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Milk and immune competence in prevention of allergy and infections
Carine Blanchard
Monday, Sept. 23, 2019 · 4:31 p.m. · 33m 29s
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if you're putting to talk today to you so it's gonna
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be hard task after this c. thirty six a very nice stock
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for me to do as well as it yet but also to avoid overlap because a lot has been said already i try to
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um don't get to scare the phase swipe some slide i quickly it's just to avoid about that
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so um at that time in the day you might see
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you all and agreeing with me is that there is a very
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strong relationship between nutrition micro by your ta in the immune system
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and he's um interaction actually has been highly studied
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uh in the context of um allergy and um
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one to which is key in the context of michael by that that is that and i'd really like this statement
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uh is that never before in human history at begin children brought up so cleanly
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uh and actually what if they spend say you heinz that we are
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becoming very by the host want me crawl with um which is are you
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combine scenes between the mike about type but this isn't the hygiene
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i put this is leading to this non e. increase non communicable disease
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and and that's gonna be very important in the context
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of a breast feeding of course because since nutrition in back
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i my quiet time michael by the time packed uh
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so you nancy stamp all of these been connected breastfeeding
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uh he's really one of the main uh things that should
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be steady in the context of beep in prevention of disease
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and uh it's very importance to do things right
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from the beginning like yeah and evaluate just mentioned earlier
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and there is a lot of inferences are of a microbe your uh and my quiet time general
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and as he's actually uh has been described by numerous paper
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this is just a review a publication that's true some of them
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and uh all of those i've been using more less to um is
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there increase risk for disease that just infection or increase risk of energy
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uh we know that some of these um in front can actually be modulated by
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breast milk or reading and one of them for example each monday could because like right
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so and this is it a a an example i like a lot i'm looking at c. here a call
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for where you have a baby switch up on from c. section and e. d. which are of action you delivered
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and you actually see very nicely how uh actually use this section born are very
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difference a micro by attack compared to the one which are back journey born in blue
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here is the population actually had been also separated insight group we just one which ah
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from the most which are able to do with facts to 'cause you like tools
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um and the the one that we are not able to actually produce that impressed me
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and you see a very nice e. that actually is a a or range population here is awake
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rose or uh to the blue one which web on that you can what it shows that is that
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specific oh you mean you could get set right actually it to with that even the mozambique and actually
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um i love hate in part the effect that see section uh could have on the get my combine them
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and so you might make a a only go slack right is of course a big parts uh
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of a breast milk but i'm not in the going too much detail instructions we we talk about in three days in two days
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actually i just wanted to say that it has
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been extremely difficult in the years before to actually study
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the beneficial effects that uh it is a human it could it was like i
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could have and hers because we do i'm not actually able to do a intervention study
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this is one which was proof um don't very recently that kind of come from
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what has been shown in a lot of obsession study that there's a trend that oops
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that um there's a trend toward a protection when you actually
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uh supplements the babies with a few 'cause we lacked was
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um the second example is really seem you know in this
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example is it has to be we also supplemented to speak
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to too few 'cause you lacked was and you can see that in this baby actually as just implementation lisp every in and
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less use often type by it takes but are still
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a lower risk for um respiratory infection specific respiratory infection
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this actually has been also shown in new there is um pretty neat and data and
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hates just to example one is a vaccine model uh against the flu vaccine modality mice
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and yeah you can see and then we'll go back to it
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later a very nice actually does response of as as you can edition
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we use it as a h. m. o.'s but what's interesting is actually there is an optimum those
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and then if you put too much actually you lose some of the uh if you guess each of the um h. m. o.s
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and yeah it's another example which is we don't hear to model well we actually infect mice
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with um through uh adapted for new reno um species
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and actually uses that says h. m. o.'s we're actually able to
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protect the mice against um the system towns which are associated with infection
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so um we have to keep in mind is that um the maternal um
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would foot two inputs remaining lacks the possibility that the most uh highest we actually
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expressing meetings that contain to focus like to the switch because it lacked
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was um can actually is actually leading to the genetic of the most it
