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Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Friday, Oct. 23, 2015 · 9:53 a.m. · 20m 55s
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Very nice over men in next
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presentation. Thank you actually a lot
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of But even also a similar type of
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chemical topics like see it must only
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tabulation crew course with that
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policeman calculate a quantitative also
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quite a quite glycogen story. But I
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didn't hear anything about I think it
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might and so I sure there must be also
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a big role for equipment at least in
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extra side no interaction I totally
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agree I don't again that's why in the
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introduction I trying to say make W and
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is because I'm sure and I think we we
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really know very little about so that
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and I hope this is the beginning for
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opening a number of questions in
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understanding how metabolism work
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particularly interesting is inactivity
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the pattern processes right yeah okay I
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don't know so much into this kind of
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sorry I forgot a natural Stockholm not
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working directly with DC so in order to
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I try to see how the rest will see that
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I see like like to myself. And the
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wonder that is this really memory
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because if I well switch in the I got
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an electric shock and a lot of the
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other oh it's a it sometime costs. And
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like in you again. I didn't see me is
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the number that was so well eh that's
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another see what we reality drive check
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which means that after some time. And
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they start to to actually go in just to
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be sure that actually get shot so I
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kinda want is the switch between this.
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And the problems between four your you
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which ones are a wonderful question I
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yes I mean there are number of
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experiments that that do that or at
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least attempt to do as much as possible
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the first thing I wanna say that there
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is individual variability in Newman
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says in France so some then let's say
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with point six million pairs shock it's
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by which are one single if that they
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don't going for a very long time you
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know we can wait eighteen minutes and
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they don't want to go in and not and
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not the right they way they have a
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latency but that they go man. So first
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of all there is individual variability
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which would be interesting to
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understand why maybe you know this
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curiosity to enter again and the second
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thing is what we need to think the lab
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is exactly what you are saying so we
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don and number of controls and for
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example is it an society is it that you
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know they on more because they are
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anxious but is it memory unexciting. So
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that can be dissected with the number
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of behaviours. And unsightly test for
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example and we see that anxiety tasks
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or not changing a response is yeah they
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have a latency. So with the number of
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test we can can close with with some
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certainty that is more the association
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and the memory of it rather than
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something else that is more controlling
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the expression of that behaviour but
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that I think I wanna say is that we are
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interested very much in this time is
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one important back about and this is
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ensures like the brain remains healthy
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so if it is a single event what happens
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over time is that the memory first
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strengthens without doing anything just
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time I mean something is happening in
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the brain clearly we can talk about
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that perhaps is that yeah division of
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that race maybe implicitly activation
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silly another type of explicit
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deactivation as well. I mean mine very
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what sense if some a close of
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experience has in the time after the
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experience we keep thinking about it.
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So that's so the activation and we have
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starting very much the activation of
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the memory three of the member yeah
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what dollars to the memory trace and
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that is interesting that in the first
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temporal window after the experience
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retrieving the memory makes the memory
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changeable. So memories as I mention
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easily by initially and then become
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stable recipient to interference is and
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the first phase is gene expression and
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so if we wait a few days and we
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interfere with gene expression
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memorised five is not gonna be
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disrupted anymore. And I'm talking
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about tip count so that number is
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considered to be stable but three three
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five makes the memory lay by again and
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again for a limited temperament which
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is I mean interesting time round window
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of opportunity because in that temporal
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we we that we can modulate memory we
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can time that we can we can so for a a
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clean application is very interesting
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what happens we time if we wait several
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weeks. And we retrieve the memory man
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with doesn't does not become anybody
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anymore but is more it becomes more
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prone to extinction meaning if we
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exposed to the context without the
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shot. They actually diminish they avoid
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those response and they to into the
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dark side more quickly exactly what
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what are saying. So that's why I'm
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saying this is an interesting process
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that keeps our our selves say so one of
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those experience should not lead to PD
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the so we I am the changes that
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occurred in the brain need that memory
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to weaken to change the quality and to
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be more sensitive to extinction and
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there for them to explore other places
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the mayor and members of of another six
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P okay we have several questions so I'm
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gonna keep agree but it was interesting
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the short out and I I I I just I don't
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know the yeah yeah ah yeah that's yeah
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I don't know or from the that is
