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thanks very much for the well welcome so my name's sarah and
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i'm i'm representing a company called fabrics and stuff but
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i just wanted to thank you organise is for inviting me here today to present about some of our research and
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um it's not really my first time to the digital health connects but it's also my first time to switzerland
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and yesterday was actually my first time having recollect if i'm channel tonight correctly and i'm definitely
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not gonna eat three days it it big so um what i wanted to talk
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about today really i want to introduce you to the well out of three d. printing
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in particular howl and it could revolutionise um
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the wealth of healthcare and pharmaceutical manufacturer
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so before we start i'm gonna talk a story and we've just had lunch so i don't think you're gonna be falling asleep i hope
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um the basic i wanna talk about the evolution of technology how are we i'm here today so
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over the past few hundred years that was going through a series of radical transformation
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i'm known as industry revolutions so fast industry revelation i had and in the late
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seventeen hundreds and it's where humans actually harness the power steam and water
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um well actually able to change the way that we communicate with one
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another uh the way that we could use and also transport goods
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the second industry revolution occurred about a hundred years later and it's where we were
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able to take let's go energy and start to mass produce gets and
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from them into that industrial revolution another hundred years later with the advent of electronics and i. t.
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we're able to automate production and actually become a lot more efficient
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at mass production but my that these first three industry
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revolutions focused on um producing more of the same thing so
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warm is kind of a one size fits all approach
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but now we stand on the brink of new industrial revolution to the fall off or industry four points there
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and it's where objects all around us uh becoming smart and there's
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actually a massive push especially especially within pharmaceuticals to and actually
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start to pass no lies um madison's personalise our treatments so
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actually the way that we have um produced madison's previously
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is not sufficient for the drive size needed and um let me give an example say
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for example the the top putting process was introduced over two hundred years ago
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that's within the second industry revolution and it hasn't really updated or changed much since then okay maybe a bit
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more efficient but still there's no major uh um revolution in the way that we manufacture top that
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so i think a technology that would really i'm kind of changed the
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the manufacture madison's would be three d. printing and um so
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three d. printing essentially is a technology that can um deposit material
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layer by layer to create objects of different shapes sizes
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and the benefit is that you can and create unique and complex objects
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which would not be easy to do by mass production techniques
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so it's already been and up taken within healthcare in
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general so especially within dentistry say these are and
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that's an example of some three d. printed braces so that the brand name is invisible line
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not sure if you've heard of it but essentially take a mode of your mouth and then every week they
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will three d. printer new brace i'm for you and because there are visible you can't see them
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it's also been used in tissue engineering research so um this is an image here which is i think pretty
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cool of and a three d. printed and kidney also three d. printed yeah and sleep today she
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and it's also been use within medical devices and prosthetics so this is a passing lies to hearing aid
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which and actually three printing 'em is being used to mask customised
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hearing aids now for patients rather than um standard technologies
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and every that fabrics and see potential it is in a three d. printing of
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tablets which sounds quite futuristic right and the actually it's it's a massive reality
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and says sebastian mention the f. t. a. um approved about first three deep into top that
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um a couple of years ago and actually where we see um three d. printing benefiting
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um from c. to cause is actually with impasse citation said the f. d. a. approved
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top that did it for mass mass production they took a standard three deep into
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and they made a big scale process they can produce many the same types of top that's
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now well fabrics and what we aim to do is try passing lies treatments instead
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so this is an image here of some of our top let's they've actually
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got madison inside days but we don't call them three deep into topless
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we call them friends that so you've had top lets you fat cat let's and now
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we're gonna have printed really improving common to cover in the next few years and
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so i was um was mention fabrics is a spinoff company um from you see elsewhere uh a relatively small startup