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and that's quite important because it genetic of the more they're predict how what will be the quantity of uh
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sorry the quantity of because you in the in in the
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mic and and it's always very important to actually look at subgroup
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in the most as that in the press me that ten secrets safe because you lack tours
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and the ones that tend not to actually uh understand data what is associated with what beneath it
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and that what we did in the courts from dachau and
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the side was provided to me by um is the opinion and
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and what we actually have found in this um cool or what
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is that actually student more says that was expressing because
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you lack too so that we have to put it
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um where actually um i've been big keys
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that we're protected at six months i'm against um
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again as respiratory infection and that's quite interesting when you look at that that six men think that a lot of these
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big you actually exclusively breastfed up to six months but what
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you don't wind attentive actually to curse words in a sense
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because it's the most there is actually nonstick ritter there is a change of secret as
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there is a change to the baby which carries a gene of secret and consecrated to
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and we have to keep in mind that we actually adding to a new slayer
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some and motif of do acquisitions that's really also a at least two because
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you um group and actually when we segregate the population by as a genetic
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of the fence yeah we see some quite interesting uh record that actually shows
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that at four months of life the maternal invented to foster's facts that you
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was i inferences differently as a protection against infection
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you see clearly here that actually in this group in
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the infant which are a negative competitor in things which are likely to get this invested core a protection
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uh which except thank you driven by the genetic of the infantry dozens of presents it
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minus ten she's ready to keep in mind that we are really look only
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seems in file most of the time when breast milk and we are actually um
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misled the by i'm not necessarily knowing all the cum folder or studying all the conform does
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the candy asses city is always the benefit was the actually love is that we are looking at
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um it's just to summarise is that a lot of things as being shown on uh the role and
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function of h. m. lies not in the good sweet it's we certainly taken care of in two days
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um i'm just gonna uh really a straight on the fact that we need to consider also the
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host genetic of them was or end of the cheats when we actually look at this association study
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and what i'm really interesting in the context of breast milk is actually a hard edge
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and um we just uh discussed yeah yes that's a an edge an introduction is quite tricky
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and uh and in the context of breast milk on the top
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of it i mean should we acts crazy prospective six months and avoid
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early introduction should we um uh introduce lecture values said very rarely like the
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new leaps that you tend to mention that we should start at four months
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yeah it's create a lot of confusion and we really need
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to study more how and when to introduce decided and of course
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um that's historically in i mean that we have been avoiding a chance for actually pregnant was there
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and during lactation and that's quite actually set any misled by the fact that
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i breastfed a big he uh actually i actually to human breast milk that
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contain an agent which didactic i mean you need avoidance for sure now what's
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uh i will talk a later in my talk is not necessary preventing
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the symptoms of energy batteries preventing the sensitive vision itself to the allergen
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and uh why it's important to look at it of course it's because i mean i imagine that's a australian data
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and the x. thing to egg energies nine percent is appropriate infant population in time of prayer and sweets you which
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uh industry yeah uh and you see that uh it's still increasing we don't know when it's gonna
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plateau but estimate says that in few yes fifty percent as it was try and population will be allergic
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so it's quite a a very important topic to tackle um
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of course um and uh that a mentions that earlier
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i'd edgy the unions you seventy mike about that has been highly linked to get going to in the church
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and here you are one example showing that actually if you have a gem free mice
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uh it it actually have the underdeveloped immune system because it
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actually wait for the mike about it that gets stimulated and um
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and uh efficient and he's actually just in this i would say absence of
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exposure to micro by that are also leads to a immune dysfunction i would say
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uh in this germ free mice and one of them is of course the uh it
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leave each elevated level of a serum i. g. e. on tight body in this uh
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heard a model which are devoid of uh mike about that
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um so as far as um h. m. all uh in breast milk
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and um i had is that what we actually uh try to study uh during the last yes
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and this is one studies that's uh i'm sure
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ones that actually uh if you look at um
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as a different composition off to because you lactose impressed me based on it's the most of consecrated or not secretive
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uh you actually would find that uh you have some kind of
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protection of guinness equator most there but only in the big is that
