no you see here a study in which we
00:32:07
measured it uh it tactic gonna propose production
00:32:11
suppression by go to sincerely in in heavy subject after the low fruit goes by it
00:32:19
and after six days on high fructose die and you see quite
00:32:23
clearly yeah that there there really is a significant reduction
00:32:28
in in salinas acted there is some degree of inches apart you can see it
00:32:35
going and that is that you can we measured messaging resistance
00:32:41
in subject all the feds ways through could was
00:32:45
although full wits and here you don't see any effect on massive insulin
00:32:51
resistance so intimidated requests disposal is not affected directly by c.
00:32:59
these are two studies from my nap but recently it as being a method energies is
00:33:06
which shows basically that's it i mean he he
00:33:10
did with lots of studies he uh uh
00:33:16
getting accessed it back to concern sensitivity and you see that
00:33:21
three times did you see that you can see in sensitivity with the it's eyes of hello recall heifer can read
00:33:28
while studies having assessed massive insulin sensitivity all intimidated 'cause
00:33:33
disposal lurch still any effect when insulin since it
00:33:40
i know i'm good to go get it quickly in us the last
00:33:46
point i would like to to make is that all these studies
00:33:52
our experiment that's that is in which we try to see with
00:33:57
the fruit was can f. t. v. t. v.s effect
00:34:01
any for these studies with it okay a full to
00:34:05
date subjects did not do too much exercise
00:34:10
and two of them quite during the the the experiment
00:34:15
but of course that's that's not real live and uh um
00:34:20
we know that athletes can consume a lot of should be and that done not
00:34:24
prone to make that with this is that we did once that you
00:34:29
there are the studies it in june this in i'm this that you we compare ad
00:34:35
the effect of a low fruit was by a high fructose than yet
00:34:40
and the sedentary condition all with physical activity
00:34:45
is that it wouldn't with physical activity
00:34:47
of course energy output increases though we increased also energy intake twelve energy back
00:34:55
and to make it short you see here uh that with the photos into each
00:35:04
and said into reconditioned you have this increasing practically separate consideration which
00:35:09
was maintain my small doses of freaked or with and that's completely prevented by
00:35:15
exercise so that the the effect will of course depend on physical activity
00:35:23
the same is true for then overlap agencies which increased and the second week and you should
00:35:29
but with even slightly it suppressed in uh exercise condition
00:35:36
yeah the thing which i once briefly to mention is that
00:35:42
i think one of the point with missed so far regarding fructose that is it
00:35:47
that when when you start the the effect of freaked all was fructose
00:35:52
in the diet will always either increased energy intake or replace some she would
00:35:57
both uh um most most of the time that's both ate it
00:36:03
increases energy into a gifted but she replace at the subject
00:36:09
so we have no that's really obsessed with the the effect would
00:36:13
be different according to which the park substrate the two cases
00:36:19
so we just finished a study in which we can compare and the effect of a
00:36:25
high school cruise by yep and that the fifty percent excess energy we soup fourth
00:36:31
and that was than twelve effusive in when healthy
00:36:35
subjects according to randomised crossover trial winds
00:36:40
they had a one week heist cruise low protein diet and
00:36:46
the second time the hives two crow's high protein by
00:36:52
what you see here are the affect and infect that click it and with the highest to
00:36:59
pros low protein diet you have very marked increase in intrepid to keep it within one
00:37:05
and this effect is match decreased was pretty
00:37:11
that two possible explanation for that and most likely both
00:37:16
artful wine with that of course when you have
00:37:19
hi pretty you and you have louis liquid intake but the
00:37:24
second is that this being shown that high protein intake
00:37:29
reduces intricate except the position through mechanism which
00:37:34
i'm not yet complete it's not clear but that's likely direct effect on a on a and and if
00:37:43
okay so
00:37:46
oh what what i show you very quickly is that freaked
00:37:50
those in human can cool with this stupid in yeah
00:37:55
so the the hypothesis that it's made clear rule in uh in the pathogen is youth
00:38:01
of a a metabolic diseases disprove was good but that's not prove for this
00:38:09
it i think it can increase the practically peed concentration and there was concerned that it made clear
00:38:15
role in uh the pathogen is is up and then not magically fifty fifty c. is
00:38:22
it does little effect and i see yeah i'm any tears direct
00:38:26
effect on me and you the insulin sensitivity and i would
00:38:31
i think that you you can't say whether in the very long term
00:38:37
fructose would cause massive insulin sensitivity but i would bet it if it does
00:38:42
that would be through in direct that that rather than direct mechanisms
00:38:49
and finally that fructose effect can merge related by other factors like a five
00:38:56
and that how freaked was consumption affects the diet composition
00:39:02
is most likely uh uh uh uh uh in issue which
00:39:07
is being and the rest are estimated so far
00:39:13
