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Introduction of Thorsten Buch
Thorsten Buch, Director, Institute of Laboratory Animal Science (LTK), University of Zurich, Switzerland
Tuesday, Dec. 12, 2017 · 10:08 a.m. · 05m 22s
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good morning and managers who i'm head of things good laboratory animals signs at the university of zurich
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and um the other lot lighter of uh of the courses i'm
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lazy and a continuing education courses for like animal experiment teachers
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it's actually are in a crime a location to
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change behaviour of scientists uh in and experimentation
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uh_huh and today i want to talk to you about um a little and
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investigation purely mathematical that i've started two
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years ago letters and friends
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after having heard a or a year in and it goes on so
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on the meeting of the space so slightly off and experimentation
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and michael fasting a statistician from great britain and
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presented a or can he claimed that
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inclusion of both sexes in animal studies that could be done and no statistical cost
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i couldn't believe that i needed it takes that uh mine mathematics fund enough to
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matter can that be too of course we can take this answer project um
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and and that all start end at you know we're on it
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now for two years that's how difficult it turned out
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the dish the difficulty stems of on one hand uh from being apologises all the just
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in in being a um a mathematician or so uh to find common ground
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and of uh in of of doing such as that it was very difficult it is to very
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difficult when i say i want to know this can you calculate that uses but that's critical
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and so one of the main uh topics here is how can include
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both sexes in animal studies and i've read
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now uh papers discussing that it's always
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refer to as if you have to double the group sizes so so in this case you have a a study
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was twelve uh males as is done in many fields and
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but you know by including the second sex emails
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had a man a double the size of animals this is
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also important as we are all under pressure into strains
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of and and and the three r.s we do supplied fine
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and to use as few animals if possible the cities the impact to them
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so we have to think hard to use not too many and so would it
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help us to include both sexes into you really have to double the size
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of the groups um as i said already fasting has the opposite opinion he uh things you
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can do this and have no it just the cost and you don't lose power well
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we we start then um some model in and um found that if you just include
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six as a compound or a second factor that you don't and lines
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in a so called multi factorial design um the increase in
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group sizes it actually marginal it's small and and
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typical animal study when you add two in a in a in
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a study that hasn't for a groups what at one or
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two animals to each group and you would be fine so that the outcome as you see in that are not well
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doing so is uh the same as a you have heard before
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you include six as a component but you don't analysts
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if you want to enlist sex you have to model it in and you have to then analysts
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whether it has a influence on and the primary better that you and i and rising
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to do so you have to um of course correct mike testing and you have
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to a model in interaction effects between and sex and the other very
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if you do that what happened is actually that you see down here in the lower graph
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um when you do model with interaction you increase the power of your experiment
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instead of losing power so knowing that you have both sexes and
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including this internal analysis and make to study at or you can continue to uh with
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our and modelling and in the morning streams
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and scenario that the uh use
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very analysed the data for sex and um for for that and alive and you
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have to include twenty percent more animals in the study
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to really get in a a meaningful result
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that said there is no reason to not include both sexes
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in an experimental studies and that uh come from me
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yeah i'm in in all the just like training um
Conference Program
Welcome Words
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 8:48 a.m.
Welcome adress
Françoise Grossetête, member of the European Parliament
Dec. 12, 2017 · 8:55 a.m.
Presentation of the day
Sylvia Day, Forum host and WBP ambassador
Dec. 12, 2017 · 9:01 a.m.
Introduction of Elena Becker-Barroso
Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology
Dec. 12, 2017 · 9:21 a.m.
230 views
Introduction of Gillian Einstein
Gillian Einstein, University of Toronto, Canada
Dec. 12, 2017 · 9:28 a.m.
Introduction of Else Charlotte Sandset
Else Charlotte Sandset, Oslo University Hospital, Norway
Dec. 12, 2017 · 9:39 a.m.
Introduction of Carol Brayne
Carol Brayne, University of Cambridge, UK
Dec. 12, 2017 · 9:44 a.m.
Introduction of Maria Teresa Ferretti
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 9:52 a.m.
158 views
Introduction of Liisa Galea
Liisa Galea, University of British Columbia, Canada
Dec. 12, 2017 · 9:56 a.m.
