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Immunomodulatory components of Human Colostrum and Milk
Helena Tlaskalova-Hogenova
Monday, Sept. 23, 2019 · 1:57 p.m. · 48m 42s
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i think i i i i i think it's for this excellent meeting
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it's first of all and uh now maybe i because
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i uh it's a little introduction about the story you
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so i was working as a clinician for
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for two years after a after a medical school
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and then how you move after a two but ah a tool the lap
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well uh yeah yeah i see my i had a and not right
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i i i see huh
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uh i started to to where it in the
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institute of microbiology research institute of jack academy of science
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and uh my uh supply visor and head
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of the department of immunology was professorship that so
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and uh then i think came from uh from hospital he told me
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that he feel that immune system is
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really a battery dependent on our bacteria
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and he the established good not a
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biological laboratory in alice six to use
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and to he told me that i have uh
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uh so well on my p. h. d. uh on
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the role of got micro flora in development of immunity
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so this was a little mine be it p. h. d. study
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and uh it during the uh my arrive i cooperated with
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this a very nice people working in the other biological laboratory
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and the the start date that uh our where our base using the
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animal model of for a chairman furry uh did arrive
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uh deprive the other animals
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a a good not a biological edge and feed bigger that and uh
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i had the the or what you're doing the uh to meet
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the people who'll ever working in the field but uh in a humans
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it was at iowa a lot you know i'm starving copy the apparition in our counter it
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and that professor hands on this home she was working
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and so i uh was involved in
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this study it doing uh and immunological analyses
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but to be did not meet uh before
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that affected evolution nana handsome and he was first
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cool quote to me up the political change in our
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can't they and invite it to me it to a slide
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so uh this was a four hour lap
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very important uh start in the in the field
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and then i met my uh uh a really good
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friends yeah john c. but ah yet also after political change
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uh at at all to me that he which to
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uh spend on sabbatical half an ear in our lap
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and in fact uh and they all get ah hey matt uh saying still using mastectomy
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who was infected working in the same laboratory
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under professorship that so but then he moved to state
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oh then it i i would like only two saying
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or this uh the people who who uh better battery
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helpful and the directed and my research also
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yeah i think i i will not a repeat a big uh things of which of matter
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excellently yet covered by uh i don't know yes we must
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take the and that they all gotta and uh and i decided
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a little select some of uh
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in normal directory in one or more bullet thirty factors which influence
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and the immune system i don't know it's not there
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so uh and i want to point out that uh all all
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in one or more to let that if factors and majority of them
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harder and influencing the and the immune cells directly
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or indirectly by info and sing and some microbe iota
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a composition and function in new bonds
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uh as you can see and uh the main uh um influence
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for the life is that was not i'll be real and they hear it
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you can see uh uh that feeding correct that it's backed is
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mail see uh the the lactation or or how that
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vision feeding is info and think and the whole life
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of uh of uh the uh the infant and term
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i am more to like to start this uh
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as some um factors v. touch in our research
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so uh this where uh mainly uh the antibodies at the
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head the possibility at to cooperate with the idea that a
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cleaning because uh i allowed you know ah and uh we have
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shown that uh in a human crossed the room and the mail
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and there are diverse uh and the bodies
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of as a of videos the specificity these
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and direct it to a tool my total by about the and
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the chance as of uh oh a tool of fruit and agents
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this was uh in hell's say markers a
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few days after they leave at it and then
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the you had a very unique possibility to study uh the effect
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uh of a cologne is asian artificial corn is asian