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because we have a you also want to do
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you do some jokes wear for civil
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defence almost what oh oh oh oh oh
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discussion was or is so this is you got
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you of a Selassie this oh this is a
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button was over this structures that
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that's too that it is almost one only
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factor oh yes yeah you're right that's
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actually yeah that's but I don't know O
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you IE oh have you have you C so you
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you buy one know we need a source for a
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lot well that we are not you should not
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one oh I see okay this see important
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issue because finally spot wrong. And
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this and that and you know what as
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going oh oh oh oh oh oh okay well and
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in in that what she wants and this
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services by that and you can buy simple
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to use the money and like you have to
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use on you but I'm oh that's used and
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is gonna concentration has a for the us
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have you have part that you to but
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usually what alright. I that's a little
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to wonderful questions I'm gonna start
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with that you have to to be more read
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the other is that really the longer the
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the my answer. So we don't have to what
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we did was to test whether I do have
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one sector alright you sort receptors
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and immediately has men and we so these
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are local or the it that they old what
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I and I just to try different and we
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found that idea one is that there is
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not for use idea to reset the that
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mediates memory has we didn't as the
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hybrids yeah but definitely I do want
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receptor had no effect. And those that
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to that very different insulin and I do
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wanna sectors lead to grow. And I just
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noticed at least two realises on Monday
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gradation many different and oh or I
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don't think that right right if it if
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in the time and we didn't terrorist
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unit but we know there is that
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distinction between those normal
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directness for the alone we have worked
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extensively on that because actually
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with the reconsideration memory
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retrieval giving the opportunity to
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distract the memories again this was
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talks to be a wonderful potential
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intervention for BT is the as well as
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addiction. So we treat the memory of
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that trauma member becomes lay by we
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block re consolidation things that
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might be good. And proper on honest
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been shown to block three consolidation
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we have no a few condition when we try
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to do you need with about that was
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perfect. So this is not all bad news
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because perhaps reconciliation is
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actually working with the I mean the
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lawn modulate. And I've had that could
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be compounds or intervention that will
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decrease the emulsion on real operation
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of the memory not the content not
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people come for the pen than content we
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don't know that and we are standing now
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experiments to test that but will maybe
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three avoidance propellant injection
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systemic we we have done a lot of
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studies with that no effect what had
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the fact is global gotta gotta sectors
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doc just I you four eight six known
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also as if it place. So that is another
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pathway because is not clearly right
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but more studies need to be done with
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the lactate metabolism we didn't look
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at the consolidation yeah so that could
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be a number of of potential questions
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that and interesting and lastly
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standing all these compounds on fear
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condition task that that I don. T is
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not the yes memories of PBSD are not of
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the same quality of these memories
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right we all started that because we
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wanted to look very consolidation of
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fat. But the more I started that the
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more I know that the memories that are
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pathological like those of the inverted
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you are not of the same quality still
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we could not as the compounds on or
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monthly conditioning members that we
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have to that that a tedious D type of
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models. And then we have the one that
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we actually have a need or or or or
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that or or you yes. I was you you were
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out somebody. But everybody else is
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that you know well question is what oh
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oh oh stores or you know that see that
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oh sure we have to pass that we don't
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know the effect we see they have a very
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strong. But the second thing it they
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probably have to be given together with
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activity. So we cannot just be proper
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analogue weeks later right we need to
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have the memory trace reactivated and
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that's why the reconciliation brought
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about is interesting but I agree with
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you for prevention not after where
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memories consolidated then either has a
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different one what what is from recent
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you you simplistic in part of their he
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can store on normal I remotely and we
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should not remote. But you can that we
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see if we easy. I mean people for what
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I think that's not what we have done
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just you what you have to be losing
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you'll oh what patients are you talking
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about it's it's okay or don okay I
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thought oh I remote vehicle what was
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what right so we we didn't ask you get
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these affect some sort of memory but
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there is a paper from all boards like
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looking at working memory. So it's a
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short term memory effect again
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targeting they campus so there is a lot
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to be done right because working memory
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in numerous is more cortical so we need
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to know more about the region
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specificity time short the bus as long
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as well. But that is these people are
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suggesting that working memory is
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actually block if like which analysis
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Oh on a spectrum SI One would be
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interesting they don't like us so once
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in the on the CC conformal from while.
