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this is this is a great on or this is a i i'm extremely
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excited about this project particularly because i look very different from panel there
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and that if i had different i don't know why why
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uh we we can't accept the fact that um the
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you know the the brain hold in the mental health is is is indeed sex tape and and and and
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and uh that's just a brief interviews you i'm i'm going to do and then i
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mean a professor at the university of zurich i work on the cellular understanding
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of how assigns posses that happens so i overcome plus uh uh the solo
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and the and it today i'm gonna talk to you about uh uh
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about uh how when we when we do research in uh huh
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and uh we we look at the look at many different aspects the uh particularly a long too
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to disease aspect and then when when uh this goes to
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when you find something and then we need to publish
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there is this huge gap between um the research that is done in the land and then when you go to publish in in
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the journals at their uh then uh the whole whole opponent and
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starts one is that in today's world you can't really publish
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i'm a negative studies you cannot publish i cannot publish a
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observations you need to publish only positive and and additive
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and this is what i would like to tell you from the uh editor and from
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the um uh as as a researcher but also as a as a publisher
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what we can do you in order to improve jen intrusion in studies
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and uh there are three main challenges that we face today uh in terms
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of size publishing one is the the value to access knowledge is you
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know very well if you if you um if you go when uh
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i i try to access publish knowledge knowledge was created by researchers
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and many publishers to put i have that here and uh this is this
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why we we try to be a an open access a publisher
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the other aspect is there's non communication of data that we we often tend to include only possible studies we try
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to remove negative data we don't we uh we tend to remove things that that don't really fit an active
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and the other aspect is is what i'm gonna focus on today is this interpret usability problems it's so
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um estimates on around sixty six percent to seventy percent of the published
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let's sure cannot be reproduced and i think the uh i would like you to take
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a moment to think about it not only that is a barrier to access knowledge
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it is about it also to create knowledge but then budget create that knowledge it seems it appeared usable
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there is a part of the data put usability that comes from the fact that
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it is for the ones yes and sorry about that that scientists also cheat
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but that proportion is very little and most of the uh part
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seems to be a seems to come from the fact that
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but it's not tested in many different uh many different uh uh systems and maria theresa for example
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a brilliantly due to the fact that it's really a a when you think about
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a disease like alzheimer's disease that is essential meeting history cannot i mean
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in in in in at the age of onset early or late
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we'd also there's affinity big variability even when you take
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um people they are different that is differences already and then there's also differences and women
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and when you try to publish a finding that is pertinent
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to the disease you don't usually publish that it works
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only in man or a you when when you see that the dog effect does not happen if sexy
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in let's say a female a female my uh my escort you
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actually conveniently leave out but then talk about in a title
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that a distraught works in alzheimer's model and i think this cherry picking of the data that
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uh and it's it's absolutely not okay and this contribution to reproduce ability when it
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pharmaceutical industry takes the status publish let's say in a in a in
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in a journal x. uh then you put in a lot of money thinking that this this data is gonna be the plug replicated
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and uh but in billions of dollars and then only to find that he does it only works in
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this very small core or even not uh uh not and this is jen not gently up
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native published an article uh two years ago talking about a repeat usability that is that stems
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from life sciences and that can mount up to thirty five point six billion dollars
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and that is something we have to think about and and and signs mattresses a journal that
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we created we found a few years ago that problems just only single observations and um
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and and and observations that would be put in it uh it can be negative it can be a positive it
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can be confronted can become a containing data uh and we kind of of the problems only single observations and
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to support the human brain help a a project
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we uh we decided to have one issue dedicated on a it's a sex differences
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in plain hot and this would be free for all the opposite contribute
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um and as maria theresa said you should go back to the data and find even if it is negative that that doesn't work
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uh you love to fight the observations and and