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Introduction to Session IV - Decline & Nutritional Intervention
Tamas Bartfai, The Scripps Research Institute, La Jolla, USA
Friday, Oct. 23, 2015 · 12:48 p.m. · 15m 27s
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Um This is the last too long session of
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that was symposium we have three
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speakers will be a address cognitive
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decline and the possibility of
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nutritional intervention my
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introduction to be but it sure because
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this I mean an speakers it all the time
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should you not find that you had enough
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of that it can does lectures that on
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many books by all of them are versus
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reading. I how about not this literally
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page even though it may appear so but
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we have shows that more colour that
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people are that a deal that really
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matters colour this is what we want of
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the and contact come a man and will
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match is you know what is your that low
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well what is your cognitive function
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performance I seen anybody writing
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about having a very high laughed low I
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have four hundred people complaining
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about well that these five all
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continues strangers informative I
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usually want that a compensate for
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changes you know actually yeah you know
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I mean for a spider form of that you is
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not easy to be a it's a serious
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business not the these but the studios
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is this the speakers had talked about
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yeah subsidy studios and complex
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problems affecting the most complex all
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down the brain cannot. And should not
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be expected to be addressed be the
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single magic with that as much as I
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have my up for that and he also meant
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the in in one or two you the the of it
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is Oh my simple introduction is to
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point out to you that you talk about
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them and what they as one important.
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One but perhaps more important aspects
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of cognition one of the speakers will
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use cognitive performance anomaly. But
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my money is very very complex and I
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only want to point out to you that two
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major trinity as many others
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participated before example know that
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more about learning and more really
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alarming can help you to come back in
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application situations. But the two
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most important ones are people compost.
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And now cortex as you would see that
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all about prop one overall. And like
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they transport that affects but
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confines to my money fast speech on I
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the associated that with people
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compound fracture working my money was
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Manson but if we are to believe what
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the market and or those too follow
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that's mostly for power cord because
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same as long as you remember a phone
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number on your violence or one or do of
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course as simple components. So what I
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want to say is that there are many
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aspects and many partly to study the
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but we collectively dig this folks talk
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about my model is make me that bond or
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said that I'll see more daily news your
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segments surely of E systems maybe in
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that that's for the slide is that you
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don't have to remember it's the as and
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the two major antigens to VHB have can
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find that major and most important
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cognitive decline aspects no oh is come
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on of after work not only fines but
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mostly intellectual affords on five the
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QS what at least on the commands as we
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have discussed it progress or Vancouver
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yeah so I mean I like the number of
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ongoing us is mind boggling if you
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think about that the average try are
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not course between four hundred million
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and the one point two billion that
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isn't for this be that on like testing
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if an isolating works which if it's a
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fine make study you'll know in time
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minutes if it is a generalised anxiety
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you know it in fourteen days if you
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want to know if any intervention in my
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cognitive impairment or alzheimer's
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disease even changes the rate of
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decline you have to be be two years
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three years. I remember the first a
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cycling as that is inhibitors like
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David it on billy I on was only six
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months we have to expand it to to a to
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they the study site a into twenty four
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months. And this is not on on spring
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chickens. So there are many other
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reasons by the dropout rate is five so
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they are not only little doubt it was
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so large then they started to add that
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fancy stuff like imaging a two dollars
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and all at a time. And so on. So this
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but I know that the number of thought
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this is mind boggling beach means that
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he by no means have give and are trying
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to find pharmacological interventions
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even though the are painfully a bad off
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that we don't understand what that that
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were that the colour on that but I want
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to remind you that morphine has been
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used for about five thousand years
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without being awaiting the mechanism of
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action how many types of receptors
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effects that what he's done that
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sequence of the and culture knows more
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morphine and carefully and then dolphin
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or the I don't know I think RC and the
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save bills and that's what it is
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incumbent upon everybody not only once
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they've got a a it from a central
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nervous system down. But on anybody
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wants to have this major problem. And
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this growing major problem to try to
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find treatments and I think that will
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be an interaction between I think
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consciously commands and or task force
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to crawl back works to understand
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holiday but certainly this was the case
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with on tips psycho text compromise
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impose made as an on these numbers and
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when it turned out that it has I mean
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that that's like what the got that's
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cool in the back with this covert
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certain aspects of my turn as well. oh
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however when this or this other know
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this about this exam is what we should
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not affect And I spoke with the
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clinical trials the local beach is a
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little bit on probably do what
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professor of all the shows the ones
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that actually interested in studying
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the not that only big problem is that I
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have I on their light is that the power
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of your progress one by at that time
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republicans decide that that it would
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be stored competition. And that for
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profitability all the different
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companies if you disclose on that
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you're try three it was a rugby the
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signal about really small that somebody
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else was just about this one but we don
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dollar what so what is the one and if
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you save them that then they are so why
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that's what on I can really relate to I
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I care about the fish oh well yeah this
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is that we use why they are so it you
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that classical but not that we every E
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back to they legislatively prohibited
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to form you over anything else that
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something which what about a buy that's
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all like to address or be or less
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relation you well that that I can smoke
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for company a dollars then they have to
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do it or whatever. But on it is that if
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they don't company B that was okay but
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that you know one really unlucky forty
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years from now they're no but but but I
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I'm not running for president idea not
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we are changed in what you have done
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this that is that least you know but
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this is the underlying these and by B
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that last one idea she off the there is
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only so this is not a band that we are
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under so that but I don't want a I'd B
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first thought that we do already
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slightly but you blocks combination
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yours start by so this is for example
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would like to try out which is could be
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a prior from that's like it sometimes
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what we should we sure so ah it was
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built in the last forty years after man
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there's change in their expectations
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about diet and do. We use the two
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balance that that they don't they're
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all the Nasa not a lot of the UWG what
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to guide that lots so fast issue dice
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sort of may have something to say and
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back onto the back into thousand that
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with one on the basis of oh it's not
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yes that of course you notes or product
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we have more for more operational and
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yeah only but despite of that you have
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not much more see the assumption about
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four oh yeah do you know only forty
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years. And forty here's in product
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development is less than a of the time
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but it takes to develop on so it's
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incredibly that's not why is that yeah
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it is because of the study which I
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normally or command to you or somebody
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body work study you chose look at all
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but for non hundred trials then by sort
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but I that him to this in grad. However
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F sizes were no more than more
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standardised mean but differences for
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but it's small ad more people main
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sound like why yeah buy Bruno about us
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and by there clearly are required but
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it basically means see is that the
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dietary interventions for the problem
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is he wants that anybody to get that
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would the bull market the components we
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should be chronically admits that and
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all around all these are music to the
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ears of everybody I know I have to be
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was that that maximum cap as the
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because we hope that they are at least
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but the if possibly synergistic
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everything is the greatest you a diet.