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she almost have to so inside the cell
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is a series and then you know you can
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do it smart minutes Daniel so
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concentration this increased activity
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if you see this concentration Drexel S
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concentration then celebrates. This
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whole using food industry actually as a
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result select it as signal to result no
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concentration zero it's high
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concentration. So we need to this
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project that's about it one one yes we
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didn't do an experiment the absolutely
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it's a it's a wonderful suggestion with
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the we know that they know now if they
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did I think that blocks but yeah we we
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should do that yeah what what what what
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what what what you do that's true but I
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I don't going for the so and then he's
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like this. And this relates to so
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because oh I just want some of yeah we
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we didn't use high concentrations of
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what I mean it's an easy it's an is
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experiment to do Actually I think a
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very much enjoyed a problem where a lot
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of nutritionists knock your socks I it
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struck me that the second approach you
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could take because your initials that
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shot survival comes in their clothes
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for us and and like at a time. And then
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you do not have access to working sure
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the there are times design what about
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the same way the results the same way
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we didn't have like that within have a
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yeah we we need to ten different types
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of memory different types of memory
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systems the valence clearly if there is
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an emotional valence. That's gonna be
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an interesting set of questions I don't
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know of anybody I mean can be someplace
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preferences being actually started so
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that is a you know and memory come
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evoked by a drug did you use cocaine by
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so and and yeah yeah scrollable well
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cinema we you know like you know it is
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so it's not only have those that one is
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but no I I agree the different types of
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memories needs to be tested to see what
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is the problem well actually two three
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for yeah I so I was different. So and
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you know they're in stock and this was
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different then generating seats fancy
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from like as opposed to like all since
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one goes where rescue than or know that
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they're they're both going into that
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yeah million dollar question I don't
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know if you have lost as expected but
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you know I I give you my answer and
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that yeah okay okay add to that so this
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such as that like it does something
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different than logos right. And so as
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we have seen glucose and others into
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ask site because these from the that as
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a sites are connected to the black. So
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the group as it is entering ostracised
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and there is gonna go like politically
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or it can form glycogen. I mean at one
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point in time. And there's gonna be the
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restoring of the glycogen stores
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probably curiously that that is the
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research was suggesting that so that we
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have enough then to be use. So and then
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lactate transporting to notice is gonna
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be supplying the energy to also volume
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they high oxidative the problem is that
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that we do curly overalls and as I
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mentioned oxidation too much of station
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willing to done. So they like they
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instead of glucose will also have a in
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every docks modulation. And in ensuring
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that ensuring that they'll mail stays
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as is cat for neurons to work well I
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mean prolog stay because when the these
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high energy them and these required the
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note on itself cannot be used so why
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glucose versus glycogen they all are
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entering through astral sites. And one
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can think that are most use when there
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is an activity that that process high
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energy them and we're gonna use we're
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gonna call loopholes in and use like
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like all these this weather was also
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gonna use the glycogen storage
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depending on how much energy is
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required and then like this formation
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and like to disallow supply energy and
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something else for most is system on us
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the functional or were I'm sorry yeah
Conference Program
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Introduction to Session I - Cognitive & Brain Development
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Oct. 22, 2015 · 9:04 a.m.
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The development of a healthy brain
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Q&A - The development of a healthy brain
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Oct. 22, 2015 · 11:38 a.m.
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Q&A - Building the physiology of thought
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Introduction to Session II - Cognitive Decline
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Brain health & brain diseases - future perspectives
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Introduction to Session III - Nutrition & Cognitive Development
Pierre Magistretti, KAUST, Thuwal, Saudi Arabia and EPFL, Lausanne, Switzerland
Oct. 23, 2015 · 9 a.m.
Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:16 a.m.
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Q&A - Energy metabolism in long-term memory formation and enhancement
Cristina M. Alberini, The Center for Neural Science, New York University, USA
Oct. 23, 2015 · 9:53 a.m.
Building the costly human brain: implications for the evolution of slow childhood growth and the origins of diabetes
Christopher Kuzawa, Northwestern University, Evanston, USA
Oct. 23, 2015 · 10:29 a.m.
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Nutrition, growth and the developing brain
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Introduction to Session IV - Decline & Nutritional Intervention
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On multi-domain approaches for prevention trials
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Oct. 23, 2015 · 1:04 p.m.
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We are what we remember: memory and age related memory disorders
Eric R. Kandel, Columbia University, New York, USA
Oct. 23, 2015 · 3:03 p.m.
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Concluding Remarks
Stefan Catsicas, Chief Technology Officer, Nestlé SA
Oct. 23, 2015 · 3:50 p.m.
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