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this is this is a great on or this is a i i'm extremely
00:00:04
excited about this project particularly because i look very different from panel there
00:00:10
and that if i had different i don't know why why
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uh we we can't accept the fact that um the
00:00:18
you know the the brain hold in the mental health is is is indeed sex tape and and and and
00:00:25
and uh that's just a brief interviews you i'm i'm going to do and then i
00:00:30
mean a professor at the university of zurich i work on the cellular understanding
00:00:34
of how assigns posses that happens so i overcome plus uh uh the solo
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and the and it today i'm gonna talk to you about uh uh
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about uh how when we when we do research in uh huh
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and uh we we look at the look at many different aspects the uh particularly a long too
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to disease aspect and then when when uh this goes to
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when you find something and then we need to publish
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there is this huge gap between um the research that is done in the land and then when you go to publish in in
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the journals at their uh then uh the whole whole opponent and
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starts one is that in today's world you can't really publish
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i'm a negative studies you cannot publish i cannot publish a
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observations you need to publish only positive and and additive
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and this is what i would like to tell you from the uh editor and from
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the um uh as as a researcher but also as a as a publisher
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what we can do you in order to improve jen intrusion in studies
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and uh there are three main challenges that we face today uh in terms
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of size publishing one is the the value to access knowledge is you
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know very well if you if you um if you go when uh
00:01:56
i i try to access publish knowledge knowledge was created by researchers
00:02:01
and many publishers to put i have that here and uh this is this
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why we we try to be a an open access a publisher
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the other aspect is there's non communication of data that we we often tend to include only possible studies we try
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to remove negative data we don't we uh we tend to remove things that that don't really fit an active
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and the other aspect is is what i'm gonna focus on today is this interpret usability problems it's so
00:02:29
um estimates on around sixty six percent to seventy percent of the published
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let's sure cannot be reproduced and i think the uh i would like you to take
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a moment to think about it not only that is a barrier to access knowledge
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it is about it also to create knowledge but then budget create that knowledge it seems it appeared usable
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there is a part of the data put usability that comes from the fact that
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it is for the ones yes and sorry about that that scientists also cheat
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but that proportion is very little and most of the uh part
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seems to be a seems to come from the fact that
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but it's not tested in many different uh many different uh uh systems and maria theresa for example
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a brilliantly due to the fact that it's really a a when you think about
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a disease like alzheimer's disease that is essential meeting history cannot i mean
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in in in in at the age of onset early or late
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we'd also there's affinity big variability even when you take
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um people they are different that is differences already and then there's also differences and women
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and when you try to publish a finding that is pertinent
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to the disease you don't usually publish that it works
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only in man or a you when when you see that the dog effect does not happen if sexy
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in let's say a female a female my uh my escort you
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actually conveniently leave out but then talk about in a title
00:03:56
that a distraught works in alzheimer's model and i think this cherry picking of the data that
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uh and it's it's absolutely not okay and this contribution to reproduce ability when it
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pharmaceutical industry takes the status publish let's say in a in a in
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in a journal x. uh then you put in a lot of money thinking that this this data is gonna be the plug replicated
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and uh but in billions of dollars and then only to find that he does it only works in
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this very small core or even not uh uh not and this is jen not gently up
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native published an article uh two years ago talking about a repeat usability that is that stems
00:04:34
from life sciences and that can mount up to thirty five point six billion dollars
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and that is something we have to think about and and and signs mattresses a journal that
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we created we found a few years ago that problems just only single observations and um
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and and and observations that would be put in it uh it can be negative it can be a positive it
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can be confronted can become a containing data uh and we kind of of the problems only single observations and
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to support the human brain help a a project
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we uh we decided to have one issue dedicated on a it's a sex differences
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in plain hot and this would be free for all the opposite contribute
00:05:16
um and as maria theresa said you should go back to the data and find even if it is negative that that doesn't work
00:05:23
uh you love to fight the observations and and

Conference Program

Opening
Gautam Maitra, Founding Member, Women's Brain Project
Dec. 12, 2017 · 8:45 a.m.
168 views
Welcome Words
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 8:48 a.m.
Welcome adress
Françoise Grossetête, member of the European Parliament
Dec. 12, 2017 · 8:55 a.m.
Presentation of the day
Sylvia Day, Forum host and WBP ambassador
Dec. 12, 2017 · 9:01 a.m.
Keynote
Khaliya
Dec. 12, 2017 · 9:04 a.m.
Introduction of Elena Becker-Barroso
Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology
Dec. 12, 2017 · 9:21 a.m.
230 views
Introduction of Gillian Einstein
Gillian Einstein, University of Toronto, Canada
Dec. 12, 2017 · 9:28 a.m.
