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Introduction of Carol Brayne
Carol Brayne, University of Cambridge, UK
Tuesday, Dec. 12, 2017 · 9:44 a.m. · 07m 51s
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and for inviting me to speak and a great to be here um just to
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say very briefly who i am and uh obstructive i'm a medical qualifies
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and then went on to train a genealogy and have spent my life
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time really doing public health research um mentoring and training uh pickles
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a specialist as well but i did neurology for quite awhile and what
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i was doing that um i was very aware that gender aspect
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but mostly and uh represented i would see um women and young girls going on adolescents
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with epilepsy and revise that the menstrual cycle for example is really important factor
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and i think it's taken decades for this kind of thinking to come along so this is really and such an important area
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i spent my korean looking at dimension um and brain imaging and i'm going
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to share with you a couple of the um some the result
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uh the dementia has been mentioned it's been alluded to many times as being a very important
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conditions and he is um it's very complex condition it's the syndrome not a disease
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as such i think the disease having a very specific sort of boundaries and so on existing room and it's partly defined
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by how we um expect people to uh and as it
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were function within society 'cause its combination of cognition
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and um functional ability to confirm the today in any
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given society so it is as a mother speak
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comedy divorce the environment and life goes from the expression of dimension societies
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so where have from high and other colleagues things starting to mention of course we've been studying it largely in high income countries
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but also there's been a lot of work done in a middle income countries which originally people so that there was very little can
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ensure in um lower middle income countries and it was somehow wasting disease but of course that is absolutely not the case
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and there is a very important uh group studies across the world calls the ten sixty six studies
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um and the lead is martin prints from king's college london but it's
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that's huge um collaborate collaboration across the across the world or some big gaps
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but it is really demonstrated variation across lower and middle income countries and it also
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is a rich source for interrogation of gender effects with in different localities
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i can talk a little bit about what we've learned within the u. k. and um what you can
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see here is down um oh well we've been thinking study it over many decades to this
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is this a big studies of dimension looking at dimension in representative population just on the
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ground so when you get the numbers when all the speakers give numbers about
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who's affected and how many and how many women and so on and what ages
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take it comes from basic epidemiological population studies that must be representative of
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the relevant population so we do those in the u. k. and i've given the results
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that you can see on the right is a cool cops function than eighteen studies
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and what we've done is repeat them across time intervals to the good change in different generations
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of older people age sixty five and over more you can see in that slot
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it's a costly this is just a concatenation of where for thirty years of
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research but it shows you the dementia in the u. k. if you
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hold your diagnostic methods steady because it's the syndrome is a difficult thing
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it's got fuzzy boundaries but if you hold a diagnostic methods steady
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we have seen a drop in the proportion of people at given ages you have dimension
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so that's what you're saying with the blue and the red on that in that slot and this the
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drop is pretty significant it's it's over twenty sentences in the province the proportion at any one time
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with the disorder and we see the same thing with the new occurrence of dimension every time well
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there are differences in the gender save for the drop in providence is not say difference in men when
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but for instance the new occurrence to mention it's at the drop is much bigger
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in men in this isn't women so the incidence drop by forty percent
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and the instance did not read or not i'm not saying women
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so the gain over two decades with seemingly in men
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so that's very interesting things going on across time in um gender with gender
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as well as uh uh between the genders in as any one time
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uh and you can see that agenda is associated with the risk of demands as
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as as has been said many times and that's in the boston that
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uh one point six times if you're women human one point one six is taking age
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differences into account we have to bear in mind that men die uh yeah
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they die at early stages with their frail they die sooner
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or later stage of the frailties nietzsche and if women
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than women what's often we seem to be tougher spice having and more of these different conditions we talked about
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but a each is incredibly important and uh this h. survival difference between generations is very
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what's taking to cancel things we talk about as being more common in women
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in uh if they're in the oldest old and some of us is
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accounted for by this bible differential which and an eighties incredibly important
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because most uh mentioned has in very old people cause early onset is incredibly important
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body movements because nobody wants it nine times agenda uh jane um the
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a demonstration common in women but in the younger age groups
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nearly once it's it's a more even more even
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so it's actually different at different ages if we talk about dimension we we talk about this one thing it isn't one thing
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the two decade to darcy um but of um dimension and
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also healthy brain imaging has allowed us to get dependence
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and these this last year on the left hand on the left and the whole thing life expectancy type
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data and they show the population the left on such as population in
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nineteen ninety one and the rice and the the twenty ten
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uh studies and they show you absolute life expectancy we should the top block lines
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um and they show you the differences between men and women salesmen women on the right man on that
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and you can see 'em you can see that the man that the change
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i'm sorry it's men on the top and women on the bottom here you can see that
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the change in life expectancy for men is is um pretty basic um and these
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lines yeah a red blue and yet and uh and
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and three of the years with high dependency need independence in their depends c. and they
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show you the changes of course the two decades uh by gender um what he's
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what that really shows is that it's not as new wants a it's more new
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wants to just women having more uh and life with a inc increase dependency
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uh we we see women having more of the life
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life has increased by considerably for both sexes
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and women have increased their not pushy in low dependency state
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so these kinds of population based studies allow us to interrogate these gender differences
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for not just the biological findings but also for the social finding
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so i'm gonna record the um i think it's incredibly important well learning from the population based studies
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is the life course aspects of seem to be very important to me
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maybe driving these changes into mentioned in the oldest age groups
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and so i'd like to introduce um will reinforce the message we've already had conti force
Conference Program
Welcome Words
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 8:48 a.m.