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quest section born and that actually do that very well what i was
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presenting earlier is the effect of twisted can have on the micro vita
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uh i love eating this difference between see section on infants conventionally diverting funds
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so um we have actually tried uh in the last yet
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to a steady deeply a human built in the context of vanity
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and we were lucky enough to be able to access to
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to court so one that we can see doesn't exploratory court
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and so one that we wanted to use as a a culture that records and any finding
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would find in the first one we would actually checking the second one how the finding shows
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and it's too cool what where uh actually um corpus it i've tried courting germany
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in collaboration with lipstick university and one in thailand uh where we also obtain abreast
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most of this quarter will show you a later have advantages and limitations of course
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but on the right of the slide you have all the different component we and then i
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uh it's only part of it but got more than fifty um and the goal was really
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to school board in the um i would say and reactive i get kind of analysis to actually
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uh try to find interaction that breast meat component could have you know we got allergy
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so the first court is a german court and uh
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we actually had one hundred fifty six modelling can pay us
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uh we have three points of collection that's three months six months
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in twelve months where uses the inclusion decrees of course of of time
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uh we uh actually the yeah a quantified more than twenty five and twenty five h. m. o.s
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and um we actually had admitted that was the components
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we haven't quantified hydrogen also in this call in this uh breast
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meat components and uh to tell a. g. in the most anti cheat
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as a time like this court's hair was extremely well so that junk what it was based on questionnaire
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uh to the parents the ways that i that he was um was actors who is apparent we
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ask ease your infants a clinically diagnosed these energy
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for the energy x. emacs interested but it was really
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parents reporting what's was nice and despite cool court is that it was actually clinically diagnosed
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and a very well um allergy walk was done in this
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population limitation we have here is actually the timing of collection
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uh was actually very difference i'm i'm somewhere collected very early on in
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the first one and somewhere connected after a one year even almost two
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so we had a very large distribution uh use um in the
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collections which created did bias 'cause the components impressed varies uh with time
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and uh we perform analysis so he actually show you
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um coalition much weeks you will get no she said
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out of it except that it's very complex to not
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um because you find all this red dot to dot things it's
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positively correlated negatively quite good and you can look at each dot
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and actually find some sense out of it and yeah you have to just be tell one digit that too i ga
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i mean the literature i've shown before that's those we are more or less quality to design breast milk
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so some you can really fine i'm a rational behind
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them and some if actually way more difficult to find something
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and uh so we actually asked a very smart statistician to actually was at that time
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the different way and to actually found based on this coalition and a lot of uh
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a statistic walk behind to fine uh how the
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the breast meat components well actually interacting one with user
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and what you see here is actually a pullout switches generating in
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c. d. called base on the uh look that we haven't breast milk
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and each uh individual components is actually link to all the other one and then the question i asked
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is it the best way to link this to compliment all easy to bake better way is there is a bit away the line is removed
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and yeah you actually end up with the lines that expend base for the coalition you have
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and i think it's a very interesting it was used in a a social network genie in a
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political and economic and a field but never necessary
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in biology and it actually created very nice a tool
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to create a new hypotheses around um breast meat competition
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and it's a show for me very nice to see how complex breast milk interaction he's because it's not one
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a component that you look at in relation to high energy it's actually uh makes very complex of a lot
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of companies that interact or to gays or any fun is moving it said ten is that a lot closer
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around actually going in a video posey toss me out direction
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i'm from i'm doing this and that is is we've
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actually also wanted to do in evaluate analysis of the regular
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and then this is where would we take each components and we look how associated it is with allergy
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we're not starting from scratch uh some publication wear out there and this is one of them
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uh showing actually is that for example and that if history is associated with cows milk
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allergy uh any any disregard that you see he is associated uh with the cows milk allergy
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and um we also had a nose there uh take their set was actually
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showings that if you doing evaluate analysis and you look at children
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since the decision actually there is no seem necessary that you would find