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and so with germany within the research and development phases at the moment say what i wanna share
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with you today isn't the research we've done and some of the potential applications for the future
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so and the main question i always get offices how do you three deep in the top and so to make a a
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simple i'm because i like illustration i have come up with the
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three d.'s of three d. printing every week or so
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if we wanna make a a formulation essentially we always start off the fast the witches design
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so um let's say we have an elderly patient who perhaps
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console of a normal um sighs casual a top that
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what we could do instead is design um using computer aided design software
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and or disposable formulation in that instance up that like a like a fellow
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and we essentially create a file which can be read by a three d. printer system
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so we know we want it to look like the next d. is develop so now
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what we want to do is make sure it's gonna perform um acceptably within human
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so what we have to do is select that like correct exceptions and also this the crack printing type
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and then the final d. is dispense so the three different is that we have it
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fabrics are actually very very small you can that you pick one up and
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but it where you want essentially so how we see it is perhaps we could
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take a three d. printer but in within a hospital or community pharmacy setting
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or even in kind of within hard to reach areas to enable on site front
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no production and always right in front of the patients very are if
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and really as i mentioned this and drives the use of past nice medicines so
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that there is a need for personalisation i think everybody in this room would agree that
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we all different we'll all different ages different genders on different medicines different disease types
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so actually the way that we treat people why one size fits all approach doesn't necessarily always work
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no i'm not saying for a full madison's three d. printing would work for example for mass manufacture of power c. to model
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it's never it's never gonna overtake that in terms of um cost effectiveness
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but where it could help is in those satin patient populations such as the
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elderly or very young also in kind of complex disease states as well
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and so i just wanted to go to some of the motivations full three
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d. printing so one of the main ones is around days flexibility
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so conventionally as i said when we must manufacture topless will
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produce thousands hundreds of thousands of exactly the same type
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and the be fixed ranks fake shape fix colour fixed size fix released very far
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and actually you that often leads patients having to maybe split top that so even crash and
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way out how does to get their exact days that they need to which can be
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pretty dangerous on is um been shown that if you break satin top let's then
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it'll maybe effectively nice profile we might not be get an exact x.
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and so and so okay and say with three d. printing you cannot she one of the benefits as you can
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to pause a set amount of material so you can change the days based on the shape and size
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so this is an example of one of off three d. printer is actually it was um developed previously as a um
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candy printer so we're collaborating with magic candy factory and what
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we're doing is we're developing formulations impinge up within it
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so what you just so on the video is the pharmacist had a truckload it's a range
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she's incest into the three d. printer and now you can see this range had to be
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pushed down and out the other end is um the the material which has been deposited
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and essentially these trait tuple top that cities are very acceptable
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for um pediatrics and we're actually conducting a clinical study
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at the moment in austin in spain which is using this um technology fall and treatment of a right disease
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so one of benefits especially with this technology is it's quite it's quite quick this is also another
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question and we always go how how long does it take so um with this um particular
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extrusion based technology we can print we printed that you tablets in around eight minutes and which
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okay compared to mass manufacture isn't very very quick but for personalisation would um be sufficient
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okay it's the second motivation would be around essential lies production
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and so as i mentioned that quite compact you can put it in whatever location that actually you want and
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even we've and conceded taking a three d. printer not you put in up in space so and
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nasa actually had um one of our um academic papers on the table and we were a we've been
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in communication with them essentially to um try and start three d. printing methods medicines and space
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and also kind of it in hard to reach areas had disasters owns um waugh ami counts
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um but they don't really ah ah m. i. where we see the may