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of children these equal why a piece every
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in time and then it was possible in our company and
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it the boss uh in introduced because
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of the the outbreak of uh then gyros
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a respiratory infection in net not then our
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hospital in um in a very very hospital
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uh institute for care of martha and one
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child and the guy as that betty operation
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uh i had the the possibility to better be some mountains and child
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beach a bad outcome what basically in this instinct to in this institute
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they offered to a single mother was based financial financial problems
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to all the spent fuel months after daily
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battery in the hospital um and uh they better
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uh_huh able and uh never had a there and
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i get really and uh to take samples for
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on a day children and also all and they
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are may look a bad every other better for research
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so we had the in the possibility uh to
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study yeah that's second at thirty i. g. a. levels
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first ins to off in fans uh at
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the college station all it now we can say
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uh over our administration of non pathogenic role by l. p. equal high
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have also than uh uh in the first four weeks
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uh this uh city times and the administration
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and it was possible uh to start they uh the
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uh the bow and dynamics of a development that of uh
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hi g. a. in uh in stools and i will
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show later also in uh and not and not may look
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so it was shown that a core nice that children
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a matter able to answer by antibody formation
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in a a a in case of a they are
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collins asian base this type of equal line
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and also uh not only those tools and
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then this in finance a better post it if
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for a a a antibodies but also all the said on a label of um
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and these uh uh antibodies there wasn't it mainly
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in a best fat a bigger threat in fans
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moreover
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uh huh
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so this was also and then uh uh published uh
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and that this was done in cooperation based a handsome slap
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so this was uh the uh the main where a curve which was published and well
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that are missing some mm
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i'm not sure what happen that there is a knock the mail
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it's too right
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uh_huh
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i'm sorry i don't know what happened because there is messing around
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uh_huh
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there is missing one slide show a side
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dish showing that also in marked unknown male
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we follow the antibodies again this equal i
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it means is that overall administration on this train
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in dues antibody response against
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uh this stain and interestingly
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yeah it be did not find the equal high eighties
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it is very nice to be travails given to children in
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a uh uh not there now uh in that then house tools
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so it doesn't seem that uh got uh got presents of
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uh all these uh bacteria in the got was the responsible so it seems that
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it was a really overall in one is
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asian which elites tool uh this antibody response
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now have you better interested also when
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routing chris uh them three weeks uh
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this uh uh the the the repair to our of antibodies
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be very interested in so called nature oh and the bodies
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and and we use the as a commander for experimental model
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as i thought germ free it cost them deprived track the peaks
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and professor all gonna uh elegantly showed that part
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of a n. a. most of which are really
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uh a life dependent on cost the room
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and uh in this case we tried to see a
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big ship at all our of so called major oh antibodies
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are formed at the beginning when they are instead rile conditions and
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well our surprise the town portal antibodies
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but isn't in this first primary i
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bet a lot of immobile leans in a germ free because there are big
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so we saw double would be interesting to them all if
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also all such a specific these ah are present in human male
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so all the the you have shown that uh
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uh that uh although and the bodies are present
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in the cost room of um monsters
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and uh it was it in a relatively high percentage
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a ball to seventy to eighty percent of mothers
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uh that uh the shoulder was it a big they uh then uh be a study the the
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presence of what although antibodies in this case using
