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thanks very much for the well welcome so my name's sarah and
i'm i'm representing a company called fabrics and stuff but
i just wanted to thank you organise is for inviting me here today to present about some of our research and
um it's not really my first time to the digital health connects but it's also my first time to switzerland
and yesterday was actually my first time having recollect if i'm channel tonight correctly and i'm definitely
not gonna eat three days it it big so um what i wanted to talk
about today really i want to introduce you to the well out of three d. printing
in particular howl and it could revolutionise um
the wealth of healthcare and pharmaceutical manufacturer
so before we start i'm gonna talk a story and we've just had lunch so i don't think you're gonna be falling asleep i hope
um the basic i wanna talk about the evolution of technology how are we i'm here today so
over the past few hundred years that was going through a series of radical transformation
i'm known as industry revolutions so fast industry revelation i had and in the late
seventeen hundreds and it's where humans actually harness the power steam and water
um well actually able to change the way that we communicate with one
another uh the way that we could use and also transport goods
the second industry revolution occurred about a hundred years later and it's where we were
able to take let's go energy and start to mass produce gets and
from them into that industrial revolution another hundred years later with the advent of electronics and i. t.
we're able to automate production and actually become a lot more efficient
at mass production but my that these first three industry
revolutions focused on um producing more of the same thing so
warm is kind of a one size fits all approach
but now we stand on the brink of new industrial revolution to the fall off or industry four points there
and it's where objects all around us uh becoming smart and there's
actually a massive push especially especially within pharmaceuticals to and actually
start to pass no lies um madison's personalise our treatments so
actually the way that we have um produced madison's previously
is not sufficient for the drive size needed and um let me give an example say
for example the the top putting process was introduced over two hundred years ago
that's within the second industry revolution and it hasn't really updated or changed much since then okay maybe a bit
more efficient but still there's no major uh um revolution in the way that we manufacture top that
so i think a technology that would really i'm kind of changed the
the manufacture madison's would be three d. printing and um so
three d. printing essentially is a technology that can um deposit material
layer by layer to create objects of different shapes sizes
and the benefit is that you can and create unique and complex objects
which would not be easy to do by mass production techniques
so it's already been and up taken within healthcare in
general so especially within dentistry say these are and
that's an example of some three d. printed braces so that the brand name is invisible line
not sure if you've heard of it but essentially take a mode of your mouth and then every week they
will three d. printer new brace i'm for you and because there are visible you can't see them
it's also been used in tissue engineering research so um this is an image here which is i think pretty
cool of and a three d. printed and kidney also three d. printed yeah and sleep today she
and it's also been use within medical devices and prosthetics so this is a passing lies to hearing aid
which and actually three printing 'em is being used to mask customised
hearing aids now for patients rather than um standard technologies
and every that fabrics and see potential it is in a three d. printing of
tablets which sounds quite futuristic right and the actually it's it's a massive reality
and says sebastian mention the f. t. a. um approved about first three deep into top that
um a couple of years ago and actually where we see um three d. printing benefiting
um from c. to cause is actually with impasse citation said the f. d. a. approved
top that did it for mass mass production they took a standard three deep into
and they made a big scale process they can produce many the same types of top that's
now well fabrics and what we aim to do is try passing lies treatments instead
so this is an image here of some of our top let's they've actually
got madison inside days but we don't call them three deep into topless
we call them friends that so you've had top lets you fat cat let's and now
we're gonna have printed really improving common to cover in the next few years and
so i was um was mention fabrics is a spinoff company um from you see elsewhere uh a relatively small startup
and so with germany within the research and development phases at the moment say what i wanna share
with you today isn't the research we've done and some of the potential applications for the future
so and the main question i always get offices how do you three deep in the top and so to make a a
simple i'm because i like illustration i have come up with the
three d.'s of three d. printing every week or so
if we wanna make a a formulation essentially we always start off the fast the witches design
so um let's say we have an elderly patient who perhaps
console of a normal um sighs casual a top that
what we could do instead is design um using computer aided design software
and or disposable formulation in that instance up that like a like a fellow
and we essentially create a file which can be read by a three d. printer system
so we know we want it to look like the next d. is develop so now
what we want to do is make sure it's gonna perform um acceptably within human
so what we have to do is select that like correct exceptions and also this the crack printing type
