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gonna be again about alzheimer's disease uh like to do things better
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for this beautiful overview of it it became a logical aspect
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and the point that i would like to add the um again just a couple of words i don't have slides but i wanted to make sure
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that is audience would appreciate the complexity of the issue of sex and
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gender for a fantasy so we heard it in a logical part
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and they're the topic that i would like to bring to you and for you to keep
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in mind for the future discussions is the topic um of the affinity peak variability
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so uh a specialist women's been project and a research activities that we've been conducting in the
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past year we've been really focusing on this aspect because we think sex and gender
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might affect not just the beast and the numbers of patients that are affected by alzheimer's disease and the men so
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but even the way this is manifest itself so we're talking about seems
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we're talking about the question we're talking about but i'm not
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indeed usual phonetic variability is absolutely crucial because alzheimer's disease
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it's a very complex disease and and it is a very high level of it it's in eating the patients
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um so people have different manifestation even with the same level even patients that are
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by marcus tactile rice with the same level by markers you with that
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certain patients that are stable certain patients that have very that
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connected the klein some will decline faster some slower so
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there are additional factors that we're missing out and i think the point i would like to
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bring to they might become messages that facts might be a very important driver affinity peabody
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and there are some evidence in the literature in the sense so we do know um that there are
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differences in the performance and verbal memory for instance which is heavily used for diagnosing a sense disease
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women out there for many this task but then when the disease kick seen um
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somehow decline even faster so that could be something important to look at
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um we have a difference is in the b. b. b. hey the manifestation of alzheimer's disease women
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tend to be more the press men tend to be more aggressive so different therapeutic treatment there
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um in terms of by your markers that the evidence is still fast we do
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not have really evidenced that women have more or less on lookers now
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but the relationship between the level of by you might use in then the the clinical manifestation of the disease
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that's something where we had some uh they thought the show that this relationship is all somewhat related by sex
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which i think is crucial when we're talking about diagnoses and set
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up a um research um discourse or cutoff values we might
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going the direction of i think um sex sensitive or a a diagnostic tools
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institute for uh the the risk factors as well so that i respect those are for that time is
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is is that we know uh the they they're gonna become for both men and women but me
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we're not considering that families factors might be might have behaviour impact on men than women
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or vice versa so also the team but of saxons and and this but
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so all you know that would like to to to keep in mind this idea affinity peak variability and that sex
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might be a major driver of these in this could have an impact in the way we diagnose the disease
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in the way uh we try and prevent the disease in in the way we are we treat the disease
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that are not so many data on this topic and i'm personally with the
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women's been project and on a mission to convince everybody to go back
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to their databases and just tell us if when you stratified data by sex
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you do see something because we have tons of information right now that it's been collected about there
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has not been a focused on certification of data by sex uh so we basically have
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you know so so so much research that we can do and i encourage everybody who's working in
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this field to really go back to their data set analyst and stratified them by sex
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come back and tell us what you see and it's really the right moment to talk about this and even to publish
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is also what we're trying to do to help finding journals that i can publish these days