Introduction of Lawrence Rajendran
Lawrence Rajendran
Dec. 12, 2017 · 10:03 a.m.
244 views
Introduction of Thorsten Buch
Thorsten Buch, Director, Institute of Laboratory Animal Science (LTK), University of Zurich, Switzerland
Dec. 12, 2017 · 10:08 a.m.
Introduction of Meryl Comer
Meryl Comer , President & CEO, Geoffrey Beene Foundation Alzheimer's Initiative
Dec. 12, 2017 · 10:59 a.m.
Introduction of Mary Mittelman
Mary Mittelman, New York University School of Medicine, US
Dec. 12, 2017 · 11:05 a.m.
Introduction of Angela Abela
Angela Abela , University of Malta, Malta
Dec. 12, 2017 · 11:13 a.m.
Introduction of Tania Dussey-Cavassini
Tania Dussey-Cavassini, Former Swiss Ambassador for Global Health, Switzerland
Dec. 12, 2017 · 11:20 a.m.
480 views
Introduction of Rajendra Dhamane
Rajendra Dhamane
Dec. 12, 2017 · 11:29 a.m.
Introduction of Sofia Petersson
Dec. 12, 2017 · 1:23 p.m.
Introduction of Raj Long
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 1:30 p.m.
200 views
Introduction of Antonella Santuccione Chadha
Antonella Santuccione Chadha , Swissmedic, Swiss Regulatory Agency, Switzerland
Dec. 12, 2017 · 1:32 p.m.
371 views
Introduction of Marsha B. Henderson
Marsha B. Henderson, Food and Drugs Administration, Office for Women's Health, US
Dec. 12, 2017 · 1:36 p.m.
Introduction of Maeve Cusack
Maeve Cusack, European Institute for Women's Health
Dec. 12, 2017 · 1:43 p.m.
Introduction of Hadine Joffe
Hadine Joffe, Harvard Medical School, US
Dec. 12, 2017 · 1:47 p.m.
Introduction of Maria Houtchens
Maria Houtchens, Harvard Medical School, US
Dec. 12, 2017 · 1:55 p.m.
Introduction of Valerie Bruemmer
Valerie Bruemmer, Senior Medical Advisor, Eli Lilly
Dec. 12, 2017 · 2:03 p.m.
Introduction of Malou Cristobal
Malou Cristobal, Polytrauma/ TBI / Vestibular Rehabilitation Program, New York Harbour
Dec. 12, 2017 · 2:08 p.m.
Panel Discussion: Sex and gender in clinical trials for brain and mental diseases – Reconsidering the way we test drugs
Dec. 12, 2017 · 2:12 p.m.
112 views
Wrap up of Panel Discussion 3
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 3:23 p.m.
Presentation of Sofia, Robot
Sofia, Robot
Dec. 12, 2017 · 3:28 p.m.
Introduction of Nicoletta Iacobacci
Nicoletta Iacobacci , Singularity University Geneva
Dec. 12, 2017 · 3:32 p.m.
Introduction of Fabrizio Renzi
Fabrizio Renzi, Innovation and Technologies Director, IBM, Rome
Dec. 12, 2017 · 3:36 p.m.
Introduction of Joanna J. Bryson
Joanna J. Bryson , University of Bath, UK
Dec. 12, 2017 · 3:48 p.m.
Introduction of Myshkin Ingawale
Myshkin Ingawale, Facebook
Dec. 12, 2017 · 3:58 p.m.
Introduction of Kathryn Goetzke
Kathryn Goetzke, President, Chief Mood Officer & Founder, The Mood Factory, and Founder, iFred
Dec. 12, 2017 · 4:07 p.m.
Introduction of Nikolaos Mavridis
Nikolaos Mavridis , Interactive Robots and Media Labs, MIT, US
Dec. 12, 2017 · 4:13 p.m.
Panel discussion: Digital biomarkers and new technologies – New tools to support women's brain health
Dec. 12, 2017 · 4:26 p.m.
Closing remarks
Mara Hank Moret
Dec. 12, 2017 · 5:12 p.m.
605 views