and then the final d. is dispense so the three different is that we have it
fabrics are actually very very small you can that you pick one up and
but it where you want essentially so how we see it is perhaps we could
take a three d. printer but in within a hospital or community pharmacy setting
or even in kind of within hard to reach areas to enable on site front
no production and always right in front of the patients very are if
and really as i mentioned this and drives the use of past nice medicines so
that there is a need for personalisation i think everybody in this room would agree that
we all different we'll all different ages different genders on different medicines different disease types
so actually the way that we treat people why one size fits all approach doesn't necessarily always work
no i'm not saying for a full madison's three d. printing would work for example for mass manufacture of power c. to model
it's never it's never gonna overtake that in terms of um cost effectiveness
but where it could help is in those satin patient populations such as the
elderly or very young also in kind of complex disease states as well
and so i just wanted to go to some of the motivations full three
d. printing so one of the main ones is around days flexibility
so conventionally as i said when we must manufacture topless will
produce thousands hundreds of thousands of exactly the same type
and the be fixed ranks fake shape fix colour fixed size fix released very far
and actually you that often leads patients having to maybe split top that so even crash and
way out how does to get their exact days that they need to which can be
pretty dangerous on is um been shown that if you break satin top let's then
it'll maybe effectively nice profile we might not be get an exact x.
and so and so okay and say with three d. printing you cannot she one of the benefits as you can
to pause a set amount of material so you can change the days based on the shape and size
so this is an example of one of off three d. printer is actually it was um developed previously as a um
candy printer so we're collaborating with magic candy factory and what
we're doing is we're developing formulations impinge up within it
so what you just so on the video is the pharmacist had a truckload it's a range
she's incest into the three d. printer and now you can see this range had to be
pushed down and out the other end is um the the material which has been deposited
and essentially these trait tuple top that cities are very acceptable
for um pediatrics and we're actually conducting a clinical study
at the moment in austin in spain which is using this um technology fall and treatment of a right disease
so one of benefits especially with this technology is it's quite it's quite quick this is also another
question and we always go how how long does it take so um with this um particular
extrusion based technology we can print we printed that you tablets in around eight minutes and which
okay compared to mass manufacture isn't very very quick but for personalisation would um be sufficient
okay it's the second motivation would be around essential lies production
and so as i mentioned that quite compact you can put it in whatever location that actually you want and
even we've and conceded taking a three d. printer not you put in up in space so and
nasa actually had um one of our um academic papers on the table and we were a we've been
in communication with them essentially to um try and start three d. printing methods medicines and space
and also kind of it in hard to reach areas had disasters owns um waugh ami counts
um but they don't really ah ah m. i. where we see the may
benefit been is within pharmacy and within the host one community sectors
suicide is around patient centred design so one of the benefits is that you can
choose the shape the size the coloured the taste so if your son
wanted his medicine to be a purple dinosaur which tasted like lemon and how
to paint i we could we could um we could theoretically do it
um so essentially it's around trying to make um taking medicines more acceptable
um it's about designing the medicine for the patient rather than just given the standard one i assume that they can take it
and we actually tested this concept in and human volunteers so
one of the benefits of been a spinoff from university is that there are a number of students
q. um i'll willing to try all three deep into top that's um so it's actually what we did is we printed
tablets of different shapes and sizes i wanted to evaluate how acceptable they wear to swallow and also to handle
and that's what we found was that the doughnut shaped oh i'm actually really acceptable which we didn't
and we didn't relies and also the normal happen and um top shape where as well
okay and finely and you can create these unique and complex dosage forms using three
d. printing so i'm just gonna give two examples because of of time and
and um essentially so with the elderly population amplify on c. can
be i must the problem so it's defined is taking more
than five medicines but myself as a pharmacist i have wants
to spend twenty eight different medicines for the same patient
so that's a minimum of twenty eight different formulations they're gonna have to take
it day a minimum and and this can become confusing i mean
if i was on twenty medicines i won't be able to keep track and um essentially with three d. printing what you can do
is that she and dispense more than one jerk into the same top let's say this topic here
is a um madison which has four different anti hypertensive this in and they're clinically relevant basis
and um it's actually we see this in um something tell madison's acceptance in the future
you can take it a step further you can even personalising forty files
so if you german offering a german flat his spanish different spanish fly i'm sorry i
haven't i haven't done this slide yeah the next time performance i promise i well