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him lawful arrest sent and it it the the
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was it a bit the of all its highest uh against the
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overriding the land against and chaotic and i'm better now in the land
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and the other their present in
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the lower a frequency marbles also detectable
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in about twenty to sell they they have sent off from mothers
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so uh be then the use also announcer metals
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uh this is also a the the in one awful
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arrests and uh using current defined a a cells so lines
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and uh be have shown and that the the
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these antibodies better mainly off i. g. eighty two class
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so uh this was a very interesting so we used also
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are the are the next salts for detection for example
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uh the using the in one all bought a techniques
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and uh we have shown that some now we're on our own label
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i'm the chance of the bad available by companies which you can buy
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uh the it had the shown that in uh these
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antibodies specific antibodies on a present that in a a map
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and now it may look a few days after deadly medley
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i'm in a here you can see we used also advice ah and um
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i'm our ice the daddy b. i. g. a. i. d. activity uh in these uh costa
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so it seems that all to antibodies are present
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in uh the repair plotter of a marked then
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our ideas second italy i. e. g. a. but
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isn't in a male can cost the room and
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then uh you can all that uh most of 'em
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uh_huh all file and the and the body specifically levels they
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take the it analyst and they're really a demonstrated against the barrios
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back you deal order microbial antigens um but uh
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that if you will be uh the the papers
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are dealing a base although and the bit bodies present
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in a human cost among these saying it and that uh in these
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antibodies at a cassette uh okay
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good late think activity in developing the
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infants got and it probably as it is discussed
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in uh and uh uh the these papers about
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the neck in a general antibodies and they function
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that say can i really um influence
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uh the immunological development of uh the infant
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uh how the the other uh in one or more directory
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factor of each of the touch a very site all kinds
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and to be like the the new approach we shouldn't have awesome
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uh right now and the possibility to work with this uh
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uh and uh uh a bail libel um
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had a is for example a propane airy
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which is uh you probably know which is
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uh based on antibodies of somebody or specific cities
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yeah but only on a knitter so rules and then you
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can at samples and see the
00:19:04
the activity any insights spectral spectra
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so me a credit card our students in this
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time add the third these uh metallurgy introduce this metallurgy
00:19:20
and the v. a. used it for a a depiction of a burial site all kinds
00:19:28
yeah this is how it looks after a depot
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meant of this uh michael at day and they
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data available in the form of twenty
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four side all kinds and and all kinds
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and also a base a sentiment in nine i think
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and you can see that it's possible then a days
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the the well the monster a uh also uh the changes
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inside talk i inspect arrow head you will incur the double in in a in a mother's
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so uh how uh these uh changes i am hearing
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you can see and we had a samples from fatter they
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uh the coaster on both apple and then for the day and
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and that of course i did not point i'll add that individual differences
00:20:36
it was a really not sold that uh or um on the head
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the same or better is similar in composition of sight all kinds and can all kinds
00:20:49
and the v. chord for all uh the uh the changes
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and the and also um uh so the at high
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is the the changes in concentration based time after dalai benny
00:21:07
now um
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and we have found that very interesting carries out because um
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uh me almost uh uh that for dispersed plus also
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does a and that more reach a andrei and uh
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and for the first time we found some of them
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and uh uh i don't do that and they bear
00:21:41
into it in inter individually very body at the bottom
00:21:49
uh and i bought the was uh the main functions
00:21:53
of these movie detected human mind middle 'cause i talk kind
00:21:58
so all can all kinds at these uh which uh harder and they are
00:22:04
described it which are really uh regulate
00:22:09
interest in a limb for a tissue development
00:22:13
and then uh the other girl a score but uh covering good roles factors
00:22:21
and uh for us it was a price that uh the only
00:22:26
uh also the the sideshow kind and expect that contain a uh
00:22:35
it's such a a good host factors which in for all and uh
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never was system be able men a note of it factors and so on
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so uh i think that the the site all