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great promise and that four if we are
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willing to spend the money on sample
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sizes and then that duration of the try
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out it may permit to show clinically
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significant that fact even and that's
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more but consistent that that's nice
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And this is why this symposium is so
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important bringing this but three parts
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of this symposium wonderfully shows and
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and represent the several aspect yeah
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shortly introducing them to you the
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first speaker prefer but the problem is
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that you were so university of on and
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in england. And she has recently got
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not price from the largest insurance
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company that's about how people on this
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and the significance and this was well
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we have to be done in the motivation
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this you would recognise tall masts and
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write the guys I did a scroll that's
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fine she "'cause" mind was not good
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enough she is also recognised by many
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others who want to develop something or
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seconds speaker BB along night that was
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organised some of the most influential
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studies in that you and I still would
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be is great on to pick one in each tool
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four speakers number one and number two
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how old are you has some no maybe
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buttons but decide for that single is
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an I Like a man that you look into
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this. But he is one of the major cigars
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behind that we simply about this for
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years fine mesh do you three thinking
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about the guidance on developing blacks
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and or similar to not exactly going and
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I decided that it is bad fourteen years
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to evaluating one years to buy useful
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line some body you can read it this was
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the model the motivation. But that by
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the pursuit of presenting the noble
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assembly for medicinal physiology and
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the price in a more maybe the chemo to
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be members and but then two dollars and
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then for the last be we'll be about man
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morally my money processes and very
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recently inside. This program began
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water have for them would like to ask
Conference Program
Introduction to the 12th Nestlé International Nutrition Symposium
Thomas Beck, NRC Director
Oct. 22, 2015 · 8:57 a.m.
790 views
Introduction to Session I - Cognitive & Brain Development
Susan Gasser, Friedrich Miescher Institute, Basel, Switzerland
Oct. 22, 2015 · 9:04 a.m.
164 views
The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:16 a.m.
398 views
Q&A - The development of a healthy brain
Michael Gazzaniga, University of California, Santa Barbara, USA
Oct. 22, 2015 · 9:56 a.m.
Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 10:49 a.m.
155 views
Q&A - Early influences on brain development and epigenetics
Stephen G. Matthews, University of Toronto, Canada
Oct. 22, 2015 · 11:29 a.m.
Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 11:38 a.m.
226 views
Q&A - Building the physiology of thought
Rebecca Saxe, Massachusetts Institute of Technology, Cambridge, USA
Oct. 22, 2015 · 12:10 p.m.
Introduction to Session II - Cognitive Decline
Kathinka Evers
Oct. 22, 2015 · 2:02 p.m.
Brain health & brain diseases - future perspectives
Richard Frackowiak, CHUV University Hospital, Lausanne, Switzerland
Oct. 22, 2015 · 2:11 p.m.
120 views
Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:15 p.m.
Q&A - Alzheimer's disease: genome-wide clues for novel therapies
Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, USA
Oct. 22, 2015 · 3:59 p.m.
Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:21 p.m.
160 views
Q&A - Immunometabolic regulators of age-related inflammation
Vishwa D. Dixit, Yale School of Medicine, New Haven, USA
Oct. 22, 2015 · 4:59 p.m.
Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
Oct. 23, 2015 · 9 a.m.
Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:16 a.m.
413 views
Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:53 a.m.
Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:29 a.m.
Q&A - Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:57 a.m.
Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:09 a.m.
152 views
Q&A - Nutrition, growth and the developing brain
Prof. Maureen Black, University of Maryland, School of Medicine, Baltimore, USA
Oct. 23, 2015 · 11:49 a.m.
Introduction to Session IV - Decline & Nutritional Intervention
Tamas Bartfai, The Scripps Research Institute, La Jolla, USA
Oct. 23, 2015 · 12:48 p.m.
179 views
On multi-domain approaches for prevention trials
Miia Kivipelto, Karolinska Institutet, Stockholm, Sweden
Oct. 23, 2015 · 1:04 p.m.
218 views
Q&A - On multi-domain approaches for prevention trials
Miia Kivipelto, MD, PhD, Karolinska Institutet
Oct. 23, 2015 · 1:39 p.m.
Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 1:49 p.m.
124 views
Q&A - Methodological challenges in Alzheimer clinical development
Lon S. Schneider, Keck School of Medicine of USC, Los Angeles, USA
Oct. 23, 2015 · 2:32 p.m.
We are what we remember: memory and age related memory disorders
Eric R. Kandel, Columbia University, New York, USA
Oct. 23, 2015 · 3:03 p.m.
230 views
Concluding Remarks
Stefan Catsicas, Chief Technology Officer, Nestlé SA
Oct. 23, 2015 · 3:50 p.m.
168 views