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benefit been is within pharmacy and within the host one community sectors
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suicide is around patient centred design so one of the benefits is that you can
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choose the shape the size the coloured the taste so if your son
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wanted his medicine to be a purple dinosaur which tasted like lemon and how
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to paint i we could we could um we could theoretically do it
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um so essentially it's around trying to make um taking medicines more acceptable
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um it's about designing the medicine for the patient rather than just given the standard one i assume that they can take it
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and we actually tested this concept in and human volunteers so
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one of the benefits of been a spinoff from university is that there are a number of students
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q. um i'll willing to try all three deep into top that's um so it's actually what we did is we printed
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tablets of different shapes and sizes i wanted to evaluate how acceptable they wear to swallow and also to handle
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and that's what we found was that the doughnut shaped oh i'm actually really acceptable which we didn't
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and we didn't relies and also the normal happen and um top shape where as well
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okay and finely and you can create these unique and complex dosage forms using three
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d. printing so i'm just gonna give two examples because of of time and
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and um essentially so with the elderly population amplify on c. can
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be i must the problem so it's defined is taking more
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than five medicines but myself as a pharmacist i have wants
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to spend twenty eight different medicines for the same patient
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so that's a minimum of twenty eight different formulations they're gonna have to take
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it day a minimum and and this can become confusing i mean
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if i was on twenty medicines i won't be able to keep track and um essentially with three d. printing what you can do
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is that she and dispense more than one jerk into the same top let's say this topic here
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is a um madison which has four different anti hypertensive this in and they're clinically relevant basis
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and um it's actually we see this in um something tell madison's acceptance in the future
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you can take it a step further you can even personalising forty files
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so if you german offering a german flat his spanish different spanish fly i'm sorry i
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haven't i haven't done this slide yeah the next time performance i promise i well
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and also we're we're kind of struggling to make the u. k. and us save a you know watch watch this space
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okay another example i want to give you was of um we can create really fast dissolving topless now
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i'm not sure if decisions much to you but me as a formulation scientists
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is super exciting okay so and essentially what we've done is the the
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image on the top right is our three different to top that some because
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the technology we've only got loose particles almost just superficially pound together
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what that means is when you put it in a few minute walk to it just rapidly disintegrates and um
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it's actually civil patient alternated it disintegrate very very quickly and the standard limits is it's three minutes to
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be class doesn't already disintegrating top that we've done in two seconds think yeah it makes me excited
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okay so there's gonna the the four main motivations and essentially um
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we see this as i said being widely applicable to that patient populations yelling yeah on and
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off the complex regimes and we hope to improve medication adherence efficacy and reduce side effects
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so this is our vision okay i digital pharmacy era so
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perhaps a patient will have a therapeutic need maybe
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they will have um information about the blood pressure will
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from certain applications we've discussed today to collect data
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and um that data can be used to send to a a clinician you can create additional prescription
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that could then be sent to um some these design that formulation and sent to a three d. printer and
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then that um three even to get them past lies at madison be administered and the cycle repeats again
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so this is our vision i mean it comes across a number challenges especially around um regulation
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but as as a company we are talking to regulate agencies and trying to establish what requirements
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uh needed from their side and what we can do um to help the facilitator
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and find an overly touch net but i wanted to mention that i
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know that this technology doesn't quite futuristic batches a reality in
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is the news impact is um so ah sprees hand by preserve
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pharmaceuticals as i said most manufactured reprinted top that so
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there's more more research coming out every day sharon the maison opportunities that reprinting could bring 'em
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so i sent you about were quite to come together and that's why it's kind of a plan should be in at this conference 'cause it
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means i can talk to and many kind of people around the room
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you and can maybe suggest different uh areas all different ways
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that we could make this company uh successes actually um and i just wanted to highlight a couple of papers that we've written if you're