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kinds are more do a thing not only immune
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system but also all are the very important system
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in uh the development of uh of the chat
00:23:04
and of course and the inflammatory side all kinds
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there uh the main uh uh content
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of a sideshow kind in human milk
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so i think that uh this is and
00:23:22
number a um a case uh showing and that
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the the the importance of uh in one or more to about thirty factors
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in uh in the milk and we believe that
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the yearly all the so called into logical factors
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it is said that uh this uh in one
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on one do outdoor activities even in this antibacterial component
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and others of which are present in costa room and the milk
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uh the last the park didn't last colour but
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the by our corey for a you g. d.
00:24:09
it it's not good
00:24:13
no
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ah i see
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it's good i apologise i say really i didn't expect it so uh we try to see it
00:24:30
and the pun channel capacity of cells which are
00:24:33
present in a in a cost the room and turn
00:24:40
and this was done a user usually by p. c. r. or
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mine detection of a gene expression
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in cost around cells and uh
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be very interested also in the
00:24:58
difference between allergic and healthy mothers
00:25:03
and because uh i i needed no doubt it down every set
00:25:07
high or you know ma b. has shown that the breast feeding influences
00:25:13
very substantially at the head table mind
00:25:19
in your own maybe eighty diseases main it mainly allergy and to buy a um
00:25:27
based feeding but also by column is asian
00:25:32
and uh this this probe while take equal i eighty thirty
00:25:37
a v. a. have shown that even ten years and twenty years
00:25:43
after all only station of uh children uh many a little snap alley
00:25:50
influences and the development of allergy
00:25:54
and it a boss shown and published
00:25:58
and that it has been haven't they've uh and inventive activity and them
00:26:05
i usually a scone thin we get this
00:26:09
or collaboration this uh these institute and hospital
00:26:13
and the s. out eyesight or the a. is mainly using v. c. r. and tools
00:26:20
study the gene expression uh in a cluster
00:26:24
of cells of how we'll see an allergic martha
00:26:29
and he has shown that uh and uh uh functional test
00:26:34
activity it means after in vitro
00:26:37
stimulation is variables immune stimulator us
00:26:42
so call only cool no in a a political activity parrots
00:26:48
there are not the difference between the response
00:26:53
often and the and the and the uh allergy can mark that's
00:27:05
uh what was shown a boss a higher
00:27:09
gene expression of th to lose sight all kinds
00:27:14
and the whole word expression off or regulatory sideshow kind did yeah but that
00:27:20
in court blocked them one on a clever cells off noon bar of allergic and healthy mothers
00:27:27
and it was down it after stimulation lists of people henman routine
00:27:34
but there was not a difference in the capacity
00:27:38
of a sideshow kind gene expression in them and
00:27:43
then it's coloured blocks else which better pop culture
00:27:47
this course there are cells of allergic or healthy mothers
00:27:58
and uh also uh and they start it uh the effect of
00:28:04
cost or on a on a production of opinion on global means
00:28:10
by corporate blocks health and they're they're
00:28:13
not the difference in the production of
00:28:17
i a. g. and forming cells but also all of any using ellis bought
00:28:24
they did not find a also a they're a different between
00:28:30
a a a cells of i a. g. n. i. d. g. n. i. g. a. forming cells
00:28:36
average better stimulated by the only problem no active eight or
00:28:43
so
00:28:47
i would like um uh to
00:28:50
stop a showing that i'm breastfeeding
00:28:58
has so many effects by
00:29:01
a really barrios factors present
00:29:05
at on immune system all the info on
00:29:10
uh uh as uh they'll be also a shown in a next that they use
00:29:18
yeah that immune system development training protecting forum apology and
00:29:25
and the influencing the gap micro by author
00:29:29
which b. b. belief ah are the most important
00:29:33
uh saying the beach uh i'm in full and
00:29:37
thing bitch info and uh the life spawn span
00:29:43
and uh the whole a life of a these in finance
00:29:49
but the uh the you have the uh to point out that
00:29:53
the breast feeding has also beneficial
00:29:56
effects on uh the mothers uh it
00:30:02
mainly these cells probably a player all in
00:30:07
uh this is the end of memory go on
00:30:10
a gains infection and and the lactation has a
00:30:15
also profound immune model i'd totally effect on the models
00:30:21
uh and uh it it is interesting yeah they did
00:30:26
it in one is a nation against infants oral cavity microbes
00:30:31
influences also the immune response of the mothers
00:30:37
and it is known uh that uh none of those uh
00:30:42
have the breast feeding harper event in a bit of and tape
00:30:48
again so okay utterance of a breast cancer and over a
00:30:52
concept there are epidemiology studies about this so i would like
00:31:01
a toast saying come my call where 'cause uh
00:31:05
doing the whole life a better thing on these
00:31:10
um aspect mark them now immunity and
00:31:15
mainly a dialogue enormous charming colour ah
00:31:18
cool in these days uh celebrate it
00:31:23
and in very good shape hair nineties and
00:31:27
cool uh uh remember she is sending
00:31:31
the bets giddy thinks it to these people
00:31:35
and uh these are uh uh uh my students uh we're working
00:31:41
in the field and these are a co workers for home institute
00:31:46
of human knowledge and mike about biology in to think what they offer
00:31:51
men see here is our lead back to be half of of course
00:31:56
a very uh they would corporation a very tight cooperation with good
00:32:01
not a biological about thirty but i did not show the results which
00:32:06
yeah which had a consenting to this uh only the asian and now also
00:32:13
the effect of micro bile that on
00:32:16
development of human diseases thank you for attention
00:32:27
it was wonderful to look
00:32:29
you see we have but you have to live with the last one question in terms of
00:32:35
the little blue elegy into action do you have any data on
00:32:42
a presence of g. h. or edison specific
00:32:49
allergens show transported across the possible to do the
00:32:53
the the the heavily backed somewhat religious question to do
00:32:58
o. b. b. not the major i. e. about the v.
00:33:03
a. had shown that there are antibodies present also again i legends
00:33:10
but we don't know the i. e. e. only uh i i and i and
00:33:19
we believe that the the presence on our hands
00:33:23
in a human male is in for them for tolerance in action
00:33:30
but the meeting major the the u. i. e. based on
00:33:35
what is new potential auto response to what this fee and all
00:33:44
can you do to help the although in the on the these i
00:33:50
have and all and all knowledge about uh this sum it in your body
00:33:57
showing other g. s. but uh what do you mean the
00:34:02
the i don't know i mean maybe somebody else okay any questions
00:34:13
uh oh rubber sort of your polish my question
00:34:24
the only one up we yeah actually it for us
00:34:33
or yeah us on there is a a really great difference
00:34:39
in a cologne is asian all the children which better worn by c.