Introduction of Else Charlotte Sandset
Else Charlotte Sandset, Oslo University Hospital, Norway
Dec. 12, 2017 · 9:39 a.m.
Introduction of Carol Brayne
Carol Brayne, University of Cambridge, UK
Dec. 12, 2017 · 9:44 a.m.
Introduction of Maria Teresa Ferretti
Maria Teresa Ferretti, President, Women's Brain Project
Dec. 12, 2017 · 9:52 a.m.
157 views
Introduction of Liisa Galea
Liisa Galea, University of British Columbia, Canada
Dec. 12, 2017 · 9:56 a.m.
Introduction of Lawrence Rajendran
Lawrence Rajendran
Dec. 12, 2017 · 10:03 a.m.
242 views
Introduction of Thorsten Buch
Thorsten Buch, Director, Institute of Laboratory Animal Science (LTK), University of Zurich, Switzerland
Dec. 12, 2017 · 10:08 a.m.
Introduction of Meryl Comer
Meryl Comer , President & CEO, Geoffrey Beene Foundation Alzheimer's Initiative
Dec. 12, 2017 · 10:59 a.m.
Introduction of Mary Mittelman
Mary Mittelman, New York University School of Medicine, US
Dec. 12, 2017 · 11:05 a.m.
Introduction of Angela Abela
Angela Abela , University of Malta, Malta
Dec. 12, 2017 · 11:13 a.m.
Introduction of Tania Dussey-Cavassini
Tania Dussey-Cavassini, Former Swiss Ambassador for Global Health, Switzerland
Dec. 12, 2017 · 11:20 a.m.
477 views
Introduction of Raj Long
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 1:30 p.m.
198 views
Introduction of Antonella Santuccione Chadha
Antonella Santuccione Chadha , Swissmedic, Swiss Regulatory Agency, Switzerland
Dec. 12, 2017 · 1:32 p.m.
370 views
Introduction of Marsha B. Henderson
Marsha B. Henderson, Food and Drugs Administration, Office for Women's Health, US
Dec. 12, 2017 · 1:36 p.m.
Introduction of Maeve Cusack
Maeve Cusack, European Institute for Women's Health
Dec. 12, 2017 · 1:43 p.m.
Introduction of Hadine Joffe
Hadine Joffe, Harvard Medical School, US
Dec. 12, 2017 · 1:47 p.m.
Introduction of Maria Houtchens
Maria Houtchens, Harvard Medical School, US
Dec. 12, 2017 · 1:55 p.m.
Introduction of Valerie Bruemmer
Valerie Bruemmer, Senior Medical Advisor, Eli Lilly
Dec. 12, 2017 · 2:03 p.m.
Introduction of Malou Cristobal
Malou Cristobal, Polytrauma/ TBI / Vestibular Rehabilitation Program, New York Harbour
Dec. 12, 2017 · 2:08 p.m.
Wrap up of Panel Discussion 3
Raj Long , Bill and Melinda Gates Foundation, Vice-Chair, World Dementia Council
Dec. 12, 2017 · 3:23 p.m.
Presentation of Sofia, Robot
Sofia, Robot
Dec. 12, 2017 · 3:28 p.m.
Introduction of Nicoletta Iacobacci
Nicoletta Iacobacci , Singularity University Geneva
Dec. 12, 2017 · 3:32 p.m.
Introduction of Fabrizio Renzi
Fabrizio Renzi, Innovation and Technologies Director, IBM, Rome
Dec. 12, 2017 · 3:36 p.m.
Introduction of Joanna J. Bryson
Joanna J. Bryson , University of Bath, UK
Dec. 12, 2017 · 3:48 p.m.
Introduction of Myshkin Ingawale
Myshkin Ingawale, Facebook
Dec. 12, 2017 · 3:58 p.m.
Introduction of Kathryn Goetzke
Kathryn Goetzke, President, Chief Mood Officer & Founder, The Mood Factory, and Founder, iFred
Dec. 12, 2017 · 4:07 p.m.
Introduction of Nikolaos Mavridis
Nikolaos Mavridis , Interactive Robots and Media Labs, MIT, US
Dec. 12, 2017 · 4:13 p.m.
Keynote
Lynn Posluns , Women's Brain Health Initiative, Canada
Dec. 12, 2017 · 4:52 p.m.
Closing remarks
Mara Hank Moret
Dec. 12, 2017 · 5:12 p.m.
600 views
Thanks
Annemarie Schumacher Dimech
Dec. 12, 2017 · 5:16 p.m.
Closing song
Sylvia Day, Forum host and WBP ambassador
Dec. 12, 2017 · 5:23 p.m.