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00:00:02
okay so good morning everybody uh thank you so much uh for all
00:00:06
for coming to visit us at e. p. f. l. campus today
00:00:09
so all be telling you about uh the work that we've been
00:00:12
doing in our lab uh related to competition operating design
00:00:16
and uh the potential applications uh for this methodologies in by madison
00:00:20
applications so if uh many of you are aware um
00:00:25
most of the proteins we know in fact a evolutionary as history meaning that um they were
00:00:30
exposed to particular environment or they were not involved in a particular context of an organism
00:00:36
about what we can do these days um if in fact i have a
00:00:40
protein design tools which in which in this case will be computational tools
00:00:44
um to in fact change at the street uh of these proteins
00:00:49
and what i say about changing the each of these proteins is essentially to manipulate them in a way that they can perform
00:00:54
new functions for us and the way we do this uh is in fact uh we can draw parallel maybe with um
00:01:01
molecular sculpture so essentially we start from protein structures and we
00:01:05
try to find new sequences that that fit to structures
00:01:08
and ultimately the aim here is really good she's a new different functions and
00:01:13
so and uh in the next slide some just gonna go through a couple of of units of projects that are lab is interested in
00:01:20
so one of the first things that we've done uh using these techniques in order to generate novel proteins
00:01:26
was to apply this and what we called the top focused vaccines and so here what
00:01:31
you see uh on the left uh is essentially the uh a structural motif
00:01:36
that are low protein displays and that our immune system can recognise and um
00:01:41
make antibodies to target at this this motif so once we put this motif into
00:01:46
what difference interpret in that we design in the computer we were then
00:01:49
uh able to use the synthetic vaccines in a animal
00:01:53
intersections and in fact um verify that we
00:01:56
could elicit i'm controlling and somebody's against intense uh
00:01:59
make uh the principal components for active vaccines
00:02:03
so up until to day um this was done in in the particular system which is called the respiratory such a virus
00:02:09
for which there still no backs in approving this is in an area of research that we are intensively working on
00:02:16
so on the next example just to give you again uh another showcase of what this technologies can do for us
00:02:21
we're also working this domain of on a anti cancer drugs and so here what we
00:02:25
did was essentially to design a new protein which the target uh an essential factor
00:02:30
in in cells which could in it it onto my growth in this essentially the data
00:02:34
that i'm showing you here which are all was also data collected in people
00:02:38
and so but what i want you to in fact appreciate up from the
00:02:40
slide is that by having and this ability to to manipulate the structures
00:02:45
with an essentially very similar structures one another uh using essentially very close proteins to each other
00:02:53
we can re purpose them for completely different applications one of them being an anti too much rock the other one being a vaccine or
00:03:02
um one other aspect that we are also working on
00:03:05
is in um designing a molecular component read
00:03:09
which we can um control a cell activities and so here the principle is is essentially very simple
00:03:15
let's say that you have to proteins in p. that come together they will yield i'm an active solar activity
00:03:21
um in the presence of the small molecule this will break the to produce a come together and
00:03:26
this will render an inactive so so right now we're still working this a very um
00:03:32
for very sometimes but um uh uh for now we have in future
00:03:37
proof of concept that we can in fact make this happen
00:03:40
and this will also have a rapid translation applications i'm into parties out there please
00:03:45
so i'll ultimately ah what it but the message that i want to convey today is really that uh
00:03:51
this uh cutting edge pretty mentioning techniques are in
00:03:54
fact enabling interest formative for um biomedical applications
00:03:58
uh and so here is just a list of um that uh applications that we are working right now obviously we're open to other ideas
00:04:05
um and at the same time i will obviously would like to thank the people that actually do the
00:04:09
work in my lap and also the terms funding that we have obtained for the last years