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interested and around three depending pharmaceuticals and i'm happy for for any questions
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and if you have any thank you for this thing and
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no sorrow for the for the presentation
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thirty question too forceful uh_huh look groups
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you know it's like you for your presentation on your show some
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warm body of three d. printer and we can you go
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everyone use gonna be of our motion you know um you come you don't make drugs uh_huh so
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all those who abuse is going to be regulated
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by the country's uses the important question
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one hundred percent is certainly an important question and so actually did to
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anybody in this room could probably buy a three d. printer
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and so what we're trying to work on as well is anti counterfeit matches so if um for example would
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be we would reduce the top there and then transport that to a hospital for patient to take
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and then used to be a way of ensuring that that probably is genuine that's somebody hasn't just manufactured it and and shit at that
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and so that's kind of what we're working on and we were using kind of non invasive tools to try and do that
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also it's gotta come from the regulate tree side as well so
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regulator agencies got to always in a way we regulate um
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like the types of three printers that can be used for pharmaceuticals but also um as actually just to ensure
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patient safety so i do agree with you i think it's it's a it's a major um challenge
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little portion last fall uh_huh
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just what what what is going to do both
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low low low vision hold who preserved to
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prison for instance results comparable to production
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and so what do you mean so i mean it instead was ah okay like buses go
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to to hold knew who the problem for some for instance was almost from from lucian
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is yeah i know well it's it's i mean it's a risk isn't it but i mean with three different
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is in general you can print for whatever you want but um i sent you that's nice be
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a way of ensuring that that that time page anyway nite doesn't that contains right second so we've been
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working on a tool which can um tell you how much of the job is within it
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and how much of a sequence of within that top as well so it can farms and ensures patient safety
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um before it would ever be administered so that's what we're working on as as a company as well
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uh_huh and so i'm using inspectors topic methods essentially is is the device which has
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a light it tells you about the composition of that top that you can
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create a model in the sense that model tells you whether it's genuine of
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fake and how much of each company out each component is within it
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yeah well well well the idea is to incorporated in the three d. printer say these devices a very very tiny so we
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would like to put one inside of three d. printer ink of a that is a genuine goes slower slow do
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so of course both proposals for mo versions
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so data security you mean all around the shows i was yes
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only to be kind of security measures in place yeah
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yeah so the idea is that somebody will will design and design the formulation kind of
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on site if you see what i mean so that'll help design not there and then um
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the send you don't be printed for the patient on the monster kind of a single
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step process in the way rather than being designed also also be like a
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pharmacist or dispenser would would design as they would be interested with

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Conference program

Mots de bienvenue
Sébastien Mabillard, CEO | Swiss Digital Health
15 June 2018 · 9:07 a.m.
Mots de bienvenue
Victor Fournier, Chef de Service de la santé publique | Canton du Valais
15 June 2018 · 9:11 a.m.
Mots de bienvenue
Jean-Albert Ferrez, Président | Fondation The Ark
15 June 2018 · 9:19 a.m.
Mots de bienvenue
Laurent Sciboz, directeur Institut Informatique de Gestion | HES-SO Valais/Wallis
15 June 2018 · 9:24 a.m.
L'écosystème d'innovation ouverte du CHU Sainte-Justine: une grande communauté gagnante!
Kathy Malas, resp. de la Plateforme de l’innovation et des Fonctions des maladies chroniques et aiguës | CHU SAINTE-JUSTINE (Canada)
15 June 2018 · 9:33 a.m.
Les livraisons par drones : vers une amélioration de la logistique dans le domaine médical
Janick Mischler, Program Manager | LA POSTE SUISSE
15 June 2018 · 10:07 a.m.
E-health et intégration des soins
Marc Cikes, CEO | MEDBASE ROMANDIE (Suisse)
15 June 2018 · 10:32 a.m.
Questions réponses
Remi Gauchoux, Business Development Director - Carenity
15 June 2018 · 11:46 a.m.
Futur de la santé mobile
Dr. med. Patricia Sigam, CEO & Co-founder, digital Med-Lab
15 June 2018 · 11:54 a.m.
Democratizing Data-Driven Medicine
Tarik Dlala, VP Marketing, Sophia Genetics
15 June 2018 · 12:14 p.m.
Ada inside
Vincent Zimmer, Ada Health, Berlin
15 June 2018 · 12:39 p.m.
biospectal, the optical revolution in hypertension monitoring
Prof. Patrick Schoettker, CMO. Biospectal
15 June 2018 · 2:06 p.m.
3D Printed Medicines: A Digital Pharmacy Era
Sarah Trenfield, MPharm, Senior Formulation Scientist, FabRx Ltd.
15 June 2018 · 2:23 p.m.
The Digipharm experience
Ahmed Abdullah, CEO & co-founder, Digipharm, Basel
15 June 2018 · 2:45 p.m.
Enabling the rehabilitative revolution
Dr. Manfredo Atzori, HES-SO Valais Wallis
15 June 2018 · 3 p.m.
Team Gamified Multi-sensory Stroke Rehab
Jean-Luc Turlan et J-P. Ghobril, Lauréats Arkathon 2018
15 June 2018 · 3:22 p.m.
Secure and Trustable EMR Sharing using Blockchain: Open Challenges and Lessons Learned
Alevtina Dubovitskaya, HES-SO Valais-Wallis
15 June 2018 · 3:38 p.m.
Conclusions
Sébastien Mabillard, CEO | Swiss Digital Health
15 June 2018 · 3:59 p.m.

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