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that's what's the use the paper say in between the lines there is
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one sentence that's actually lower level of twelve fed where actually associated with
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um well i'm in prevention of energy which does to sing
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first the association between allergy initial might not does actually me or
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and um the second thing is that uh may be tasty
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association is we did a little bit further into the data
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and if you remember early or not was presenting the slide on infection and that i
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washing a very nice actually better shape reaction showing that you have an effective those which is
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protect uh and the rest actually if you put too much structure did was the protection
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and actually when we get into that that that is something similar that we actually found
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and we wanted to test that uh you know i'm sorry i'm just go back yeah so before that's testing it
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i just wanted to say that we also look at the genetic of the infant and how that would actually influence uh
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energy in the offspring and we actually identified that some snip here again
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where i've in that instance use the um cluster of puts three jean was associated with some
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kind of um um um research to develop
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allergies and this is of interest meeting foot three
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and the interesting thing is that when you have a mutation this foot three actually have an increased level of
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twelve fair because you don't make for three anymore and you have this increase developed within which is a compensatory mechanism
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so here we wanted really to see easy it's the genetic or is it really may resume
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to the gene i mean says it to f. l.'s that is protected so we test in mice
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um in the mice model and yeah we use kingston situation and
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that's we discussed earlier as a model to actually test our hypotheses
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and what we found and which are shut show you that that time sensitive action is that actually
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um is a mix of um h. m. o. able to at one percent were able to protect again
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uh i actually solicited session how have or is
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it beneficial effect was lost at a higher doses so
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we really needs to actually be very smart when we look at such complex ingredients
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because utility it doesn't function like a regular provided takes the more you puts the better it is
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uh in my section is that usually what we see was probably provided expect you we actually have a better shape um
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four and that was actually a troubling yes because we knew
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from prior that ah is that um that we did a few years back is that
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production eight for example was right when you feed mice with propane they'd already feeder mice
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which is um fibres you actually protects against
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a sense decision and also a link information
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so basically the two that are we are not fitting together and that um we just
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check what was going on in the context of micro buy into instruction fetch s. production
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and here is the height yeah that was still over products project so we don't have a drop of propane it with a high of those
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but we do have a drop in sun city station which
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we are actually not necessarily expecting so we looked at um
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that was their data out there and we found that in
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the context of a foot allergy action was already being tested
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but it was a month there wherever they were using um i'm in taipei would take
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the necessity session so we said any press treatment not prevention so we said okay maybe
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we can actually look how uh or or sensitive issues this
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time uh would be prevented by uh h. m. o. exposure
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and here we were thinking that maybe in this mode that we will have a dose
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response effect of the h. and one who would not lose the effect has hired those
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and what we found actually is actually very similar are a kinetic
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well actually we lose the effect that wasn't hired those so um
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it's very uh interesting for has to see that actually the
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and fox peace re regulatory um and says well actually following
00:21:09
so as a protection we resting with the sensitive vision but it's really tell us that you to make she
00:21:15
um it doesn't walk is the same on every system and yeah it's a necessity stand that we look at
00:21:21
it's actually a n. c. p. t. one detections the serum and
00:21:25
yeah you see that actually it going down on the b. r. bases
00:21:29
so we had this very um surprising interaction with the immune system with this
00:21:35
h. m. o.'s that we have still trying to understand how it said walking
00:21:40
um that's a a two that night she may say just i want to convey that um
00:21:45
uh we always need in the context of breast me to see the larger picture to look at the host
00:21:50
uh what and try to find all the conform there's that could really interfere with the systems
00:21:56
um as we i've seen that h. m. o. such asked with an identical
00:21:59
decrease actually allergic sensitive vision that regulatory t. set might be associated with this protection
00:22:05
that's however uh we didn't find any effect owning information which is very surprising if it was just that
00:22:12
provided take effect so there is something more something very specific about action without any
00:22:17
that we don't understand yes and we are working on it and
00:22:22
that's yeah i think it's very interesting to what i'm too
00:22:26
to understand that um what we see with h. m. was not a simple privileged effect
00:22:31
and they're starting to direct and indirect effects on the immune system that we don't uh
00:22:36
uh understand i'm really well and here is my acknowledgement slide a lot of people are involved
00:22:42
uh in the study i showed uh some collaborator it when
00:22:46
i get sick was the access to the uh basic centres
00:22:49
um as a uh infection and a l. way a disease uh where uh
00:22:55
uh from cool water thing from a international centre for direct disease reception bangladesh
00:23:01
and uh sit tight and a cool what was obtained from a shoe
00:23:06
law room come in your city thank you very much for your attention
00:23:13
yep
00:23:15
so which can learn or with her from the simple and quite a bit of time for questions
00:23:24
just very nice presentation is there any beta arm or go back to the cows milk our g. children
00:23:32
is there any data or picture mall competition in breast milk
00:23:37
of infant or mothers of infant would develop colour work our g.