and also we're we're kind of struggling to make the u. k. and us save a you know watch watch this space
okay another example i want to give you was of um we can create really fast dissolving topless now
i'm not sure if decisions much to you but me as a formulation scientists
is super exciting okay so and essentially what we've done is the the
image on the top right is our three different to top that some because
the technology we've only got loose particles almost just superficially pound together
what that means is when you put it in a few minute walk to it just rapidly disintegrates and um
it's actually civil patient alternated it disintegrate very very quickly and the standard limits is it's three minutes to
be class doesn't already disintegrating top that we've done in two seconds think yeah it makes me excited
okay so there's gonna the the four main motivations and essentially um
we see this as i said being widely applicable to that patient populations yelling yeah on and
off the complex regimes and we hope to improve medication adherence efficacy and reduce side effects
so this is our vision okay i digital pharmacy era so
perhaps a patient will have a therapeutic need maybe
they will have um information about the blood pressure will
from certain applications we've discussed today to collect data
and um that data can be used to send to a a clinician you can create additional prescription
that could then be sent to um some these design that formulation and sent to a three d. printer and
then that um three even to get them past lies at madison be administered and the cycle repeats again
so this is our vision i mean it comes across a number challenges especially around um regulation
but as as a company we are talking to regulate agencies and trying to establish what requirements
uh needed from their side and what we can do um to help the facilitator
and find an overly touch net but i wanted to mention that i
know that this technology doesn't quite futuristic batches a reality in
is the news impact is um so ah sprees hand by preserve
pharmaceuticals as i said most manufactured reprinted top that so
there's more more research coming out every day sharon the maison opportunities that reprinting could bring 'em
so i sent you about were quite to come together and that's why it's kind of a plan should be in at this conference 'cause it
means i can talk to and many kind of people around the room
you and can maybe suggest different uh areas all different ways
that we could make this company uh successes actually um and i just wanted to highlight a couple of papers that we've written if you're
interested and around three depending pharmaceuticals and i'm happy for for any questions
and if you have any thank you for this thing and
no sorrow for the for the presentation
thirty question too forceful uh_huh look groups
you know it's like you for your presentation on your show some
warm body of three d. printer and we can you go
everyone use gonna be of our motion you know um you come you don't make drugs uh_huh so
all those who abuse is going to be regulated
by the country's uses the important question
one hundred percent is certainly an important question and so actually did to
anybody in this room could probably buy a three d. printer
and so what we're trying to work on as well is anti counterfeit matches so if um for example would
be we would reduce the top there and then transport that to a hospital for patient to take
and then used to be a way of ensuring that that probably is genuine that's somebody hasn't just manufactured it and and shit at that
and so that's kind of what we're working on and we were using kind of non invasive tools to try and do that
also it's gotta come from the regulate tree side as well so
regulator agencies got to always in a way we regulate um
like the types of three printers that can be used for pharmaceuticals but also um as actually just to ensure
patient safety so i do agree with you i think it's it's a it's a major um challenge
little portion last fall uh_huh
just what what what is going to do both
low low low vision hold who preserved to
prison for instance results comparable to production
and so what do you mean so i mean it instead was ah okay like buses go
to to hold knew who the problem for some for instance was almost from from lucian
is yeah i know well it's it's i mean it's a risk isn't it but i mean with three different
is in general you can print for whatever you want but um i sent you that's nice be
a way of ensuring that that that time page anyway nite doesn't that contains right second so we've been
working on a tool which can um tell you how much of the job is within it
and how much of a sequence of within that top as well so it can farms and ensures patient safety
um before it would ever be administered so that's what we're working on as as a company as well
uh_huh and so i'm using inspectors topic methods essentially is is the device which has
a light it tells you about the composition of that top that you can
create a model in the sense that model tells you whether it's genuine of
fake and how much of each company out each component is within it
yeah well well well the idea is to incorporated in the three d. printer say these devices a very very tiny so we
would like to put one inside of three d. printer ink of a that is a genuine goes slower slow do
so of course both proposals for mo versions
so data security you mean all around the shows i was yes
only to be kind of security measures in place yeah
yeah so the idea is that somebody will will design and design the formulation kind of
on site if you see what i mean so that'll help design not there and then um
the send you don't be printed for the patient on the monster kind of a single
step process in the way rather than being designed also also be like a
pharmacist or dispenser would would design as they would be interested with

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Conference program