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Conference program

Welcome
Marc Gruber, VP Innovation, EPFL
16 March 2017 · 9:04 a.m.
1,141 views
Logitech
Jean-Michel Chardon, Logitech
16 March 2017 · 9:07 a.m.
529 views
Intro of S. Gautsch
Marc Gruber, VP Innovation, EPFL
16 March 2017 · 9:21 a.m.
Context and Logistics of the Industry Day
Sebastian Gautsch, STI-EPFL
16 March 2017 · 9:22 a.m.
213 views
Master Thesis in Industry Context
Pierre-André Besse, Adjunct VP Education, EPFL
16 March 2017 · 9:34 a.m.
161 views
Role of distributed energy storage in smart grids 
Mario Paolone, Distributed Electrical Systems Laboratory - EOS Holding Chair
16 March 2017 · 9:39 a.m.
119 views
Materials and nanostructures for next generation photovoltaics
Anna Fontcuberta, Laboratory of Semiconductor Materials
16 March 2017 · 9:46 a.m.
131 views
Medium Voltage High Power Electronics
Drazen Dujic, Power Electronics Laboratory
16 March 2017 · 9:50 a.m.
361 views
Ubiquitous high performance PV energy scavengers in all shapes and colors : from IOT to buildings 
Christophe Ballif, Photovoltaics and Thin Film Electronics Laboratory
16 March 2017 · 9:54 a.m.
Highly efficient and clean conversion in fuel cells & electrolysers
Jan van Herle, Group of Energy Materials GEM
16 March 2017 · 9:59 a.m.
Small electromechanical moving devices 
Paolo Germano, Integrated Actuators Laboratory
16 March 2017 · 10:06 a.m.
Novel actuation methods for reconfigurable soft robots
Jamie Paik, Reconfigurable Robotics Lab
16 March 2017 · 10:12 a.m.
269 views
Revolutionary optical tools for Ophthalmology 
Christophe Moser, Laboratory of Applied Photonics Devices
16 March 2017 · 10:18 a.m.
166 views
Mighty soft materials
Dario Floreano, Laboratory of Intelligent Systems
16 March 2017 · 10:29 a.m.
101 views
Intro words, VP Research
Andreas Mortensen, VP Recherche, EPFL
16 March 2017 · 11:18 a.m.
131 views
The endovirome, source of biomarkers and potentiel therapeutic targets
Didier Trono , Laboratory of Virology and Genetics
16 March 2017 · 11:23 a.m.
107 views
New strategies to fight infections, hidden in the human genome
Jacques Fellay , Fellay Group
16 March 2017 · 11:29 a.m.
Smart Wearables for the Medical IoT Context
David Atienza, Embedded Systems Laboratory
16 March 2017 · 11:33 a.m.
203 views
Rational protein design for vaccine development
Bruno Correia, Laboratory of Protein Design & Immunoengineering
16 March 2017 · 11:39 a.m.
159 views
Medical Image Analysis 
Jean-Philippe Thiran, Signal Processing Laboratory 5
16 March 2017 · 11:43 a.m.
Advanced Functional Fibers
Fabien Sorin, Laboratory of Photonic Materials and Fibre Devices
16 March 2017 · 11:51 a.m.
183 views
Production of amorphous particles
Esther Amstad, Soft Material Laboratory
16 March 2017 · 11:57 a.m.
143 views
Mechanobiology and tissue engineering
Dominique Pioletti, Laboratoire de biomécanique en orthopédie
16 March 2017 · noon
125 views
High Performance Elastomers, Thermoplastics, and Lubricative Coatings
Holger Frauenrath, Laboratory of Macromolecular and Organic Materials
16 March 2017 · 12:06 p.m.
166 views
Simple models for complex flows
François Gallaire, Laboratory of Fluid Mechanics and Instabilities
16 March 2017 · 12:11 p.m.
245 views
Présentation du partenaire Alliance
Roland Luthier, Directeur du Programme Alliance, EPFL
16 March 2017 · 12:17 p.m.
Présentation du partenaire FSRM
Philippe Fischer, FSRM
16 March 2017 · 12:21 p.m.
Présentation du partenaire Swissmem
Philippe Cordonier, Swissmem
16 March 2017 · 12:25 p.m.
Presentation of Innovaud
Jean-Michel Stauffer, Innovaud, Conseiller en Innovation
16 March 2017 · 1:46 p.m.
Arcoptix
Gerben Boer, Arcoptix
16 March 2017 · 1:51 p.m.
189 views
Fast3D
Claude Forin, CEO
16 March 2017 · 1:55 p.m.
Unitechnologies
Denis Bubendorf, Unitechnologies
16 March 2017 · 1:59 p.m.
193 views
Etudiant EPFL
Firmin Manoury, Etudiant EPFL
16 March 2017 · 2:04 p.m.
ABB Sécheron
Pablo Furrer, ABB Sécheron
16 March 2017 · 2:09 p.m.
108 views
Schindler
Martin Kusserow, Schindler
16 March 2017 · 2:14 p.m.
191 views
CSEM
Stéphane Emery, CSEM
16 March 2017 · 2:21 p.m.
266 views
Flyability
Adrien Briod, Flyability
16 March 2017 · 2:30 p.m.
120 views
CEA
Philippe Garrec, CEA
16 March 2017 · 2:35 p.m.
Meyer Burger / Pasan SA
Vahid Fakhfouri, Meyer Burger / Pasan SA
16 March 2017 · 2:41 p.m.
117 views
Mikron SA
Sylvie Leggiadro, Mikron SA
16 March 2017 · 2:46 p.m.
282 views
Etudiant EPFL
Luc Conti, Etudiant EPFL
16 March 2017 · 2:51 p.m.
Johnson & Johnson
Grégoire Veber, Johnson & Johnson
16 March 2017 · 2:55 p.m.
140 views
Micronarc
Danick Bionda , Micronarc
16 March 2017 · 4:01 p.m.
101 views
Festo
Nicolas Godel, Festo
16 March 2017 · 4:05 p.m.
140 views
Melexis
Caroline Heid, Melexis
16 March 2017 · 4:14 p.m.
256 views
Etudiante EPFL
Sueda Turk, Etudiante EPFL
16 March 2017 · 4:19 p.m.
140 views
Maxon Motor
Olivier Chappuis, Maxon Motor
16 March 2017 · 4:24 p.m.
234 views
Philip Morris
Marja Talikka, Philip Morris
16 March 2017 · 4:30 p.m.
125 views
Radar Swiss
Radmila Belavina, Radar Swiss
16 March 2017 · 4:33 p.m.
Tag Heuer
Cyrill Cattin, Tag Heuer
16 March 2017 · 4:37 p.m.
224 views
Vidi Systems
Reto Wyss, Vidi Systems
16 March 2017 · 4:50 p.m.
208 views
Suss microoptics
Wilfried Noell, Suss microoptics
16 March 2017 · 4:55 p.m.
143 views
Novelis
Gilles Hodel, Novelis
16 March 2017 · 4:59 p.m.
Fischer Connectors
Stéphane Rohrbach, Fischer Connectors
16 March 2017 · 5:04 p.m.
216 views
Etudiant EPFL
Maxime Valdemarin, Etudiant EPFL
16 March 2017 · 5:09 p.m.
111 views
Bobst
Leonard Badet, Bobst
16 March 2017 · 5:14 p.m.
621 views
Frontiers
Stefano Battaglia, Frontiers
16 March 2017 · 5:19 p.m.
160 views
Xsensio
Hoël Guerin, Xsensio
16 March 2017 · 5:25 p.m.
164 views
Closing remarks
Sebastian Gautsch, STI-EPFL
16 March 2017 · 5:30 p.m.

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