00:23:42
yes there is one state d. that's a a show that i think that the only one in humid
00:23:48
that shows that there is three action with that stand out as protective for cows
00:23:52
milk allergy um and one in particular which is a standing still after confounding factors
00:24:00
but i miss that a use for example would do show or what exclusion repressed for
00:24:06
however very developed cows milk allergy desert h. m. o. competition there for
00:24:12
from other cute who might be at risk but do not develop cow milk allergy it's
00:24:20
so i just thought ha malls that's the only that that
00:24:25
is a study i shoots and that's the only one out six
00:24:28
uh showing a little bit lower level of uh ellen if peacefully
00:24:33
uh in the children was that's where a allergic to cause me
00:24:38
so the observation enjoyed the beckons a newsreel so to learn to four hundred
00:24:44
you mentioned it to so we're due to to serve would work and
00:24:49
due to the the colluded to souls which i've been up to get rid of a lot of other
00:24:55
no disease process so that we could do that would you can look at uh we actually
00:25:01
to the only group that we got to your t. cells we we are actually opening liked
00:25:06
uh what we usually see with this um free but you take effect in increasing surrogates every
00:25:11
do was with a bit of very those dependent but we didn't get anything if it worked okay
00:25:18
what word do the more clothes for a large shoes to mention use it
00:25:24
logic workgroups for us to use u. b. m. to so existing
00:25:29
with that we looked at a lot of 'em clinical symptoms that
00:25:32
we have the skins call we asked for that particular what alice
00:25:36
them there we have mass selling feature shunning the skiing that we have
00:25:40
uh so we looked at a lot of things and we are really trying
00:25:43
to put the pedal or to be there to see what components i mean what's
00:25:47
um compartment of the of the mouse react differently to the different um
00:25:53
to just send intervention utility because it's it's a model where we can have the
00:25:57
line is a scheme that gets information so it's allows to actually have a very
00:26:02
a nice model to dig out the differences um
00:26:06
in them of targeting all idea again targeted for
00:26:09
the protection and it seems there is there is there is there a lot of discrepancy compared to
00:26:14
classical um results that we with obtaining this month and so it's quite interesting
00:26:20
oh oh do you question so
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just
00:26:26
yeah sure frank remote emperors thank you for the wonderful presentation how
00:26:31
many farmers to draw from the stories you sure can humans you
00:26:34
only have three gone systemic or or simply don't care of a
00:26:38
marxist wouldn't causing the problem i think a particular to build your
00:26:42
or postponement crusoe animal more mature folks also citrus harlow traumas from
00:26:48
the modern colour mechanisms to all come problems so or arm to you
00:26:55
your animal mourns for for your other true top you read
00:26:59
through soon humans with regard to the problem of haitians although
00:27:04
conversation also for the film creams which was discussed before up
00:27:09
to post your offices so even is that what's yeah put this
00:27:13
is was the i put this is was scanned we decrease was it easy strewn with h. m. o. in analogy with it
00:27:20
we tested to we can decrease the sensitive visions of his without skins
00:27:24
on the decision of gets on the decision it does walk testing policies
00:27:29
yes we we had only model actually you can have
00:27:33
um and we tested them and now of course i mean they are not the fish unflattering uh
00:27:39
as the one we put the patch it's actually two in pairs of by and for sensitive issue
00:27:44
so it's a for solicitation mice or the myself the same genotype we still have you
00:27:49
know outliers number them so but yeah i think it's more it's um it's part of that
00:27:54
of modelling disease and modelling and nutrition it's quite complex
00:27:59
and we can only have a little piece of information not spies immunology is concerned
00:28:04
uh rodents and she was mentioning uh send her
00:28:07
affection for over read dante's is quite um uh um
00:28:13
well recognised for the immune system now for at the pig
00:28:16
vomit i tease of for milk allergy and a clear clinic i've
00:28:19
seen times um can we translate sat in human i we don't
00:28:25