Mots de bienvenue
Sébastien Mabillard, CEO | Swiss Digital Health
15 June 2018 · 9:07 a.m.
Mots de bienvenue
Victor Fournier, Chef de Service de la santé publique | Canton du Valais
15 June 2018 · 9:11 a.m.
Mots de bienvenue
Jean-Albert Ferrez, Président | Fondation The Ark
15 June 2018 · 9:19 a.m.
Mots de bienvenue
Laurent Sciboz, directeur Institut Informatique de Gestion | HES-SO Valais/Wallis
15 June 2018 · 9:24 a.m.
L'écosystème d'innovation ouverte du CHU Sainte-Justine: une grande communauté gagnante!
Kathy Malas, resp. de la Plateforme de l’innovation et des Fonctions des maladies chroniques et aiguës | CHU SAINTE-JUSTINE (Canada)
15 June 2018 · 9:33 a.m.
Les livraisons par drones : vers une amélioration de la logistique dans le domaine médical
Janick Mischler, Program Manager | LA POSTE SUISSE
15 June 2018 · 10:07 a.m.
E-health et intégration des soins
Marc Cikes, CEO | MEDBASE ROMANDIE (Suisse)
15 June 2018 · 10:32 a.m.
Questions réponses
Remi Gauchoux, Business Development Director - Carenity
15 June 2018 · 11:46 a.m.
Futur de la santé mobile
Dr. med. Patricia Sigam, CEO & Co-founder, digital Med-Lab
15 June 2018 · 11:54 a.m.
Democratizing Data-Driven Medicine
Tarik Dlala, VP Marketing, Sophia Genetics
15 June 2018 · 12:14 p.m.
Ada inside
Vincent Zimmer, Ada Health, Berlin
15 June 2018 · 12:39 p.m.
biospectal, the optical revolution in hypertension monitoring
Prof. Patrick Schoettker, CMO. Biospectal
15 June 2018 · 2:06 p.m.
3D Printed Medicines: A Digital Pharmacy Era
Sarah Trenfield, MPharm, Senior Formulation Scientist, FabRx Ltd.
15 June 2018 · 2:23 p.m.
The Digipharm experience
Ahmed Abdullah, CEO & co-founder, Digipharm, Basel
15 June 2018 · 2:45 p.m.
Enabling the rehabilitative revolution
Dr. Manfredo Atzori, HES-SO Valais Wallis
15 June 2018 · 3 p.m.
Team Gamified Multi-sensory Stroke Rehab
Jean-Luc Turlan et J-P. Ghobril, Lauréats Arkathon 2018
15 June 2018 · 3:22 p.m.
Secure and Trustable EMR Sharing using Blockchain: Open Challenges and Lessons Learned
Alevtina Dubovitskaya, HES-SO Valais-Wallis
15 June 2018 · 3:38 p.m.
Conclusions
Sébastien Mabillard, CEO | Swiss Digital Health
15 June 2018 · 3:59 p.m.

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