and uh of course many open questions which i want uh
00:39:18
command and i would like to and by an uh thinking
00:39:24
all the people worked uh with me in the land
00:39:28
and outside but i but most particularly my colleagues in there and we did all the
00:39:34
magnetic resonance spectroscopy kick measurement of that into attached to thank you for your
00:39:46
yeah
00:39:53
thank you very much it should be a specially such i used
00:40:09
sure sure question it's
00:40:16
after you're from atlanta x. talk about comment or question so first of all um
00:40:21
i like the i like it a on a exercise to modulator died effects
00:40:26
um because so far this meeting as the first date we've seen exercise or physical activity
00:40:32
can modulator mediate some potential a that sex and ah so that was nice um
00:40:39
so are the effects of high fructose on liver metabolism
00:40:45
partially mediated but effects on i i asked oxidation
00:40:51
yeah
00:40:55
the difficult question to to to address one of their facts of of freaked tools
00:41:03
when they leave a is to that even though that is uh eh it's a
00:41:07
whole back in the the will be two in the bits set oxidation
00:41:12
and uh of course the accumulation of setting that you've uh
00:41:17
would depend on sets up the that will be
00:41:22
she said yes it uh attic from the plant the language in
00:41:27
is is the l. d. a. uh on one end and
00:41:31
uh uh uh stages disposal that you've and that will be
00:41:35
the l. d. l. to decides seclusion and and oxidation
00:41:39
in in in this regard to decreasing in type attic set oxidation
00:41:46
most likely contributes to to set accumulation with it
00:41:51
contributes to additional uh s. acts like a
00:41:57
effect on a on a attic insulin sensitivity you all information i i don't think so
00:42:08
anyway i care much there was a great presentation and here or there
00:42:15
i tried i understand it myself how toxic shock rates and i'm struggling
00:42:21
so i'll yeah you can give us a actually message yeah our isn't as strong toxicity which ah
00:42:29
i would like to have any oh yeah i get a comment i i also scientific question
00:42:36
yeah that's okay sorry hold produce a letter from fox in essence actually i'm here
00:42:47
or yeah sorry tell as a product up tells metabolism or
00:42:54
okay maybe maybe maybe the the question of us uh no i i've not
00:43:01
measured that and i i don't know if i would
00:43:06
expect much so beetle being synthesise from freak too
00:43:10
the the the there is a an indigenous focus
00:43:15
production uh which will lead to go
00:43:18
from group was been converted to so beautiful and so beetle to freak too
00:43:24
that's some indication that you may of indigenous freaked was production in
00:43:30
that you've and and that it may play a role in
00:43:37
then that could effectively disease that that that's not really
00:43:41
well substantiated now and i'm i'm presently working and
00:43:47
so be too and so close and goes to maybe i will be able to answer
00:43:55
a couple of years from now regarding the effects toxic effective should do
00:44:02
it's difficult to make politically correct hands
00:44:07
the if you didn't see the trick to this can be deteriorates it very high do these
00:44:13
is very strong in the evidence that it is easy to use
00:44:20
it usually do with is that we and but by
00:44:25
itself you would not be sufficient to support
00:44:29
but we we have to reduce should the intake to less than five percent
00:44:36
now i would make another comment in a showing that uh i should
00:44:43
get a that is responsible for metabolic disease is one thing and
00:44:50
thinking in showing that should the reduction will
00:44:56
b. if efficient to reduce body which isn't that the thing
00:45:00
that may not be this scene question
00:45:04
i yeah i it's worked out quite source that solar office now also all right
00:45:17
uh oh here are experimenting yep that's extreme shapes
00:45:26
well i froze out it's
00:45:33
well how is ah
00:45:39
i sort sort o. s. i'll start stuff which is still
00:45:45
i i i just change things yeah
00:45:50
that that's a very good point
00:45:54
uh there's been an n. i. h. the consults its concerns
00:45:59
three or four years ago and one of the major conclusion of
00:46:03
the conference is that most of the data and that
00:46:08
actually you with sure freaked was and that we should study
00:46:13
fructose together with schools but maybe you didn't pay attention but our last that
00:46:18
you was that was so close state of the fruit goes the
00:46:24
as you as you uh you have seen that they affect and infect attics that is
00:46:28
to that we have already also read than a couple of the trace experiments
00:46:35
to trace the the the the major metabolic possibly useful for those disclose it and
00:46:41
it's a little bit or to a mike lynn just it could cause but
00:46:46
who goes production then like to it's a really is remained the me to
00:46:52
uh possibly you don't want to of putting she she and of uh of like which
00:46:57
analyses like the sector of cool cause in its it in at the same time
00:47:06
thank you for i. o. row i i point
00:47:11
ooh it out
00:47:18
for i
00:47:23
i want to know what yeah i think it's high fructose corn syrup was so cruel as
00:47:36
and unless it's really very high in front of but that's not used by the big gastric
00:47:43
it's absolutely to see that they have been many many studies trying
00:47:47
to show differences between the two and all turn out
00:47:52
to to be negative you you you don't see any different effect