00:34:45
syrians action or not but but but generally and uh this was shown and
00:34:52
it it only eats in some deli that evil
00:34:56
spittle maybe you had about it that they you also
00:35:00
a backchannel some me or a tool
00:35:03
covered a scheme of new warms that'll enable
00:35:09
uh the column is asian which it cares unnaturally
00:35:13
do you think the nature of like the null delivery
00:35:19
would be here more appropriate to the tableau
00:35:22
station also you i just want some new word
00:35:32
i have no problems you though but more so low
00:35:42
he really did not uh
00:35:45
uh and continue because yeah the cup would be on
00:35:49
a lot uh had two children and so she left
00:35:54
and we had not and other student will continue i i hope
00:35:59
to to start this uh news do then but uh she also
00:36:06
had now a baby height will tell it to
00:36:17
oh okay i'm i'm i'm oh what
00:36:25
as you well know ah yeah i just cracked the most number one
00:36:33
sure but very short hop three days people one of the way of you
00:36:42
but it is a switch over from the present right
00:36:49
i'm sure she's told me that ah through
00:36:54
more of our own team i mean everybody
00:36:59
all those gesture of our own also
00:37:03
so what are your results may you
00:37:09
so charge ah system might be your
00:37:16
that's why i was asking girls you because it's a different source so
00:37:20
i wanted to mull over but i think this is interesting because that's not
00:37:25
oh so so so cool you got
00:37:31
from ah um to this committee
00:37:38
the soles so that's all we're using about
00:37:42
yeah i seen this is uh not excluded and a possible but we
00:37:48
believe more in control so the activity had the t. v. in a a
00:37:55
the shoe and the agents and the bacteria or microbial uh antigens
00:38:02
in fact now i i have a year
00:38:06
and a discovered that is a data bases
00:38:11
i have about a local and did yeah and
00:38:14
it's a cross any acting this comments of bacteria antigens
00:38:20
so it is not excluded that this is the uh uh also
00:38:25
one over those souls for in one is asian but of course
00:38:32
although antigens are present because over this as a
00:38:36
as you a tall and on the hot other hand
00:38:41
yeah our uh results from these uh models germ free
00:38:48
because that's been out cost them the better surprise
00:38:53
that between their into all and won't off him in
00:38:57
humble bruins which are form with al known and
00:39:01
to jenny could uh uh on the generates the movie
00:39:05
yeah in this uh more tales about six ally layered placenta re band the
00:39:13
and not only a minimal boring spot owns all a big there and the jets
00:39:19
the you found in the setup that are also although antibodies and to be
00:39:25
a cultivate it is professor our amounts will like it also because the bar
00:39:31
on the regulatory a function of so called
00:39:36
the nature role antibodies and in one on
00:39:40
global links which are present in so called tall tall immune number only in in in humans
00:39:47
but they work mainly in sierra but uh i think that this is a also
00:39:53
uh probably somehow very important that the first uh
00:39:59
and the body specific these which are not high i
00:40:03
think they they are more uh for the the active
00:40:07
but they if the activists all dull antigens
00:40:12
are important information which was what people remember
00:40:15
and that was good result your decisions yeah so what do you mean
00:40:21
ha as well no one should have higher incidence of disease
00:40:29
oh and it's not that you're responsible who's also thought and it's very well
00:40:37
that's true with older people well backs this up
00:40:42
from by g. m. i. g. m. or compliment look giving the oh yes
00:40:52
so i probably i hope it works tremendously important
00:40:57
and the last thing which were going real was once or
00:41:01
twice as much oh gee all other programmers combine multiply by tool
00:41:08
so it is by far the more rooms
00:41:13
i think uh uh in addition to these uh
00:41:17
activities i. e. g. i. is very important in a
00:41:22
in a hole to save strengthening and a body
00:41:27
a function of uh all of new cars all surfaces
00:41:31
so uh uh then uh it is uh that vision
00:41:34
probably most all these comments so buggy up old antigens
00:41:40
can penetrate a into system make
00:41:44
a circulation and induce him human responses
00:41:50
in the middle of the the question is that in a
00:41:53
loose just adjusted these order into borders or absorbed did it
00:41:59
how they ordered lot across from the got it i really
00:42:05
don't know what this ideal desserts large quantities coming call it
00:42:13
out of circulation i don't see i really don't know if uh
00:42:22
somebody in the data i i don't know because the amount of
00:42:29
oh what what would be as you showman others from the good remote control so much so
00:42:39
for so that's sort of what it would be it would i know if i go
00:42:52
i see yeah oh yeah i'll probably will be interesting call so
00:42:57
to just to see the the fate of of these although antibodies
00:43:02
but uh i didn't expect i sing that the them at
00:43:06
costco antibodies and or four factors
00:43:10
are very important the in uh
00:43:14
the local um uh f. x. because
00:43:19
and they act uh in fact uh and they inflammatory
00:43:24
on the place that that is the the this danger of uh infection and so on
00:43:31
so i sing the the uh that
00:43:33
it's very important local a local activity
00:43:39
uh and only maybe fatter they ought to base
00:43:43
uh the uh body of fun function is not the at the uh ooh and ready
00:43:50
and maybe some of the same you know probably into ideally going through that
00:43:56
i don't know about any better uh describing these these
00:44:03
uh activity or duty comments or questions or
00:44:10
uh i just i want to lower the cost
00:44:21
about how much you choose who you e. m. i.