Welcome adress
Françoise Grossetête, member of the European Parliament
Dec. 12, 2017 · 8:55 a.m.
Presentation of the day
Sylvia Day, Forum host and WBP ambassador
Dec. 12, 2017 · 9:01 a.m.
Introduction of Elena Becker-Barroso
Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology
Dec. 12, 2017 · 9:21 a.m.
230 views
Introduction of Gillian Einstein
Gillian Einstein, University of Toronto, Canada
Dec. 12, 2017 · 9:28 a.m.
Introduction of Else Charlotte Sandset
Else Charlotte Sandset, Oslo University Hospital, Norway
Dec. 12, 2017 · 9:39 a.m.
Introduction of Carol Brayne
Carol Brayne, University of Cambridge, UK
Dec. 12, 2017 · 9:44 a.m.
Introduction of Maria Teresa Ferretti
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 9:52 a.m.
158 views
Introduction of Liisa Galea
Liisa Galea, University of British Columbia, Canada
Dec. 12, 2017 · 9:56 a.m.
Introduction of Lawrence Rajendran
Lawrence Rajendran
Dec. 12, 2017 · 10:03 a.m.
243 views
Introduction of Thorsten Buch
Thorsten Buch, Director, Institute of Laboratory Animal Science (LTK), University of Zurich, Switzerland
Dec. 12, 2017 · 10:08 a.m.
Introduction of Meryl Comer
Meryl Comer , President & CEO, Geoffrey Beene Foundation Alzheimer's Initiative
Dec. 12, 2017 · 10:59 a.m.
Introduction of Mary Mittelman
Mary Mittelman, New York University School of Medicine, US
Dec. 12, 2017 · 11:05 a.m.
Introduction of Angela Abela
Angela Abela , University of Malta, Malta
Dec. 12, 2017 · 11:13 a.m.
Introduction of Tania Dussey-Cavassini
Tania Dussey-Cavassini, Former Swiss Ambassador for Global Health, Switzerland
Dec. 12, 2017 · 11:20 a.m.
479 views
Introduction of Rajendra Dhamane
Rajendra Dhamane
Dec. 12, 2017 · 11:29 a.m.
Introduction of Sofia Petersson
Dec. 12, 2017 · 1:23 p.m.
Introduction of Raj Long
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 1:30 p.m.
200 views
Introduction of Antonella Santuccione Chadha
Antonella Santuccione Chadha , Swissmedic, Swiss Regulatory Agency, Switzerland
Dec. 12, 2017 · 1:32 p.m.
370 views
Introduction of Marsha B. Henderson
Marsha B. Henderson, Food and Drugs Administration, Office for Women's Health, US
Dec. 12, 2017 · 1:36 p.m.
Introduction of Maeve Cusack
Maeve Cusack, European Institute for Women's Health
Dec. 12, 2017 · 1:43 p.m.
Introduction of Hadine Joffe
Hadine Joffe, Harvard Medical School, US
Dec. 12, 2017 · 1:47 p.m.
Introduction of Maria Houtchens
Maria Houtchens, Harvard Medical School, US
Dec. 12, 2017 · 1:55 p.m.
Introduction of Valerie Bruemmer
Valerie Bruemmer, Senior Medical Advisor, Eli Lilly
Dec. 12, 2017 · 2:03 p.m.
Introduction of Malou Cristobal
Malou Cristobal, Polytrauma/ TBI / Vestibular Rehabilitation Program, New York Harbour
Dec. 12, 2017 · 2:08 p.m.
Panel Discussion: Sex and gender in clinical trials for brain and mental diseases – Reconsidering the way we test drugs
Dec. 12, 2017 · 2:12 p.m.
111 views
Wrap up of Panel Discussion 3
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 3:23 p.m.
Presentation of Sofia, Robot
Sofia, Robot
Dec. 12, 2017 · 3:28 p.m.
Introduction of Nicoletta Iacobacci
Nicoletta Iacobacci , Singularity University Geneva
Dec. 12, 2017 · 3:32 p.m.
Introduction of Fabrizio Renzi
Fabrizio Renzi, Innovation and Technologies Director, IBM, Rome
Dec. 12, 2017 · 3:36 p.m.
Introduction of Joanna J. Bryson
Joanna J. Bryson , University of Bath, UK
Dec. 12, 2017 · 3:48 p.m.
Introduction of Myshkin Ingawale
Myshkin Ingawale, Facebook
Dec. 12, 2017 · 3:58 p.m.
Introduction of Kathryn Goetzke
Kathryn Goetzke, President, Chief Mood Officer & Founder, The Mood Factory, and Founder, iFred
Dec. 12, 2017 · 4:07 p.m.
Introduction of Nikolaos Mavridis
Nikolaos Mavridis , Interactive Robots and Media Labs, MIT, US
Dec. 12, 2017 · 4:13 p.m.
Panel discussion: Digital biomarkers and new technologies – New tools to support women's brain health
Dec. 12, 2017 · 4:26 p.m.
Closing remarks
Mara Hank Moret
Dec. 12, 2017 · 5:12 p.m.
604 views