know we would have to do intervention study two twenty of course
00:28:31
course shoes comment
00:28:35
just
00:28:42
up at the packing usual from start it's critical starters shows to do stuff is
00:28:51
to put troops are you you mentioned
00:28:54
re infection or a secretarial comes sorry you mentioned that the actors yeah uh oh sorry
00:29:02
this was just so if you start to correct and of
00:29:05
usual briefly infection but there's you know like to chew one
00:29:11
so i see no income of prevents us you know the terms of prevention one sure that's true yeah
00:29:19
oh associations was whoa oh one sort of yeah i i don't think
00:29:24
they we have seven groups similar might be because uh and so less difference
00:29:30
uh i don't i don't know i i would have to check with national hustler yeah eventually uh oh
00:29:45
wow
00:29:55
yeah
00:29:57
to use this one um it's twenty three percent this is eight
00:30:03
and this one shows other issues it's difficult to uh one two
00:30:09
normal use external to the previous show which will show this one in a fashion event
00:30:16
that are yeah there are some no this was yeah it was yeah yeah of course but
00:30:24
okay
00:30:28
you'd all
00:30:34
oh wow who want to comment at all about
00:30:37
the group brought him or or or or just remember
00:30:43
probably will remote rural speech you know all the ah m. capo current version to conclusion hurt
00:30:52
for sure uh so there is there is thirty showing that there is a lot of geographical
00:30:57
differences i in actual position uh as if it was one of of course are part of that
00:31:03
uh it's always important to good sensitivity because j. t.s knots is
00:31:06
there a partition of this nips on that's require according to the geography
00:31:12
um and even the ones that's company yeah a little band this use um
00:31:18
a rural parts and showing differences in actual position
00:31:22
yes yeah well not control fortunate because it was it's always
00:31:25
very difficult to know what's confirms environments that confirms the genetics
00:31:29
but yes there is a there's a lot of violation across a geographic
00:31:34
but also across um timing when you actually collects image and that was a big issue we had
00:31:42
here in the tie cool what well yeah it's a collection of different time fun because some actually fall down drastically
00:31:48
income of concentration beef between you know the first week and the the off h. so
00:31:53
yeah i mean viability is huge um hi i'm even but i have a that
00:31:57
but i can show you one with the repetition which go from zero when
00:32:01
you on on sea creature to five thousand so five five gram to heater
00:32:05
so is it and you have the whole spectrum in between these average for example in the tight cohorts
00:32:11
with l. was average at one point three gram and in the german court it was one point nine
00:32:17
image also it's made young one constraint one point nine so oh yeah as a
00:32:21
as a major already there is quite a lot of diversity between these two court so
00:32:26
yeah viability you use the it's it's quite impressive but it
00:32:30
it's quite interesting to to understand what is really necessary and
00:32:35
coming from the adaptation and we need it's off survival somehow
00:32:39
is not yet and generation of evolution and what is actually lecturing
00:32:47
which the limbs or most variables vision to home so
00:32:51
h. m. o. or show any no reno off short
00:32:56
reporter go perfectly one individual should cruel shorten chaucer which
00:33:02
sure sure sure sure remote which are really form or whatever uh_huh i agree i don't know
00:33:12
oh okay or to retool good solution for the knowledge of look uh look to shun under
Conference Program
NNIW94 Opening
Dr. Natalia Wagemans, MD
Sept. 23, 2019 · 9 a.m.
Dedication to Lars A Hanson
Pearay L. Ogra
Sept. 23, 2019 · 9:10 a.m.
139 views
Key Note Lecture: The Evolution of Lactation in Mammalian Species
Olav T. Oftedal
Sept. 23, 2019 · 9:29 a.m.
678 views
Immunology of Milk and Lactation: Historical overview
Pearay L. Ogra
Sept. 23, 2019 · 11:01 a.m.
450 views
Common Mucosal Immune System
Jiri Mestecky
Sept. 23, 2019 · 1:03 p.m.
446 views
Immunomodulatory components of Human Colostrum and Milk
Helena Tlaskalova-Hogenova
Sept. 23, 2019 · 1:57 p.m.
481 views
Influence of Breastfeeding on Immune Trajectory and long-term Immune Health
Valerie Verhasselt
Sept. 23, 2019 · 3:33 p.m.
426 views
Milk and immune competence in prevention of allergy and infections
Carine Blanchard
Sept. 23, 2019 · 4:31 p.m.
511 views