00:44:28
l. r. wrongdoers mao zoom ah i'm out there about speech
00:44:36
a very difficult question i analogue clinician maybe
00:44:42
somebody they'll hans or uh from uh uh
00:44:46
the teller ethical aspect of you it's uh
00:44:52
on one hand it's very important and uh that's that's that it on the other hand
00:44:58
it is a is a very often all soul highlighted a
00:45:02
legend which can induce the yeah these other good v. activities
00:45:08
but i really don't know uh about the the
00:45:11
animals and maybe some connection can on so they
00:45:16
have so and so's mood to more or returns a room that would that would probably know read
00:45:26
oh wow i say something which replace it morally with
00:45:31
ah ah from the intestinal tract of the one where
00:45:37
programs are wow how armed i just get the circulation
00:45:44
depending on the program but somehow along the minus
00:45:47
five of grammar and get the circulation more importantly this
00:45:53
call is from me oak ridge just the colours are mobile right some of them get into the u. s.
00:46:04
action into the middle and the child may become our you know more
00:46:12
no no
00:46:14
or our our solo okay before i or questions or
00:46:26
any for questions and comments yeah
00:46:31
oh sorry to interrupt
00:46:34
or relationship is ordered worries to like you you know you stole it
00:46:43
it is interesting that uh for example in case
00:46:49
all of uh i mean it will age it's awfully styles like
00:46:55
ah now and i think of a like a while come and
00:47:03
and uh the function in it was all that uh
00:47:09
high level i which is not go well all that are in the well uh well
00:47:18
that it's uh somehow but i think that the well
00:47:23
and all uh all in your and other inflammatory diseases
00:47:29
which are in goodies now in incidence in with the
00:47:34
audio count it sort of seems that the uh these uh
00:47:40
activities of uh my while by everything they
00:47:46
is also in or on in in this direction
00:47:51
it is all to it which would do you some good really
00:47:56
it was really rude because uh
00:48:07
oh sh sh sh
00:48:15
ah it's
00:48:18
just think how much ah o. h. uh_huh uh_huh
00:48:26
yeah okay yeah that's your comment will with virginia about fifteen
00:48:32
years that you had to do a coffee break medically related problems
Conference Program
NNIW94 Opening
Dr. Natalia Wagemans, MD
Sept. 23, 2019 · 9 a.m.
Dedication to Lars A Hanson
Pearay L. Ogra
Sept. 23, 2019 · 9:10 a.m.
136 views
Key Note Lecture: The Evolution of Lactation in Mammalian Species
Olav T. Oftedal
Sept. 23, 2019 · 9:29 a.m.
678 views
Immunology of Milk and Lactation: Historical overview
Pearay L. Ogra
Sept. 23, 2019 · 11:01 a.m.
450 views
Common Mucosal Immune System
Jiri Mestecky
Sept. 23, 2019 · 1:03 p.m.
444 views
Immunomodulatory components of Human Colostrum and Milk
Helena Tlaskalova-Hogenova
Sept. 23, 2019 · 1:57 p.m.
481 views
Influence of Breastfeeding on Immune Trajectory and long-term Immune Health
Valerie Verhasselt
Sept. 23, 2019 · 3:33 p.m.
426 views
Milk and immune competence in prevention of allergy and infections
Carine Blanchard
Sept. 23, 2019 · 4:31 p.m.
511 views