Share this talk: 


Conference Program

Nutrition advocacy in action: the politics of sugar vs. fat
Marion Nestle, New York University, USA
Sept. 28, 2017 · 9:27 a.m.
1328 views
Fat and carbohydrate recommendations - Have they changed?
Barbara Schneeman, University of California, Davis, USA
Sept. 28, 2017 · 10:14 a.m.
477 views
Promoting equitable health and wellbeing around the globe
Nancy Brown, American Heart Association, Dallas, USA
Sept. 28, 2017 · 11:30 a.m.
481 views
Gut hormones and nutrition
Sir Stephen Bloom, Imperial College London, England
Sept. 28, 2017 · 1:38 p.m.
1081 views
Nutrition, metabolic health, cancer and NCDs
Elio Riboli, Imperial College London, England
Sept. 28, 2017 · 2:27 p.m.
562 views
Infant and child nutrition and cognitive development
Wendy Oddy, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Sept. 28, 2017 · 3:51 p.m.
987 views
Microbes, metabolism and autoimmunity
Ramnik Xavier, Massachusetts General Hospital, Boston, USA
Sept. 29, 2017 · 9:06 a.m.
1946 views
Lipid metabolism in high fructose fed humans
Luc Tappy, University of Lausanne, Switzerland
Sept. 29, 2017 · 10:03 a.m.
1113 views
Food, health and disease: The evidence and reporting the evidence
Dennis Bier, Children's Nutrition Research Center, Baylor College of Medicine, Houston, USA
Sept. 29, 2017 · 11:11 a.m.
544 views
Deeper down the rabbit hole of data, analysis, and inference errors and suggestions for digging back out
David Allison, Indiana University School of Public Health, Bloomington, USA
Sept. 29, 2017 · 1 p.m.
500 views
Neural circuits of food intake - is it all about calories?
Harvey Grill, University of Pennsylvania, Philadelphia, USA
Sept. 29, 2017 · 1:55 p.m.
508 views

Recommended talks

Relationship of diet to gut microbiota diversity, stability and health in older people
Paul O'Toole, University College Cork, Ireland
Oct. 23, 2014 · 3:52 p.m.
241 views